JP2013513384A - 合成ガスまたは他のガス状の炭素源およびメタノールを1,3−ブタンジオールへ変換するための方法および生物 - Google Patents
合成ガスまたは他のガス状の炭素源およびメタノールを1,3−ブタンジオールへ変換するための方法および生物 Download PDFInfo
- Publication number
- JP2013513384A JP2013513384A JP2012543135A JP2012543135A JP2013513384A JP 2013513384 A JP2013513384 A JP 2013513384A JP 2012543135 A JP2012543135 A JP 2012543135A JP 2012543135 A JP2012543135 A JP 2012543135A JP 2013513384 A JP2013513384 A JP 2013513384A
- Authority
- JP
- Japan
- Prior art keywords
- reductase
- protein
- coa
- encoding
- nucleic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C1CC*CC1 Chemical compound C1CC*CC1 0.000 description 4
- HGCIXCUEYOPUTN-UHFFFAOYSA-N C1CC=CCC1 Chemical compound C1CC=CCC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N C1CCCCC1 Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/16—Butanols
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28531209P | 2009-12-10 | 2009-12-10 | |
| US61/285,312 | 2009-12-10 | ||
| PCT/US2010/057525 WO2011071682A1 (en) | 2009-12-10 | 2010-11-19 | Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013513384A true JP2013513384A (ja) | 2013-04-22 |
| JP2013513384A5 JP2013513384A5 (enExample) | 2014-01-09 |
Family
ID=44069194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543135A Pending JP2013513384A (ja) | 2009-12-10 | 2010-11-19 | 合成ガスまたは他のガス状の炭素源およびメタノールを1,3−ブタンジオールへ変換するための方法および生物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8268607B2 (enExample) |
| EP (1) | EP2510102A4 (enExample) |
| JP (1) | JP2013513384A (enExample) |
| KR (1) | KR20120120493A (enExample) |
| CN (3) | CN109136161A (enExample) |
| BR (1) | BR112012014062A2 (enExample) |
| CA (1) | CA2783096A1 (enExample) |
| MX (1) | MX2012006602A (enExample) |
| RU (1) | RU2012128843A (enExample) |
| SG (1) | SG181607A1 (enExample) |
| WO (1) | WO2011071682A1 (enExample) |
| ZA (1) | ZA201204217B (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017534268A (ja) * | 2014-09-30 | 2017-11-24 | ズヴァシンサ リミテッド | 有用産物の生産のための改変微生物および方法 |
| JP2018530342A (ja) * | 2015-10-13 | 2018-10-18 | ランザテク・ニュージーランド・リミテッド | エネルギー発生発酵経路を含む遺伝子操作細菌 |
| JP2020512351A (ja) * | 2017-03-31 | 2020-04-23 | ジェノマティカ, インコーポレイテッド | 発酵ブロスから1,3−ブタンジオールを取得するためのプロセスおよびシステム |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| CA2712779C (en) * | 2008-01-22 | 2021-03-16 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
| SI2265709T1 (en) * | 2008-03-27 | 2018-03-30 | Genomatica, Inc. | MICROORGANISMS FOR PREPARATION OF ADYPIC ACID AND OTHER COMPOUNDS |
| JP2011519561A (ja) * | 2008-05-01 | 2011-07-14 | ジェノマティカ, インコーポレイテッド | メタクリル酸の産生のための微生物 |
| US8129154B2 (en) | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| CA2735883C (en) * | 2008-09-10 | 2020-05-05 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol |
| KR20110097951A (ko) * | 2008-12-16 | 2011-08-31 | 게노마티카 인코포레이티드 | 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법 |
| BRPI1013426A2 (pt) | 2009-04-30 | 2016-11-08 | Genomatica Inc | organismos para produção de 1,3-butanodiol |
| SI3392340T1 (sl) | 2009-06-04 | 2022-05-31 | Genomatica, Inc. | Mikroorganizmi za proizvodnjo 1,4-BUTANDIOLA in pripadajoči postopki |
| LT2438036T (lt) | 2009-06-04 | 2017-06-26 | Genomatica, Inc. | Fermentacijos sultinio komponentų išskyrimo būdas |
| JP2012529889A (ja) | 2009-06-10 | 2012-11-29 | ゲノマチカ, インク. | Mek及び2−ブタノールの炭素効率のよい生合成のための微生物及び方法 |
| AU2010306785B2 (en) * | 2009-10-13 | 2016-01-14 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto |
| US8530210B2 (en) * | 2009-11-25 | 2013-09-10 | Genomatica, Inc. | Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone |
| CN109136161A (zh) * | 2009-12-10 | 2019-01-04 | 基因组股份公司 | 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体 |
| CA2787314A1 (en) | 2010-01-29 | 2011-08-04 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of p-toluate and terephthalate |
| US8048661B2 (en) | 2010-02-23 | 2011-11-01 | Genomatica, Inc. | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes |
| US8637286B2 (en) * | 2010-02-23 | 2014-01-28 | Genomatica, Inc. | Methods for increasing product yields |
| US9023636B2 (en) | 2010-04-30 | 2015-05-05 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of propylene |
| MX336229B (es) | 2010-05-05 | 2016-01-08 | Genomatica Inc | Microorganismos y metodos para la biosintesis de butadieno. |
| JP2013535203A (ja) | 2010-07-26 | 2013-09-12 | ジェノマティカ・インコーポレイテッド | 芳香族、2,4−ペンタジエノエートおよび1,3−ブタジエンを生合成するための微生物および方法 |
| WO2012177619A2 (en) * | 2011-06-22 | 2012-12-27 | Genomatica, Inc. | Microorganisms for producing 1,3-butanediol and methods related thereto |
| SG11201400113XA (en) * | 2011-08-19 | 2014-08-28 | Genomatica Inc | Microorganisms and methods for producing 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol and related alcohols |
| AU2013203770B2 (en) * | 2011-09-08 | 2016-03-17 | Genomatica, Inc. | Eukaryotic organisms and methods for producing 1,3-butanediol |
| MX2014002787A (es) * | 2011-09-08 | 2014-12-08 | Genomatica Inc | Organismos eucarioticos y metodos para producir 1, 3 -butanodiol. |
| US8940509B2 (en) | 2011-11-02 | 2015-01-27 | Genomatica, Inc. | Microorganisms and methods for the production of caprolactone |
