JP2013516190A5 - - Google Patents
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- JP2013516190A5 JP2013516190A5 JP2012548108A JP2012548108A JP2013516190A5 JP 2013516190 A5 JP2013516190 A5 JP 2013516190A5 JP 2012548108 A JP2012548108 A JP 2012548108A JP 2012548108 A JP2012548108 A JP 2012548108A JP 2013516190 A5 JP2013516190 A5 JP 2013516190A5
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- Prior art keywords
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- 239000002773 nucleotide Substances 0.000 claims 16
- 125000003729 nucleotide group Chemical group 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 208000035657 Abasia Diseases 0.000 claims 5
- 150000004713 phosphodiesters Chemical class 0.000 claims 5
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine group Chemical group [C@@H]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=NC=2C(N)=NC=NC12 OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 4
- 230000000692 anti-sense effect Effects 0.000 claims 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 3
- 108091081021 Sense strand Proteins 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229910052816 inorganic phosphate Inorganic materials 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- MXHRCPNRJAMMIM-SHYZEUOFSA-N 2'-deoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-SHYZEUOFSA-N 0.000 claims 1
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 claims 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 claims 1
- 239000005547 deoxyribonucleotide Substances 0.000 claims 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 claims 1
- MXHRCPNRJAMMIM-UHFFFAOYSA-N desoxyuridine Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 125000002652 ribonucleotide group Chemical group 0.000 claims 1
- DWRXFEITVBNRMK-JXOAFFINSA-N ribothymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 DWRXFEITVBNRMK-JXOAFFINSA-N 0.000 claims 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims 1
- 229940045145 uridine Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29287810P | 2010-01-07 | 2010-01-07 | |
| US61/292,878 | 2010-01-07 | ||
| PCT/US2010/049047 WO2011084193A1 (en) | 2010-01-07 | 2010-09-16 | Oligonucleotide compounds comprising non-nucleotide overhangs |
| USPCT/US2010/049047 | 2010-09-16 | ||
| PCT/US2011/020298 WO2011085056A1 (en) | 2010-01-07 | 2011-01-06 | Oligonucleotide compounds comprising non-nucleotide overhangs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013516190A JP2013516190A (ja) | 2013-05-13 |
| JP2013516190A5 true JP2013516190A5 (enExample) | 2014-01-30 |
| JP5824463B2 JP5824463B2 (ja) | 2015-11-25 |
Family
ID=44305677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012548108A Expired - Fee Related JP5824463B2 (ja) | 2010-01-07 | 2011-01-06 | 非ヌクレオチドオーバーハングを含むオリゴヌクレオチド化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8859751B2 (enExample) |
| EP (1) | EP2521783B1 (enExample) |
| JP (1) | JP5824463B2 (enExample) |
| CN (1) | CN102770541B (enExample) |
| ES (1) | ES2640091T3 (enExample) |
| WO (2) | WO2011084193A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2801928C (en) | 2010-06-24 | 2018-04-10 | Quark Pharmaceuticals, Inc. | Double stranded rna compounds to rhoa and use thereof |
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| EP2649181B1 (en) | 2010-12-06 | 2016-04-27 | Quark Pharmaceuticals, Inc. | Double stranded oligonucleotide compounds comprising positional modifications |
| EP2681315B1 (en) | 2011-03-03 | 2017-05-03 | Quark Pharmaceuticals, Inc. | Oligonucleotide modulators of the toll-like receptor pathway |
| US9796979B2 (en) | 2011-03-03 | 2017-10-24 | Quark Pharmaceuticals Inc. | Oligonucleotide modulators of the toll-like receptor pathway |
| SG11201401648RA (en) | 2011-11-03 | 2014-05-29 | Quark Pharmaceuticals Inc | Methods and compositions for neuroprotection |
| US20140323549A1 (en) | 2011-11-08 | 2014-10-30 | Quark Pharmaceuticals, Inc. | Methods and compositions for treating diseases, disorders or injury of the nervous system |
| JP2015509085A (ja) | 2012-01-01 | 2015-03-26 | キュービーアイ エンタープライゼズ リミテッドＱｂｉ Ｅｎｔｅｒｐｒｉｓｅｓ Ｌｔｄ． | 治療剤および診断剤の選択的送達のためのｅｎｄｏ１８０を標的とする粒子 |
| EA036003B1 (ru) * | 2012-01-04 | 2020-09-11 | Кварк Фармасьютикалс, Инк. | Способ лечения оптической нейропатии с применением двухцепочечной рнк к casp2 |
| US9707235B1 (en) | 2012-01-13 | 2017-07-18 | University Of Kentucky Research Foundation | Protection of cells from degeneration and treatment of geographic atrophy |
| US10125362B2 (en) | 2012-05-22 | 2018-11-13 | Olix Pharmaceuticals, Inc. | RNA-interference-inducing nucleic acid molecule able to penetrate into cells, and use therefor |
| CN104619844A (zh) | 2012-09-12 | 2015-05-13 | 夸克制药公司 | 靶向p53的双链寡核苷酸分子及其使用方法 |
