JP2016510041A5 - - Google Patents
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- Publication number
- JP2016510041A5 JP2016510041A5 JP2015560385A JP2015560385A JP2016510041A5 JP 2016510041 A5 JP2016510041 A5 JP 2016510041A5 JP 2015560385 A JP2015560385 A JP 2015560385A JP 2015560385 A JP2015560385 A JP 2015560385A JP 2016510041 A5 JP2016510041 A5 JP 2016510041A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- semi
- excipient
- solid gel
- local anesthetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 35
- 239000007787 solid Substances 0.000 claims 25
- 239000000546 pharmaceutical excipient Substances 0.000 claims 24
- 239000003589 local anesthetic agent Substances 0.000 claims 21
- 125000005456 glyceride group Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 238000004090 dissolution Methods 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 3
- 229930195729 fatty acid Natural products 0.000 claims 3
- 239000000194 fatty acid Substances 0.000 claims 3
- 150000004665 fatty acids Chemical class 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- OIQOAYVCKAHSEJ-UHFFFAOYSA-N 2-[2,3-bis(2-hydroxyethoxy)propoxy]ethanol;hexadecanoic acid;octadecanoic acid Chemical compound OCCOCC(OCCO)COCCO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O OIQOAYVCKAHSEJ-UHFFFAOYSA-N 0.000 claims 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000001261 hydroxy acids Chemical class 0.000 claims 2
- 239000002736 nonionic surfactant Substances 0.000 claims 2
- 231100000252 nontoxic Toxicity 0.000 claims 2
- 230000003000 nontoxic effect Effects 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 2
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 claims 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
- VTUSIVBDOCDNHS-UHFFFAOYSA-N Etidocaine Chemical compound CCCN(CC)C(CC)C(=O)NC1=C(C)C=CC=C1C VTUSIVBDOCDNHS-UHFFFAOYSA-N 0.000 claims 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 229960003150 bupivacaine Drugs 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229960003976 etidocaine Drugs 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 239000002563 ionic surfactant Substances 0.000 claims 1
- 229960004194 lidocaine Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960002409 mepivacaine Drugs 0.000 claims 1
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 claims 1
- 229960001549 ropivacaine Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000008299 semisolid dosage form Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361771011P | 2013-02-28 | 2013-02-28 | |
| US61/771,011 | 2013-02-28 | ||
| PCT/US2014/019704 WO2014134586A2 (en) | 2013-02-28 | 2014-02-28 | Injectable long-acting local anesthetic semi-solid formulations and its compostions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016510041A JP2016510041A (ja) | 2016-04-04 |
| JP2016510041A5 true JP2016510041A5 (https=) | 2016-05-19 |
| JP6363115B2 JP6363115B2 (ja) | 2018-07-25 |
Family
ID=50288331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015560385A Expired - Fee Related JP6363115B2 (ja) | 2013-02-28 | 2014-02-28 | 注射可能局所麻酔半固体製剤およびその組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10500281B2 (https=) |
| EP (1) | EP2961380B1 (https=) |
| JP (1) | JP6363115B2 (https=) |
| KR (1) | KR101768843B1 (https=) |
| CN (1) | CN105120839B (https=) |
| AU (1) | AU2014223993B2 (https=) |
| CA (1) | CA2903020C (https=) |
| WO (1) | WO2014134586A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9849180B2 (en) | 2014-09-15 | 2017-12-26 | Hui Rong Shen | Long-acting semi-solid lipid formulations |
| US10220093B2 (en) | 2013-02-28 | 2019-03-05 | Mira Pharma Corporation | Long-acting semi-solid lipid formulations |
| CN105120839B (zh) | 2013-02-28 | 2020-07-28 | 湖州惠中济世生物科技有限公司 | 可注射长效局麻药半固体制剂及其组成成分 |
| KR20180088415A (ko) * | 2015-11-23 | 2018-08-03 | 그레이스 테라퓨틱스 엘엘씨 | 국소적 막형성 스프레이 |
| AU2017261160A1 (en) * | 2016-05-02 | 2018-11-22 | The General Hospital Corporation | Implant surfaces for pain control |
| EP3558279A4 (en) * | 2016-12-26 | 2020-12-02 | Cellix Bio Private Limited | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CHRONIC PAIN |
| JP7046396B2 (ja) * | 2017-12-06 | 2022-04-04 | 湖州惠中濟世生物科技有限公司 | 注射可能な長時間作用性局所麻酔薬半固形製剤 |
| US10561606B2 (en) | 2017-12-06 | 2020-02-18 | Mira Pharma Corporation | Injectable long-acting local anesthetic semi-solid gel formulations |
| US11426418B2 (en) | 2017-12-06 | 2022-08-30 | Mira Pharma Corporation | Injectable long-acting semi-solid gel formulations |
