JP2013523619A5 - - Google Patents
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- Publication number
- JP2013523619A5 JP2013523619A5 JP2013500535A JP2013500535A JP2013523619A5 JP 2013523619 A5 JP2013523619 A5 JP 2013523619A5 JP 2013500535 A JP2013500535 A JP 2013500535A JP 2013500535 A JP2013500535 A JP 2013500535A JP 2013523619 A5 JP2013523619 A5 JP 2013523619A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- ethoxy
- carboxy
- butanoyl
- acetyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 183
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 174
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 127
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 87
- -1 X 20 Chemical compound 0.000 claims 51
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 45
- 229960004666 glucagon Drugs 0.000 claims 43
- 108060003199 Glucagon Proteins 0.000 claims 27
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 21
- 229910052757 nitrogen Inorganic materials 0.000 claims 12
- 208000013016 Hypoglycemia Diseases 0.000 claims 10
- 230000002218 hypoglycaemic effect Effects 0.000 claims 8
- 150000001413 amino acids Chemical group 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
- 102000051325 Glucagon Human genes 0.000 claims 5
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 5
- 208000002705 Glucose Intolerance Diseases 0.000 claims 4
- 239000004472 Lysine Substances 0.000 claims 4
- 201000009104 prediabetes syndrome Diseases 0.000 claims 4
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 3
- 208000008589 Obesity Diseases 0.000 claims 3
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 3
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Substances N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 235000020824 obesity Nutrition 0.000 claims 3
- 229960003104 ornithine Drugs 0.000 claims 3
- 208000032841 Bulimia Diseases 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- 206010033307 Overweight Diseases 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 229940125396 insulin Drugs 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010004716 Binge eating Diseases 0.000 claims 1
- 206010006550 Bulimia nervosa Diseases 0.000 claims 1
- 206010010356 Congenital anomaly Diseases 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- 206010061818 Disease progression Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 1
- 206010018464 Glycogen storage disease type I Diseases 0.000 claims 1
- 206010019708 Hepatic steatosis Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 102100040918 Pro-glucagon Human genes 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 235000021407 appetite control Nutrition 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 229940097320 beta blocking agent Drugs 0.000 claims 1
- 208000014679 binge eating disease Diseases 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000005750 disease progression Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000005516 engineering process Methods 0.000 claims 1
- 230000037406 food intake Effects 0.000 claims 1
- 235000012631 food intake Nutrition 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 201000004541 glycogen storage disease I Diseases 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000007689 inspection Methods 0.000 claims 1
- 206010022498 insulinoma Diseases 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
- 208000021255 pancreatic insulinoma Diseases 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000035935 pregnancy Effects 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000036186 satiety Effects 0.000 claims 1
- 235000019627 satiety Nutrition 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
- WTNGPLGFFGCYMU-ZQWQDMLBSA-N CC([C@H](CCCCNC(CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(COCCOCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)=O)NC)=O Chemical compound CC([C@H](CCCCNC(CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(COCCOCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)=O)NC)=O WTNGPLGFFGCYMU-ZQWQDMLBSA-N 0.000 description 1
- RUKXKBJQLHBSJS-KDHDBVBQSA-N CN[C@@H](CCCCNC(CC[C@@H](C(O)=O)NC(CCC(C(O)=O)NC(COCCOCCNC(COCCOCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCOc(cc1)ccc1C(O)=O)=O)=O)=O)=O)=O)=O)C(C=C)=O Chemical compound CN[C@@H](CCCCNC(CC[C@@H](C(O)=O)NC(CCC(C(O)=O)NC(COCCOCCNC(COCCOCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCOc(cc1)ccc1C(O)=O)=O)=O)=O)=O)=O)=O)C(C=C)=O RUKXKBJQLHBSJS-KDHDBVBQSA-N 0.000 description 1
- 0 CN[C@@](CCCCNC(CC[C@@](C(O)=O)NC(CCC(CO)NC(COCCOCCNC(COCCOCCNC(CC[C@@](*(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)=O)=O)C(*)=O Chemical compound CN[C@@](CCCCNC(CC[C@@](C(O)=O)NC(CCC(CO)NC(COCCOCCNC(COCCOCCNC(CC[C@@](*(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)=O)=O)C(*)=O 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10157901.9 | 2010-03-26 | ||
| EP10157901 | 2010-03-26 | ||
| US31999410P | 2010-04-01 | 2010-04-01 | |
| US61/319,994 | 2010-04-01 | ||
| PCT/EP2011/054714 WO2011117416A1 (en) | 2010-03-26 | 2011-03-28 | Novel glucagon analogues |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016141243A Division JP2016183192A (ja) | 2010-03-26 | 2016-07-19 | 新規のグルカゴンアナログ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013523619A JP2013523619A (ja) | 2013-06-17 |
| JP2013523619A5 true JP2013523619A5 (enExample) | 2014-05-22 |
| JP6026993B2 JP6026993B2 (ja) | 2016-11-16 |
Family
ID=42710766
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013500534A Expired - Fee Related JP6054861B2 (ja) | 2010-03-26 | 2011-03-28 | 新規のグルカゴン類似体 |
| JP2013500535A Expired - Fee Related JP6026993B2 (ja) | 2010-03-26 | 2011-03-28 | 新規のグルカゴンアナログ |
| JP2016141243A Withdrawn JP2016183192A (ja) | 2010-03-26 | 2016-07-19 | 新規のグルカゴンアナログ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013500534A Expired - Fee Related JP6054861B2 (ja) | 2010-03-26 | 2011-03-28 | 新規のグルカゴン類似体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016141243A Withdrawn JP2016183192A (ja) | 2010-03-26 | 2016-07-19 | 新規のグルカゴンアナログ |
Country Status (12)
| Country | Link |
|---|---|
| US (8) | US20130143798A1 (enExample) |
| EP (2) | EP2552950A1 (enExample) |
| JP (3) | JP6054861B2 (enExample) |
| KR (1) | KR20130018410A (enExample) |
| CN (2) | CN102918055B (enExample) |
| AU (1) | AU2011231503C1 (enExample) |
| BR (1) | BR112012024379A2 (enExample) |
| CA (1) | CA2792663A1 (enExample) |
| MX (1) | MX336412B (enExample) |
| RU (1) | RU2559320C2 (enExample) |
| WO (2) | WO2011117416A1 (enExample) |
| ZA (1) | ZA201206838B (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2013145013A (ru) * | 2011-03-28 | 2015-05-10 | Ново Нордиск А/С | Новые аналоги глюкагона |
| HRP20181591T1 (hr) | 2011-06-10 | 2018-11-30 | Hanmi Science Co., Ltd. | Novi derivati oksintomodulina i farmaceutski pripravci za liječenje pretilosti koji ih sadrže |
| TWI601744B (zh) | 2011-06-17 | 2017-10-11 | 韓美科學股份有限公司 | 包含調酸素與免疫球蛋白片段之複合物及其用途 |
| MX354705B (es) | 2011-09-23 | 2018-03-16 | Novo Nordisk As | Analogos de glucagon novedosos. |
| JP2015525226A (ja) * | 2012-06-14 | 2015-09-03 | サノフイ | エキセンディン−４ペプチドアナログ |
| NZ704043A (en) * | 2012-07-23 | 2017-07-28 | Zealand Pharma As | Glucagon analogues |
| KR101968344B1 (ko) | 2012-07-25 | 2019-04-12 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| KR101993393B1 (ko) | 2012-11-06 | 2019-10-01 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물 |
| EA039082B1 (ru) | 2012-11-06 | 2021-12-01 | Ханми Фарм. Ко., Лтд. | Жидкая композиция белкового конъюгата, содержащего оксинтомодулин и фрагмент иммуноглобулина |
| WO2014081872A1 (en) | 2012-11-20 | 2014-05-30 | Mederis Diabetes, Llc | Improved peptide pharmaceuticals for insulin resistance |
| HUE035803T2 (en) | 2012-12-21 | 2018-05-28 | Sanofi Sa | Dual GLP1 / GIP or trigonal GLP1 / GIP / glucagon agonists |
| US10450343B2 (en) | 2013-03-21 | 2019-10-22 | Sanofi-Aventis Deutschland Gmbh | Synthesis of cyclic imide containing peptide products |
| HUE034308T2 (en) | 2013-03-21 | 2018-02-28 | Sanofi Aventis Deutschland | Preparation of hydantoin-containing peptide products |
| AR095986A1 (es) | 2013-04-03 | 2015-11-25 | Sanofi Sa | Proteínas modificadas que regulan glucosa en sangre con perfil alterado de actividad farmacológica y preparación de las mismas |
| BR112015025464A2 (pt) * | 2013-04-18 | 2017-10-10 | Novo Nordisk As | coagonistas do receptor de glp-1/glucagon estáveis, prolongados para uso médico |
| HUE045573T2 (hu) * | 2013-04-18 | 2020-01-28 | Novo Nordisk As | Stabil, hosszú hatóidejû GLP-1/glükagon receptor ko-agonisták, gyógyászati alkalmazásra |
| AU2014283221A1 (en) | 2013-06-20 | 2015-12-03 | Novo Nordisk A/S | GLP-1 derivatives and uses thereof |
| GB201315335D0 (en) * | 2013-08-29 | 2013-10-09 | Of Singapore | Amino diacids containing peptide modifiers |
