AU2011234415C1 - Bioadhesive compositions of local anaesthetics - Google Patents

Bioadhesive compositions of local anaesthetics Download PDF

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Publication number
AU2011234415C1
AU2011234415C1 AU2011234415A AU2011234415A AU2011234415C1 AU 2011234415 C1 AU2011234415 C1 AU 2011234415C1 AU 2011234415 A AU2011234415 A AU 2011234415A AU 2011234415 A AU2011234415 A AU 2011234415A AU 2011234415 C1 AU2011234415 C1 AU 2011234415C1
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AU
Australia
Prior art keywords
weight
composition according
lamellar
composition
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2011234415A
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English (en)
Other versions
AU2011234415A1 (en
AU2011234415B2 (en
Inventor
Arne Brodin
Jonas Gustafsson
Mark Sundberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Palette Life Sciences AB
Original Assignee
Pharmanest AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44278867&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2011234415(C1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmanest AB filed Critical Pharmanest AB
Publication of AU2011234415A1 publication Critical patent/AU2011234415A1/en
Application granted granted Critical
Publication of AU2011234415B2 publication Critical patent/AU2011234415B2/en
Publication of AU2011234415C1 publication Critical patent/AU2011234415C1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2011234415A 2010-04-01 2011-03-31 Bioadhesive compositions of local anaesthetics Ceased AU2011234415C1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE1050322 2010-04-01
SE1050322-5 2010-04-01
US32542510P 2010-04-19 2010-04-19
US61/325,425 2010-04-19
PCT/EP2011/055025 WO2011121082A1 (en) 2010-04-01 2011-03-31 Bioadhesive compositions of local anaesthetics

Publications (3)

Publication Number Publication Date
AU2011234415A1 AU2011234415A1 (en) 2012-10-18
AU2011234415B2 AU2011234415B2 (en) 2014-04-10
AU2011234415C1 true AU2011234415C1 (en) 2014-07-10

Family

ID=44278867

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011234415A Ceased AU2011234415C1 (en) 2010-04-01 2011-03-31 Bioadhesive compositions of local anaesthetics

Country Status (17)

Country Link
US (1) US20130079371A1 (https=)
EP (1) EP2552409A1 (https=)
JP (1) JP2013523694A (https=)
KR (1) KR20130080435A (https=)
CN (1) CN102869344A (https=)
AU (1) AU2011234415C1 (https=)
BR (1) BR112012024885A2 (https=)
CA (1) CA2794280A1 (https=)
CL (1) CL2012002705A1 (https=)
EA (1) EA201290790A1 (https=)
IL (1) IL222225A0 (https=)
MX (1) MX2012011261A (https=)
NZ (1) NZ602540A (https=)
PH (1) PH12012501887A1 (https=)
SG (1) SG184072A1 (https=)
WO (1) WO2011121082A1 (https=)
ZA (1) ZA201206989B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9642912B2 (en) 2006-03-06 2017-05-09 Crescita Therapeutics Inc. Topical formulations for treating skin conditions
US9308181B2 (en) 2006-03-06 2016-04-12 Nuvo Research Inc. Topical formulations, systems and methods
WO2010033726A2 (en) 2008-09-17 2010-03-25 The Brigham And Women's Hospital, Inc. Drug delivery composition comprising a self-assembled gelator
BR112013008697A2 (pt) 2010-09-24 2016-06-21 Massachusetts Inst Technology géis nanoestruturados capazes de liberação controlada de agentes encapsulados
CN105120839B (zh) * 2013-02-28 2020-07-28 湖州惠中济世生物科技有限公司 可注射长效局麻药半固体制剂及其组成成分
US10220093B2 (en) * 2013-02-28 2019-03-05 Mira Pharma Corporation Long-acting semi-solid lipid formulations
GB201317718D0 (en) 2013-10-07 2013-11-20 Buzzz Pharmaceuticals Ltd Novel formulation
JP6678946B2 (ja) 2015-03-25 2020-04-15 テルモ株式会社 ゲル状局所麻酔剤およびそれを用いたゲル状局所麻酔製剤
EP3375456B1 (en) 2015-11-12 2023-05-03 Terumo Kabushiki Kaisha Sustained-release topically administered agent
US11020410B2 (en) 2017-02-03 2021-06-01 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
US10881745B2 (en) * 2017-05-08 2021-01-05 Alivio Therapeutics, Inc. Formulation of nanostructured gels for increased agent loading and adhesion
JP7046396B2 (ja) 2017-12-06 2022-04-04 湖州惠中濟世生物科技有限公司 注射可能な長時間作用性局所麻酔薬半固形製剤
US10561606B2 (en) 2017-12-06 2020-02-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid gel formulations
US11426418B2 (en) 2017-12-06 2022-08-30 Mira Pharma Corporation Injectable long-acting semi-solid gel formulations
CA3113948A1 (en) 2018-10-11 2020-04-16 Alivio Therapeutics, Inc. Non-injectable hydrogel formulations for smart release
JP2024505227A (ja) * 2021-01-29 2024-02-05 インシツ バイオロジクス、インク． 疼痛の持続的治療のための組成物および方法
CN118697692B (zh) * 2024-06-27 2024-11-26 山东中医药大学附属医院 一种防苦麻醉胶浆剂、方法及应用
CN119587525B (zh) * 2024-11-07 2025-09-05 海南三帝制药有限公司 一种二甲卡因复合制剂及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009408A2 (en) * 2003-06-25 2005-02-03 Alza Corporation Sustained release dosage forms of anesthetics for pain management
WO2007110694A2 (en) * 2005-09-27 2007-10-04 Efrat Biopolymers Ltd. Gelling hydrophobic injectable polymer compositions
US20070280972A1 (en) * 2006-04-25 2007-12-06 Zars, Inc. Adhesive solid gel-forming formulations for dermal drug delivery

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
US5045553A (en) * 1987-06-24 1991-09-03 Fujisawa Pharmaceutical Company, Ltd. Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter
ATE180971T1 (de) * 1994-03-30 1999-06-15 Gs Dev Ab Verwendung von fettsäureester als bioklebstoffe
SE9601421D0 (sv) 1996-04-12 1996-04-12 Astra Ab New composition
BR9711911A (pt) * 1996-10-14 2000-01-18 Kowa Co Anestésico lopcal para uso externo.
EP1594484A2 (en) * 2003-02-17 2005-11-16 Cipla Ltd. Pharmaceutical patch
US20050084508A1 (en) 2003-07-22 2005-04-21 Vancaillie Thierry G. Topical anesthesia formulation for bodily cavities
US9757461B2 (en) * 2005-01-14 2017-09-12 Camurus Ab GnRH analogue formulations
JP4931369B2 (ja) 2005-05-31 2012-05-16 ポーラ化成工業株式会社 リポソームおよびそれを含む処置用の組成物
GB0524958D0 (en) * 2005-12-07 2006-01-18 Pharmakodex Ltd Transdermal administration of active agents
US20070269386A1 (en) * 2006-05-16 2007-11-22 Per Steen New product and use and manufacture thereof
JP5181320B2 (ja) * 2006-10-18 2013-04-10 ニチバン株式会社 皮膚刺激の少ない経皮吸収型製剤
US9918934B2 (en) 2006-12-12 2018-03-20 Edgar Joel Acosta-Zara Linker-based lecithin microemulsion delivery vehicles
US20090247494A1 (en) 2008-04-01 2009-10-01 Phillip Mark Kofsky Omega-3 essential fatty acid composition and method for treatment of anal and colon-rectal disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009408A2 (en) * 2003-06-25 2005-02-03 Alza Corporation Sustained release dosage forms of anesthetics for pain management
WO2007110694A2 (en) * 2005-09-27 2007-10-04 Efrat Biopolymers Ltd. Gelling hydrophobic injectable polymer compositions
US20070280972A1 (en) * 2006-04-25 2007-12-06 Zars, Inc. Adhesive solid gel-forming formulations for dermal drug delivery

Also Published As

Publication number Publication date
AU2011234415A1 (en) 2012-10-18
CN102869344A (zh) 2013-01-09
US20130079371A1 (en) 2013-03-28
ZA201206989B (en) 2014-04-30
PH12012501887A1 (en) 2012-12-17
NZ602540A (en) 2014-05-30
SG184072A1 (en) 2012-10-30
KR20130080435A (ko) 2013-07-12
IL222225A0 (en) 2012-12-31
CL2012002705A1 (es) 2013-02-01
BR112012024885A2 (pt) 2016-06-21
AU2011234415B2 (en) 2014-04-10
EP2552409A1 (en) 2013-02-06
WO2011121082A1 (en) 2011-10-06
EA201290790A1 (ru) 2013-04-30
JP2013523694A (ja) 2013-06-17
CA2794280A1 (en) 2011-10-06
MX2012011261A (es) 2012-12-05

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Legal Events

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DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 02 APR 2014 .

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 02 APR 2014

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired