JP2013513384A - 合成ガスまたは他のガス状の炭素源およびメタノールを1,3−ブタンジオールへ変換するための方法および生物 - Google Patents
合成ガスまたは他のガス状の炭素源およびメタノールを1,3−ブタンジオールへ変換するための方法および生物 Download PDFInfo
- Publication number
- JP2013513384A JP2013513384A JP2012543135A JP2012543135A JP2013513384A JP 2013513384 A JP2013513384 A JP 2013513384A JP 2012543135 A JP2012543135 A JP 2012543135A JP 2012543135 A JP2012543135 A JP 2012543135A JP 2013513384 A JP2013513384 A JP 2013513384A
- Authority
- JP
- Japan
- Prior art keywords
- reductase
- protein
- coa
- encoding
- nucleic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C1CC*CC1 Chemical compound C1CC*CC1 0.000 description 4
- HGCIXCUEYOPUTN-UHFFFAOYSA-N C1CC=CCC1 Chemical compound C1CC=CCC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N C1CCCCC1 Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/16—Butanols
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28531209P | 2009-12-10 | 2009-12-10 | |
| US61/285,312 | 2009-12-10 | ||
| PCT/US2010/057525 WO2011071682A1 (en) | 2009-12-10 | 2010-11-19 | Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013513384A true JP2013513384A (ja) | 2013-04-22 |
| JP2013513384A5 JP2013513384A5 (OSRAM) | 2014-01-09 |
Family
ID=44069194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543135A Pending JP2013513384A (ja) | 2009-12-10 | 2010-11-19 | 合成ガスまたは他のガス状の炭素源およびメタノールを1,3−ブタンジオールへ変換するための方法および生物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8268607B2 (OSRAM) |
| EP (1) | EP2510102A4 (OSRAM) |
| JP (1) | JP2013513384A (OSRAM) |
| KR (1) | KR20120120493A (OSRAM) |
| CN (3) | CN109136161A (OSRAM) |
| BR (1) | BR112012014062A2 (OSRAM) |
| CA (1) | CA2783096A1 (OSRAM) |
| MX (1) | MX2012006602A (OSRAM) |
| RU (1) | RU2012128843A (OSRAM) |
| SG (1) | SG181607A1 (OSRAM) |
| WO (1) | WO2011071682A1 (OSRAM) |
| ZA (1) | ZA201204217B (OSRAM) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017534268A (ja) * | 2014-09-30 | 2017-11-24 | ズヴァシンサ リミテッド | 有用産物の生産のための改変微生物および方法 |
| JP2018530342A (ja) * | 2015-10-13 | 2018-10-18 | ランザテク・ニュージーランド・リミテッド | エネルギー発生発酵経路を含む遺伝子操作細菌 |
| JP2020512351A (ja) * | 2017-03-31 | 2020-04-23 | ジェノマティカ, インコーポレイテッド | 発酵ブロスから1,3−ブタンジオールを取得するためのプロセスおよびシステム |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| BRPI0907385A2 (pt) | 2008-01-22 | 2015-07-21 | Genomatica Inc | Métodos e organismos para utilização de gás de síntese e outras fontes de carbono gasosas e metanol |
| NO2265709T3 (OSRAM) * | 2008-03-27 | 2018-04-07 | ||
| WO2009135074A2 (en) * | 2008-05-01 | 2009-11-05 | Genomatica, Inc. | Microorganisms for the production of methacrylic acid |
| US8129154B2 (en) | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| CA2735883C (en) * | 2008-09-10 | 2020-05-05 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol |
| BRPI0922276A2 (pt) * | 2008-12-16 | 2015-08-04 | Genomatica Inc | "organismo microbiano de ocorrência não-natural, e , método para produzir isopropanol, 4-hidroxibutirato,e, 1,4-butanodiol." |
| WO2010127319A2 (en) | 2009-04-30 | 2010-11-04 | Genomatica, Inc. | Organisms for the production of 1,3-butanediol |
| CN113528417A (zh) | 2009-06-04 | 2021-10-22 | 基因组股份公司 | 生产1,4-丁二醇的微生物和相关方法 |
| SG176654A1 (en) | 2009-06-04 | 2012-01-30 | Genomatica Inc | Process of separating components of a fermentation broth |
| EP2440669A4 (en) | 2009-06-10 | 2013-08-28 | Genomatica Inc | MICROOGANISMS AND PROCEDURES FOR THE CARBON EFFECTIVE BIOSYNTHESIS MEK AND 2-BUTANOL |
| CN105441374A (zh) * | 2009-10-13 | 2016-03-30 | 基因组股份公司 | 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法 |
| US8530210B2 (en) | 2009-11-25 | 2013-09-10 | Genomatica, Inc. | Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone |
| KR20120120493A (ko) | 2009-12-10 | 2012-11-01 | 게노마티카 인코포레이티드 | 합성 가스 또는 기타 가스상 탄소원 및 메탄올을 1,3-부탄디올로 변환하는 방법 및 변환용 유기체 |
| WO2011094131A1 (en) | 2010-01-29 | 2011-08-04 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of p-toluate and terephthalate |
| US8445244B2 (en) | 2010-02-23 | 2013-05-21 | Genomatica, Inc. | Methods for increasing product yields |
| US8048661B2 (en) | 2010-02-23 | 2011-11-01 | Genomatica, Inc. | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes |
| US9023636B2 (en) | 2010-04-30 | 2015-05-05 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of propylene |
| JP5911847B2 (ja) | 2010-05-05 | 2016-04-27 | ジェノマティカ, インコーポレイテッド | ブタジエンの生合成のための微生物および方法 |
| MX2013001071A (es) | 2010-07-26 | 2013-06-28 | Genomatica Inc | Microorganismos y metodos para la biosintesis de aromaticos, 2, 4-pentadienoato y 1, 3-butadieno. |
| AU2012273177A1 (en) * | 2011-06-22 | 2013-05-02 | Genomatica, Inc. | Microorganisms for producing 1,3-butanediol and methods related thereto |
| JP6272757B2 (ja) | 2011-08-19 | 2018-01-31 | ジェノマティカ, インコーポレイテッド | 2,4−ペンタジエノエート、ブタジエン、プロピレン、1,3−ブタンジオールおよび関連アルコールを生成するための微生物および方法 |
| MX2014002787A (es) * | 2011-09-08 | 2014-12-08 | Genomatica Inc | Organismos eucarioticos y metodos para producir 1, 3 -butanodiol. |
| AU2013203770B2 (en) * | 2011-09-08 | 2016-03-17 | Genomatica, Inc. | Eukaryotic organisms and methods for producing 1,3-butanediol |
| MY197970A (en) | 2011-11-02 | 2023-07-25 | Genomatica Inc | Microorganisms and methods for the production of caprolactone |
| WO2013071226A1 (en) * | 2011-11-11 | 2013-05-16 | Genomatica, Inc. | Eukaryotic organisms and methods for increasing the availability of cytosolic acetyl-coa, and for producing 1,3-butanediol |
| KR101865779B1 (ko) * | 2011-11-16 | 2018-06-12 | 한국과학기술원 | 이산화탄소 고정능을 가지는 재조합 미생물 및 이를 이용한 유용물질의 제조 방법 |
| CN104508136A (zh) * | 2012-05-30 | 2015-04-08 | 新西兰郎泽科技公司 | 重组微生物及其用途 |
| EP2855687B1 (en) | 2012-06-04 | 2020-04-22 | Genomatica, Inc. | Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds |
| JP5638041B2 (ja) * | 2012-07-25 | 2014-12-10 | 住友ゴム工業株式会社 | タイヤ用ゴム組成物、タイヤ部材、及び空気入りタイヤ |
| WO2014045781A1 (ja) * | 2012-09-24 | 2014-03-27 | 昭和電工株式会社 | ブタンジオール類の製造方法 |
| US10501714B2 (en) | 2012-10-08 | 2019-12-10 | Calysta Energy, Inc. | Gas-fed fermentation systems |
| EP2909325A4 (en) * | 2012-10-22 | 2016-05-25 | Genomatica Inc | MICROORGANISMS AND METHOD FOR IMPROVING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL AND FOR PRODUCING SUCCINATE THEREOF |
| JP6243851B2 (ja) * | 2012-11-27 | 2017-12-06 | 昭和電工株式会社 | 1,4−ブタンジオールの製造方法及び微生物 |
| EP2930239A4 (en) | 2012-12-05 | 2016-06-29 | Showa Denko Kk | 1,4-butanediol production method, microorganism, and gene |
| JPWO2014091991A1 (ja) * | 2012-12-12 | 2017-01-12 | 昭和電工株式会社 | ブタンジオール類の製造方法、ブタンジオール類製造用微生物の作製方法及び微生物 |
| AU2014212462B2 (en) * | 2013-01-30 | 2019-01-31 | Lanzatech Nz, Inc. | Recombinant microorganisms comprising NADPH dependent enzymes and methods of production thereof |
| WO2014152434A2 (en) | 2013-03-15 | 2014-09-25 | Genomatica, Inc. | Microorganisms and methods for producing butadiene and related compounds by formate assimilation |
| EP4403543A3 (en) | 2013-03-15 | 2024-11-20 | Genomatica, Inc. | Process and systems for obtaining 1,4-butanediol from fermentation broths |
| EP3017051B1 (en) * | 2013-07-03 | 2021-06-30 | Scientist of Fortune S.A. | Method for the enzymatic production of 3-buten-2-one |
| US20150147791A1 (en) * | 2013-11-21 | 2015-05-28 | The Penn State Research Foundation | Methane-to-acetate pathway for producing liquid biofuels and biorenewables |
