CR20120443A - Derivados de (imidazopirimidina-7-il)-heteroarilamida y su uso como inhibidores de pde10a - Google Patents
Derivados de (imidazopirimidina-7-il)-heteroarilamida y su uso como inhibidores de pde10aInfo
- Publication number
- CR20120443A CR20120443A CR20120443A CR20120443A CR20120443A CR 20120443 A CR20120443 A CR 20120443A CR 20120443 A CR20120443 A CR 20120443A CR 20120443 A CR20120443 A CR 20120443A CR 20120443 A CR20120443 A CR 20120443A
- Authority
- CR
- Costa Rica
- Prior art keywords
- derivatives
- imidazopirimidina
- heteroarilamida
- pde10a inhibitors
- pde10a
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La invención se refiere a nuevos derivados de imidazopirimidina de la fórmula (I) en la que R1, R2 y R8 tienen los significados definidos en la descripción y en las reivindicaciones, así como a sus sales y ésteres fisiológicamente aceptables. Estos compuestos inhiben la PDE10A y pueden utilizarse como medicamentos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10158011 | 2010-03-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20120443A true CR20120443A (es) | 2012-10-11 |
Family
ID=43989818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20120443A CR20120443A (es) | 2010-03-26 | 2012-08-24 | Derivados de (imidazopirimidina-7-il)-heteroarilamida y su uso como inhibidores de pde10a |
Country Status (25)
Country | Link |
---|---|
US (1) | US8410117B2 (es) |
EP (1) | EP2552918B1 (es) |
JP (1) | JP5764196B2 (es) |
KR (1) | KR20130073876A (es) |
CN (1) | CN102791714B (es) |
AR (1) | AR080785A1 (es) |
AU (1) | AU2011231668A1 (es) |
BR (1) | BR112012024199A2 (es) |
CA (1) | CA2786213A1 (es) |
CL (1) | CL2012002497A1 (es) |
CR (1) | CR20120443A (es) |
EC (1) | ECSP12012174A (es) |
ES (1) | ES2478448T3 (es) |
HK (1) | HK1173440A1 (es) |
IL (1) | IL220932A0 (es) |
MA (1) | MA34069B1 (es) |
MX (1) | MX2012010880A (es) |
NZ (1) | NZ600927A (es) |
PE (1) | PE20130382A1 (es) |
RU (1) | RU2562066C2 (es) |
SG (1) | SG183824A1 (es) |
TW (1) | TWI478924B (es) |
UA (1) | UA108640C2 (es) |
WO (1) | WO2011117264A1 (es) |
ZA (1) | ZA201206257B (es) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8772316B2 (en) | 2011-02-18 | 2014-07-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (PDE10A) |
AU2012325909B2 (en) | 2011-10-20 | 2016-06-09 | Glaxosmithkline Llc | Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators |
JP2014530870A (ja) * | 2011-10-20 | 2014-11-20 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | サーチュイン調節因子としての置換された二環式アザ複素環およびアナログ |
EP2768833A4 (en) * | 2011-10-20 | 2015-04-15 | Sirtris Pharmaceuticals Inc | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS MODULATORS OF SIRTUINS |
MX348635B (es) * | 2012-08-17 | 2017-06-22 | Hoffmann La Roche | Proceso para preparación de derivados de ácido pirazol carboxílico. |
WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
MX2015005375A (es) * | 2012-11-07 | 2015-07-21 | Hoffmann La Roche | Compuestos de triazolo. |
CN102964308B (zh) * | 2012-11-30 | 2015-03-18 | 中国药科大学 | 新型嘧啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途 |
AU2014221799B2 (en) * | 2013-02-27 | 2017-09-28 | Mochida Pharmaceutical Co., Ltd. | Novel pyrazole derivative |
WO2014187762A1 (en) | 2013-05-23 | 2014-11-27 | F. Hoffmann-La Roche Ag | 2-phenylimidazo[1,2-a]pyrimidines as imaging agents |
WO2015006689A1 (en) | 2013-07-12 | 2015-01-15 | University Of South Alabama | Treatment and diagnosis of cancer and precancerous conditions using pde10a inhibitors and methods to measure pde10a expression |
CA2920068A1 (en) * | 2013-09-26 | 2015-04-02 | F. Hoffmann-La Roche Ag | Imidazo[1,2-a]pyridin-7-amines as imaging tools |
US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
PL408251A1 (pl) | 2014-05-19 | 2015-11-23 | Celon Pharma Spółka Z Ograniczoną Odpowiedzialnością | Skondensowane pochodne triazolu jako inhibitory fosfodiesterazy 10A |
WO2016017711A1 (ja) * | 2014-07-30 | 2016-02-04 | 持田製薬株式会社 | ピラゾール誘導体の製造方法 |
EP3365340B1 (en) | 2015-10-19 | 2022-08-10 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
MD3377488T2 (ro) | 2015-11-19 | 2023-02-28 | Incyte Corp | Compuși heterociclici ca imunomodulatori |
SG11201805300QA (en) | 2015-12-22 | 2018-07-30 | Incyte Corp | Heterocyclic compounds as immunomodulators |
ES2906460T3 (es) | 2016-05-06 | 2022-04-18 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
US20170342060A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
CA3028685A1 (en) | 2016-06-20 | 2017-12-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
US20180016260A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
ES2941716T3 (es) | 2016-08-29 | 2023-05-25 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
HRP20221216T1 (hr) | 2016-12-22 | 2022-12-23 | Incyte Corporation | Derivati tetrahidro imidazo[4,5-c]piridina kao induktori internalizacije pd-l1 |
US20180179201A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
ES2934230T3 (es) | 2016-12-22 | 2023-02-20 | Incyte Corp | Derivados de benzooxazol como inmunomoduladores |
US20180179179A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
TWI674260B (zh) | 2017-02-01 | 2019-10-11 | 德商菲尼克斯製藥股份有限公司 | 芳基烴受體(AhR)調節劑化合物 |
TWI752155B (zh) * | 2017-02-01 | 2022-01-11 | 德商菲尼克斯製藥股份有限公司 | 芳香烴受體(AhR)調節劑化合物 |
FI3774791T3 (fi) | 2018-03-30 | 2023-03-21 | Incyte Corp | Heterosyklisiä yhdisteitä immunomodulaattoreina |
CN112752756A (zh) | 2018-05-11 | 2021-05-04 | 因赛特公司 | 作为PD-L1免疫调节剂的四氢-咪唑并[4,5-c]吡啶衍生物 |
WO2020094592A1 (en) | 2018-11-06 | 2020-05-14 | H. Lundbeck A/S | Compounds for treating negative symptoms and cognitive impairments |
WO2020094591A1 (en) | 2018-11-06 | 2020-05-14 | H. Lundbeck A/S | Pde10a inhibitors for treating negative symptoms and cognitive impairments in a patient suffering from schizophrenia |
TW202115059A (zh) | 2019-08-09 | 2021-04-16 | 美商英塞特公司 | Pd—1/pd—l1抑制劑之鹽 |
AU2020357514A1 (en) | 2019-09-30 | 2022-04-07 | Incyte Corporation | Pyrido[3,2-d]pyrimidine compounds as immunomodulators |
JP2022553323A (ja) * | 2019-10-21 | 2022-12-22 | エスケー バイオファーマスティカルズ カンパニー リミテッド | 認知障害の予防、軽減又は治療、又は認知機能の改善のためのイミダゾピリミジン又はイミダゾトリアジン化合物の使用 |
WO2021096849A1 (en) | 2019-11-11 | 2021-05-20 | Incyte Corporation | Salts and crystalline forms of a pd-1/pd-l1 inhibitor |
US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
US11760756B2 (en) | 2020-11-06 | 2023-09-19 | Incyte Corporation | Crystalline form of a PD-1/PD-L1 inhibitor |
IL302590A (en) | 2020-11-06 | 2023-07-01 | Incyte Corp | Process for preparing PD-1/PD-L1 inhibitor and salts and crystalline forms thereof |
CN115572282A (zh) * | 2021-07-05 | 2023-01-06 | 华东理工大学 | 含芳杂环结构的吡唑酰胺类化合物及其制备方法和应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES493459A0 (es) | 1980-07-17 | 1981-07-01 | Consejo Superior Investigacion | Procedimiento para la preparacion de 3(6 5)-formilpira- zol-4-carboxilatos de alquilo |
NZ512957A (en) * | 1999-11-10 | 2005-01-28 | Ortho Mcneil Pharm Inc | Substituted 2-aryl-3-(heteroaryl)-imidazo[1,2-a] pyrimidines and their use in inhibiting in vitro secretion of TNF-alpha and IL-1beta to treat neurodegenerative diseases |
AU783521B2 (en) | 2000-05-24 | 2005-11-03 | Merck Sharp & Dohme Limited | 3-phenyl-imidazo-pyrimidine derivatives as ligands for GABA receptors |
US6596731B2 (en) | 2001-03-27 | 2003-07-22 | Hoffmann-La Roche Inc. | Substituted imidazo[1,2-A] pyridine derivatives |
FR2825705B1 (fr) | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
KR20060034303A (ko) * | 2003-07-30 | 2006-04-21 | 라보라토리오스 에스.에이.엘.브이.에이.티., 에스.에이. | 암을 예방하고 치료하기 위한 치환된 이미다조피리미딘 |
US20070032404A1 (en) | 2003-07-31 | 2007-02-08 | Bayer Pharmaceuticals Corporation | Methods for treating diabetes and related disorders using pde10a inhibitors |