| AR098065A1 (es) | 2013-10-17 | 2016-04-27 | Zealand Pharma As | Análogos de glucagón acilados |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
| AU2014345570B2 (en) * | 2013-11-06 | 2019-01-24 | Zealand Pharma A/S | Glucagon-GLP-1-GIP triple agonist compounds |
| CA2929459C (en) | 2013-11-06 | 2022-05-03 | Zealand Pharma A/S | Gip-glp-1 dual agonist compounds and methods |
| WO2015086731A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists |
| TW201609797A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重ｇｌｐ－１／升糖素受體促效劑 |
| EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
| AR098616A1 (es) * | 2013-12-18 | 2016-06-01 | Lilly Co Eli | Péptido para el tratamiento de hipoglicemia severa |
| AR100306A1 (es) | 2014-02-18 | 2016-09-28 | Novo Nordisk As | Análogos de glucagón estables y uso para el tratamiento de la hipoglucemia |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| JP2017525656A (ja) * | 2014-06-04 | 2017-09-07 | ノヴォ ノルディスク アー／エス | 医療用のｇｌｐ−１／グルカゴン受容体コアゴニスト |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| TWI772252B (zh) | 2014-09-16 | 2022-08-01 | 南韓商韓美藥品股份有限公司 | 長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途 |
| JP2017536343A (ja) * | 2014-10-10 | 2017-12-07 | ノヴォ ノルディスク アー／エス | 安定したｇｌｐ−１ベースのｇｌｐ−１／グルカゴン受容体コアゴニスト |
| EP3212218B1 (en) | 2014-10-29 | 2021-06-30 | Zealand Pharma A/S | Gip agonist compounds and methods |
| JP6730278B2 (ja) | 2014-11-27 | 2020-07-29 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１誘導体及びその使用 |
| EP3233898A1 (en) | 2014-12-17 | 2017-10-25 | Novo Nordisk A/S | Glp-1 derivatives and uses thereof |
| KR102418477B1 (ko) | 2014-12-30 | 2022-07-08 | 한미약품 주식회사 | 글루카곤 유도체 |
| KR102291020B1 (ko) * | 2014-12-30 | 2021-08-20 | 한미약품 주식회사 | 안정성이 증가된 글루카곤 유도체 |
| UA121874C2 (uk) | 2015-02-17 | 2020-08-10 | Елі Ліллі Енд Компані | Порошкова назальна композиція для лікування гіпоглікемії |
| PL3283507T3 (pl) | 2015-04-16 | 2020-05-18 | Zealand Pharma A/S | Acylowany analog glukagonu |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| WO2016198628A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists |
| WO2016198624A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists |
| FI3322437T3 (fi) | 2015-06-30 | 2024-02-20 | Hanmi Pharmaceutical Co Ltd | Glukagonijohdannainen ja sen pitkävaikutteisen konjugaatin käsittävä koostumus |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物 |
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-
2011
- 2011-03-28 KR KR1020127027952A patent/KR20130018410A/ko not_active Ceased
- 2011-03-28 WO PCT/EP2011/054714 patent/WO2011117416A1/en not_active Ceased
- 2011-03-28 US US13/637,522 patent/US20130143798A1/en not_active Abandoned
- 2011-03-28 US US13/637,454 patent/US20130035285A1/en not_active Abandoned
- 2011-03-28 RU RU2012144289/04A patent/RU2559320C2/ru not_active IP Right Cessation
- 2011-03-28 JP JP2013500534A patent/JP6054861B2/ja not_active Expired - Fee Related
- 2011-03-28 CN CN201180025875.1A patent/CN102918055B/zh not_active Expired - Fee Related
- 2011-03-28 AU AU2011231503A patent/AU2011231503C1/en not_active Ceased
- 2011-03-28 WO PCT/EP2011/054712 patent/WO2011117415A1/en not_active Ceased
- 2011-03-28 MX MX2012010881A patent/MX336412B/es unknown
- 2011-03-28 JP JP2013500535A patent/JP6026993B2/ja not_active Expired - Fee Related
- 2011-03-28 BR BR112012024379A patent/BR112012024379A2/pt not_active Application Discontinuation
- 2011-03-28 CN CN201180025883.6A patent/CN102918056B/zh not_active Expired - Fee Related
- 2011-03-28 EP EP11710218A patent/EP2552950A1/en not_active Withdrawn
- 2011-03-28 EP EP11710504A patent/EP2552951A1/en not_active Withdrawn
- 2011-03-28 CA CA2792663A patent/CA2792663A1/en not_active Withdrawn
-
2012
- 2012-09-12 ZA ZA2012/06838A patent/ZA201206838B/en unknown
-
2015
- 2015-06-15 US US14/739,614 patent/US20150274801A1/en not_active Abandoned
- 2015-08-17 US US14/827,539 patent/US20160002311A1/en not_active Abandoned
-
2016
- 2016-05-16 US US15/155,541 patent/US20160271263A1/en not_active Abandoned
- 2016-07-19 JP JP2016141243A patent/JP2016183192A/ja not_active Withdrawn
- 2016-09-12 US US15/262,450 patent/US20170051034A1/en not_active Abandoned
-
2017
- 2017-03-13 US US15/456,912 patent/US20170190757A1/en not_active Abandoned
- 2017-07-26 US US15/660,458 patent/US20180016319A1/en not_active Abandoned
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