| WO2015084633A1 (en) | 2013-12-03 | 2015-06-11 | Genomatica, Inc. | Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis |
| CA2935069C (en) | 2013-12-27 | 2023-05-09 | Genomatica, Inc. | Methods and organisms with increased carbon flux efficiencies |
| WO2015108777A1 (en) | 2014-01-16 | 2015-07-23 | Papoutsakis Eleftherios T | Synthetic methylotrophy to liquid fuels and chemicals |
| CN107208118A (zh) | 2014-09-18 | 2017-09-26 | 基因组股份公司 | 具有提高的能源效率的非天然微生物 |
| PL3230459T3 (pl) * | 2014-12-08 | 2021-03-08 | Lanzatech New Zealand Limited | Rekombinowane mikroorganizmy wykazujące zwiększony strumień przez szlak fermentacji |
| EP3273782B9 (en) * | 2015-02-27 | 2022-07-13 | White Dog Labs, Inc. | Mixotrophic fermentation method for making acetone, isopropanol, and other bioproducts, and mixtures thereof |
| US10941454B2 (en) | 2015-05-30 | 2021-03-09 | Genomatica, Inc. | Vinylisomerase-dehydratases, alkenol dehydratases, linalool dehydratases and crotyl alcohol dehydratases and methods for making and using them |
| WO2017006183A1 (en) | 2015-07-08 | 2017-01-12 | Conradie Alex Van Eck | Methods and host cells for enhancing production of 1,3-butanediol |
| SG11201803164SA (en) | 2015-10-30 | 2018-05-30 | Genomatica Inc | Methanol dehydrogenase fusion proteins |
| JP7042741B2 (ja) | 2015-12-03 | 2022-03-28 | フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ | SynP161、桿体光受容器における遺伝子の特異的発現のためのプロモーター |
| GB201605354D0 (en) | 2016-03-30 | 2016-05-11 | Zuvasyntha Ltd | Modified enzyme |
| US20210079334A1 (en) | 2018-01-30 | 2021-03-18 | Genomatica, Inc. | Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| EP3814515A2 (en) | 2018-06-26 | 2021-05-05 | Genomatica, Inc. | Engineered microorganisms with g3p---> 3pg enzyme and/or fructose-1,6-bisphosphatase including those having synthetic or enhanced methylotrophy |
| CN109593663B (zh) * | 2018-12-27 | 2021-12-07 | 山东海景天环保科技股份公司 | 一种高效生物脱硫菌剂及其应用方法 |
| MY201959A (en) | 2021-02-08 | 2024-03-26 | Lanzatech Inc | Recombinant microorganisms and uses therefor |
| CN113106047B (zh) * | 2021-04-12 | 2024-01-26 | 南京工业大学 | 一种重组食甲基丁酸杆菌及其构建方法与应用 |
| CN114107147B (zh) * | 2021-11-10 | 2023-12-29 | 清华大学 | 一种可利用甲醇生产光学纯1,3-丁二醇的重组微生物及其应用 |
| WO2023201208A1 (en) * | 2022-04-11 | 2023-10-19 | Genomatica, Inc. | 1,3-butylene glycol compositions and methods of use |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002345479A (ja) * | 2001-05-28 | 2002-12-03 | Daicel Chem Ind Ltd | 新規な(r)−2,3−ブタンジオール脱水素酵素、その製造方法、及びこれを利用した光学活性アルコールの製造方法 |
| WO2009031766A2 (en) * | 2007-09-07 | 2009-03-12 | Lg Chem, Ltd. | Mutants having capability to produce 1,4-butanediol and method for preparing 1,4-butanediol using the same |
| WO2009094485A1 (en) * | 2008-01-22 | 2009-07-30 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
Family Cites Families (201)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3513209A (en) * | 1968-08-19 | 1970-05-19 | Du Pont | Method of making 1,4-cyclohexadiene |
| US4076948A (en) * | 1968-10-10 | 1978-02-28 | El Paso Products Company | Process for treatment of adipic acid mother liquor |
| US3965182A (en) * | 1969-10-02 | 1976-06-22 | Ethyl Corporation | Preparation of aniline from phenol and ammonia |
| JPS4831084B1 (OSRAM) | 1970-09-04 | 1973-09-26 | ||
| JPS5543759B2 (OSRAM) | 1972-06-28 | 1980-11-07 | ||
| DE2455617C3 (de) | 1974-11-23 | 1982-03-18 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran über die Zwischenstufe des γ-Butyrolactons |
| US4190495A (en) * | 1976-09-27 | 1980-02-26 | Research Corporation | Modified microorganisms and method of preparing and using same |
| US4301077A (en) | 1980-12-22 | 1981-11-17 | Standard Oil Company | Process for the manufacture of 1-4-butanediol and tetrahydrofuran |
