JP2013517798A - ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター - Google Patents

ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター Download PDF

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JP2013517798A
JP2013517798A JP2012551228A JP2012551228A JP2013517798A JP 2013517798 A JP2013517798 A JP 2013517798A JP 2012551228 A JP2012551228 A JP 2012551228A JP 2012551228 A JP2012551228 A JP 2012551228A JP 2013517798 A JP2013517798 A JP 2013517798A
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aav
vector
particles
factor
growth factor
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JP2013517798A5 (enExample
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ライト、ジョン、フレイザー
ク、グアング
ホウク、バーント
ハイ、キャサリン
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ザ チルドレンズ ホスピタル オブ フィラデルフィア
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    • A61K39/12—Viral antigens
    • A61K39/23—Parvoviridae, e.g. feline panleukopenia virus
    • A—HUMAN NECESSITIES
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JP2012551228A 2010-01-28 2011-01-25 ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター Pending JP2013517798A (ja)

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US29918410P 2010-01-28 2010-01-28
US61/299,184 2010-01-28
PCT/US2011/022371 WO2011094198A1 (en) 2010-01-28 2011-01-25 A scalable manufacturing platform for viral vector purification and viral vectors so purified for use in gene therapy

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JP2016107298A Division JP2016185153A (ja) 2010-01-28 2016-05-30 ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター

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JP2012551228A Pending JP2013517798A (ja) 2010-01-28 2011-01-25 ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター
JP2016107298A Pending JP2016185153A (ja) 2010-01-28 2016-05-30 ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター
JP2017186157A Pending JP2018046820A (ja) 2010-01-28 2017-09-27 ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター
JP2018072783A Active JP6991095B2 (ja) 2010-01-28 2018-04-04 ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター

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JP2017186157A Pending JP2018046820A (ja) 2010-01-28 2017-09-27 ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター
JP2018072783A Active JP6991095B2 (ja) 2010-01-28 2018-04-04 ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター

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US (4) US9408904B2 (enExample)
EP (1) EP2529020B1 (enExample)
JP (4) JP2013517798A (enExample)
CN (2) CN102947453A (enExample)
AU (1) AU2011209743B2 (enExample)
CA (1) CA2787827C (enExample)
DK (1) DK2529020T3 (enExample)
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Cited By (9)

* Cited by examiner, † Cited by third party
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JP2017509632A (ja) * 2014-03-21 2017-04-06 ジェンザイム・コーポレーション 網膜色素変性症のための遺伝子治療
JP2018507707A (ja) * 2015-02-09 2018-03-22 インスティチュート ナショナル デ ラ サンテ エ デ ラ ルシェルシュ メディカル （インセルム） アフィニティー精製工程を含む組換えアデノ随伴ウイルス粒子の精製
JP2018518164A (ja) * 2015-02-09 2018-07-12 インスティチュート ナショナル デ ラ サンテ エ デ ラ ルシェルシュ メディカル （インセルム） 多段階陰イオン交換クロマトグラフィーによる組換えアデノ随伴ウイルス粒子の精製
JP2018121653A (ja) * 2010-01-28 2018-08-09 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアＴｈｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ Ｏｆ Ｐｈｉｌａｄｅｌｐｈｉａ ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター
KR20190006951A (ko) * 2016-03-31 2019-01-21 스파크 테라퓨틱스, 인코포레이티드 컬럼-기반 완전히 확장 가능한 rAAV 제조 공정
JP2019524101A (ja) * 2016-07-21 2019-09-05 スパーク セラピューティクス インコーポレイテッドＳｐａｒｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 高収率の組換えアデノ随伴ウイルス（ｒＡＡＶ）ベクターを生成するための、規模拡大可能な高回収率の方法、及びそれにより生成される組換えアデノ随伴ウイルス（ｒＡＡＶ）ベクター
JP2020502997A (ja) * 2016-11-04 2020-01-30 バクスアルタ インコーポレイテッド アデノ随伴ウイルスの精製法
JP2020526190A (ja) * 2017-06-30 2020-08-31 スパーク セラピューティクス インコーポレイテッドＳｐａｒｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Ａａｖベクターのカラム精製方法
JP2021502123A (ja) * 2017-11-08 2021-01-28 アヴェクシス インコーポレーテッド ウイルスベクターの調製手段及び方法並びにその使用

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AU2012304993B2 (en) * 2011-09-08 2017-09-14 Uniqure Ip B.V. Removal of contaminating viruses from AAV preparations
EP4282419A1 (en) 2012-12-20 2023-11-29 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
FR3002237B1 (fr) * 2013-02-15 2017-12-15 Genethon Methodes pour la production de particules virales aav double brin
US9644216B2 (en) 2013-11-26 2017-05-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adeno-associated virus vectors for treatment of glycogen storage disease
GB201401707D0 (en) 2014-01-31 2014-03-19 Sec Dep For Health The Adeno-associated viral vectors
US10072251B2 (en) 2014-02-19 2018-09-11 University Of Massachusetts Recombinant AAVS having useful transcytosis properties
CA3276269A1 (en) 2014-03-18 2026-03-02 University Of Massachusetts Raav-based compositions and methods for treating amyotrophic lateral sclerosis
US10975391B2 (en) 2014-04-25 2021-04-13 University Of Massachusetts Recombinant AAV vectors useful for reducing immunity against transgene products
CA2946392A1 (en) 2014-04-25 2015-10-29 James M. Wilson Ldlr variants and their use in compositions for reducing cholesterol levels
WO2015187825A2 (en) 2014-06-03 2015-12-10 University Of Massachusetts Compositions and methods for modulating dysferlin expression
EP3200830B1 (en) 2014-10-03 2020-09-09 University of Massachusetts High efficiency library-identified aav vectors
US10370432B2 (en) 2014-10-03 2019-08-06 University Of Massachusetts Heterologous targeting peptide grafted AAVS
RU2020140209A (ru) 2014-10-21 2021-01-25 Юниверсити Оф Массачусетс Варианты рекомбинантных aav и их применения
BR112017011217A2 (pt) * 2014-11-28 2018-02-06 Uniqure Ip B.V. impurezas de dna em uma composição compreendendo um vírion parvoviral
ES2824829T3 (es) 2014-12-23 2021-05-13 Us Health Vectores de virus adenoasociado que codifican G6PC modificada y usos de estos
CN107428799A (zh) 2015-01-13 2017-12-01 阿尔法韦士曼公司 纯化腺相关病毒(AAV)及/或重组腺相关病毒(rAAV)之方法及其梯度和流通式缓冲液
WO2016131009A1 (en) 2015-02-13 2016-08-18 University Of Massachusetts Compositions and methods for transient delivery of nucleases
EP3262162A4 (en) * 2015-02-23 2018-08-08 Voyager Therapeutics, Inc. Regulatable expression using adeno-associated virus (aav)
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JP2020526190A (ja) * 2017-06-30 2020-08-31 スパーク セラピューティクス インコーポレイテッドＳｐａｒｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Ａａｖベクターのカラム精製方法
JP2021502123A (ja) * 2017-11-08 2021-01-28 アヴェクシス インコーポレーテッド ウイルスベクターの調製手段及び方法並びにその使用
JP7587422B2 (ja) 2017-11-08 2024-11-20 ノバルティス アーゲー ウイルスベクターの調製手段及び方法並びにその使用
JP2025017361A (ja) * 2017-11-08 2025-02-05 ノバルティス アーゲー ウイルスベクターの調製手段及び方法並びにその使用

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AU2011209743B2 (en) 2016-03-10
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US11878056B2 (en) 2024-01-23
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US20200405845A1 (en) 2020-12-31
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