AU2011234415C1 - Bioadhesive compositions of local anaesthetics - Google Patents

Bioadhesive compositions of local anaesthetics Download PDF

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Publication number
AU2011234415C1
AU2011234415C1 AU2011234415A AU2011234415A AU2011234415C1 AU 2011234415 C1 AU2011234415 C1 AU 2011234415C1 AU 2011234415 A AU2011234415 A AU 2011234415A AU 2011234415 A AU2011234415 A AU 2011234415A AU 2011234415 C1 AU2011234415 C1 AU 2011234415C1
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AU
Australia
Prior art keywords
weight
composition according
lamellar
composition
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2011234415A
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English (en)
Other versions
AU2011234415A1 (en
AU2011234415B2 (en
Inventor
Arne Brodin
Jonas Gustafsson
Mark Sundberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Palette Life Sciences AB
Original Assignee
Pharmanest AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44278867&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2011234415(C1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmanest AB filed Critical Pharmanest AB
Publication of AU2011234415A1 publication Critical patent/AU2011234415A1/en
Publication of AU2011234415B2 publication Critical patent/AU2011234415B2/en
Application granted granted Critical
Publication of AU2011234415C1 publication Critical patent/AU2011234415C1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2011234415A 2010-04-01 2011-03-31 Bioadhesive compositions of local anaesthetics Ceased AU2011234415C1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE1050322-5 2010-04-01
SE1050322 2010-04-01
US32542510P 2010-04-19 2010-04-19
US61/325,425 2010-04-19
PCT/EP2011/055025 WO2011121082A1 (en) 2010-04-01 2011-03-31 Bioadhesive compositions of local anaesthetics

Publications (3)

Publication Number Publication Date
AU2011234415A1 AU2011234415A1 (en) 2012-10-18
AU2011234415B2 AU2011234415B2 (en) 2014-04-10
AU2011234415C1 true AU2011234415C1 (en) 2014-07-10

Family

ID=44278867

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011234415A Ceased AU2011234415C1 (en) 2010-04-01 2011-03-31 Bioadhesive compositions of local anaesthetics

Country Status (17)

Country Link
US (1) US20130079371A1 (https=)
EP (1) EP2552409A1 (https=)
JP (1) JP2013523694A (https=)
KR (1) KR20130080435A (https=)
CN (1) CN102869344A (https=)
AU (1) AU2011234415C1 (https=)
BR (1) BR112012024885A2 (https=)
CA (1) CA2794280A1 (https=)
CL (1) CL2012002705A1 (https=)
EA (1) EA201290790A1 (https=)
IL (1) IL222225A0 (https=)
MX (1) MX2012011261A (https=)
NZ (1) NZ602540A (https=)
PH (1) PH12012501887A1 (https=)
SG (1) SG184072A1 (https=)
WO (1) WO2011121082A1 (https=)
ZA (1) ZA201206989B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9642912B2 (en) 2006-03-06 2017-05-09 Crescita Therapeutics Inc. Topical formulations for treating skin conditions
US9308181B2 (en) 2006-03-06 2016-04-12 Nuvo Research Inc. Topical formulations, systems and methods
WO2010033726A2 (en) 2008-09-17 2010-03-25 The Brigham And Women's Hospital, Inc. Drug delivery composition comprising a self-assembled gelator
JP2013540757A (ja) 2010-09-24 2013-11-07 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド カプセル化された作用物質の放出を制御する能力を有するナノ構造ゲル
JP6363115B2 (ja) * 2013-02-28 2018-07-25 ミラ ファーマ コーポレイション 注射可能局所麻酔半固体製剤およびその組成物
US10220093B2 (en) 2013-02-28 2019-03-05 Mira Pharma Corporation Long-acting semi-solid lipid formulations
GB201317718D0 (en) * 2013-10-07 2013-11-20 Buzzz Pharmaceuticals Ltd Novel formulation
AU2016237984B2 (en) 2015-03-25 2019-01-31 Terumo Kabushiki Kaisha Gel type local anesthetic agent and gel type local anesthetic preparation using same
WO2017082121A1 (ja) 2015-11-12 2017-05-18 テルモ株式会社 徐放性局所投与剤
WO2018144991A1 (en) 2017-02-03 2018-08-09 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
EP3621594A1 (en) * 2017-05-08 2020-03-18 Alivio Therapeutics, Inc. Formulation of nanostructured gels for increased agent loading and adhesion
US10561606B2 (en) 2017-12-06 2020-02-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid gel formulations
EP3720420B1 (en) 2017-12-06 2025-08-27 HuZhou Hui Zhong Ji Shi Biotechnology Co., Ltd. Injectable long-acting local anesthetic semi-solid gel formulations
US11426418B2 (en) 2017-12-06 2022-08-30 Mira Pharma Corporation Injectable long-acting semi-solid gel formulations
CA3113948A1 (en) 2018-10-11 2020-04-16 Alivio Therapeutics, Inc. Non-injectable hydrogel formulations for smart release
EP4284272A4 (en) * 2021-01-29 2024-12-25 Insitu Biologics, Inc. COMPOSITIONS AND METHODS OF SUSTAINED TREATMENT OF PAIN
CN118697692B (zh) * 2024-06-27 2024-11-26 山东中医药大学附属医院 一种防苦麻醉胶浆剂、方法及应用
CN119587525B (zh) * 2024-11-07 2025-09-05 海南三帝制药有限公司 一种二甲卡因复合制剂及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009408A2 (en) * 2003-06-25 2005-02-03 Alza Corporation Sustained release dosage forms of anesthetics for pain management
WO2007110694A2 (en) * 2005-09-27 2007-10-04 Efrat Biopolymers Ltd. Gelling hydrophobic injectable polymer compositions
US20070280972A1 (en) * 2006-04-25 2007-12-06 Zars, Inc. Adhesive solid gel-forming formulations for dermal drug delivery

