JP2013517798A - ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター - Google Patents

ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター Download PDF

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JP2013517798A
JP2013517798A JP2012551228A JP2012551228A JP2013517798A JP 2013517798 A JP2013517798 A JP 2013517798A JP 2012551228 A JP2012551228 A JP 2012551228A JP 2012551228 A JP2012551228 A JP 2012551228A JP 2013517798 A JP2013517798 A JP 2013517798A
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aav
vector
particles
factor
growth factor
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JP2013517798A5 (enExample
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ライト、ジョン、フレイザー
ク、グアング
ホウク、バーント
ハイ、キャサリン
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ザ チルドレンズ ホスピタル オブ フィラデルフィア
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    • A61K39/23—Parvoviridae, e.g. feline panleukopenia virus
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JP2012551228A 2010-01-28 2011-01-25 ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター Pending JP2013517798A (ja)

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US29918410P 2010-01-28 2010-01-28
US61/299,184 2010-01-28
PCT/US2011/022371 WO2011094198A1 (en) 2010-01-28 2011-01-25 A scalable manufacturing platform for viral vector purification and viral vectors so purified for use in gene therapy

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JP2016107298A Division JP2016185153A (ja) 2010-01-28 2016-05-30 ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター

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JP2012551228A Pending JP2013517798A (ja) 2010-01-28 2011-01-25 ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター
JP2016107298A Pending JP2016185153A (ja) 2010-01-28 2016-05-30 ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター
JP2017186157A Pending JP2018046820A (ja) 2010-01-28 2017-09-27 ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター
JP2018072783A Active JP6991095B2 (ja) 2010-01-28 2018-04-04 ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター

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JP2017186157A Pending JP2018046820A (ja) 2010-01-28 2017-09-27 ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター
JP2018072783A Active JP6991095B2 (ja) 2010-01-28 2018-04-04 ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター

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US (4) US9408904B2 (enExample)
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JP (4) JP2013517798A (enExample)
CN (2) CN102947453A (enExample)
AU (1) AU2011209743B2 (enExample)
CA (1) CA2787827C (enExample)
DK (1) DK2529020T3 (enExample)
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Cited By (9)

* Cited by examiner, † Cited by third party
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JP2017509632A (ja) * 2014-03-21 2017-04-06 ジェンザイム・コーポレーション 網膜色素変性症のための遺伝子治療
JP2018507707A (ja) * 2015-02-09 2018-03-22 インスティチュート ナショナル デ ラ サンテ エ デ ラ ルシェルシュ メディカル （インセルム） アフィニティー精製工程を含む組換えアデノ随伴ウイルス粒子の精製
JP2018518164A (ja) * 2015-02-09 2018-07-12 インスティチュート ナショナル デ ラ サンテ エ デ ラ ルシェルシュ メディカル （インセルム） 多段階陰イオン交換クロマトグラフィーによる組換えアデノ随伴ウイルス粒子の精製
JP2018121653A (ja) * 2010-01-28 2018-08-09 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアＴｈｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ Ｏｆ Ｐｈｉｌａｄｅｌｐｈｉａ ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター
KR20190006951A (ko) * 2016-03-31 2019-01-21 스파크 테라퓨틱스, 인코포레이티드 컬럼-기반 완전히 확장 가능한 rAAV 제조 공정
JP2019524101A (ja) * 2016-07-21 2019-09-05 スパーク セラピューティクス インコーポレイテッドＳｐａｒｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 高収率の組換えアデノ随伴ウイルス（ｒＡＡＶ）ベクターを生成するための、規模拡大可能な高回収率の方法、及びそれにより生成される組換えアデノ随伴ウイルス（ｒＡＡＶ）ベクター
JP2020502997A (ja) * 2016-11-04 2020-01-30 バクスアルタ インコーポレイテッド アデノ随伴ウイルスの精製法
JP2020526190A (ja) * 2017-06-30 2020-08-31 スパーク セラピューティクス インコーポレイテッドＳｐａｒｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Ａａｖベクターのカラム精製方法
JP2021502123A (ja) * 2017-11-08 2021-01-28 アヴェクシス インコーポレーテッド ウイルスベクターの調製手段及び方法並びにその使用

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WO2011133874A1 (en) 2010-04-23 2011-10-27 University Of Massachusetts Multicistronic expression constructs
US9102949B2 (en) 2010-04-23 2015-08-11 University Of Massachusetts CNS targeting AAV vectors and methods of use thereof
WO2013036118A1 (en) * 2011-09-08 2013-03-14 Uniqure Ip B.V. Removal of contaminating viruses from aav preparations
ES2949648T3 (es) 2012-12-20 2023-10-02 Purdue Research Foundation Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer
FR3002237B1 (fr) * 2013-02-15 2017-12-15 Genethon Methodes pour la production de particules virales aav double brin
CA2930872C (en) 2013-11-26 2022-05-31 University Of Florida Research Foundation, Incorporated Adeno-associated virus vectors for treatment of glycogen storage disease
GB201401707D0 (en) 2014-01-31 2014-03-19 Sec Dep For Health The Adeno-associated viral vectors
WO2015127128A2 (en) 2014-02-19 2015-08-27 University Of Massachusetts Recombinant aavs having useful transcytosis properties
AU2015231294B2 (en) 2014-03-18 2020-10-29 University Of Massachusetts rAAV-based compositions and methods for treating amyotrophic lateral sclerosis
JP6741590B2 (ja) 2014-04-25 2020-08-19 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア コレステロールレベルを低下させるためのｌｄｌｒ変異体および組成物中でのそれらの使用
US10975391B2 (en) 2014-04-25 2021-04-13 University Of Massachusetts Recombinant AAV vectors useful for reducing immunity against transgene products
US10689653B2 (en) 2014-06-03 2020-06-23 University Of Massachusetts Compositions and methods for modulating dysferlin expression
WO2016054557A1 (en) 2014-10-03 2016-04-07 University Of Massachusetts Novel high efficiency library-identified aav vectors
WO2016054554A1 (en) 2014-10-03 2016-04-07 University Of Massachusetts Heterologous targeting peptide grafted aavs
CA2964272A1 (en) 2014-10-21 2016-04-28 Guangping Gao Recombinant aav variants and uses thereof
WO2016083560A1 (en) * 2014-11-28 2016-06-02 Uniqure Ip B.V. Dna impurities in a composition comprising a parvoviral virion
US10415044B2 (en) 2014-12-23 2019-09-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adeno-associated virus vectors encoding modified G6PC and uses thereof
EP3245218A4 (en) 2015-01-13 2018-10-03 Alfa Wassermann, Inc. Methods of purifying adeno-associated virus (aav) and/or recombinant adeno-associated virus (raav) and gradients and flow-through buffers therefore
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JP7587422B2 (ja) 2017-11-08 2024-11-20 ノバルティス アーゲー ウイルスベクターの調製手段及び方法並びにその使用
JP2025017361A (ja) * 2017-11-08 2025-02-05 ノバルティス アーゲー ウイルスベクターの調製手段及び方法並びにその使用

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