ES2640091T3 - Compuestos de oligonucleótidos que comprenden excedentes no nucleótidos - Google Patents
Compuestos de oligonucleótidos que comprenden excedentes no nucleótidos Download PDFInfo
- Publication number
- ES2640091T3 ES2640091T3 ES11701706.1T ES11701706T ES2640091T3 ES 2640091 T3 ES2640091 T3 ES 2640091T3 ES 11701706 T ES11701706 T ES 11701706T ES 2640091 T3 ES2640091 T3 ES 2640091T3
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- structural unit
- nucleotide
- phosphate
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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| WOPCT/US2010/049047 | 2010-09-16 | ||
| PCT/US2010/049047 WO2011084193A1 (en) | 2010-01-07 | 2010-09-16 | Oligonucleotide compounds comprising non-nucleotide overhangs |
| PCT/US2011/020298 WO2011085056A1 (en) | 2010-01-07 | 2011-01-06 | Oligonucleotide compounds comprising non-nucleotide overhangs |
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| EP2046993A4 (en) | 2006-07-07 | 2010-11-17 | Univ Massachusetts | RNA SILENCING COMPOSITIONS, AND METHODS OF TREATING HUNTINGTON CHOREA |
| JP2010507387A (ja) | 2006-10-25 | 2010-03-11 | クアーク・ファーマスーティカルス、インコーポレイテッド | 新規のｓｉＲＮＡおよびその使用方法 |
| US20100292301A1 (en) | 2007-02-28 | 2010-11-18 | Elena Feinstein | Novel sirna structures |
| US7812002B2 (en) | 2007-03-21 | 2010-10-12 | Quark Pharmaceuticals, Inc. | Oligoribonucleotide inhibitors of NRF2 and methods of use thereof for treatment of cancer |
| US8614309B2 (en) | 2007-10-03 | 2013-12-24 | Quark Pharmaceuticals, Inc. | Double-stranded RNA directed to CASP2 and methods of use thereof |
| US8188060B2 (en) * | 2008-02-11 | 2012-05-29 | Dharmacon, Inc. | Duplex oligonucleotides with enhanced functionality in gene regulation |
| EP2504435B1 (en) | 2009-11-26 | 2019-11-13 | Quark Pharmaceuticals, Inc. | Sirna compounds comprising terminal substitutions |
| TWI611021B (zh) | 2009-12-09 | 2018-01-11 | 日東電工股份有限公司 | Ｈｓｐ４７表現之調節 |
| AU2011338682B2 (en) | 2010-12-06 | 2017-04-27 | Quark Pharmaceuticals, Inc. | Double stranded oligonucleotide compounds comprising threose modifications |
-
2010
- 2010-09-16 WO PCT/US2010/049047 patent/WO2011084193A1/en not_active Ceased
-
2011
- 2011-01-06 WO PCT/US2011/020298 patent/WO2011085056A1/en not_active Ceased
- 2011-01-06 ES ES11701706.1T patent/ES2640091T3/es active Active
- 2011-01-06 JP JP2012548108A patent/JP5824463B2/ja not_active Expired - Fee Related
- 2011-01-06 US US13/521,033 patent/US8859751B2/en active Active
- 2011-01-06 EP EP11701706.1A patent/EP2521783B1/en not_active Not-in-force
- 2011-01-06 CN CN201180011234.0A patent/CN102770541B/zh not_active Expired - Fee Related
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2014
- 2014-09-15 US US14/485,828 patent/US9249414B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN102770541A (zh) | 2012-11-07 |
| CN102770541B (zh) | 2016-03-09 |
| HK1178566A1 (zh) | 2013-09-13 |
| US20130035368A1 (en) | 2013-02-07 |
| US20150159154A1 (en) | 2015-06-11 |
| US8859751B2 (en) | 2014-10-14 |
| WO2011084193A1 (en) | 2011-07-14 |
| US9249414B2 (en) | 2016-02-02 |
| EP2521783A1 (en) | 2012-11-14 |
| EP2521783B1 (en) | 2017-08-09 |
| WO2011085056A1 (en) | 2011-07-14 |
| JP2013516190A (ja) | 2013-05-13 |
| JP5824463B2 (ja) | 2015-11-25 |
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