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
US5045553A (en) * 1987-06-24 1991-09-03 Fujisawa Pharmaceutical Company, Ltd. Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter
JP4137179B2 (ja) * 1994-03-30 2008-08-20 ジーエス ディベロップメント エービー 生物付着性物質としての脂肪酸エステルの使用
SE9601421D0 (sv) * 1996-04-12 1996-04-12 Astra Ab New composition
PL332724A1 (en) * 1996-10-14 1999-10-11 Kowa Co Local anaesthetic for extracorporeal use
WO2004071398A2 (en) * 2003-02-17 2004-08-26 Cipla Ltd Pharmaceutical patch
US20050084508A1 (en) 2003-07-22 2005-04-21 Vancaillie Thierry G. Topical anesthesia formulation for bodily cavities
JP5144277B2 (ja) * 2005-01-14 2013-02-13 カムルス エービー 局所用生体付着性製剤
JP4931369B2 (ja) 2005-05-31 2012-05-16 ポーラ化成工業株式会社 リポソームおよびそれを含む処置用の組成物
GB0524958D0 (en) * 2005-12-07 2006-01-18 Pharmakodex Ltd Transdermal administration of active agents
US20070269386A1 (en) * 2006-05-16 2007-11-22 Per Steen New product and use and manufacture thereof
JP5181320B2 (ja) * 2006-10-18 2013-04-10 ニチバン株式会社 皮膚刺激の少ない経皮吸収型製剤
US9918934B2 (en) 2006-12-12 2018-03-20 Edgar Joel Acosta-Zara Linker-based lecithin microemulsion delivery vehicles
US20090247494A1 (en) 2008-04-01 2009-10-01 Phillip Mark Kofsky Omega-3 essential fatty acid composition and method for treatment of anal and colon-rectal disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009408A2 (en) * 2003-06-25 2005-02-03 Alza Corporation Sustained release dosage forms of anesthetics for pain management
WO2007110694A2 (en) * 2005-09-27 2007-10-04 Efrat Biopolymers Ltd. Gelling hydrophobic injectable polymer compositions
US20070280972A1 (en) * 2006-04-25 2007-12-06 Zars, Inc. Adhesive solid gel-forming formulations for dermal drug delivery

Also Published As

Publication number Publication date
ZA201206989B (en) 2014-04-30
BR112012024885A2 (pt) 2016-06-21
AU2011234415A1 (en) 2012-10-18
CA2794280A1 (en) 2011-10-06
PH12012501887A1 (en) 2012-12-17
SG184072A1 (en) 2012-10-30
AU2011234415B2 (en) 2014-04-10
EA201290790A1 (ru) 2013-04-30
IL222225A0 (en) 2012-12-31
JP2013523694A (ja) 2013-06-17
WO2011121082A1 (en) 2011-10-06
EP2552409A1 (en) 2013-02-06
NZ602540A (en) 2014-05-30
KR20130080435A (ko) 2013-07-12
MX2012011261A (es) 2012-12-05
CL2012002705A1 (es) 2013-02-01
US20130079371A1 (en) 2013-03-28
CN102869344A (zh) 2013-01-09

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Legal Events

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DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 02 APR 2014 .

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 02 APR 2014

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired