JP6363115B2 - 注射可能局所麻酔半固体製剤およびその組成物 - Google Patents

注射可能局所麻酔半固体製剤およびその組成物 Download PDF

Info

Publication number
JP6363115B2
JP6363115B2 JP2015560385A JP2015560385A JP6363115B2 JP 6363115 B2 JP6363115 B2 JP 6363115B2 JP 2015560385 A JP2015560385 A JP 2015560385A JP 2015560385 A JP2015560385 A JP 2015560385A JP 6363115 B2 JP6363115 B2 JP 6363115B2
Authority
JP
Japan
Prior art keywords
semi
solid
pharmaceutical composition
bupivacaine
glyceryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2015560385A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016510041A (ja
JP2016510041A5 (https=
Inventor
フイ ロン シェン，
フイ ロン シェン，
ナ ガン，
ナ ガン，
Original Assignee
ミラ ファーマ コーポレイション
ミラ ファーマ コーポレイション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ミラ ファーマ コーポレイション, ミラ ファーマ コーポレイション filed Critical ミラ ファーマ コーポレイション
Publication of JP2016510041A publication Critical patent/JP2016510041A/ja
Publication of JP2016510041A5 publication Critical patent/JP2016510041A5/ja
Application granted granted Critical
Publication of JP6363115B2 publication Critical patent/JP6363115B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pain & Pain Management (AREA)
JP2015560385A 2013-02-28 2014-02-28 注射可能局所麻酔半固体製剤およびその組成物 Expired - Fee Related JP6363115B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361771011P 2013-02-28 2013-02-28
US61/771,011 2013-02-28
PCT/US2014/019704 WO2014134586A2 (en) 2013-02-28 2014-02-28 Injectable long-acting local anesthetic semi-solid formulations and its compostions

Publications (3)

Publication Number Publication Date
JP2016510041A JP2016510041A (ja) 2016-04-04
JP2016510041A5 JP2016510041A5 (https=) 2016-05-19
JP6363115B2 true JP6363115B2 (ja) 2018-07-25

Family

ID=50288331

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015560385A Expired - Fee Related JP6363115B2 (ja) 2013-02-28 2014-02-28 注射可能局所麻酔半固体製剤およびその組成物

Country Status (8)

Country Link
US (1) US10500281B2 (https=)
EP (1) EP2961380B1 (https=)
JP (1) JP6363115B2 (https=)
KR (1) KR101768843B1 (https=)
CN (1) CN105120839B (https=)
AU (1) AU2014223993B2 (https=)
CA (1) CA2903020C (https=)
WO (1) WO2014134586A2 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9849180B2 (en) 2014-09-15 2017-12-26 Hui Rong Shen Long-acting semi-solid lipid formulations
US10220093B2 (en) 2013-02-28 2019-03-05 Mira Pharma Corporation Long-acting semi-solid lipid formulations
CN105120839B (zh) 2013-02-28 2020-07-28 湖州惠中济世生物科技有限公司 可注射长效局麻药半固体制剂及其组成成分
KR20180088415A (ko) * 2015-11-23 2018-08-03 그레이스 테라퓨틱스 엘엘씨 국소적 막형성 스프레이
AU2017261160A1 (en) * 2016-05-02 2018-11-22 The General Hospital Corporation Implant surfaces for pain control
EP3558279A4 (en) * 2016-12-26 2020-12-02 Cellix Bio Private Limited COMPOSITIONS AND METHODS FOR THE TREATMENT OF CHRONIC PAIN
JP7046396B2 (ja) * 2017-12-06 2022-04-04 湖州惠中濟世生物科技有限公司 注射可能な長時間作用性局所麻酔薬半固形製剤
US10561606B2 (en) 2017-12-06 2020-02-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid gel formulations
US11426418B2 (en) 2017-12-06 2022-08-30 Mira Pharma Corporation Injectable long-acting semi-solid gel formulations
BR112021004199A2 (pt) 2018-09-07 2021-05-25 R.P. Scherer Technologies, Llc estabilização de formas de dosagem à base de lipídio sólido ou semissólido através da cura e da adição de tensoativo(s) de baixo teor de hlb
CN113262302B (zh) * 2020-02-17 2022-12-09 湖州惠中济世生物科技有限公司 可注射长效半固体凝胶制剂
JP2024505227A (ja) * 2021-01-29 2024-02-05 インシツ バイオロジクス、インク． 疼痛の持続的治療のための組成物および方法
CA3211413A1 (en) * 2021-02-18 2022-08-25 Navin Saxena Research And Technology Private Limited Non-aqueous injectable composition for sustained release of buprenorphine and use thereof
JP7802471B2 (ja) * 2021-08-17 2026-01-20 株式会社カネカ 貼付剤、貼付剤の製造方法、加水分解抑制剤、及び加水分解抑制方法
CN121909022A (zh) * 2024-08-20 2026-04-21 南光化学制药股份有限公司 医药组成物及其粒剂与针剂

