CN105120839B - 可注射长效局麻药半固体制剂及其组成成分 - Google Patents

可注射长效局麻药半固体制剂及其组成成分 Download PDF

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Publication number
CN105120839B
CN105120839B CN201480011256.0A CN201480011256A CN105120839B CN 105120839 B CN105120839 B CN 105120839B CN 201480011256 A CN201480011256 A CN 201480011256A CN 105120839 B CN105120839 B CN 105120839B
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semi
pharmaceutical composition
solid
semisolid
bupivacaine
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Chinese (zh)
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CN105120839A (zh
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沈惠荣
甘娜
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Huzhou Huizhong Jishi Biotechnology Co ltd
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Huzhou Huizhong Jishi Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pain & Pain Management (AREA)
CN201480011256.0A 2013-02-28 2014-02-28 可注射长效局麻药半固体制剂及其组成成分 Active CN105120839B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361771011P 2013-02-28 2013-02-28
US61/771,011 2013-02-28
PCT/US2014/019704 WO2014134586A2 (en) 2013-02-28 2014-02-28 Injectable long-acting local anesthetic semi-solid formulations and its compostions

Publications (2)

Publication Number Publication Date
CN105120839A CN105120839A (zh) 2015-12-02
CN105120839B true CN105120839B (zh) 2020-07-28

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CN201480011256.0A Active CN105120839B (zh) 2013-02-28 2014-02-28 可注射长效局麻药半固体制剂及其组成成分

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Country Link
US (1) US10500281B2 (https=)
EP (1) EP2961380B1 (https=)
JP (1) JP6363115B2 (https=)
KR (1) KR101768843B1 (https=)
CN (1) CN105120839B (https=)
AU (1) AU2014223993B2 (https=)
CA (1) CA2903020C (https=)
WO (1) WO2014134586A2 (https=)

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* Cited by examiner, † Cited by third party
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JP6363115B2 (ja) 2013-02-28 2018-07-25 ミラ ファーマ コーポレイション 注射可能局所麻酔半固体製剤およびその組成物
US9849180B2 (en) * 2014-09-15 2017-12-26 Hui Rong Shen Long-acting semi-solid lipid formulations
US10220093B2 (en) 2013-02-28 2019-03-05 Mira Pharma Corporation Long-acting semi-solid lipid formulations
JP7145363B2 (ja) * 2015-11-23 2022-10-03 グレイス セラピューティクス インコーポレイテッド 局所皮膜形成スプレー
EP3452119A1 (en) * 2016-05-02 2019-03-13 The General Hospital Corporation Implant surfaces for pain control
KR102442753B1 (ko) * 2016-12-26 2022-09-16 셀릭스 바이오 프라이빗 리미티드 만성 통증 치료를 위한 화합물
US10561606B2 (en) 2017-12-06 2020-02-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid gel formulations
US11426418B2 (en) 2017-12-06 2022-08-30 Mira Pharma Corporation Injectable long-acting semi-solid gel formulations
EP3720420B1 (en) * 2017-12-06 2025-08-27 HuZhou Hui Zhong Ji Shi Biotechnology Co., Ltd. Injectable long-acting local anesthetic semi-solid gel formulations
EP3846852A4 (en) 2018-09-07 2022-06-15 R.P. Scherer Technologies, LLC Solid or semisolid lipid based dosage form stabilization through curing and addition of low hlb surfactant(s)
CN113262302B (zh) * 2020-02-17 2022-12-09 湖州惠中济世生物科技有限公司 可注射长效半固体凝胶制剂
EP4284272A4 (en) * 2021-01-29 2024-12-25 Insitu Biologics, Inc. COMPOSITIONS AND METHODS OF SUSTAINED TREATMENT OF PAIN
WO2022175974A1 (en) * 2021-02-18 2022-08-25 Navin Saxena Research And Technology Private Limited Non-aqueous injectable composition for sustained release of buprenorphine and use thereof
JP7802471B2 (ja) * 2021-08-17 2026-01-20 株式会社カネカ 貼付剤、貼付剤の製造方法、加水分解抑制剤、及び加水分解抑制方法
WO2026040167A1 (zh) * 2024-08-20 2026-02-26 南光化学制药股份有限公司 医药组成物及其粒剂与针剂