| EP2895608B1 (en) | 2012-09-12 | 2018-12-05 | Quark Pharmaceuticals, Inc. | Double-stranded oligonucleotide molecules to p53 and methods of use thereof |
| JP6346568B2 (ja) * | 2012-11-29 | 2018-06-20 | 国立大学法人岐阜大学 | Ｒｎａ干渉剤、その製造方法及びその利用 |
| CN105452465B (zh) | 2013-07-31 | 2019-06-21 | 奇比艾企业有限公司 | 鞘脂-聚烷基胺-寡核苷酸化合物 |
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| KR101696704B1 (ko) | 2013-12-17 | 2017-01-16 | 주식회사 인코드젠 | 오프-타겟을 막기 위해 변형된 rna 간섭 유도 핵산 및 그 용도 |
| HUE054226T2 (hu) | 2014-05-29 | 2021-08-30 | Quark Pharmaceuticals Inc | Módszerek és készítmények az ischaemia reperfúziós károsodás megelõzésére a szervekben |
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| PL3350333T3 (pl) | 2015-09-17 | 2022-03-07 | Modernatx, Inc. | Polinukleotydy zawierające region stabilizujący ogon |
| CN108699556B (zh) | 2015-11-16 | 2023-02-17 | 奥利克斯医药有限公司 | 使用靶向myd88或tlr3的rna复合物治疗老年性黄斑变性 |
| CN108779464B (zh) | 2016-02-02 | 2022-05-17 | 奥利克斯医药有限公司 | 使用靶向angpt2和pdgfb的rna复合物治疗血管生成相关性疾病 |
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| CN109072238B (zh) | 2016-04-11 | 2022-05-24 | 奥利克斯医药有限公司 | 使用靶向结缔组织生长因子的rna复合物治疗特发性肺纤维化 |
| KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
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| EP3941483A4 (en) * | 2019-03-21 | 2023-10-18 | Arnay Sciences, Llc | ANTISEN OLIGONUCLEOTIDES FOR ALLEL SPECIFICITY |
| JP7539493B2 (ja) * | 2020-05-26 | 2024-08-23 | オリックス ファーマシューティカルズ，インコーポレーテッド | ＭｙＤ８８を標的とするＲＮＡｉ製剤及びその用途 |
| BR112023014443A2 (pt) * | 2021-01-30 | 2024-01-23 | E Therapeutics Plc | Ácidos nucleicos contendo nucleotídeos abásicos |
| WO2022162155A1 (en) * | 2021-01-30 | 2022-08-04 | E-Therapeutics Plc | Nucleic acids containing abasic nucleotides |
| CA3232053A1 (en) * | 2021-10-08 | 2023-04-13 | E-Therapeutics Plc | Nucleic acids containing abasic nucleosides |
| EP4562150A2 (en) * | 2022-07-27 | 2025-06-04 | E-Therapeutics plc | Nucleic acid compounds |
| WO2024023254A1 (en) * | 2022-07-27 | 2024-02-01 | E-Therapeutics Plc | Nucleic acid compounds |
| EP4562148A1 (en) * | 2022-07-27 | 2025-06-04 | E-Therapeutics plc | Nucleic acid compounds |
| WO2024165571A2 (en) * | 2023-02-06 | 2024-08-15 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025125576A2 (en) * | 2023-12-15 | 2025-06-19 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| EP4686757A1 (en) * | 2024-07-31 | 2026-02-04 | e-therapeutics PLC | Inhibitors of expression and/or function |
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| US20090176725A1 (en) * | 2005-08-17 | 2009-07-09 | Sirna Therapeutics Inc. | Chemically modified short interfering nucleic acid molecules that mediate rna interference |
| WO2007031877A2 (en) * | 2005-09-16 | 2007-03-22 | Coley Pharmaceutical Gmbh | Modulation of immunostimulatory properties of short interfering ribonucleic acid (sirna) by nucleotide modification |
| WO2007087451A2 (en) | 2006-01-25 | 2007-08-02 | University Of Massachusetts | Compositions and methods for enhancing discriminatory rna interference |
| GB0608838D0 (en) | 2006-05-04 | 2006-06-14 | Novartis Ag | Organic compounds |
| JP2010507387A (ja) | 2006-10-25 | 2010-03-11 | クアーク・ファーマスーティカルス、インコーポレイテッド | 新規のｓｉＲＮＡおよびその使用方法 |
| US20100292301A1 (en) | 2007-02-28 | 2010-11-18 | Elena Feinstein | Novel sirna structures |
| US7812002B2 (en) | 2007-03-21 | 2010-10-12 | Quark Pharmaceuticals, Inc. | Oligoribonucleotide inhibitors of NRF2 and methods of use thereof for treatment of cancer |
| WO2009044392A2 (en) | 2007-10-03 | 2009-04-09 | Quark Pharmaceuticals, Inc. | Novel sirna structures |
| US8188060B2 (en) * | 2008-02-11 | 2012-05-29 | Dharmacon, Inc. | Duplex oligonucleotides with enhanced functionality in gene regulation |
| CA2776568A1 (en) | 2009-11-26 | 2011-06-03 | Quark Pharmaceuticals, Inc. | Sirna compounds comprising terminal substitutions |
| WO2011072082A2 (en) | 2009-12-09 | 2011-06-16 | Nitto Denko Corporation | Modulation of hsp47 expression |
| EP2649181B1 (en) | 2010-12-06 | 2016-04-27 | Quark Pharmaceuticals, Inc. | Double stranded oligonucleotide compounds comprising positional modifications |
-
2010
- 2010-09-16 WO PCT/US2010/049047 patent/WO2011084193A1/en not_active Ceased
-
2011
- 2011-01-06 EP EP11701706.1A patent/EP2521783B1/en not_active Not-in-force
- 2011-01-06 US US13/521,033 patent/US8859751B2/en active Active
- 2011-01-06 WO PCT/US2011/020298 patent/WO2011085056A1/en not_active Ceased
- 2011-01-06 CN CN201180011234.0A patent/CN102770541B/zh not_active Expired - Fee Related
- 2011-01-06 JP JP2012548108A patent/JP5824463B2/ja not_active Expired - Fee Related
- 2011-01-06 ES ES11701706.1T patent/ES2640091T3/es active Active
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2014
- 2014-09-15 US US14/485,828 patent/US9249414B2/en not_active Expired - Fee Related
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