| WO2013071226A1 (en) * | 2011-11-11 | 2013-05-16 | Genomatica, Inc. | Eukaryotic organisms and methods for increasing the availability of cytosolic acetyl-coa, and for producing 1,3-butanediol |
| KR101865779B1 (ko) * | 2011-11-16 | 2018-06-12 | 한국과학기술원 | 이산화탄소 고정능을 가지는 재조합 미생물 및 이를 이용한 유용물질의 제조 방법 |
| KR102098849B1 (ko) * | 2012-05-30 | 2020-04-09 | 란자테크 뉴질랜드 리미티드 | 재조합 미생물 및 이의 용도 |
| EP3831951A3 (en) | 2012-06-04 | 2021-09-15 | Genomatica, Inc. | Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds |
| JP5638041B2 (ja) * | 2012-07-25 | 2014-12-10 | 住友ゴム工業株式会社 | タイヤ用ゴム組成物、タイヤ部材、及び空気入りタイヤ |
| EP2899270A4 (en) * | 2012-09-24 | 2016-07-20 | Showa Denko Kk | PROCESS FOR PREPARING BUTANEDIOL |
| JP6487325B2 (ja) | 2012-10-08 | 2019-03-20 | キャリスタ, インコーポレイテッド | Gas−fed発酵システム |
| US11535874B2 (en) | 2012-10-22 | 2022-12-27 | Genomatica, Inc. | Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing succinate related thereto |
| CN104797713A (zh) * | 2012-11-27 | 2015-07-22 | 昭和电工株式会社 | 1,4-丁二醇的制造方法及微生物 |
| EP2930239A4 (en) | 2012-12-05 | 2016-06-29 | Showa Denko Kk | 1,4-butanediol production method, microorganism, and gene |
| JPWO2014091991A1 (ja) * | 2012-12-12 | 2017-01-12 | 昭和電工株式会社 | ブタンジオール類の製造方法、ブタンジオール類製造用微生物の作製方法及び微生物 |
| US9422565B2 (en) * | 2013-01-30 | 2016-08-23 | Lanzatech New Zealand Limited | Recombinant microorganisms comprising NADPH dependent enzymes and methods of production therefor |
| EP2971021A4 (en) | 2013-03-15 | 2016-12-21 | Genomatica Inc | MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION |
| CA2900536A1 (en) | 2013-03-15 | 2014-09-25 | Genomatica, Inc. | Process and systems for obtaining 1,4-butanediol from fermentation broths |
| US9850504B2 (en) * | 2013-07-03 | 2017-12-26 | Scientist of Fortune, S.A. | Method for the enzymatic production of 3-buten-2-one |
| WO2015077616A2 (en) * | 2013-11-21 | 2015-05-28 | The Penn State Research Foundation | Methane-to-acetate pathway for producing liquid biofuels and biorenewables |
| PL3077501T3 (pl) | 2013-12-03 | 2022-01-31 | Genomatica, Inc. | Mikroorganizmy i sposoby poprawy wydajności produktu na metanolu z użyciem syntezy acetylo-coa |
| WO2015100338A2 (en) | 2013-12-27 | 2015-07-02 | Genomatica, Inc. | Methods and organisms with increased carbon flux efficiencies |
| US10059920B2 (en) | 2014-01-16 | 2018-08-28 | University Of Delaware | Synthetic methylotrophy to liquid fuels and chemicals |
| EP3741865B1 (en) | 2014-09-18 | 2024-03-13 | Genomatica, Inc. | Non-natural microbial organisms with improved energetic efficiency |
| EA035950B1 (ru) * | 2014-12-08 | 2020-09-04 | Ланцатек Нью Зилэнд Лимитед | Рекомбинантные микроорганизмы, проявляющие повышенный поток при ферментационном пути |
| MX387737B (es) | 2015-02-27 | 2025-03-18 | White Dog Labs Inc | Método de fermentación mixotrófica para producir acetona, isopropanol, acido butírico y otros bioproductos, y mezclas de los mismos. |
| CN108026214B (zh) | 2015-05-30 | 2021-03-02 | 基因组股份公司 | 乙烯基异构酶-脱水酶、烯醇脱水酶、芳樟醇脱水酶和/或巴豆醇脱水酶及其制备和使用 |
| WO2017006183A1 (en) | 2015-07-08 | 2017-01-12 | Conradie Alex Van Eck | Methods and host cells for enhancing production of 1,3-butanediol |
| SG11201803164SA (en) | 2015-10-30 | 2018-05-30 | Genomatica Inc | Methanol dehydrogenase fusion proteins |
| CA3006952A1 (en) | 2015-12-03 | 2017-06-08 | Friedrich Miescher Institute For Biomedical Research | Synp161, a promoter for the specific expression of genes in rod photoreceptors |
| GB201605354D0 (en) | 2016-03-30 | 2016-05-11 | Zuvasyntha Ltd | Modified enzyme |
| US20210079334A1 (en) | 2018-01-30 | 2021-03-18 | Genomatica, Inc. | Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| EP3814515A2 (en) | 2018-06-26 | 2021-05-05 | Genomatica, Inc. | Engineered microorganisms with g3p---> 3pg enzyme and/or fructose-1,6-bisphosphatase including those having synthetic or enhanced methylotrophy |
| CN109593663B (zh) * | 2018-12-27 | 2021-12-07 | 山东海景天环保科技股份公司 | 一种高效生物脱硫菌剂及其应用方法 |
| AU2022218205A1 (en) | 2021-02-08 | 2023-05-25 | Lanzatech, Inc. | Recombinant microorganisms and uses therefor |
| CN113106047B (zh) * | 2021-04-12 | 2024-01-26 | 南京工业大学 | 一种重组食甲基丁酸杆菌及其构建方法与应用 |
| CN114107147B (zh) * | 2021-11-10 | 2023-12-29 | 清华大学 | 一种可利用甲醇生产光学纯1,3-丁二醇的重组微生物及其应用 |
| WO2023201208A1 (en) * | 2022-04-11 | 2023-10-19 | Genomatica, Inc. | 1,3-butylene glycol compositions and methods of use |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002345479A (ja) * | 2001-05-28 | 2002-12-03 | Daicel Chem Ind Ltd | 新規な(r)−2,3−ブタンジオール脱水素酵素、その製造方法、及びこれを利用した光学活性アルコールの製造方法 |
| WO2009031766A2 (en) * | 2007-09-07 | 2009-03-12 | Lg Chem, Ltd. | Mutants having capability to produce 1,4-butanediol and method for preparing 1,4-butanediol using the same |
| WO2009094485A1 (en) * | 2008-01-22 | 2009-07-30 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
Family Cites Families (201)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3513209A (en) * | 1968-08-19 | 1970-05-19 | Du Pont | Method of making 1,4-cyclohexadiene |
