JP2013523179A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013523179A5 JP2013523179A5 JP2013505069A JP2013505069A JP2013523179A5 JP 2013523179 A5 JP2013523179 A5 JP 2013523179A5 JP 2013505069 A JP2013505069 A JP 2013505069A JP 2013505069 A JP2013505069 A JP 2013505069A JP 2013523179 A5 JP2013523179 A5 JP 2013523179A5
- Authority
- JP
- Japan
- Prior art keywords
- fniii
- comprises seq
- scaffold
- multimeric
- multimeric scaffold
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000002090 Fibronectin type III Human genes 0.000 claims 17
- 108050009401 Fibronectin type III Proteins 0.000 claims 17
- 239000000178 monomer Substances 0.000 claims 13
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32370810P | 2010-04-13 | 2010-04-13 | |
US61/323,708 | 2010-04-13 | ||
PCT/US2011/032184 WO2011130324A1 (en) | 2010-04-13 | 2011-04-12 | Fibronectin type iii domain-based multimeric scaffolds |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013523179A JP2013523179A (ja) | 2013-06-17 |
JP2013523179A5 true JP2013523179A5 (US20090208454A1-20090820-C00047.png) | 2014-05-29 |
Family
ID=44799000
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013505069A Pending JP2013523179A (ja) | 2010-04-13 | 2011-04-12 | フィブロネクチンタイプiiiドメインに基づく多量体足場 |
JP2013505070A Active JP6041799B2 (ja) | 2010-04-13 | 2011-04-12 | Trailr2特異的多量体足場 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013505070A Active JP6041799B2 (ja) | 2010-04-13 | 2011-04-12 | Trailr2特異的多量体足場 |
Country Status (13)
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0417302A (pt) | 2003-12-05 | 2007-03-06 | Compound Therapeutics Inc | inibidores de receptores de fator de crescimento endotelial vascular do tipo 2 |
AU2007325838B2 (en) | 2006-11-22 | 2013-09-19 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR |
WO2009102421A2 (en) | 2008-02-14 | 2009-08-20 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind egfr |
EP2291399B1 (en) | 2008-05-22 | 2014-06-25 | Bristol-Myers Squibb Company | Multivalent fibronectin based scaffold domain proteins |
TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
JP2013523179A (ja) * | 2010-04-13 | 2013-06-17 | メディミューン,エルエルシー | フィブロネクチンタイプiiiドメインに基づく多量体足場 |
TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
US9562089B2 (en) | 2010-05-26 | 2017-02-07 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins having improved stability |
DK2697257T3 (en) | 2011-04-13 | 2017-01-30 | Bristol Myers Squibb Co | FC FUSION PROTEINS INCLUDING UNKNOWN LINKERS OR EVENTS |
EP3318880B1 (en) | 2011-05-17 | 2020-12-16 | Bristol-Myers Squibb Company | Improved methods for the selection of binding proteins |
US20140187488A1 (en) | 2011-05-17 | 2014-07-03 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
ES2819075T3 (es) | 2011-10-11 | 2021-04-14 | Viela Bio Inc | Matrices de soporte derivadas de TN3 específicas para CD40L y sus métodos de empleo |
US9522951B2 (en) | 2011-10-31 | 2016-12-20 | Bristol-Myers Squibb Company | Fibronectin binding domains with reduced immunogenicity |
CA2854806A1 (en) | 2011-11-07 | 2013-05-16 | Medimmune, Llc | Multispecific and multivalent binding proteins and uses thereof |
JP6284482B2 (ja) | 2011-11-08 | 2018-02-28 | ユーエムセー・ユトレヒト・ホールディング・ベー・フェー | インターロイキン4およびインターロイキンを含む融合タンパク質 |
TWI694085B (zh) | 2012-09-13 | 2020-05-21 | 美商必治妥美雅史谷比公司 | 結合至肌肉生長抑制素(myostatin)以纖維連接蛋白爲主之支架結構域蛋白質 |
US9695228B2 (en) * | 2012-11-21 | 2017-07-04 | Janssen Biotech, Inc. | EGFR and c-Met fibronectin type III domain binding molecules |
WO2014120891A2 (en) | 2013-02-01 | 2014-08-07 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins |
EP2953968B1 (en) | 2013-02-06 | 2018-07-25 | Bristol-Myers Squibb Company | Fibronectin type iii domain proteins with enhanced solubility |
EP3744728A1 (en) | 2013-02-12 | 2020-12-02 | Bristol-Myers Squibb Company | Tangential flow filtration based protein refolding methods |
ES2645634T3 (es) | 2013-02-12 | 2017-12-07 | Bristol-Myers Squibb Company | Métodos de replegado de proteínas a elevado pH |
WO2014165093A2 (en) | 2013-03-13 | 2014-10-09 | Bristol-Myers Squibb Company | Fibronectin based scaffold domains linked to serum albumin or a moiety binding thereto |
SI2970473T1 (sl) | 2013-03-14 | 2017-10-30 | Bristol-Myers Squibb Company | Kombinacija dr5 agonista in anti-pd-1 antagonista in postopek uporabe |
US10392611B2 (en) | 2013-05-30 | 2019-08-27 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
US10364451B2 (en) | 2013-05-30 | 2019-07-30 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
CN105899226B (zh) * | 2013-10-14 | 2020-05-12 | 詹森生物科技公司 | 半胱氨酸工程化iii型纤连蛋白域结合分子 |
US11299528B2 (en) | 2014-03-11 | 2022-04-12 | D&D Pharmatech Inc. | Long acting TRAIL receptor agonists for treatment of autoimmune diseases |
JP6591437B2 (ja) | 2014-03-20 | 2019-10-16 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 血清アルブミン結合フィブロネクチンiii型ドメイン |
MX371403B (es) | 2014-03-20 | 2020-01-29 | Bristol Myers Squibb Co | Moleculas de andamiaje a base de fibronectina estabilizada. |
WO2015148269A2 (en) * | 2014-03-24 | 2015-10-01 | Medimmune, Llc | Stabilized tnfn3 scaffold proteins |
NO2776305T3 (US20090208454A1-20090820-C00047.png) | 2014-04-23 | 2018-01-27 | ||
CN114057857A (zh) * | 2014-06-20 | 2022-02-18 | 豪夫迈·罗氏有限公司 | 基于chagasin的支架组合物、方法和应用 |
BR112017006602A2 (pt) | 2014-10-01 | 2017-12-19 | Medimmune Llc | método de conjugação de um polipeptídeo |
WO2016086036A2 (en) | 2014-11-25 | 2016-06-02 | Bristol-Myers Squibb Company | Methods and compositions for 18f-radiolabeling of biologics |
AU2016228806B2 (en) | 2015-03-12 | 2020-10-22 | Medimmune, Llc | Method of purifying albumin-fusion proteins |
US10385115B2 (en) | 2015-03-26 | 2019-08-20 | Duke University | Fibronectin type III domain-based fusion proteins |
KR20180002782A (ko) | 2015-05-06 | 2018-01-08 | 얀센 바이오테크 인코포레이티드 | 전립선 특이적 막 항원(psma) 이중특이성 결합제 및 그의 용도 |
BR112018002342A2 (pt) | 2015-08-04 | 2018-12-11 | Univ Duke | polímeros furtivos intrinsecamente desordenados e geneticamente modificados para entrega e métodos para uso dos mesmos |
US11124791B2 (en) | 2015-09-14 | 2021-09-21 | Arizona Board Of Regents On Behalf Of Arizona State University | Generating recombinant affinity reagents with arrayed targets |
ES2967078T3 (es) | 2015-09-23 | 2024-04-25 | Bristol Myers Squibb Co | Dominios de fibronectina de tipo III de unión a seroalbúmina con velocidad de disociación rápida |
CN108884147B (zh) * | 2015-09-23 | 2024-02-27 | 百时美施贵宝公司 | 结合磷脂酰肌醇蛋白聚糖3的基于纤连蛋白的支架分子 |
WO2017069627A1 (en) * | 2015-10-23 | 2017-04-27 | Universiteit Twente | Integrin binding peptides and uses thereof |
EA038551B1 (ru) | 2015-12-17 | 2021-09-14 | Дзе Джонс Хопкинс Юниверсити | Способ лечения или профилактики системного склероза |
US11752213B2 (en) | 2015-12-21 | 2023-09-12 | Duke University | Surfaces having reduced non-specific binding and antigenicity |
WO2017177148A1 (en) | 2016-04-07 | 2017-10-12 | The Johns Hopkins University | Compositions and methods for treating pancreatitis and pain with death receptor agonists |
CN105802970A (zh) * | 2016-05-30 | 2016-07-27 | 东北师范大学 | 靶向沉默Gβ1的shRNA |
US10994033B2 (en) | 2016-06-01 | 2021-05-04 | Bristol-Myers Squibb Company | Imaging methods using 18F-radiolabeled biologics |
US11467156B2 (en) | 2016-06-01 | 2022-10-11 | Duke University | Nonfouling biosensors |
AU2017281083B2 (en) | 2016-06-21 | 2022-01-27 | Janssen Biotech, Inc. | Cysteine engineered fibronectin type III domain binding molecules |
RU2019110848A (ru) | 2016-09-14 | 2020-10-15 | Дьюк Юниверсити | Наночастицы на основе триблочных полипептидов для доставки гидрофильных лекарственных средств |
KR20190064600A (ko) | 2016-09-23 | 2019-06-10 | 듀크 유니버시티 | Lcst 거동을 갖는 비구조화된 비-반복적 폴리펩티드 |
US10597438B2 (en) | 2016-12-14 | 2020-03-24 | Janssen Biotech, Inc. | PD-L1 binding fibronectin type III domains |
WO2018111978A1 (en) | 2016-12-14 | 2018-06-21 | Janssen Biotech, Inc. | Cd137 binding fibronectin type iii domains |
JP7104703B2 (ja) | 2016-12-14 | 2022-07-21 | ヤンセン バイオテツク,インコーポレーテツド | Cd8a結合フィブロネクチンiii型ドメイン |
WO2018132732A1 (en) | 2017-01-12 | 2018-07-19 | Duke University | Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly |
US10787499B2 (en) * | 2017-02-13 | 2020-09-29 | Regents Of The University Of Minnesota | EpCAM targeted polypeptides, conjugates thereof, and methods of use thereof |
US11554097B2 (en) | 2017-05-15 | 2023-01-17 | Duke University | Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents |
AR111963A1 (es) | 2017-05-26 | 2019-09-04 | Univ California | Método y moléculas |
EP3658168A4 (en) | 2017-06-30 | 2021-07-14 | Duke University | ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-RESPONDING BIOPOLYMER NETWORKS |
US11491206B1 (en) | 2018-02-13 | 2022-11-08 | Duke University | Compositions and methods for the treatment of trail-resistant cancer |
US11680091B2 (en) | 2018-02-23 | 2023-06-20 | The University Of Chicago | Methods and composition involving thermophilic fibronectin type III (FN3) monobodies |
CA3098420A1 (en) | 2018-06-01 | 2019-12-05 | Novartis Ag | Binding molecules against bcma and uses thereof |
CN110724198B (zh) * | 2018-07-17 | 2023-05-26 | 上海一宸医药科技有限公司 | 长效纤连蛋白iii型结构域融合蛋白 |
EP3829622A4 (en) | 2018-08-02 | 2022-05-11 | Duke University | DUAL AGONIST FUSION PROTEINS |
US11986536B2 (en) | 2019-03-23 | 2024-05-21 | Ablevia Biotech Gmbh | Compound for the sequestration of undesirable antibodies in a patient |
EP3715376A1 (en) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Compound for the prevention or treatment of myasthenia gravis |
EP3715374A1 (en) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Compound for the sequestration of undesirable antibodies in a patient |
EP3955955A1 (en) | 2019-04-19 | 2022-02-23 | Synerkine Pharma B.V. | A fusion protein comprising il13 |