| BR112021004199A2 (pt) | 2018-09-07 | 2021-05-25 | R.P. Scherer Technologies, Llc | estabilização de formas de dosagem à base de lipídio sólido ou semissólido através da cura e da adição de tensoativo(s) de baixo teor de hlb |
| CN113262302B (zh) * | 2020-02-17 | 2022-12-09 | 湖州惠中济世生物科技有限公司 | 可注射长效半固体凝胶制剂 |
| JP2024505227A (ja) * | 2021-01-29 | 2024-02-05 | インシツ バイオロジクス、インク． | 疼痛の持続的治療のための組成物および方法 |
| CA3211413A1 (en) * | 2021-02-18 | 2022-08-25 | Navin Saxena Research And Technology Private Limited | Non-aqueous injectable composition for sustained release of buprenorphine and use thereof |
| JP7802471B2 (ja) * | 2021-08-17 | 2026-01-20 | 株式会社カネカ | 貼付剤、貼付剤の製造方法、加水分解抑制剤、及び加水分解抑制方法 |
| CN121909022A (zh) * | 2024-08-20 | 2026-04-21 | 南光化学制药股份有限公司 | 医药组成物及其粒剂与针剂 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4775659A (en) * | 1985-08-19 | 1988-10-04 | Eli Lilly And Company | Injectable semi-solid formulations |
| SE9200952D0 (sv) | 1992-03-27 | 1992-03-27 | Kabi Pharmacia Ab | Pharmaceutical carrier system containing defined lipids |
| US5700485A (en) | 1992-09-10 | 1997-12-23 | Children's Medical Center Corporation | Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid |
| JPH08143449A (ja) * | 1994-11-17 | 1996-06-04 | Lederle Japan Ltd | 徐放性局所麻酔用注射剤 |
| US6413536B1 (en) | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
| MX9700850A (es) | 1995-06-09 | 1997-09-30 | Euro Celtique Sa | Formulaciones y metodos para proporcionar anestesia local prolongada. |
| GB9610862D0 (en) * | 1996-05-23 | 1996-07-31 | Evans Brian K | Pharmaceutical products |
| CA2304096C (en) | 1997-09-18 | 2003-09-09 | Pacira Pharmaceuticals, Inc. | Sustained-release liposomal anesthetic compositions |
| AU781682B2 (en) * | 2000-03-20 | 2005-06-09 | Zoetis Services Llc | Sustained-release compositions for parenteral administration |
| US6613355B2 (en) | 2000-05-11 | 2003-09-02 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| GB0015617D0 (en) * | 2000-06-26 | 2000-08-16 | Vectura Ltd | Improved preparations for dermal delivery of active substances |
| DE10033059A1 (de) * | 2000-07-07 | 2002-01-31 | Wacker Chemie Gmbh | Komplexe aus gamma-Cyclodextrin und Benzocain, Verfahren zu ihrer Herstellung und ihre Verwendung |
| DE10041478A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
| US20040001889A1 (en) * | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| US20070184089A1 (en) * | 2002-07-15 | 2007-08-09 | Alcon, Inc. | Non-Polymeric Lipophilic Pharmaceutical Implant Compositions for Intraocular Use |
| US8221778B2 (en) | 2005-01-12 | 2012-07-17 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
| US7666914B2 (en) | 2004-06-03 | 2010-02-23 | Richlin David M | Topical preparation and method for transdermal delivery and localization of therapeutic agents |
| GB0524958D0 (en) * | 2005-12-07 | 2006-01-18 | Pharmakodex Ltd | Transdermal administration of active agents |
| LT3085363T (lt) | 2007-03-28 | 2019-06-25 | Innocoll Pharmaceuticals Limited | Vaistų įvedimo priemonė, skirta vietiniam nuskausminimui, vietinei anestezijai arba nervų blokadai |
| SI2440199T1 (sl) * | 2009-06-11 | 2016-05-31 | Photocure Asa | Poltrdni sestavki in farmacevtski proizvodi |
| WO2011075623A1 (en) | 2009-12-18 | 2011-06-23 | Latitude Pharmaceuticals, Inc. | One - phase gel compos ition compri s ing phos pholi pids |
| KR20130080435A (ko) | 2010-04-01 | 2013-07-12 | 파마네스트 아베 | 국소마취의 생체 점착성 조성물 |
| US20140066481A1 (en) * | 2010-04-01 | 2014-03-06 | Pharmanest Ab | Water-Free Pharmaceutical Compositions Suitable for Local Anaesthetics |
| AU2011234492B2 (en) * | 2010-04-01 | 2014-02-27 | Palette Life Sciences AB | Thermogelling anaesthetic compositions |
| CN105120839B (zh) | 2013-02-28 | 2020-07-28 | 湖州惠中济世生物科技有限公司 | 可注射长效局麻药半固体制剂及其组成成分 |
| PT3134068T (pt) | 2014-04-21 | 2021-10-18 | Heron Therapeutics Inc | Sistemas de libertação poliméricos de longa duração |
-
2014
- 2014-02-28 CN CN201480011256.0A patent/CN105120839B/zh active Active
- 2014-02-28 AU AU2014223993A patent/AU2014223993B2/en not_active Ceased
- 2014-02-28 WO PCT/US2014/019704 patent/WO2014134586A2/en not_active Ceased
- 2014-02-28 CA CA2903020A patent/CA2903020C/en not_active Expired - Fee Related
- 2014-02-28 JP JP2015560385A patent/JP6363115B2/ja not_active Expired - Fee Related
- 2014-02-28 EP EP14710751.0A patent/EP2961380B1/en active Active
- 2014-02-28 KR KR1020157026862A patent/KR101768843B1/ko not_active Expired - Fee Related
-
2015
- 2015-08-28 US US14/839,352 patent/US10500281B2/en active Active
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