WO2007034282A2 (en) * | 2005-09-19 | 2007-03-29 | Pfizer Products Inc. | Diaryl-imidazole compounds condensed with a heterocycle as c3a receptor antagonists |
BRPI0706560A2 (pt) * | 2006-01-17 | 2011-03-29 | Hoffmann La Roche | derivados de aril-isoxazol-4-il-imidazo [1,2-a] piridina úteis para o tratamento de doença de alzheimer por intermédio de receptores gaba |
US7951824B2 (en) | 2006-02-17 | 2011-05-31 | Hoffman-La Roche Inc. | 4-aryl-pyridine-2-carboxyamide derivatives |
ES2689444T3 (es) * | 2006-11-22 | 2018-11-14 | Incyte Holdings Corporation | Imidazotriazinas e imidazopirimidinas como inhibidores de la quinasa |
EP1964841A1 (en) * | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]azine and their use as pharmaceuticals |
DE102007048716A1 (de) * | 2007-10-11 | 2009-04-23 | Merck Patent Gmbh | Imidazo[1,2-a]pyrimidinderivate |
FR2926556B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
TWI501965B (zh) * | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之新穎苯基咪唑衍生物 |
-
2011
- 2011-03-17 US US13/049,941 patent/US8410117B2/en active Active
- 2011-03-22 TW TW100109761A patent/TWI478924B/zh active
- 2011-03-23 ES ES11711068.4T patent/ES2478448T3/es active Active
- 2011-03-23 WO PCT/EP2011/054385 patent/WO2011117264A1/en active Application Filing
- 2011-03-23 BR BR112012024199A patent/BR112012024199A2/pt active Search and Examination
- 2011-03-23 CA CA2786213A patent/CA2786213A1/en not_active Abandoned
- 2011-03-23 PE PE2012001636A patent/PE20130382A1/es not_active Application Discontinuation
- 2011-03-23 RU RU2012143794/04A patent/RU2562066C2/ru not_active IP Right Cessation
- 2011-03-23 EP EP11711068.4A patent/EP2552918B1/en not_active Not-in-force
- 2011-03-23 CN CN201180013745.6A patent/CN102791714B/zh not_active Expired - Fee Related
- 2011-03-23 MA MA35218A patent/MA34069B1/fr unknown
- 2011-03-23 MX MX2012010880A patent/MX2012010880A/es active IP Right Grant
- 2011-03-23 KR KR1020127027825A patent/KR20130073876A/ko not_active Application Discontinuation
- 2011-03-23 UA UAA201211970A patent/UA108640C2/uk unknown
- 2011-03-23 JP JP2013501753A patent/JP5764196B2/ja not_active Expired - Fee Related
- 2011-03-23 SG SG2012064044A patent/SG183824A1/en unknown
- 2011-03-23 AU AU2011231668A patent/AU2011231668A1/en not_active Abandoned
- 2011-03-23 AR ARP110100945A patent/AR080785A1/es unknown
- 2011-03-23 NZ NZ600927A patent/NZ600927A/xx not_active IP Right Cessation
-
2012
- 2012-07-12 IL IL220932A patent/IL220932A0/en unknown
- 2012-08-20 ZA ZA2012/06257A patent/ZA201206257B/en unknown
- 2012-08-24 CR CR20120443A patent/CR20120443A/es unknown
- 2012-09-10 CL CL2012002497A patent/CL2012002497A1/es unknown
- 2012-09-24 EC ECSP12012174 patent/ECSP12012174A/es unknown
-
2013
- 2013-01-15 HK HK13100592.7A patent/HK1173440A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
UA108640C2 (uk) | 2015-05-25 |
ECSP12012174A (es) | 2012-10-30 |
BR112012024199A2 (pt) | 2016-07-05 |
US8410117B2 (en) | 2013-04-02 |
ZA201206257B (en) | 2013-05-29 |
CA2786213A1 (en) | 2011-09-29 |
CL2012002497A1 (es) | 2013-03-22 |
TWI478924B (zh) | 2015-04-01 |
WO2011117264A1 (en) | 2011-09-29 |
RU2012143794A (ru) | 2014-05-10 |
JP5764196B2 (ja) | 2015-08-12 |
SG183824A1 (en) | 2012-10-30 |
MA34069B1 (fr) | 2013-03-05 |
AU2011231668A1 (en) | 2012-07-19 |
EP2552918A1 (en) | 2013-02-06 |
US20110237564A1 (en) | 2011-09-29 |
CN102791714A (zh) | 2012-11-21 |
JP2013523673A (ja) | 2013-06-17 |
TW201136937A (en) | 2011-11-01 |
KR20130073876A (ko) | 2013-07-03 |
RU2562066C2 (ru) | 2015-09-10 |
EP2552918B1 (en) | 2014-06-11 |
HK1173440A1 (en) | 2013-05-16 |
NZ600927A (en) | 2013-08-30 |
ES2478448T3 (es) | 2014-07-22 |
AR080785A1 (es) | 2012-05-09 |
MX2012010880A (es) | 2012-10-15 |
PE20130382A1 (es) | 2013-03-30 |
CN102791714B (zh) | 2015-03-25 |
IL220932A0 (en) | 2012-09-24 |
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