JP2013519371A5 - - Google Patents
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- JP2013519371A5 JP2013519371A5 JP2012552617A JP2012552617A JP2013519371A5 JP 2013519371 A5 JP2013519371 A5 JP 2013519371A5 JP 2012552617 A JP2012552617 A JP 2012552617A JP 2012552617 A JP2012552617 A JP 2012552617A JP 2013519371 A5 JP2013519371 A5 JP 2013519371A5
- Authority
- JP
- Japan
- Prior art keywords
- oct3
- sox2
- myc
- klf4
- see
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 101150086694 SLC22A3 gene Proteins 0.000 description 30
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 description 24
- 102100038895 Myc proto-oncogene protein Human genes 0.000 description 21
- 101710135898 Myc proto-oncogene protein Proteins 0.000 description 21
- 101710150448 Transcriptional regulator Myc Proteins 0.000 description 21
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 description 19
- 210000004027 cell Anatomy 0.000 description 16
- -1 TERT Proteins 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 101150111214 lin-28 gene Proteins 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 101000857270 Homo sapiens Zinc finger protein GLIS1 Proteins 0.000 description 5
- 102100025883 Zinc finger protein GLIS1 Human genes 0.000 description 5
- 108020004707 nucleic acids Proteins 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 230000008672 reprogramming Effects 0.000 description 4
- 101150099612 Esrrb gene Proteins 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 210000001082 somatic cell Anatomy 0.000 description 3
- 210000000130 stem cell Anatomy 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- 101100342337 Caenorhabditis elegans klf-1 gene Proteins 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 2
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 2
- 101100540311 Human papillomavirus type 16 E6 gene Proteins 0.000 description 2
- 101000767631 Human papillomavirus type 16 Protein E7 Proteins 0.000 description 2
- 101150072501 Klf2 gene Proteins 0.000 description 2
- 101100310650 Mus musculus Sox18 gene Proteins 0.000 description 2
- 239000005090 green fluorescent protein Substances 0.000 description 2
- 230000000877 morphologic effect Effects 0.000 description 2
- RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- 101100257372 Caenorhabditis elegans sox-3 gene Proteins 0.000 description 1
- 241000131390 Glis Species 0.000 description 1
- 229920000209 Hexadimethrine bromide Polymers 0.000 description 1
- 108010025815 Kanamycin Kinase Proteins 0.000 description 1
- 101710128836 Large T antigen Proteins 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 101100058550 Mus musculus Bmi1 gene Proteins 0.000 description 1
- 101100310657 Mus musculus Sox1 gene Proteins 0.000 description 1
- 101100310648 Mus musculus Sox17 gene Proteins 0.000 description 1
- 101100257376 Mus musculus Sox3 gene Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 102220595793 Myc proto-oncogene protein_T58A_mutation Human genes 0.000 description 1
- 239000012124 Opti-MEM Substances 0.000 description 1
- 108700008625 Reporter Genes Proteins 0.000 description 1
- 101150001847 Sox15 gene Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 102000005936 beta-Galactosidase Human genes 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229950010131 puromycin Drugs 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000012096 transfection reagent Substances 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30510710P | 2010-02-16 | 2010-02-16 | |
| US61/305,107 | 2010-02-16 | ||
| US37994910P | 2010-09-03 | 2010-09-03 | |
| US61/379,949 | 2010-09-03 | ||
| PCT/JP2011/053874 WO2011102531A1 (en) | 2010-02-16 | 2011-02-16 | Method of efficiently establishing induced pluripotent stem cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013519371A JP2013519371A (ja) | 2013-05-30 |
| JP2013519371A5 true JP2013519371A5 (enExample) | 2014-06-26 |
| JP5765746B2 JP5765746B2 (ja) | 2015-08-19 |
Family
ID=44483114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012552617A Active JP5765746B2 (ja) | 2010-02-16 | 2011-02-16 | 効率的な人工多能性幹細胞の樹立方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8927277B2 (enExample) |
| EP (1) | EP2536828B1 (enExample) |
| JP (1) | JP5765746B2 (enExample) |
| KR (1) | KR101857302B1 (enExample) |
| CN (1) | CN102782122B (enExample) |
| CA (1) | CA2789749C (enExample) |
| IL (1) | IL221481A (enExample) |
| SG (1) | SG183315A1 (enExample) |
| WO (1) | WO2011102531A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101764100B1 (ko) | 2009-02-27 | 2017-08-02 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 신규한 핵 재프로그래밍 물질 |
