KR101857302B1 - 유도된 다능성 줄기 세포의 효율적 확립 방법 - Google Patents

유도된 다능성 줄기 세포의 효율적 확립 방법 Download PDF

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KR101857302B1
KR101857302B1 KR1020127023784A KR20127023784A KR101857302B1 KR 101857302 B1 KR101857302 B1 KR 101857302B1 KR 1020127023784 A KR1020127023784 A KR 1020127023784A KR 20127023784 A KR20127023784 A KR 20127023784A KR 101857302 B1 KR101857302 B1 KR 101857302B1
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KR20120131180A (ko
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신야 야마나카
나오키 고시마
모모코 마에카와
요시후미 가와무라
히로미 모치즈키
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고쿠리츠 다이가쿠 호진 교토 다이가쿠
고쿠리츠켄큐카이하츠호진 상교기쥬츠 소고켄큐쇼
샤단호진 바이오산교죠호카 콘소시아무
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/602—Sox-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/603—Oct-3/4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/604—Klf-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

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  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020127023784A 2010-02-16 2011-02-16 유도된 다능성 줄기 세포의 효율적 확립 방법 Active KR101857302B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30510710P 2010-02-16 2010-02-16
US61/305,107 2010-02-16
US37994910P 2010-09-03 2010-09-03
US61/379,949 2010-09-03
PCT/JP2011/053874 WO2011102531A1 (en) 2010-02-16 2011-02-16 Method of efficiently establishing induced pluripotent stem cells

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KR20120131180A KR20120131180A (ko) 2012-12-04
KR101857302B1 true KR101857302B1 (ko) 2018-05-11

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KR1020127023784A Active KR101857302B1 (ko) 2010-02-16 2011-02-16 유도된 다능성 줄기 세포의 효율적 확립 방법

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US (1) US8927277B2 (enExample)
EP (1) EP2536828B1 (enExample)
JP (1) JP5765746B2 (enExample)
KR (1) KR101857302B1 (enExample)
CN (1) CN102782122B (enExample)
CA (1) CA2789749C (enExample)
IL (1) IL221481A (enExample)
SG (1) SG183315A1 (enExample)
WO (1) WO2011102531A1 (enExample)