EP3972993A1 (en) | 2019-05-21 | 2022-03-30 | Novartis AG | Variant cd58 domains and uses thereof |
PE20220568A1 (es) | 2019-05-21 | 2022-04-20 | Novartis Ag | Moleculas de union a cd19 y usos de las mismas |
WO2020236795A2 (en) | 2019-05-21 | 2020-11-26 | Novartis Ag | Trispecific binding molecules against bcma and uses thereof |
US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
CN114127304A (zh) | 2019-07-15 | 2022-03-01 | 免疫医疗有限公司 | 用于蛋白二聚化的三部分型系统和使用方法 |
US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
US11628222B2 (en) | 2019-10-14 | 2023-04-18 | Aro Biotherapeutics Company | CD71 binding fibronectin type III domains |
CN111217903B (zh) * | 2020-02-25 | 2022-11-15 | 芜湖天明生物技术有限公司 | 一种重组人纤连蛋白ⅲ1-c及其制备方法和应用 |
EP4110407A1 (en) | 2020-02-28 | 2023-01-04 | Bristol-Myers Squibb Company | Radiolabeled fibronectin based scaffolds and antibodies and theranostic uses thereof |
WO2021195513A1 (en) | 2020-03-27 | 2021-09-30 | Novartis Ag | Bispecific combination therapy for treating proliferative diseases and autoimmune disorders |
US11767353B2 (en) | 2020-06-05 | 2023-09-26 | Theraly Fibrosis, Inc. | Trail compositions with reduced immunogenicity |
CN111944204B (zh) * | 2020-07-24 | 2022-03-08 | 南京理工大学 | 一种Fe3O4磁性细菌纤维素及其制备方法 |
US20230381334A1 (en) | 2020-09-23 | 2023-11-30 | Ablevia Biotech Gmbh | Compound for the sequestration of undesirable antibodies in a patient |
TW202228784A (zh) | 2020-09-23 | 2022-08-01 | 奧地利商艾柏力維亞生技有限公司 | 用以於一患者中螯合非預期的抗peg抗體的化合物 |
BR112023005257A2 (pt) | 2020-09-23 | 2023-04-25 | Ablevia Biotech Gmbh | Composto para a prevenção ou tratamento de condições mediadas por autoanticorpos |
AU2021347582A1 (en) | 2020-09-23 | 2023-05-18 | Ablevia Biotech Gmbh | Compound for increasing the efficacy of factor viii replacement therapy |
KR20230074775A (ko) | 2020-09-23 | 2023-05-31 | 아블레비아 바이오테크 게엠베하 | 바이러스 벡터의 효능 증가를 위한 화합물 |
CN116710143A (zh) | 2020-09-24 | 2023-09-05 | 艾柏力维亚生技有限公司 | 用于预防或治疗重症肌无力的化合物 |
IL302412A (en) | 2020-11-06 | 2023-06-01 | Novartis Ag | Anti-CD19 and B-cell targeting agent combination therapy for the treatment of B-cell malignancies |
EP4240491A1 (en) | 2020-11-06 | 2023-09-13 | Novartis AG | Cd19 binding molecules and uses thereof |
WO2023180502A1 (en) | 2022-03-24 | 2023-09-28 | Ablevia Biotech Gmbh | Compound for increasing efficacy of oncolytic viruses |
KR102459313B1 (ko) * | 2022-04-11 | 2022-10-26 | 주식회사 대영방재산업 | 내구성이 개선된 소방용 수격 흡수기 |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10505750A (ja) | 1994-09-16 | 1998-06-09 | ザ スクリップス リサーチ インスティテュート | 粘着および軸索の成長を刺激するサイトタクチン誘導体並びにその製造および使用方法 |
DK0985039T3 (da) | 1997-06-12 | 2008-06-09 | Novartis Int Pharm Ltd | Kunstige antistof-polypeptider |
US6160089A (en) | 1998-07-08 | 2000-12-12 | Mitsui Chemicals, Inc. | Method for secretory production of human growth hormone |
AU766551C (en) * | 1998-08-28 | 2005-02-17 | Genentech Inc. | Human anti-factor IX/IXa antibodies |
WO2000034784A1 (en) | 1998-12-10 | 2000-06-15 | Phylos, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
CA2416219C (en) * | 2000-07-11 | 2016-10-11 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
CA2418835A1 (en) | 2000-10-16 | 2002-04-25 | Phylos, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
AU2003228393A1 (en) | 2002-03-29 | 2003-10-13 | Genencor International, Inc. | Ehanced protein expression in bacillus |