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775659A (en) * 1985-08-19 1988-10-04 Eli Lilly And Company Injectable semi-solid formulations
SE9200952D0 (sv) 1992-03-27 1992-03-27 Kabi Pharmacia Ab Pharmaceutical carrier system containing defined lipids
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
JPH08143449A (ja) * 1994-11-17 1996-06-04 Lederle Japan Ltd 徐放性局所麻酔用注射剤
US6413536B1 (en) 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
MX9700850A (es) 1995-06-09 1997-09-30 Euro Celtique Sa Formulaciones y metodos para proporcionar anestesia local prolongada.
GB9610862D0 (en) * 1996-05-23 1996-07-31 Evans Brian K Pharmaceutical products
CA2304096C (en) 1997-09-18 2003-09-09 Pacira Pharmaceuticals, Inc. Sustained-release liposomal anesthetic compositions
AU781682B2 (en) * 2000-03-20 2005-06-09 Zoetis Services Llc Sustained-release compositions for parenteral administration
US6613355B2 (en) 2000-05-11 2003-09-02 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
GB0015617D0 (en) * 2000-06-26 2000-08-16 Vectura Ltd Improved preparations for dermal delivery of active substances
DE10033059A1 (de) * 2000-07-07 2002-01-31 Wacker Chemie Gmbh Komplexe aus gamma-Cyclodextrin und Benzocain, Verfahren zu ihrer Herstellung und ihre Verwendung
DE10041478A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US20070184089A1 (en) * 2002-07-15 2007-08-09 Alcon, Inc. Non-Polymeric Lipophilic Pharmaceutical Implant Compositions for Intraocular Use
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US7666914B2 (en) 2004-06-03 2010-02-23 Richlin David M Topical preparation and method for transdermal delivery and localization of therapeutic agents
GB0524958D0 (en) * 2005-12-07 2006-01-18 Pharmakodex Ltd Transdermal administration of active agents
LT3085363T (lt) 2007-03-28 2019-06-25 Innocoll Pharmaceuticals Limited Vaistų įvedimo priemonė, skirta vietiniam nuskausminimui, vietinei anestezijai arba nervų blokadai
SI2440199T1 (sl) * 2009-06-11 2016-05-31 Photocure Asa Poltrdni sestavki in farmacevtski proizvodi
WO2011075623A1 (en) 2009-12-18 2011-06-23 Latitude Pharmaceuticals, Inc. One - phase gel compos ition compri s ing phos pholi pids
KR20130080435A (ko) 2010-04-01 2013-07-12 파마네스트 아베 국소마취의 생체 점착성 조성물
US20140066481A1 (en) * 2010-04-01 2014-03-06 Pharmanest Ab Water-Free Pharmaceutical Compositions Suitable for Local Anaesthetics
AU2011234492B2 (en) * 2010-04-01 2014-02-27 Palette Life Sciences AB Thermogelling anaesthetic compositions
CN105120839B (zh) 2013-02-28 2020-07-28 湖州惠中济世生物科技有限公司 可注射长效局麻药半固体制剂及其组成成分
PT3134068T (pt) 2014-04-21 2021-10-18 Heron Therapeutics Inc Sistemas de libertação poliméricos de longa duração

Also Published As

Publication number Publication date
AU2014223993A1 (en) 2015-10-15
JP2016510041A (ja) 2016-04-04
KR20150126375A (ko) 2015-11-11
US20150366967A1 (en) 2015-12-24
EP2961380A2 (en) 2016-01-06
WO2014134586A2 (en) 2014-09-04
CN105120839A (zh) 2015-12-02
WO2014134586A3 (en) 2014-11-06
CA2903020A1 (en) 2014-09-04
KR101768843B1 (ko) 2017-08-17
CA2903020C (en) 2019-06-18
AU2014223993B2 (en) 2016-09-08
EP2961380B1 (en) 2020-04-08
US10500281B2 (en) 2019-12-10
CN105120839B (zh) 2020-07-28

Similar Documents

Publication Publication Date Title
JP6363115B2 (ja) 注射可能局所麻酔半固体製剤およびその組成物
JP2022017553A (ja) 長期作用性ポリマー送達系
JP2007521225A (ja) 疼痛を管理するための麻酔薬の徐放性剤形
US10561606B2 (en) Injectable long-acting local anesthetic semi-solid gel formulations
JP6417327B2 (ja) オピオイド製剤
EP3846811A1 (en) Post-surgical pain treatment
US10220093B2 (en) Long-acting semi-solid lipid formulations
US11426418B2 (en) Injectable long-acting semi-solid gel formulations
CN113262302B (zh) 可注射长效半固体凝胶制剂
EP3720420B1 (en) Injectable long-acting local anesthetic semi-solid gel formulations
KR102912936B1 (ko) 통증 치료용 제약 조성물
US9849180B2 (en) Long-acting semi-solid lipid formulations
HK1150982B (en) Low viscosity liquid polymeric delivery system

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151022

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20151022

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160304

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160812

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161114

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161215

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170314

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170613

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170711

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171226

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180322

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180510

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20180605

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180627

R150 Certificate of patent or registration of utility model

Ref document number: 6363115

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees