SG11202009698PA - Aav compositions, methods of making and methods of use - Google Patents
Aav compositions, methods of making and methods of useInfo
- Publication number
- SG11202009698PA SG11202009698PA SG11202009698PA SG11202009698PA SG11202009698PA SG 11202009698P A SG11202009698P A SG 11202009698PA SG 11202009698P A SG11202009698P A SG 11202009698PA SG 11202009698P A SG11202009698P A SG 11202009698PA SG 11202009698P A SG11202009698P A SG 11202009698PA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- making
- aav compositions
- aav
- compositions
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0091—Purification or manufacturing processes for gene therapy compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0031—Serum-free culture media
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/005—Protein-free medium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/0106—Protein geranylgeranyltransferase type II (2.5.1.60)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862653139P | 2018-04-05 | 2018-04-05 | |
US201862746980P | 2018-10-17 | 2018-10-17 | |
US201862773975P | 2018-11-30 | 2018-11-30 | |
PCT/US2019/026064 WO2019195729A1 (en) | 2018-04-05 | 2019-04-05 | Aav compositions, methods of making and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202009698PA true SG11202009698PA (en) | 2020-10-29 |
Family
ID=66223873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202009698PA SG11202009698PA (en) | 2018-04-05 | 2019-04-05 | Aav compositions, methods of making and methods of use |
Country Status (19)
Country | Link |
---|---|
US (1) | US20210145929A1 (en) |
EP (1) | EP3775234A1 (en) |
JP (1) | JP2021520233A (en) |
KR (1) | KR20210005045A (en) |
CN (1) | CN112384626A (en) |
AU (1) | AU2019247866A1 (en) |
BR (1) | BR112020020174A2 (en) |
CA (1) | CA3096051A1 (en) |
CL (1) | CL2020002566A1 (en) |
CO (1) | CO2020013699A2 (en) |
CR (1) | CR20200507A (en) |
IL (1) | IL277786A (en) |
JO (1) | JOP20200250A1 (en) |
MA (1) | MA52200A (en) |
MX (1) | MX2020010191A (en) |
PH (1) | PH12020551642A1 (en) |
SG (1) | SG11202009698PA (en) |
TW (1) | TW202000905A (en) |
WO (1) | WO2019195729A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115461453A (en) * | 2020-03-16 | 2022-12-09 | 奥特吉尼克斯制药公司 | Method for improving yield of recombinant adeno-associated virus |
CA3191545A1 (en) | 2020-09-02 | 2022-03-10 | David H. Kirn | Codon optimized rep1 genes and uses thereof |
WO2022109247A1 (en) * | 2020-11-20 | 2022-05-27 | Biogen Ma Inc. | Viral vector potency assay |
WO2023165969A1 (en) | 2022-03-03 | 2023-09-07 | Evonik Operations Gmbh | Process to enhance viral vector production in cell-culture using glycyl-glutamine |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2787827C (en) * | 2010-01-28 | 2020-11-10 | The Children's Hospital Of Philadelphia | A scalable manufacturing platform for viral vector purification and viral vectors so purified for use in gene therapy |
GB201103062D0 (en) | 2011-02-22 | 2011-04-06 | Isis Innovation | Method |
EP3054007A1 (en) * | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant adeno-associated virus particle purification comprising an immuno-affinity purification step |
-
2019
- 2019-04-05 SG SG11202009698PA patent/SG11202009698PA/en unknown
- 2019-04-05 BR BR112020020174-0A patent/BR112020020174A2/en not_active Application Discontinuation
- 2019-04-05 CN CN201980037670.1A patent/CN112384626A/en not_active Withdrawn
- 2019-04-05 CA CA3096051A patent/CA3096051A1/en not_active Withdrawn
- 2019-04-05 AU AU2019247866A patent/AU2019247866A1/en not_active Withdrawn
- 2019-04-05 US US17/045,093 patent/US20210145929A1/en not_active Abandoned
- 2019-04-05 JO JOP/2020/0250A patent/JOP20200250A1/en unknown
- 2019-04-05 KR KR1020207031797A patent/KR20210005045A/en unknown
- 2019-04-05 WO PCT/US2019/026064 patent/WO2019195729A1/en active Application Filing
- 2019-04-05 EP EP19718558.0A patent/EP3775234A1/en not_active Withdrawn
- 2019-04-05 JP JP2021504132A patent/JP2021520233A/en not_active Withdrawn
- 2019-04-05 MX MX2020010191A patent/MX2020010191A/en unknown
- 2019-04-05 CR CR20200507A patent/CR20200507A/en unknown
- 2019-04-05 MA MA052200A patent/MA52200A/en unknown
- 2019-04-08 TW TW108112198A patent/TW202000905A/en unknown
-
2020
- 2020-10-04 IL IL277786A patent/IL277786A/en unknown
- 2020-10-05 CL CL2020002566A patent/CL2020002566A1/en unknown
- 2020-10-05 PH PH12020551642A patent/PH12020551642A1/en unknown
- 2020-10-30 CO CONC2020/0013699A patent/CO2020013699A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
MA52200A (en) | 2021-02-17 |
AU2019247866A1 (en) | 2020-10-22 |
CO2020013699A2 (en) | 2021-04-08 |
IL277786A (en) | 2020-11-30 |
CR20200507A (en) | 2021-03-02 |
KR20210005045A (en) | 2021-01-13 |
PH12020551642A1 (en) | 2021-07-26 |
BR112020020174A2 (en) | 2021-01-19 |
MX2020010191A (en) | 2021-02-26 |
JOP20200250A1 (en) | 2020-10-04 |
CA3096051A1 (en) | 2019-10-10 |
CN112384626A (en) | 2021-02-19 |
US20210145929A1 (en) | 2021-05-20 |
WO2019195729A1 (en) | 2019-10-10 |
TW202000905A (en) | 2020-01-01 |
JP2021520233A (en) | 2021-08-19 |
EP3775234A1 (en) | 2021-02-17 |
CL2020002566A1 (en) | 2021-04-16 |
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