| WO2011016588A1 (en) | 2009-08-07 | 2011-02-10 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| US9758765B2 (en) | 2011-04-08 | 2017-09-12 | Osaka University | Modified laminin and use thereof |
| WO2012141181A1 (ja) * | 2011-04-11 | 2012-10-18 | 国立大学法人京都大学 | 核初期化物質 |
| EP2853592B1 (en) | 2012-05-23 | 2019-02-20 | Kyoto University | Highly efficient method for establishing artificial pluripotent stem cell |
| EP2873727B1 (en) * | 2012-07-12 | 2019-11-06 | Kyoto Prefectural Public University Corporation | Brown fat cells and method for preparing same |
| SG11201503167XA (en) * | 2012-10-23 | 2015-05-28 | Univ Kyoto | Method of efficiently establishing induced pluripotent stem cells |
| AU2014324233B2 (en) * | 2013-09-24 | 2020-07-23 | Id Pharma Co., Ltd. | Method for improving efficiency of inducing pluripotent stem cell |
| CN104017777A (zh) * | 2014-01-07 | 2014-09-03 | 中国人民解放军第三军医大学第一附属医院 | 用于治疗视网膜疾病的试剂盒 |
| EP3165603B1 (en) * | 2014-07-03 | 2019-09-18 | Juntendo Educational Foundation | Pancreatic endocrine cells, method for producing same, and transdifferentiation agent |
| WO2017073740A1 (ja) | 2015-10-29 | 2017-05-04 | 学校法人埼玉医科大学 | 膵内分泌細胞の製造方法、及び分化転換剤 |
| US9936734B2 (en) | 2016-03-11 | 2018-04-10 | Altria Client Services, Llc. | Personal carrying case for electronic vaping device |
| CN106086071B (zh) * | 2016-06-13 | 2019-08-09 | 广州市搏克生物技术有限公司 | 一种非病毒iPSCs诱导方法及其诱导组合物、试剂盒及其获得的iPSCs |
| CN105861447B (zh) * | 2016-06-13 | 2017-12-19 | 广州市搏克生物技术有限公司 | 一种非病毒iPSCs诱导组合物及其试剂盒 |
| US11845960B2 (en) | 2016-09-12 | 2023-12-19 | President And Fellows Of Harvard College | Transcription factors controlling differentiation of stem cells |
| CN106939299B (zh) * | 2017-02-04 | 2022-11-15 | 滨州医学院 | microRNA重编程体细胞为神经干细胞的制备方法及应用 |
| WO2018232079A1 (en) | 2017-06-14 | 2018-12-20 | Daley George Q | Hematopoietic stem and progenitor cells derived from hemogenic endothelial cells by episomal plasmid gene transfer |
| WO2019108894A1 (en) | 2017-12-01 | 2019-06-06 | President And Fellows Of Harvard College | Methods and compositions for the production of oligodendrocyte progenitor cells |
| US11788131B2 (en) | 2018-04-06 | 2023-10-17 | President And Fellows Of Harvard College | Methods of identifying combinations of transcription factors |
| US20220145255A1 (en) | 2019-02-26 | 2022-05-12 | Tohoku University | Method for producing osteoblast cluster using ips cells |
| CN110079459A (zh) * | 2019-05-15 | 2019-08-02 | 刘宝全 | 一种干细胞培养容器内气体平衡的调节方法 |
| EP4060023A4 (en) | 2019-11-12 | 2023-12-13 | Juntendo Educational Foundation | METHOD FOR DIRECT TRANSDIFFERENTIATION OF SOMATIC CELL |
| MX2022008648A (es) | 2020-01-23 | 2022-12-15 | The Children´S Medical Center Corp | Diferenciacion de celulas t sin estroma a partir de celulas madre pluripotentes humanas. |
| CN116426573A (zh) * | 2023-04-14 | 2023-07-14 | 臻赫医药(杭州)有限公司 | 重编程因子抗衰老表达系统、生物材料及用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101420740B1 (ko) | 2005-12-13 | 2014-07-17 | 교또 다이가꾸 | 핵초기화 인자 |
| EP2137296A2 (en) | 2007-03-23 | 2009-12-30 | Wisconsin Alumni Research Foundation | Somatic cell reprogramming |
| KR101564044B1 (ko) | 2007-10-31 | 2015-10-28 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 핵초기화 방법 |
| US20110231944A1 (en) | 2008-09-04 | 2011-09-22 | Riken | B cell-derived ips cells and application thereof |
| ES2549155T3 (es) | 2008-09-08 | 2015-10-23 | Riken | Células iPS obtenidas a partir de células NKT y células NKT obtenidas a partir de las mismas |
| KR101764100B1 (ko) | 2009-02-27 | 2017-08-02 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 신규한 핵 재프로그래밍 물질 |
| CN101613717B (zh) * | 2009-04-17 | 2012-01-11 | 中国科学院广州生物医药与健康研究院 | 用猪成纤维细胞生成诱导的多能性干细胞的方法 |
| WO2011016588A1 (en) | 2009-08-07 | 2011-02-10 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
-
2011
- 2011-02-16 JP JP2012552617A patent/JP5765746B2/ja active Active
- 2011-02-16 US US13/579,234 patent/US8927277B2/en active Active
- 2011-02-16 EP EP11744817.5A patent/EP2536828B1/en active Active
- 2011-02-16 CA CA2789749A patent/CA2789749C/en active Active
- 2011-02-16 KR KR1020127023784A patent/KR101857302B1/ko active Active
- 2011-02-16 CN CN201180009618.9A patent/CN102782122B/zh active Active
- 2011-02-16 SG SG2012060208A patent/SG183315A1/en unknown
- 2011-02-16 WO PCT/JP2011/053874 patent/WO2011102531A1/en not_active Ceased
-
2012
- 2012-08-15 IL IL221481A patent/IL221481A/en active IP Right Grant
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