| JPS60114197A (ja) | 1983-11-25 | 1985-06-20 | Agency Of Ind Science & Technol | 微生物によるジカルボン酸の製造法 |
| US4871667A (en) | 1984-11-26 | 1989-10-03 | Agency Of Industrial Science & Technology | Process for preparing muconic acid |
| US4652685A (en) * | 1985-11-15 | 1987-03-24 | General Electric Company | Hydrogenation of lactones to glycols |
| US5143834A (en) * | 1986-06-11 | 1992-09-01 | Glassner David A | Process for the production and purification of succinic acid |
| US5168055A (en) | 1986-06-11 | 1992-12-01 | Rathin Datta | Fermentation and purification process for succinic acid |
| DE3783081T2 (de) * | 1986-06-11 | 1993-04-15 | Michigan Biotech Inst | Verfahren zur herstellung von bernsteinsaeure durch anaerobe fermentation. |
| US5182199A (en) * | 1987-05-27 | 1993-01-26 | Hartley Brian S | Thermophilic ethanol production in a two-stage closed system |
| US5229279A (en) * | 1987-06-29 | 1993-07-20 | Massachusetts Institute Of Technology | Method for producing novel polyester biopolymers |
| US5219757A (en) | 1988-04-27 | 1993-06-15 | Daicel Chemical Industries, Ltd. | Production of optically active 1,3-butanediol by asymmetric assimilation or reduction of 4-hydroxy-2-butanone |
| DE69020555T2 (de) * | 1989-04-27 | 1995-11-02 | Biocontrol Systems Inc | Fällungstest für mikroorganismen. |
| US5192673A (en) * | 1990-04-30 | 1993-03-09 | Michigan Biotechnology Institute | Mutant strain of C. acetobutylicum and process for making butanol |
| US5079143A (en) * | 1990-05-02 | 1992-01-07 | The Upjohn Company | Method of indentifying compounds useful as antiparasitic drugs |
| DE69126298T2 (de) * | 1990-10-15 | 1997-09-04 | Daicel Chem | Verfahren zur Herstellung optisch aktiven (R)-1,3-Butanediols mittels eines Mikroorganismus der Gattung Rhodococcus |
| US5173429A (en) | 1990-11-09 | 1992-12-22 | The Board Of Trustees Of The University Of Arkansas | Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism |
| IL100572A (en) | 1991-01-03 | 1997-01-10 | Lepetit Spa | Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them |
| GB9115245D0 (en) * | 1991-07-16 | 1991-08-28 | Ici Plc | Production of polyalkanoate |
| US5416020A (en) * | 1992-09-29 | 1995-05-16 | Bio-Technical Resources | Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid |
| US6136577A (en) | 1992-10-30 | 2000-10-24 | Bioengineering Resources, Inc. | Biological production of ethanol from waste gases with Clostridium ljungdahlii |
| US5807722A (en) * | 1992-10-30 | 1998-09-15 | Bioengineering Resources, Inc. | Biological production of acetic acid from waste gases with Clostridium ljungdahlii |
| FR2702492B1 (fr) | 1993-03-12 | 1995-05-24 | Rhone Poulenc Chimie | Procédé de production par fermentation d'acide itaconique. |
| US5487987A (en) * | 1993-09-16 | 1996-01-30 | Purdue Research Foundation | Synthesis of adipic acid from biomass-derived carbon sources |
| US5646203A (en) * | 1994-03-31 | 1997-07-08 | Toppan Moore Co., Ltd. | Microcapsule-containing oil-based coating liquid, ink, coated sheet, and method of preparing the same |
| US5521075A (en) * | 1994-12-19 | 1996-05-28 | Michigan Biotechnology Institute | Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants |
| US5504004A (en) * | 1994-12-20 | 1996-04-02 | Michigan Biotechnology Institute | Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms |
| US5700934A (en) | 1995-03-01 | 1997-12-23 | Dsm N.V. | Process for the preparation of epsilon-caprolactam and epsilon-caprolactam precursors |
| US5478952A (en) | 1995-03-03 | 1995-12-26 | E. I. Du Pont De Nemours And Company | Ru,Re/carbon catalyst for hydrogenation in aqueous solution |