| US4076948A (en) * | 1968-10-10 | 1978-02-28 | El Paso Products Company | Process for treatment of adipic acid mother liquor |
| US3965182A (en) * | 1969-10-02 | 1976-06-22 | Ethyl Corporation | Preparation of aniline from phenol and ammonia |
| JPS4831084B1 (enExample) | 1970-09-04 | 1973-09-26 | ||
| JPS5543759B2 (enExample) | 1972-06-28 | 1980-11-07 | ||
| DE2455617C3 (de) | 1974-11-23 | 1982-03-18 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran über die Zwischenstufe des γ-Butyrolactons |
| US4190495A (en) * | 1976-09-27 | 1980-02-26 | Research Corporation | Modified microorganisms and method of preparing and using same |
| US4301077A (en) | 1980-12-22 | 1981-11-17 | Standard Oil Company | Process for the manufacture of 1-4-butanediol and tetrahydrofuran |
| JPS60114197A (ja) | 1983-11-25 | 1985-06-20 | Agency Of Ind Science & Technol | 微生物によるジカルボン酸の製造法 |
| US4871667A (en) | 1984-11-26 | 1989-10-03 | Agency Of Industrial Science & Technology | Process for preparing muconic acid |
| US4652685A (en) * | 1985-11-15 | 1987-03-24 | General Electric Company | Hydrogenation of lactones to glycols |
| ES2036188T3 (es) * | 1986-06-11 | 1993-05-16 | Michigan Biotechnology Institute | Un procedimiento para la produccion de acido succinico por fermentacion anaerobia. |
| US5143834A (en) * | 1986-06-11 | 1992-09-01 | Glassner David A | Process for the production and purification of succinic acid |
| US5168055A (en) | 1986-06-11 | 1992-12-01 | Rathin Datta | Fermentation and purification process for succinic acid |
| US5182199A (en) * | 1987-05-27 | 1993-01-26 | Hartley Brian S | Thermophilic ethanol production in a two-stage closed system |
| US5229279A (en) * | 1987-06-29 | 1993-07-20 | Massachusetts Institute Of Technology | Method for producing novel polyester biopolymers |
| US5219757A (en) | 1988-04-27 | 1993-06-15 | Daicel Chemical Industries, Ltd. | Production of optically active 1,3-butanediol by asymmetric assimilation or reduction of 4-hydroxy-2-butanone |
| CA2062753C (en) * | 1989-04-27 | 2005-04-26 | N. Robert Ward, Jr. | Precipitate test for microorganisms |
| US5192673A (en) * | 1990-04-30 | 1993-03-09 | Michigan Biotechnology Institute | Mutant strain of C. acetobutylicum and process for making butanol |
| US5079143A (en) * | 1990-05-02 | 1992-01-07 | The Upjohn Company | Method of indentifying compounds useful as antiparasitic drugs |
| EP0769557B1 (en) * | 1990-10-15 | 2000-11-15 | Daicel Chemical Industries, Ltd. | Process for producing optically active 1,3-butanediol |
| US5173429A (en) | 1990-11-09 | 1992-12-22 | The Board Of Trustees Of The University Of Arkansas | Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism |
| IL100572A (en) | 1991-01-03 | 1997-01-10 | Lepetit Spa | Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them |
| GB9115245D0 (en) * | 1991-07-16 | 1991-08-28 | Ici Plc | Production of polyalkanoate |
| US5416020A (en) * | 1992-09-29 | 1995-05-16 | Bio-Technical Resources | Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid |
| US6136577A (en) | 1992-10-30 | 2000-10-24 | Bioengineering Resources, Inc. | Biological production of ethanol from waste gases with Clostridium ljungdahlii |
| US5807722A (en) * | 1992-10-30 | 1998-09-15 | Bioengineering Resources, Inc. | Biological production of acetic acid from waste gases with Clostridium ljungdahlii |
| FR2702492B1 (fr) | 1993-03-12 | 1995-05-24 | Rhone Poulenc Chimie | Procédé de production par fermentation d'acide itaconique. |
| US5487987A (en) * | 1993-09-16 | 1996-01-30 | Purdue Research Foundation | Synthesis of adipic acid from biomass-derived carbon sources |
| US5646203A (en) * | 1994-03-31 | 1997-07-08 | Toppan Moore Co., Ltd. | Microcapsule-containing oil-based coating liquid, ink, coated sheet, and method of preparing the same |
| US5521075A (en) * | 1994-12-19 | 1996-05-28 | Michigan Biotechnology Institute | Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants |
| US5504004A (en) * | 1994-12-20 | 1996-04-02 | Michigan Biotechnology Institute | Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms |
| US5700934A (en) | 1995-03-01 | 1997-12-23 | Dsm N.V. | Process for the preparation of epsilon-caprolactam and epsilon-caprolactam precursors |
| US5478952A (en) | 1995-03-03 | 1995-12-26 | E. I. Du Pont De Nemours And Company | Ru,Re/carbon catalyst for hydrogenation in aqueous solution |
| US5863782A (en) * | 1995-04-19 | 1999-01-26 | Women's And Children's Hospital | Synthetic mammalian sulphamidase and genetic sequences encoding same |
| US5686276A (en) | 1995-05-12 | 1997-11-11 | E. I. Du Pont De Nemours And Company | Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism |
| FR2736927B1 (fr) * | 1995-07-18 | 1997-10-17 | Rhone Poulenc Fibres & Polymer | Enzymes a activite amidase, outils genetiques et microorganismes hotes permettant leur obtention et procede d'hydrolyse mettant en oeuvre lesdites enzymes |
| US5573931A (en) | 1995-08-28 | 1996-11-12 | Michigan Biotechnology Institute | Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants |
| US5770435A (en) * | 1995-11-02 | 1998-06-23 | University Of Chicago | Mutant E. coli strain with increased succinic acid production |