WO2003104418A2 (en) | 2002-06-06 | 2003-12-18 | Research Corporation Technologies, Inc. | Reconstituted polypeptides |
EP2500032A1 (en) | 2002-06-24 | 2012-09-19 | Genentech, Inc. | APO-2 ligand/trail variants and uses thereof |
BRPI0417302A (pt) | 2003-12-05 | 2007-03-06 | Compound Therapeutics Inc | inibidores de receptores de fator de crescimento endotelial vascular do tipo 2 |
JPWO2005056605A1 (ja) * | 2003-12-12 | 2007-12-06 | 中外製薬株式会社 | 3量体以上の受容体を認識する改変抗体 |
GB0416651D0 (en) | 2004-07-26 | 2004-08-25 | Proteo Target Aps | Polypeptide |
UA97096C2 (ru) * | 2005-08-31 | 2012-01-10 | Емджен Інк. | Выделенное антитело, которое специфически связывает рецептор-2 trail (tr-2) |
US10183986B2 (en) | 2005-12-15 | 2019-01-22 | Industrial Technology Research Institute | Trimeric collagen scaffold antibodies |
EP1989529A4 (en) | 2006-02-13 | 2010-09-01 | Agency Science Tech & Res | PROCESS FOR PROCESSING A BIOLOGICAL AND / OR CHEMICAL SAMPLE |
CN101074261A (zh) * | 2006-04-30 | 2007-11-21 | 北京同为时代生物技术有限公司 | Trail受体1和/或trail受体2特异性抗体及其应用 |
WO2008031098A1 (en) | 2006-09-09 | 2008-03-13 | The University Of Chicago | Binary amino acid libraries for fibronectin type iii polypeptide monobodies |
AU2007325838B2 (en) | 2006-11-22 | 2013-09-19 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR |
WO2009023184A2 (en) | 2007-08-10 | 2009-02-19 | Protelix, Inc. | Universal fibronectin type iii binding-domain libraries |
US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
ES2533874T3 (es) * | 2007-10-31 | 2015-04-15 | Medimmune, Llc | Armazón proteico |
EA201000979A1 (ru) | 2007-12-27 | 2011-02-28 | Новартис Аг | Улучшенные связывающие молекулы на основе фибронектина и их применение |
BRPI0913007A2 (pt) | 2008-05-02 | 2019-09-24 | Novartis Ag | moléculas de ligação aprimoradas à base de fibronectina e usos das mesmas |
EP2291399B1 (en) | 2008-05-22 | 2014-06-25 | Bristol-Myers Squibb Company | Multivalent fibronectin based scaffold domain proteins |
AU2009303304A1 (en) * | 2008-10-10 | 2010-04-15 | Anaphore, Inc. | Polypeptides that bind TRAIL-RI and TRAIL-R2 |
PL2356269T3 (pl) | 2008-10-31 | 2016-12-30 | Kompozycje białek rusztowania oparte na domenie fibronektyny typu III, sposoby i zastosowania | |
TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
DK2396011T3 (en) | 2009-02-12 | 2016-04-25 | Janssen Biotech Inc | Fibronectin TYPE III DOMAIN-BASED SCAFFOLD COMPOSITIONS, METHODS AND USES |
WO2011020033A2 (en) | 2009-08-13 | 2011-02-17 | Massachusetts Institute Of Technology | Engineered proteins including mutant fibronectin domains |
JP2013523179A (ja) * | 2010-04-13 | 2013-06-17 | メディミューン,エルエルシー | フィブロネクチンタイプiiiドメインに基づく多量体足場 |
-
2011
- 2011-04-12 JP JP2013505069A patent/JP2013523179A/ja active Pending
- 2011-04-12 WO PCT/US2011/032184 patent/WO2011130324A1/en active Application Filing
- 2011-04-12 SG SG10201505470QA patent/SG10201505470QA/en unknown
- 2011-04-12 US US13/639,381 patent/US9212231B2/en active Active
- 2011-04-12 BR BR112012026003-0A patent/BR112012026003B1/pt active IP Right Grant
- 2011-04-12 SG SG2012070108A patent/SG184185A1/en unknown
- 2011-04-12 CA CA2796010A patent/CA2796010C/en active Active
- 2011-04-12 EP EP11769477.8A patent/EP2560684A4/en not_active Withdrawn