| US5863782A (en) * | 1995-04-19 | 1999-01-26 | Women's And Children's Hospital | Synthetic mammalian sulphamidase and genetic sequences encoding same |
| US5686276A (en) | 1995-05-12 | 1997-11-11 | E. I. Du Pont De Nemours And Company | Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism |
| FR2736927B1 (fr) * | 1995-07-18 | 1997-10-17 | Rhone Poulenc Fibres & Polymer | Enzymes a activite amidase, outils genetiques et microorganismes hotes permettant leur obtention et procede d'hydrolyse mettant en oeuvre lesdites enzymes |
| US5573931A (en) | 1995-08-28 | 1996-11-12 | Michigan Biotechnology Institute | Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants |
| US5770435A (en) | 1995-11-02 | 1998-06-23 | University Of Chicago | Mutant E. coli strain with increased succinic acid production |
| US5869301A (en) | 1995-11-02 | 1999-02-09 | Lockhead Martin Energy Research Corporation | Method for the production of dicarboxylic acids |
| EP0883683A1 (en) | 1996-02-27 | 1998-12-16 | Michigan State University | Cloning and expression of the gene encoding thermoanaerobacter ethanolicus 39e secondary-alcohol dehydrogenase and enzyme biochemical characterization |
| US5958745A (en) * | 1996-03-13 | 1999-09-28 | Monsanto Company | Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants |
| JP4101295B2 (ja) * | 1996-07-01 | 2008-06-18 | バイオエンジニアリング・リソーシズ・インコーポレーテツド | 廃ガスからの酢酸の生物学的生産 |
| KR100459818B1 (ko) * | 1996-09-02 | 2004-12-03 | 이. 아이. 두퐁 드 느무르 앤드 컴퍼니 | ε-카프로락탐의 제조방법 |
| EP0977865A1 (en) | 1997-02-13 | 2000-02-09 | James Madison University | Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units |
| KR100516986B1 (ko) * | 1997-02-19 | 2005-09-26 | 코닌클리즈케 디에스엠 엔.브이. | 6-아미노카프론산 유도체를 과열 수증기와 접촉시킴으로써 촉매 없이 카프로락탐을 제조하는 방법 |
| US6274790B1 (en) * | 1997-04-14 | 2001-08-14 | The University Of British Columbia | Nucleic acids encoding a plant enzyme involved in very long chain fatty acid synthesis |
| KR19990013007A (ko) * | 1997-07-31 | 1999-02-25 | 박원훈 | 형질전환된 대장균 ss373(kctc 8818p)과 이를 이용한숙신산의 생산방법 |
| JPH11103863A (ja) | 1997-10-08 | 1999-04-20 | Nippon Shokubai Co Ltd | マレイン酸異性化酵素遺伝子 |
| US6280986B1 (en) | 1997-12-01 | 2001-08-28 | The United States Of America As Represented By The Secretary Of Agriculture | Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities |
| US20030087381A1 (en) * | 1998-04-13 | 2003-05-08 | University Of Georgia Research Foundation, Inc. | Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals |
| MY121380A (en) * | 1998-04-13 | 2006-01-28 | Univ Georgia | Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells |
| US6159738A (en) | 1998-04-28 | 2000-12-12 | University Of Chicago | Method for construction of bacterial strains with increased succinic acid production |
| DE19820652A1 (de) | 1998-05-08 | 1999-11-11 | Basf Ag | Kationische Rutheniumkomplexe, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US6432686B1 (en) | 1998-05-12 | 2002-08-13 | E. I. Du Pont De Nemours And Company | Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport |
| US6444784B1 (en) * | 1998-05-29 | 2002-09-03 | Exxonmobil Research & Engineering Company | Wax crystal modifiers (LAW657) |
| AU756960B2 (en) * | 1998-06-26 | 2003-01-30 | Iowa State University Research Foundation Inc. | Materials and methods for the alteration of enzyme and acetyl CoA levels in plants |
| EP2305825B1 (en) * | 1998-07-06 | 2015-01-14 | DCV Inc. doing business as Bio-Technical Resourses | Method of vitamin production |
| WO2000004163A1 (en) * | 1998-07-15 | 2000-01-27 | E.I. Du Pont De Nemours And Company | Tetrahydrofolate metabolism enzymes |
| DE19856136C2 (de) * | 1998-12-04 | 2002-10-24 | Pasteur Institut | Verfahren und Vorrichtung zur Selektion beschleunigter Proliferation lebender Zellen in Suspension |
| US6835820B2 (en) | 1999-01-07 | 2004-12-28 | The University Of Massachusetts | Polyhydroxyalkanoate biosynthesis associated proteins and coding region in bacillus megaterium |
| AU3482200A (en) | 1999-02-02 | 2000-08-25 | Bernhard Palsson | Methods for identifying drug targets based on genomic sequence data |
| US6686310B1 (en) | 1999-02-09 | 2004-02-03 | E. I. Du Pont De Nemours And Company | High surface area sol-gel route prepared hydrogenation catalysts |
| US6365376B1 (en) * | 1999-02-19 | 2002-04-02 | E. I. Du Pont De Nemours And Company | Genes and enzymes for the production of adipic acid intermediates |
| EP1159435A1 (en) | 1999-03-05 | 2001-12-05 | Monsanto Technology LLC | Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways |
| JP4637372B2 (ja) | 1999-05-21 | 2011-02-23 | カーギル ダウ エルエルシー | 有機生成物の合成方法および合成材料 |
| US6852517B1 (en) * | 1999-08-30 | 2005-02-08 | Wisconsin Alumni Research Foundation | Production of 3-hydroxypropionic acid in recombinant organisms |
| US6660857B2 (en) | 2000-02-03 | 2003-12-09 | Dsm N.V. | Process for the preparation of ε-caprolactam |
| KR100359171B1 (ko) * | 2000-05-16 | 2002-10-31 | 한국과학기술원 | 폴리하이드록시알칸산 생합성 효소와 세포내폴리하이드록시알칸산 분해효소를 발현시키는 재조합미생물 및 그를 이용한 (r)-3-하이드록시카르복실산의제조방법 |
| US6878861B2 (en) * | 2000-07-21 | 2005-04-12 | Washington State University Research Foundation | Acyl coenzyme A thioesterases |
| CA2416500C (en) | 2000-07-25 | 2010-07-13 | Bioengineering Resources, Inc. | Methods for increasing the production of ethanol from microbial fermentation |
| CN1556855A (zh) | 2000-11-20 | 2004-12-22 | 卡吉尔公司 | 3-羟基丙酸及其它有机化合物 |
| CN1249239C (zh) * | 2000-11-22 | 2006-04-05 | 加吉尔·道聚合物公司 | 合成有机产物的方法和材料 |
| CN1358841A (zh) | 2000-12-11 | 2002-07-17 | 云南省微生物研究所 | 云南链霉菌 |
| US7501268B2 (en) | 2000-12-28 | 2009-03-10 | Toyota Jidosha Kabushiki Kaisha | Methods of producing prenyl alcohols |
| WO2002055995A2 (en) | 2001-01-10 | 2002-07-18 | Penn State Res Found | Method and system for modeling cellular metabolism |
| US7127379B2 (en) | 2001-01-31 | 2006-10-24 | The Regents Of The University Of California | Method for the evolutionary design of biochemical reaction networks |
| CA2439260C (en) | 2001-03-01 | 2012-10-23 | The Regents Of The University Of California | Models and methods for determining systemic properties of regulated reaction networks |
| US6743610B2 (en) * | 2001-03-30 | 2004-06-01 | The University Of Chicago | Method to produce succinic acid from raw hydrolysates |
| US6998471B2 (en) * | 2001-07-25 | 2006-02-14 | E.I. Du Pont De Nemours And Company | Polynucleotides encoding an acetyl-CoA acetyltransferase from Hevea brasiliensis, related products, and methods |
| CA2356540A1 (en) * | 2001-08-30 | 2003-02-28 | Emory University | Expressed dna sequences involved in mitochondrial functions |
| WO2003040690A2 (en) * | 2001-11-02 | 2003-05-15 | Rice University | Recycling system for manipulation of intracellular nadh availability |
| JP4532116B2 (ja) | 2002-01-18 | 2010-08-25 | ノボザイムズ エー/エス | アラニン2,3−アミノムターゼ |
| JPWO2003066863A1 (ja) * | 2002-02-06 | 2005-06-02 | 昭和電工株式会社 | α−置換−α,β−不飽和カルボニル化合物の還元酵素遺伝子 |
| US20030224363A1 (en) | 2002-03-19 | 2003-12-04 | Park Sung M. | Compositions and methods for modeling bacillus subtilis metabolism |
| CA2480216A1 (en) | 2002-03-29 | 2003-10-09 | Genomatica, Inc. | Human metabolic models and methods |
| EP1510583A1 (en) | 2002-05-10 | 2005-03-02 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing mevalonic acid |
| US7856317B2 (en) | 2002-06-14 | 2010-12-21 | Genomatica, Inc. | Systems and methods for constructing genomic-based phenotypic models |
| WO2004018621A2 (en) | 2002-07-10 | 2004-03-04 | The Penn State Research Foundation | Method for determining gene knockout strategies |
| US7826975B2 (en) * | 2002-07-10 | 2010-11-02 | The Penn State Research Foundation | Method for redesign of microbial production systems |
| AU2003253949A1 (en) | 2002-07-15 | 2004-02-02 | Kosan Biosciences, Inc. | Metabolic pathways for starter units in polyketide biosynthesis |
| KR101148255B1 (ko) * | 2002-10-04 | 2012-08-08 | 다니스코 유에스 인크. | 고수율을 갖는 1,3-프로판디올의 생물학적 제조 방법 |
| JP5064656B2 (ja) | 2002-10-15 | 2012-10-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 実施反応経路を同定するための方法およびシステム |
| WO2004044210A2 (en) * | 2002-11-06 | 2004-05-27 | University Of Florida | Materials and methods for the efficient production of acetate and other products |
| BRPI0406756A (pt) | 2003-01-13 | 2005-12-20 | Cargill Inc | Método para fabricação de agentes quìmicos industriais |
| JP4275666B2 (ja) | 2003-02-24 | 2009-06-10 | 財団法人地球環境産業技術研究機構 | 微生物による高効率水素製造方法 |
| US20040199941A1 (en) | 2003-03-24 | 2004-10-07 | Rice University | Increased bacterial CoA and acetyl-CoA pools |
| RU2268300C2 (ru) * | 2003-04-07 | 2006-01-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ОБЛАДАЮЩИХ ПОВЫШЕННОЙ ЭКСПРЕССИЕЙ ГЕНА pckA |
| DE10316109A1 (de) * | 2003-04-09 | 2004-10-21 | Degussa Ag | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
| ATE462002T1 (de) | 2003-07-29 | 2010-04-15 | Res Inst Innovative Tech Earth | Transformanten eines coryneformen bakteriums und deren verwendung in verfahren zur produktion von dicarbonsäure |
| US7927859B2 (en) | 2003-08-22 | 2011-04-19 | Rice University | High molar succinate yield bacteria by increasing the intracellular NADH availability |
| BRPI0414300A (pt) | 2003-09-17 | 2006-11-07 | Mitsubishi Chem Corp | método para produzir ácido orgánico não amino |
| US7244610B2 (en) * | 2003-11-14 | 2007-07-17 | Rice University | Aerobic succinate production in bacteria |
| RU2006125498A (ru) * | 2003-12-18 | 2008-01-27 | БАСФ Акциенгезельшафт (DE) | Способы получения химического продукта тонкого органического синтеза путем ферментации |
| US20080032374A1 (en) * | 2003-12-18 | 2008-02-07 | Basf Aktiengesellschaft | Method for the Preparation of Lysine by Fermentation of Corynebacterium Glutamicum |
| CA2548125A1 (en) * | 2003-12-18 | 2005-06-30 | Basf Aktiengesellschaft | Methods for the preparation of a fine chemical by fermentation |
| FR2864967B1 (fr) | 2004-01-12 | 2006-05-19 | Metabolic Explorer Sa | Microorganisme evolue pour la production de 1,2-propanediol |
| ATE455181T1 (de) * | 2004-01-19 | 2010-01-15 | Dsm Ip Assets Bv | Biochemische synthese von 6-aminocapronsäure |
| US7608700B2 (en) | 2004-03-08 | 2009-10-27 | North Carolina State University | Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor |
| DE102004031177A1 (de) | 2004-06-29 | 2006-01-19 | Henkel Kgaa | Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren |
| US7262046B2 (en) * | 2004-08-09 | 2007-08-28 | Rice University | Aerobic succinate production in bacteria |
| KR101245428B1 (ko) | 2004-08-27 | 2013-03-19 | 라이스 유니버시티 | 숙신산 생산이 증가된 돌연변이 대장균 균주 |
| ES2444785T3 (es) | 2004-09-09 | 2014-02-26 | Research Institute Of Innovative Technology For The Earth | Fragmento de ADN que tiene función promotora |
| US20060073577A1 (en) * | 2004-09-17 | 2006-04-06 | San Ka-Yiu | High succinate producing bacteria |
| US7569380B2 (en) * | 2004-12-22 | 2009-08-04 | Rice University | Simultaneous anaerobic production of isoamyl acetate and succinic acid |