| US5869301A (en) | 1995-11-02 | 1999-02-09 | Lockhead Martin Energy Research Corporation | Method for the production of dicarboxylic acids |
| JP2000506012A (ja) | 1996-02-27 | 2000-05-23 | ミシガン ステイト ユニヴァーシティー | サーモアンエアロバクター・エタノリカス39eの第二級アルコールデヒドロゲナーゼをコードする遺伝子のクローニング及び発現並びに酵素の生化学的特徴付け |
| US5958745A (en) * | 1996-03-13 | 1999-09-28 | Monsanto Company | Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants |
| JP4101295B2 (ja) * | 1996-07-01 | 2008-06-18 | バイオエンジニアリング・リソーシズ・インコーポレーテツド | 廃ガスからの酢酸の生物学的生産 |
| KR100459818B1 (ko) * | 1996-09-02 | 2004-12-03 | 이. 아이. 두퐁 드 느무르 앤드 컴퍼니 | ε-카프로락탐의 제조방법 |
| US6117658A (en) | 1997-02-13 | 2000-09-12 | James Madison University | Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units |
| KR100516986B1 (ko) * | 1997-02-19 | 2005-09-26 | 코닌클리즈케 디에스엠 엔.브이. | 6-아미노카프론산 유도체를 과열 수증기와 접촉시킴으로써 촉매 없이 카프로락탐을 제조하는 방법 |
| US6274790B1 (en) * | 1997-04-14 | 2001-08-14 | The University Of British Columbia | Nucleic acids encoding a plant enzyme involved in very long chain fatty acid synthesis |
| KR19990013007A (ko) * | 1997-07-31 | 1999-02-25 | 박원훈 | 형질전환된 대장균 ss373(kctc 8818p)과 이를 이용한숙신산의 생산방법 |
| JPH11103863A (ja) | 1997-10-08 | 1999-04-20 | Nippon Shokubai Co Ltd | マレイン酸異性化酵素遺伝子 |
| US6280986B1 (en) | 1997-12-01 | 2001-08-28 | The United States Of America As Represented By The Secretary Of Agriculture | Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities |
| US20030087381A1 (en) * | 1998-04-13 | 2003-05-08 | University Of Georgia Research Foundation, Inc. | Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals |
| WO1999053035A1 (en) * | 1998-04-13 | 1999-10-21 | The University Of Georgia Research Foundation, Inc. | Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells |
| US6159738A (en) | 1998-04-28 | 2000-12-12 | University Of Chicago | Method for construction of bacterial strains with increased succinic acid production |
| DE19820652A1 (de) | 1998-05-08 | 1999-11-11 | Basf Ag | Kationische Rutheniumkomplexe, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US6432686B1 (en) | 1998-05-12 | 2002-08-13 | E. I. Du Pont De Nemours And Company | Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport |
| US6444784B1 (en) * | 1998-05-29 | 2002-09-03 | Exxonmobil Research & Engineering Company | Wax crystal modifiers (LAW657) |
| TR200100705T2 (tr) * | 1998-06-26 | 2001-10-22 | Iowa State University Research Foundation, Inc. | Bitkilerde enzim ve asetil'in değiştirilmesi için yöntemler. |
| US6531303B1 (en) | 1998-07-06 | 2003-03-11 | Arkion Life Sciences Llc | Method of producing geranylgeraniol |
| WO2000004163A1 (en) * | 1998-07-15 | 2000-01-27 | E.I. Du Pont De Nemours And Company | Tetrahydrofolate metabolism enzymes |
| DE19856136C2 (de) * | 1998-12-04 | 2002-10-24 | Pasteur Institut | Verfahren und Vorrichtung zur Selektion beschleunigter Proliferation lebender Zellen in Suspension |
| US6835820B2 (en) | 1999-01-07 | 2004-12-28 | The University Of Massachusetts | Polyhydroxyalkanoate biosynthesis associated proteins and coding region in bacillus megaterium |
| WO2000046405A2 (en) | 1999-02-02 | 2000-08-10 | Bernhard Palsson | Methods for identifying drug targets based on genomic sequence data |
| US6686310B1 (en) | 1999-02-09 | 2004-02-03 | E. I. Du Pont De Nemours And Company | High surface area sol-gel route prepared hydrogenation catalysts |
| US6365376B1 (en) * | 1999-02-19 | 2002-04-02 | E. I. Du Pont De Nemours And Company | Genes and enzymes for the production of adipic acid intermediates |
| US6448473B1 (en) | 1999-03-05 | 2002-09-10 | Monsanto Technology Llc | Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways |
| CA2374482C (en) | 1999-05-21 | 2012-09-18 | Cargill Dow Llc | Methods and materials for the synthesis of organic products |
| US6852517B1 (en) * | 1999-08-30 | 2005-02-08 | Wisconsin Alumni Research Foundation | Production of 3-hydroxypropionic acid in recombinant organisms |
| US6660857B2 (en) | 2000-02-03 | 2003-12-09 | Dsm N.V. | Process for the preparation of ε-caprolactam |
| KR100359171B1 (ko) * | 2000-05-16 | 2002-10-31 | 한국과학기술원 | 폴리하이드록시알칸산 생합성 효소와 세포내폴리하이드록시알칸산 분해효소를 발현시키는 재조합미생물 및 그를 이용한 (r)-3-하이드록시카르복실산의제조방법 |
| US6878861B2 (en) * | 2000-07-21 | 2005-04-12 | Washington State University Research Foundation | Acyl coenzyme A thioesterases |
| NZ523484A (en) | 2000-07-25 | 2005-01-28 | Emmaus Foundation Inc | Methods for increasing the production of ethanol from microbial fermentation |
| JP4490628B2 (ja) | 2000-11-20 | 2010-06-30 | カーギル インコーポレイテッド | 3−ヒドロキシプロピオン酸および他の有機化合物 |
| US7109010B2 (en) * | 2000-11-22 | 2006-09-19 | Nature Works Llc | Methods and materials for the synthesis of organic products |
| CN1358841A (zh) | 2000-12-11 | 2002-07-17 | 云南省微生物研究所 | 云南链霉菌 |
| US7501268B2 (en) | 2000-12-28 | 2009-03-10 | Toyota Jidosha Kabushiki Kaisha | Methods of producing prenyl alcohols |
| CA2434224C (en) | 2001-01-10 | 2013-04-02 | The Penn State Research Foundation | Method and system for modeling cellular metabolism |
| US7127379B2 (en) | 2001-01-31 | 2006-10-24 | The Regents Of The University Of California | Method for the evolutionary design of biochemical reaction networks |
| US20030059792A1 (en) | 2001-03-01 | 2003-03-27 | Palsson Bernhard O. | Models and methods for determining systemic properties of regulated reaction networks |
| US6743610B2 (en) * | 2001-03-30 | 2004-06-01 | The University Of Chicago | Method to produce succinic acid from raw hydrolysates |
| US6998471B2 (en) * | 2001-07-25 | 2006-02-14 | E.I. Du Pont De Nemours And Company | Polynucleotides encoding an acetyl-CoA acetyltransferase from Hevea brasiliensis, related products, and methods |
| CA2356540A1 (en) * | 2001-08-30 | 2003-02-28 | Emory University | Expressed dna sequences involved in mitochondrial functions |
| CA2466133A1 (en) * | 2001-11-02 | 2003-05-15 | Rice University | Recycling system for manipulation of intracellular nadh availability |
| DE60327804D1 (de) | 2002-01-18 | 2009-07-09 | Novozymes As | Alanin-2,3-aminomutase |
| WO2003066863A1 (fr) * | 2002-02-06 | 2003-08-14 | Showa Denko K.K. | Gene reductase d'un compose carbonyle alpha-substitue-alpha, beta-insature |
| US20030224363A1 (en) | 2002-03-19 | 2003-12-04 | Park Sung M. | Compositions and methods for modeling bacillus subtilis metabolism |
| CA2480216A1 (en) | 2002-03-29 | 2003-10-09 | Genomatica, Inc. | Human metabolic models and methods |
| US20050287655A1 (en) | 2002-05-10 | 2005-12-29 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing mevalonic acid |
| US7856317B2 (en) | 2002-06-14 | 2010-12-21 | Genomatica, Inc. | Systems and methods for constructing genomic-based phenotypic models |
| EP1532516A4 (en) | 2002-07-10 | 2007-05-23 | Penn State Res Found | Method for determining gene knockout strategies |
| US7826975B2 (en) * | 2002-07-10 | 2010-11-02 | The Penn State Research Foundation | Method for redesign of microbial production systems |
| WO2004007688A2 (en) | 2002-07-15 | 2004-01-22 | Kosan Biosciences, Inc. | Metabolic pathways for starter units in polyketide biosynthesis |
| AU2003287028B2 (en) * | 2002-10-04 | 2008-09-04 | E.I. Du Pont De Nemours And Company | Process for the biological production of 1,3-propanediol with high yield |
| AU2003222214B2 (en) | 2002-10-15 | 2010-08-12 | The Regents Of The University Of California | Methods and systems to identify operational reaction pathways |
| AU2003287625A1 (en) * | 2002-11-06 | 2004-06-03 | University Of Florida | Materials and methods for the efficient production of acetate and other products |
| CN1802341A (zh) | 2003-01-13 | 2006-07-12 | 卡吉尔公司 | 制备工业化学品的方法 |
| US7432091B2 (en) | 2003-02-24 | 2008-10-07 | Research Institute Of Innovative Technology For The Earth | Highly efficient hydrogen production method using microorganism |
| US20040199941A1 (en) | 2003-03-24 | 2004-10-07 | Rice University | Increased bacterial CoA and acetyl-CoA pools |
| RU2268300C2 (ru) * | 2003-04-07 | 2006-01-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ОБЛАДАЮЩИХ ПОВЫШЕННОЙ ЭКСПРЕССИЕЙ ГЕНА pckA |
| DE10316109A1 (de) * | 2003-04-09 | 2004-10-21 | Degussa Ag | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
| WO2005010182A1 (ja) | 2003-07-29 | 2005-02-03 | Research Institute Of Innovative Technology For The Earth | コリネ型細菌形質転換体及びそれを用いるジカルボン酸の製造方法 |
| US7927859B2 (en) | 2003-08-22 | 2011-04-19 | Rice University | High molar succinate yield bacteria by increasing the intracellular NADH availability |
| WO2005026349A1 (ja) | 2003-09-17 | 2005-03-24 | Mitsubishi Chemical Corporation | 非アミノ有機酸の製造方法 |
| US7244610B2 (en) * | 2003-11-14 | 2007-07-17 | Rice University | Aerobic succinate production in bacteria |
| BRPI0417706A (pt) * | 2003-12-18 | 2007-03-20 | Basf Ag | métodos para aumentar o fluxo metabólico através da via pentose fosfato em um microorganismo, e para produzir um produto quimico fino, e microorganismo recombinante |
| MXPA06006759A (es) * | 2003-12-18 | 2006-09-04 | Basf Ag | Metodos para la preparacion de lisina por fermentacion de corynebacterium glutamicum. |
| JP2007514436A (ja) * | 2003-12-18 | 2007-06-07 | ビーエーエスエフ アクチェンゲゼルシャフト | 発酵による精密化学物質の製造方法 |
| FR2864967B1 (fr) | 2004-01-12 | 2006-05-19 | Metabolic Explorer Sa | Microorganisme evolue pour la production de 1,2-propanediol |
| CN1926240B (zh) * | 2004-01-19 | 2010-06-02 | 帝斯曼知识产权资产管理有限公司 | 6-氨基己酸的生物化学合成 |
| US7608700B2 (en) | 2004-03-08 | 2009-10-27 | North Carolina State University | Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor |
| DE102004031177A1 (de) | 2004-06-29 | 2006-01-19 | Henkel Kgaa | Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren |
| US7262046B2 (en) * | 2004-08-09 | 2007-08-28 | Rice University | Aerobic succinate production in bacteria |
| CN101044245B (zh) | 2004-08-27 | 2012-05-02 | 莱斯大学 | 具有增加的琥珀酸产量的突变大肠杆菌菌株 |
| EP2434015B1 (en) | 2004-09-09 | 2013-11-20 | Research Institute Of Innovative Technology For The Earth | DNA fragment having promoter function |
| EP1789569A2 (en) * | 2004-09-17 | 2007-05-30 | Rice University | High succinate producing bacteria |
| US7569380B2 (en) * | 2004-12-22 | 2009-08-04 | Rice University | Simultaneous anaerobic production of isoamyl acetate and succinic acid |
| JP2006204255A (ja) * | 2005-01-31 | 2006-08-10 | Canon Inc | アセチル−CoAアシルトランスフェラーゼ遺伝子破壊ポリヒドロキシアルカノエート生産菌、またこれを利用したポリヒドロキシアルカノエート生産方法 |
| EP1874334A4 (en) * | 2005-04-15 | 2011-03-30 | Vascular Biogenics Ltd | COMPOSITIONS WITH BETA 2-GLYCOPROTEIN I-PEPTIDES FOR THE PREVENTION AND / OR TREATMENT OF VASCULAR DISEASES |
| KR100679638B1 (ko) * | 2005-08-19 | 2007-02-06 | 한국과학기술원 | 포메이트 디하이드로게나제 d 또는 e를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법 |
| KR100676160B1 (ko) * | 2005-08-19 | 2007-02-01 | 한국과학기술원 | 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법 |
| AU2006287257A1 (en) * | 2005-09-09 | 2007-03-15 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of succinate |
| US9297028B2 (en) | 2005-09-29 | 2016-03-29 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| NZ566406A (en) * | 2005-10-26 | 2012-04-27 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| US8206970B2 (en) | 2006-05-02 | 2012-06-26 | Butamax(Tm) Advanced Biofuels Llc | Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase |
| DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
| US20080293101A1 (en) | 2006-07-27 | 2008-11-27 | Peters Matthew W | Engineered microorganisms for increasing product yield in biotransformations, related methods and systems |
| EP2097528A2 (en) * | 2006-10-31 | 2009-09-09 | DSMIP Assets B.V. | Butanol production in a eukaryotic cell |
| CA2715093A1 (en) * | 2006-12-01 | 2008-11-27 | Gevo, Inc. | Engineered microorganisms for producing n-butanol and related methods |
| US8017364B2 (en) | 2006-12-12 | 2011-09-13 | Butamax(Tm) Advanced Biofuels Llc | Solvent tolerant microorganisms |
| WO2008080124A2 (en) | 2006-12-21 | 2008-07-03 | Gevo, Inc. | Butanol production by metabolically engineered yeast |
| AU2008206403A1 (en) | 2007-01-12 | 2008-07-24 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms |
| US8673601B2 (en) | 2007-01-22 | 2014-03-18 | Genomatica, Inc. | Methods and organisms for growth-coupled production of 3-hydroxypropionic acid |
| MY156388A (en) * | 2007-02-08 | 2016-02-15 | Biofuelchem Co Ltd | Method for preparing butanol through butyryl-coa as an intermediate using yeast |
| CA2678946C (en) | 2007-03-16 | 2019-02-12 | Genomatica, Inc. | Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors |
| WO2008124523A1 (en) * | 2007-04-04 | 2008-10-16 | The Regents Of The University Of California | Butanol production by recombinant microorganisms |
| EP2147111A4 (en) | 2007-04-18 | 2010-06-23 | Gevo Inc | MANIPULATED MICROORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL |
| US20080274522A1 (en) | 2007-05-02 | 2008-11-06 | Bramucci Michael G | Method for the production of 2-butanone |
| WO2008144060A2 (en) * | 2007-05-17 | 2008-11-27 | Tetravitae Bioscience, Inc. | Methods and compositions for producing solvents |
| JP2010528627A (ja) * | 2007-06-01 | 2010-08-26 | ソラザイム、インク | 微生物による油の生産 |
| EP2158324A1 (en) | 2007-06-15 | 2010-03-03 | Evonik Degussa GmbH | Microorganisms with deregulated vitamin b12 system |
| EP2017344A1 (en) | 2007-07-20 | 2009-01-21 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Production of itaconic acid |
| CN101970673A (zh) | 2007-07-23 | 2011-02-09 | 帝斯曼知识产权资产管理有限公司 | 真核细胞中的丁醇生产 |
| WO2009013157A1 (en) | 2007-07-23 | 2009-01-29 | Dsm Ip Assets B.V. | Butanol production in a eukaryotic cell |
| KR101114918B1 (ko) * | 2007-08-09 | 2012-02-15 | 주식회사 엘지화학 | 재조합 미생물을 이용한 광학활성(s)-3-하이드록시부탄산 및(s)-3-하이드록시부티레이트 에스테르의 제조방법 |
| CA2696018A1 (en) | 2007-08-10 | 2009-04-09 | Genomatica, Inc. | Methods for the synthesis of olefins and derivatives |
| US7947483B2 (en) * | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| US20090139134A1 (en) * | 2007-10-04 | 2009-06-04 | Bio Architecture Lab, Inc. | Biofuel production |
| AU2008310573A1 (en) | 2007-10-12 | 2009-04-16 | The Regents Of The University Of California | Microorganism engineered to produce isopropanol |
| CA2703191A1 (en) | 2007-10-26 | 2009-04-30 | Arbor Fuel Inc. | Methods for the production of n-butanol |
| US8183028B2 (en) * | 2007-12-21 | 2012-05-22 | Ls9, Inc. | Methods and compositions for producing olefins |
| US8455239B2 (en) * | 2007-12-23 | 2013-06-04 | Gevo, Inc. | Yeast organism producing isobutanol at a high yield |
| KR20100119877A (ko) * | 2008-01-28 | 2010-11-11 | 바이오 아키텍쳐 랩, 인크. | 단리된 알코올 디하이드로게나제 효소 및 이의 용도 |
| CN102015995B (zh) | 2008-03-03 | 2014-10-22 | 焦耳无限科技公司 | 产生碳基目的产物的二氧化碳固定工程微生物 |
| JP5755884B2 (ja) | 2008-03-05 | 2015-07-29 | ジェノマティカ, インコーポレイテッド | 第一級アルコールを産生する生物 |
| SI2265709T1 (en) | 2008-03-27 | 2018-03-30 | Genomatica, Inc. | MICROORGANISMS FOR PREPARATION OF ADYPIC ACID AND OTHER COMPOUNDS |
| WO2009124321A1 (en) | 2008-04-04 | 2009-10-08 | University Of Massachusetts | Methods and compositions for improving the production of fuels in microorganisms |
| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| JP2011519561A (ja) | 2008-05-01 | 2011-07-14 | ジェノマティカ, インコーポレイテッド | メタクリル酸の産生のための微生物 |
| US8129154B2 (en) * | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| US20100021978A1 (en) | 2008-07-23 | 2010-01-28 | Genomatica, Inc. | Methods and organisms for production of 3-hydroxypropionic acid |
