JP2013518115A - 代謝疾患及び肥満の治療のためのグルカゴンアンタゴニスト‐gipアゴニスト複合体及び組成物 - Google Patents

代謝疾患及び肥満の治療のためのグルカゴンアンタゴニスト‐gipアゴニスト複合体及び組成物 Download PDF

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JP2013518115A
JP2013518115A JP2012551270A JP2012551270A JP2013518115A JP 2013518115 A JP2013518115 A JP 2013518115A JP 2012551270 A JP2012551270 A JP 2012551270A JP 2012551270 A JP2012551270 A JP 2012551270A JP 2013518115 A JP2013518115 A JP 2013518115A
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amino acid
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ディマルキ,リチャード,ディー.
マ,タオ
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Indiana University Research and Technology Corp
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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  • Genetics & Genomics (AREA)
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  • Toxicology (AREA)
  • Hematology (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2012551270A 2010-01-27 2011-01-26 代謝疾患及び肥満の治療のためのグルカゴンアンタゴニスト‐gipアゴニスト複合体及び組成物 Pending JP2013518115A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29881210P 2010-01-27 2010-01-27
US61/298,812 2010-01-27
PCT/US2011/022608 WO2011094337A1 (en) 2010-01-27 2011-01-26 Glucagon antagonist - gip agonist conjugates and compositions for the treatment of metabolic disorders and obesity

Related Child Applications (1)

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JP2016100832A Division JP2016183177A (ja) 2010-01-27 2016-05-19 代謝疾患及び肥満の治療のためのグルカゴンアンタゴニスト‐gipアゴニスト複合体及び組成物

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JP2013518115A5 JP2013518115A5 (enExample) 2014-03-27

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JP2012551270A Pending JP2013518115A (ja) 2010-01-27 2011-01-26 代謝疾患及び肥満の治療のためのグルカゴンアンタゴニスト‐gipアゴニスト複合体及び組成物
JP2016100832A Pending JP2016183177A (ja) 2010-01-27 2016-05-19 代謝疾患及び肥満の治療のためのグルカゴンアンタゴニスト‐gipアゴニスト複合体及び組成物

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US (2) US8551946B2 (enExample)
EP (1) EP2528618A4 (enExample)
JP (2) JP2013518115A (enExample)
KR (1) KR20120123443A (enExample)
CN (1) CN102834108A (enExample)
BR (1) BR112012018585A2 (enExample)
CA (1) CA2788304A1 (enExample)
IN (1) IN2012DN06437A (enExample)
MX (1) MX2012008603A (enExample)
RU (1) RU2012136450A (enExample)
WO (1) WO2011094337A1 (enExample)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016503772A (ja) * 2012-12-21 2016-02-08 サノフイ 二重glp1/gipまたは三方glp1/gip/グルカゴンアゴニスト
JP2018500282A (ja) * 2014-10-29 2018-01-11 ジーランド ファーマ アクティーゼルスカブ Gipアゴニスト化合物及び方法
JP2018521043A (ja) * 2015-06-22 2018-08-02 イーライ リリー アンド カンパニー グルカゴン及びglp−1共アゴニスト化合物
JP2019510014A (ja) * 2016-03-10 2019-04-11 メドイミューン・リミテッドMedImmune Limited 肥満の治療のためのグルカゴン及びglp−1コアゴニスト
JP2020505472A (ja) * 2017-01-27 2020-02-20 ボード オブ スーパーバイザーズ オブ ルイジアナ ステート ユニバーシティ アンド アグリカルチュアル アンド メカニカル カレッジ 自己免疫性糖尿病のための二官能性低分子ペプチド
JP2020521784A (ja) * 2017-05-31 2020-07-27 ユニバーシティ オブ コペンハーゲン 長時間作用性gipペプチド類似体
JP2022532332A (ja) * 2019-05-16 2022-07-14 浙江道尓生物科技有限公司 代謝性疾患を治療するための融合タンパク質
JP2023530515A (ja) * 2020-06-22 2023-07-18 サン ファーマシューティカル インダストリーズ リミテッド 長時間作用性glp-1/gipデュアルアゴニスト
JP2023534130A (ja) * 2020-07-22 2023-08-08 ノヴォ ノルディスク アー/エス Glp-1受容体およびgip受容体共作動薬

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CN101534846B (zh) 2005-11-07 2014-11-05 印第安纳大学研究及科技有限公司 显示生理学溶解性和稳定性的胰高血糖素类似物
JP5890085B2 (ja) 2007-01-05 2016-03-22 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation 生理学的pHの緩衝液中で向上した溶解度を示すグルカゴン類縁体
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EP2217701B9 (en) 2007-10-30 2015-02-18 Indiana University Research and Technology Corporation Glucagon antagonists
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BR112014031671A2 (pt) 2012-06-21 2018-08-07 Hoffmann La Roche análogos de glucagon exibindo atividade de receptor gip
RU2015101697A (ru) 2012-06-21 2016-08-10 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Аналоги глюкагона, обладающие активностью рецептора gip
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PL2916819T3 (pl) 2012-11-06 2020-01-31 Hanmi Pharm. Co., Ltd. Płynna formuła koniugatu białka zawierająca oksyntomodulinę i fragment immunoglobulinowy
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CN105440102B (zh) * 2014-09-24 2018-09-25 中国科学院大连化学物理研究所 一种源于鹿皮的具有dpp-iv抑制活性的多肽及其应用
CN105504010B (zh) * 2014-09-24 2018-09-21 中国科学院大连化学物理研究所 一种具有dpp-iv抑制活性的多肽及其应用
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JP2020007338A (ja) * 2015-06-22 2020-01-16 イーライ リリー アンド カンパニー グルカゴン及びglp−1共アゴニスト化合物
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JP7237590B6 (ja) 2016-03-10 2023-03-28 メドイミューン・リミテッド 肥満の治療のためのグルカゴン及びglp-1コアゴニスト
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CN102834108A (zh) 2012-12-19
MX2012008603A (es) 2013-01-25
BR112012018585A2 (pt) 2017-01-10
WO2011094337A8 (en) 2012-08-16
JP2016183177A (ja) 2016-10-20
IN2012DN06437A (enExample) 2015-10-09
EP2528618A4 (en) 2015-05-27
KR20120123443A (ko) 2012-11-08
US8551946B2 (en) 2013-10-08
US20120322725A1 (en) 2012-12-20
CA2788304A1 (en) 2011-08-04
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