- 2011-04-12 WO PCT/US2011/032188 patent/WO2011130328A1/en active Application Filing
- 2011-04-12 CA CA2795325A patent/CA2795325A1/en not_active Abandoned
- 2011-04-12 CN CN201180018796.8A patent/CN102906112B/zh active Active
- 2011-04-12 KR KR1020127029323A patent/KR101747991B1/ko active IP Right Grant
- 2011-04-12 JP JP2013505070A patent/JP6041799B2/ja active Active
- 2011-04-12 EP EP11769481.0A patent/EP2558495B1/en active Active
- 2011-04-12 AU AU2011240624A patent/AU2011240624B2/en active Active
- 2011-04-12 CN CN2011800187879A patent/CN102834114A/zh active Pending
- 2011-04-12 US US13/640,057 patent/US20130079280A1/en not_active Abandoned
- 2011-04-12 AU AU2011240620A patent/AU2011240620A1/en not_active Abandoned
- 2011-04-12 KR KR1020127029343A patent/KR20130056870A/ko not_active Application Discontinuation
- 2011-04-12 ES ES11769481T patent/ES2755398T3/es active Active
- 2011-04-12 RU RU2012147960A patent/RU2628699C2/ru active
- 2011-04-12 MX MX2012011840A patent/MX341119B/es active IP Right Grant
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2013523179A5 (US20090208454A1-20090820-C00047.png) | ||
CL2019002280A1 (es) | Vectores virales, adenovirales y composiciones a base de una secuencia de ornitina transcarbamilasa humana (hotch) modificada genéticamente y su uso en el tratamiento de deficiencia de la otc. (divisional solicitud 201602235) | |
JP2010273685A5 (US20090208454A1-20090820-C00047.png) | ||
EA201692359A1 (ru) | Композиция на основе нового штамма prrsv или его белков, продукт, их применение, вирус prrsv, выделенная нк и рекомбинантный вектор экспрессии для получения этого вируса | |
JP2013048638A5 (US20090208454A1-20090820-C00047.png) | ||
AR094141A1 (es) | Composiciones y metodos para proteinas de accion prolongada | |
GB201206559D0 (en) | Polypeptide | |
JP2010518833A5 (US20090208454A1-20090820-C00047.png) | ||
WO2014202616A3 (en) | Rasamsonia gene and use thereof | |
JP2011504721A5 (US20090208454A1-20090820-C00047.png) | ||
JP2015514423A5 (US20090208454A1-20090820-C00047.png) | ||
MX2012015142A (es) | Polipeptidos que tiene actividad beta-glucosidasa y usos del mismo. | |
JP2011177189A5 (US20090208454A1-20090820-C00047.png) | ||
JP2012126742A5 (US20090208454A1-20090820-C00047.png) | ||
MX2012015139A (es) | Polipéptido que tiene o que ayuda en la actividad de degradación del material de carbohidratos y usos del mismo. | |
JP2011087580A5 (US20090208454A1-20090820-C00047.png) | ||
JP2011514139A5 (US20090208454A1-20090820-C00047.png) | ||
JP2012115277A5 (US20090208454A1-20090820-C00047.png) | ||
MX2010004548A (es) | Genes de dc-sign, icam-3 y lsectin porcinas y usos de los mismos. | |
JP2015533791A5 (US20090208454A1-20090820-C00047.png) | ||
RU2015112625A (ru) | Пептид, применение пептида для лечения сердечно-сосудистых заболеваний, нуклеотидная последовательность, вектор экспрессии, хозяйская клетка, фармацевтическая композиция | |
WO2007124327A3 (en) | Methods and compositions for expressing negative-sense viral rna in canine cells | |
WO2014202622A3 (en) | Rasamsonia gene and use thereof | |
PH12015500771A1 (en) | Novel fc gamma receptor iib variants | |
WO2014097113A3 (en) | Production of therapeutic proteins in genetically modified mammalian cells |