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WO2007066148A1 (en) * 2005-12-07 2007-06-14 Pharmakodex Ltd Transdermal administration of active agents , in particular diclofenac
CN102458388A (zh) * 2009-06-11 2012-05-16 光治疗Asa公司 半固体组合物及药物制品
CN102858374A (zh) * 2010-04-01 2013-01-02 帕玛内斯特公司 热胶凝麻醉剂组合物
CN102869344A (zh) * 2010-04-01 2013-01-09 帕玛内斯特公司 局部麻醉剂的生物黏附性组合物
CN102892408A (zh) * 2010-04-01 2013-01-23 帕玛内斯特公司 适于局部麻醉剂的无水药物组合物

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JPH08143449A (ja) * 1994-11-17 1996-06-04 Lederle Japan Ltd 徐放性局所麻酔用注射剤
US6413536B1 (en) 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
NZ311474A (en) 1995-06-09 1997-09-22 Euro Celtique Sa Formulations for providing prolonged local anesthesia
GB9610862D0 (en) * 1996-05-23 1996-07-31 Evans Brian K Pharmaceutical products
EP2198854B1 (en) 1997-09-18 2011-11-30 Pacira Pharmaceuticals, Inc. Sustained-release liposomal anesthetic compositions
AU781682B2 (en) * 2000-03-20 2005-06-09 Zoetis Services Llc Sustained-release compositions for parenteral administration
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GB0015617D0 (en) * 2000-06-26 2000-08-16 Vectura Ltd Improved preparations for dermal delivery of active substances
DE10033059A1 (de) * 2000-07-07 2002-01-31 Wacker Chemie Gmbh Komplexe aus gamma-Cyclodextrin und Benzocain, Verfahren zu ihrer Herstellung und ihre Verwendung
DE10041478A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
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US20070184089A1 (en) * 2002-07-15 2007-08-09 Alcon, Inc. Non-Polymeric Lipophilic Pharmaceutical Implant Compositions for Intraocular Use
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EP3085363B1 (en) * 2007-03-28 2019-03-20 Innocoll Pharmaceuticals Limited A drug delivery device for providing local analgesia, local anesthesia or nerve blockade
CN102933200B (zh) 2009-12-18 2015-11-25 莱迪杜德制药公司 包含磷脂的单相凝胶组合物
JP6363115B2 (ja) 2013-02-28 2018-07-25 ミラ ファーマ コーポレイション 注射可能局所麻酔半固体製剤およびその組成物
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WO2007066148A1 (en) * 2005-12-07 2007-06-14 Pharmakodex Ltd Transdermal administration of active agents , in particular diclofenac
CN102458388A (zh) * 2009-06-11 2012-05-16 光治疗Asa公司 半固体组合物及药物制品
CN102858374A (zh) * 2010-04-01 2013-01-02 帕玛内斯特公司 热胶凝麻醉剂组合物
CN102869344A (zh) * 2010-04-01 2013-01-09 帕玛内斯特公司 局部麻醉剂的生物黏附性组合物
CN102892408A (zh) * 2010-04-01 2013-01-23 帕玛内斯特公司 适于局部麻醉剂的无水药物组合物

Also Published As

Publication number Publication date
CN105120839A (zh) 2015-12-02
KR101768843B1 (ko) 2017-08-17
JP2016510041A (ja) 2016-04-04
CA2903020A1 (en) 2014-09-04
CA2903020C (en) 2019-06-18
EP2961380A2 (en) 2016-01-06
AU2014223993A1 (en) 2015-10-15
EP2961380B1 (en) 2020-04-08
US20150366967A1 (en) 2015-12-24
KR20150126375A (ko) 2015-11-11
WO2014134586A2 (en) 2014-09-04
US10500281B2 (en) 2019-12-10
JP6363115B2 (ja) 2018-07-25
WO2014134586A3 (en) 2014-11-06
AU2014223993B2 (en) 2016-09-08

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Applicant before: MIRA PHARMA Corp.

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