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Publication number Priority date Publication date Assignee Title
KR101764100B1 (ko) 2009-02-27 2017-08-02 고쿠리츠 다이가쿠 호진 교토 다이가쿠 신규한 핵 재프로그래밍 물질
WO2011016588A1 (en) 2009-08-07 2011-02-10 Kyoto University Method of efficiently establishing induced pluripotent stem cells
US9758765B2 (en) 2011-04-08 2017-09-12 Osaka University Modified laminin and use thereof
WO2012141181A1 (ja) * 2011-04-11 2012-10-18 国立大学法人京都大学 核初期化物質
EP2853592B1 (en) 2012-05-23 2019-02-20 Kyoto University Highly efficient method for establishing artificial pluripotent stem cell
EP2873727B1 (en) * 2012-07-12 2019-11-06 Kyoto Prefectural Public University Corporation Brown fat cells and method for preparing same
SG11201503167XA (en) * 2012-10-23 2015-05-28 Univ Kyoto Method of efficiently establishing induced pluripotent stem cells
AU2014324233B2 (en) * 2013-09-24 2020-07-23 Id Pharma Co., Ltd. Method for improving efficiency of inducing pluripotent stem cell
CN104017777A (zh) * 2014-01-07 2014-09-03 中国人民解放军第三军医大学第一附属医院 用于治疗视网膜疾病的试剂盒
EP3165603B1 (en) * 2014-07-03 2019-09-18 Juntendo Educational Foundation Pancreatic endocrine cells, method for producing same, and transdifferentiation agent
WO2017073740A1 (ja) 2015-10-29 2017-05-04 学校法人埼玉医科大学 膵内分泌細胞の製造方法、及び分化転換剤
US9936734B2 (en) 2016-03-11 2018-04-10 Altria Client Services, Llc. Personal carrying case for electronic vaping device
CN106086071B (zh) * 2016-06-13 2019-08-09 广州市搏克生物技术有限公司 一种非病毒iPSCs诱导方法及其诱导组合物、试剂盒及其获得的iPSCs
CN105861447B (zh) * 2016-06-13 2017-12-19 广州市搏克生物技术有限公司 一种非病毒iPSCs诱导组合物及其试剂盒
US11845960B2 (en) 2016-09-12 2023-12-19 President And Fellows Of Harvard College Transcription factors controlling differentiation of stem cells
CN106939299B (zh) * 2017-02-04 2022-11-15 滨州医学院 microRNA重编程体细胞为神经干细胞的制备方法及应用
WO2018232079A1 (en) 2017-06-14 2018-12-20 Daley George Q Hematopoietic stem and progenitor cells derived from hemogenic endothelial cells by episomal plasmid gene transfer
WO2019108894A1 (en) 2017-12-01 2019-06-06 President And Fellows Of Harvard College Methods and compositions for the production of oligodendrocyte progenitor cells
US11788131B2 (en) 2018-04-06 2023-10-17 President And Fellows Of Harvard College Methods of identifying combinations of transcription factors
US20220145255A1 (en) 2019-02-26 2022-05-12 Tohoku University Method for producing osteoblast cluster using ips cells
CN110079459A (zh) * 2019-05-15 2019-08-02 刘宝全 一种干细胞培养容器内气体平衡的调节方法
EP4060023A4 (en) 2019-11-12 2023-12-13 Juntendo Educational Foundation METHOD FOR DIRECT TRANSDIFFERENTIATION OF SOMATIC CELL
MX2022008648A (es) 2020-01-23 2022-12-15 The Children´S Medical Center Corp Diferenciacion de celulas t sin estroma a partir de celulas madre pluripotentes humanas.
CN116426573A (zh) * 2023-04-14 2023-07-14 臻赫医药(杭州)有限公司 重编程因子抗衰老表达系统、生物材料及用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101420740B1 (ko) 2005-12-13 2014-07-17 교또 다이가꾸 핵초기화 인자
EP2137296A2 (en) 2007-03-23 2009-12-30 Wisconsin Alumni Research Foundation Somatic cell reprogramming
KR101564044B1 (ko) 2007-10-31 2015-10-28 고쿠리츠 다이가쿠 호진 교토 다이가쿠 핵초기화 방법
US20110231944A1 (en) 2008-09-04 2011-09-22 Riken B cell-derived ips cells and application thereof
ES2549155T3 (es) 2008-09-08 2015-10-23 Riken Células iPS obtenidas a partir de células NKT y células NKT obtenidas a partir de las mismas
KR101764100B1 (ko) 2009-02-27 2017-08-02 고쿠리츠 다이가쿠 호진 교토 다이가쿠 신규한 핵 재프로그래밍 물질
CN101613717B (zh) * 2009-04-17 2012-01-11 中国科学院广州生物医药与健康研究院 用猪成纤维细胞生成诱导的多能性干细胞的方法
WO2011016588A1 (en) 2009-08-07 2011-02-10 Kyoto University Method of efficiently establishing induced pluripotent stem cells

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Publication number Publication date
KR20120131180A (ko) 2012-12-04
EP2536828B1 (en) 2015-09-09
CN102782122B (zh) 2015-02-25
JP5765746B2 (ja) 2015-08-19
US20130029423A1 (en) 2013-01-31
WO2011102531A1 (en) 2011-08-25
US8927277B2 (en) 2015-01-06
IL221481A (en) 2016-06-30
CN102782122A (zh) 2012-11-14
CA2789749A1 (en) 2011-08-25
EP2536828A4 (en) 2014-01-15
IL221481A0 (en) 2012-10-31
EP2536828A1 (en) 2012-12-26
SG183315A1 (en) 2012-09-27
CA2789749C (en) 2018-09-04
JP2013519371A (ja) 2013-05-30

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