| WO2010022763A1 (en) | 2008-08-25 | 2010-03-04 | Metabolic Explorer | Method for the preparation of 2-hydroxy-isobutyrate |
| CA2735883C (en) | 2008-09-10 | 2020-05-05 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol |
| WO2010034115A1 (en) * | 2008-09-26 | 2010-04-01 | Kesen Ma | Thermostable alcohol dehydrogenase derived from thermococcus guaymasensis |
| US8357826B2 (en) | 2008-10-16 | 2013-01-22 | Karl Kharas | Methods and apparatus for synthesis of alcohols from syngas |
| US20100184173A1 (en) | 2008-11-14 | 2010-07-22 | Genomatica, Inc. | Microorganisms for the production of methyl ethyl ketone and 2-butanol |
| EP3260532A1 (en) * | 2008-12-12 | 2017-12-27 | CJ Research Center LLC | Green process and compositions for producing poly(5hv) and 5 carbon chemicals |
| KR20110097951A (ko) | 2008-12-16 | 2011-08-31 | 게노마티카 인코포레이티드 | 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법 |
| US8557562B2 (en) * | 2008-12-29 | 2013-10-15 | Butamax(Tm) Advanced Biofuels Llc | Yeast with increased butanol tolerance involving filamentous growth response |
| US8455225B2 (en) * | 2008-12-29 | 2013-06-04 | Butamax Advanced Biofuels Llc | Yeast with increased butanol tolerance involving high osmolarity/glycerol response pathway |
| US8795992B2 (en) * | 2008-12-29 | 2014-08-05 | Butamax Advanced Biofuels Llc | Yeast with increased butanol tolerance involving cell wall integrity pathway |
| US20100086981A1 (en) * | 2009-06-29 | 2010-04-08 | Qteros, Inc. | Compositions and methods for improved saccharification of biomass |
| US9034616B2 (en) | 2009-04-06 | 2015-05-19 | Syracuse University | Butanal production using engineered Streptomyces coelicolor |
| US8993285B2 (en) | 2009-04-30 | 2015-03-31 | Genomatica, Inc. | Organisms for the production of isopropanol, n-butanol, and isobutanol |
| BRPI1013426A2 (pt) | 2009-04-30 | 2016-11-08 | Genomatica Inc | organismos para produção de 1,3-butanodiol |
| ES2749423T3 (es) | 2009-05-07 | 2020-03-20 | Genomatica Inc | Microorganismos y métodos para la biosíntesis de adipato, hexametilendiamina y ácido 6-aminocaproico |
| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
| EP2429587A4 (en) | 2009-05-15 | 2014-10-08 | Genomatica Inc | ORGANISMS FOR THE PREPARATION OF CYCLOHEXANONE |
| LT2438036T (lt) | 2009-06-04 | 2017-06-26 | Genomatica, Inc. | Fermentacijos sultinio komponentų išskyrimo būdas |
| SI3392340T1 (sl) | 2009-06-04 | 2022-05-31 | Genomatica, Inc. | Mikroorganizmi za proizvodnjo 1,4-BUTANDIOLA in pripadajoči postopki |
| JP2012529889A (ja) | 2009-06-10 | 2012-11-29 | ゲノマチカ, インク. | Mek及び2−ブタノールの炭素効率のよい生合成のための微生物及び方法 |
| BR112012005296A2 (pt) | 2009-09-09 | 2019-01-15 | Genomatica Inc | microorganismos e métodos para a coprodução de isopropanol com alcoóis primários, diós e ácidos. |
| WO2011041426A1 (en) * | 2009-09-29 | 2011-04-07 | Butamax(Tm) Advanced Biofuels Llc | Improved yeast production host cells |
| AU2010306785B2 (en) | 2009-10-13 | 2016-01-14 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto |
| KR20180014240A (ko) | 2009-10-23 | 2018-02-07 | 게노마티카 인코포레이티드 | 아닐린의 제조를 위한 미생물 |
| US20120276606A1 (en) * | 2009-10-30 | 2012-11-01 | Daicel Corporation | Recombinant microorganisms with 1,3-butanediol-producing function and uses thereof |
| US8530210B2 (en) | 2009-11-25 | 2013-09-10 | Genomatica, Inc. | Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone |
| US20110137088A1 (en) * | 2009-12-03 | 2011-06-09 | Bp Corporation North America Inc. | Methods and Apparatuses for Producing Renewable Materials From Inhibiting Compounds |
| CN109136161A (zh) * | 2009-12-10 | 2019-01-04 | 基因组股份公司 | 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体 |
| WO2011081658A2 (en) * | 2009-12-15 | 2011-07-07 | Qteros, Inc. | Methods and compositions for producing chemical products from c. phytofermentants |
| CA2787314A1 (en) | 2010-01-29 | 2011-08-04 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of p-toluate and terephthalate |
| RU2012138943A (ru) * | 2010-02-12 | 2014-03-20 | Джево, Инк. | Дрожжевые микроорганизмы с пониженным накоплением побочных продуктов для улучшенного производства топлив, химикатов и аминокислот |
| US8048661B2 (en) | 2010-02-23 | 2011-11-01 | Genomatica, Inc. | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes |
| US8637286B2 (en) | 2010-02-23 | 2014-01-28 | Genomatica, Inc. | Methods for increasing product yields |
| EP2558582A4 (en) | 2010-04-13 | 2013-12-04 | Genomatica Inc | MICROORGANISMS AND PROCESSES FOR THE PRODUCTION OF ETHYLENE GLYCOL |
| US9023636B2 (en) | 2010-04-30 | 2015-05-05 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of propylene |
| MX336229B (es) | 2010-05-05 | 2016-01-08 | Genomatica Inc | Microorganismos y metodos para la biosintesis de butadieno. |
| JP2013535203A (ja) | 2010-07-26 | 2013-09-12 | ジェノマティカ・インコーポレイテッド | 芳香族、2,4−ペンタジエノエートおよび1,3−ブタジエンを生合成するための微生物および方法 |
| BR112013015058A2 (pt) | 2010-12-17 | 2017-12-19 | Genomatica Inc | micro-organismos e métodos para a produção de 1,4-ciclo-hexanodimetanol |
| MX348334B (es) | 2011-02-02 | 2017-06-07 | Genomatica Inc | Microorganismo y metodos para la biosintesis de butadieno. |
| SG11201400113XA (en) * | 2011-08-19 | 2014-08-28 | Genomatica Inc | Microorganisms and methods for producing 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol and related alcohols |
| BR112019020461A2 (pt) * | 2017-03-31 | 2020-06-09 | Genomatica Inc | variantes de aldeído desidrogenase e métodos de uso |
| WO2018183640A1 (en) * | 2017-03-31 | 2018-10-04 | Genomatica, Inc. | 3-hydroxybutyryl-coa dehydrogenase variants and methods of use |
-
2010
- 2010-11-19 CN CN201811072486.4A patent/CN109136161A/zh active Pending
- 2010-11-19 KR KR1020127017813A patent/KR20120120493A/ko not_active Withdrawn
- 2010-11-19 EP EP10836412.6A patent/EP2510102A4/en not_active Withdrawn
- 2010-11-19 WO PCT/US2010/057525 patent/WO2011071682A1/en not_active Ceased
- 2010-11-19 RU RU2012128843/10A patent/RU2012128843A/ru not_active Application Discontinuation
- 2010-11-19 CN CN201910187957.4A patent/CN109880782A/zh active Pending
- 2010-11-19 CN CN2010800635936A patent/CN102753698A/zh active Pending
- 2010-11-19 BR BR112012014062A patent/BR112012014062A2/pt not_active IP Right Cessation
- 2010-11-19 JP JP2012543135A patent/JP2013513384A/ja active Pending
- 2010-11-19 MX MX2012006602A patent/MX2012006602A/es not_active Application Discontinuation
- 2010-11-19 CA CA2783096A patent/CA2783096A1/en not_active Abandoned
- 2010-11-19 SG SG2012042537A patent/SG181607A1/en unknown
- 2010-11-19 US US12/950,954 patent/US8268607B2/en active Active
-
2012
- 2012-06-08 ZA ZA2012/04217A patent/ZA201204217B/en unknown
- 2012-08-28 US US13/597,095 patent/US9284581B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002345479A (ja) * | 2001-05-28 | 2002-12-03 | Daicel Chem Ind Ltd | 新規な(r)−2,3−ブタンジオール脱水素酵素、その製造方法、及びこれを利用した光学活性アルコールの製造方法 |
| WO2009031766A2 (en) * | 2007-09-07 | 2009-03-12 | Lg Chem, Ltd. | Mutants having capability to produce 1,4-butanediol and method for preparing 1,4-butanediol using the same |
| WO2009094485A1 (en) * | 2008-01-22 | 2009-07-30 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
Non-Patent Citations (2)
| Title |
|---|
| JPN6015005055; Applied Microbiology and Biotechnology Vol.75, 2007, p.1249-1256 * |
| JPN6015005059; Journal of Molecular Catalysis B: Enzymatic Vol.11, 2001, p.513-521 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017534268A (ja) * | 2014-09-30 | 2017-11-24 | ズヴァシンサ リミテッド | 有用産物の生産のための改変微生物および方法 |
| JP2018530342A (ja) * | 2015-10-13 | 2018-10-18 | ランザテク・ニュージーランド・リミテッド | エネルギー発生発酵経路を含む遺伝子操作細菌 |
| JP2020512351A (ja) * | 2017-03-31 | 2020-04-23 | ジェノマティカ, インコーポレイテッド | 発酵ブロスから1,3−ブタンジオールを取得するためのプロセスおよびシステム |
| JP2022173383A (ja) * | 2017-03-31 | 2022-11-18 | ジェノマティカ, インコーポレイテッド | 発酵ブロスから1,3-ブタンジオールを取得するためのプロセスおよびシステム |
Also Published As
| Publication number | Publication date |
|---|---|
| US8268607B2 (en) | 2012-09-18 |
| US9284581B2 (en) | 2016-03-15 |
| CN109136161A (zh) | 2019-01-04 |
| KR20120120493A (ko) | 2012-11-01 |
| EP2510102A4 (en) | 2014-01-22 |
| SG181607A1 (en) | 2012-07-30 |
| CN109880782A (zh) | 2019-06-14 |
| CN102753698A (zh) | 2012-10-24 |
| WO2011071682A1 (en) | 2011-06-16 |
| EP2510102A1 (en) | 2012-10-17 |
| RU2012128843A (ru) | 2014-01-20 |
| US20130131262A1 (en) | 2013-05-23 |
| BR112012014062A2 (pt) | 2017-04-04 |
| CA2783096A1 (en) | 2011-06-16 |
| ZA201204217B (en) | 2013-08-28 |
| MX2012006602A (es) | 2012-08-01 |
| US20110129904A1 (en) | 2011-06-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9284581B2 (en) | Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol | |
| US11708589B2 (en) | Microorganisms for producing 1,3-butanediol and methods related thereto | |
| US20250320531A1 (en) | Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,4-butanediol related thereto | |
| US10087470B2 (en) | Methods for increasing product yields | |
| US9109236B2 (en) | Microorganisms and methods for conversion of syngas and other carbon sources to useful products | |
| US8048661B2 (en) | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes | |
| US20230287464A1 (en) | Microorganisms and methods for the production of butadiene using acetyl-coa | |
| KR20140058691A (ko) | 1,3-부탄디올을 생산하기 위한 진핵 유기체 및 방법 | |
| CN107586753A (zh) | 协同产生异丙醇与伯醇,二元醇和酸的微生物和方法 | |
| WO2012177599A2 (en) | Microorganisms for producing n-propanol 1, 3-propanediol, 1,2-propanediol or glycerol and methods related thereto | |
| WO2013012975A1 (en) | Methods for increasing product yields | |
| AU2013203770B2 (en) | Eukaryotic organisms and methods for producing 1,3-butanediol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131118 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20131118 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150210 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150508 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150629 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150807 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160112 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20160406 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20160927 |