| JP2006204255A (ja) * | 2005-01-31 | 2006-08-10 | Canon Inc | アセチル−CoAアシルトランスフェラーゼ遺伝子破壊ポリヒドロキシアルカノエート生産菌、またこれを利用したポリヒドロキシアルカノエート生産方法 |
| WO2006109312A2 (en) * | 2005-04-15 | 2006-10-19 | Vascular Biogenics Ltd. | Compositions containing beta 2-glycoprotein i-derived peptides for the prevention and/or treatment of vascular disease |
| KR100676160B1 (ko) * | 2005-08-19 | 2007-02-01 | 한국과학기술원 | 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법 |
| KR100679638B1 (ko) * | 2005-08-19 | 2007-02-06 | 한국과학기술원 | 포메이트 디하이드로게나제 d 또는 e를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법 |
| EP1937821A4 (en) * | 2005-09-09 | 2009-11-11 | Genomatica Inc | PROCESS AND ORGANISMS FOR GROWTH-COUPLED PRODUCTION OF SUCCINATE |
| US9297028B2 (en) | 2005-09-29 | 2016-03-29 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| JP5276986B2 (ja) * | 2005-10-26 | 2013-08-28 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | 四炭素アルコールの発酵性生産 |
| US8962298B2 (en) | 2006-05-02 | 2015-02-24 | Butamax Advanced Biofuels Llc | Recombinant host cell comprising a diol dehydratase |
| DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
| WO2008013996A2 (en) | 2006-07-27 | 2008-01-31 | Gevo Inc. | Engineered microorganisms for increasing product yield in biotransformations, related methods and systems |
| EP2097528A2 (en) * | 2006-10-31 | 2009-09-09 | DSMIP Assets B.V. | Butanol production in a eukaryotic cell |
| BRPI0719748A2 (pt) * | 2006-12-01 | 2013-12-10 | Gevo Inc | Microrganismo modificados por engenharia para produzir n-butanol e métodos relacionados |
| US8017364B2 (en) | 2006-12-12 | 2011-09-13 | Butamax(Tm) Advanced Biofuels Llc | Solvent tolerant microorganisms |
| EP2121949B1 (en) * | 2006-12-21 | 2013-05-08 | GEVO, Inc. | Butanol production by metabolically engineered yeast |
| CN101903513B (zh) | 2007-01-12 | 2013-08-21 | 科罗拉多大学董事会法人 | 增强微生物对产生的有机化学物质的耐受性的组合物和方法 |
| US8673601B2 (en) | 2007-01-22 | 2014-03-18 | Genomatica, Inc. | Methods and organisms for growth-coupled production of 3-hydroxypropionic acid |
| KR100971792B1 (ko) * | 2007-02-08 | 2010-07-23 | 바이오퓨얼켐 주식회사 | Butyryl-CoA를 중간체로 하여 부탄올을 생합성하는 능력을가지는 효모를 이용하여 부탄올을 제조하는 방법 |
| EP3800262A1 (en) * | 2007-03-16 | 2021-04-07 | Genomatica, Inc. | Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors |
| WO2008124523A1 (en) * | 2007-04-04 | 2008-10-16 | The Regents Of The University Of California | Butanol production by recombinant microorganisms |
| WO2008131286A1 (en) | 2007-04-18 | 2008-10-30 | Gevo, Inc. | Engineered microorganisms for producing isopropanol |
| US20080274522A1 (en) | 2007-05-02 | 2008-11-06 | Bramucci Michael G | Method for the production of 2-butanone |
| EP2152852A2 (en) * | 2007-05-17 | 2010-02-17 | Tetravitae Bioscience, Inc. | Methods and compositions for producing solvents |
| MX2009012850A (es) * | 2007-06-01 | 2010-02-15 | Solazyme Inc | Produccion de aceite en microorganismos. |
| US20100047881A1 (en) | 2007-06-15 | 2010-02-25 | Oskar Zelder | Microorganisms with Deregulated Vitamin B12 System |
| EP2017344A1 (en) | 2007-07-20 | 2009-01-21 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Production of itaconic acid |
| CN104789638A (zh) | 2007-07-23 | 2015-07-22 | 帝斯曼知识产权资产管理有限公司 | 酵母中生产乙酰-CoA的酶 |
| WO2009013160A2 (en) * | 2007-07-23 | 2009-01-29 | Dsm Ip Assets B.V. | Butanol production in a eukaryotic cell |
| KR101114918B1 (ko) * | 2007-08-09 | 2012-02-15 | 주식회사 엘지화학 | 재조합 미생물을 이용한 광학활성(s)-3-하이드록시부탄산 및(s)-3-하이드록시부티레이트 에스테르의 제조방법 |
| CA2696018A1 (en) | 2007-08-10 | 2009-04-09 | Genomatica, Inc. | Methods for the synthesis of olefins and derivatives |
| US7947483B2 (en) * | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| CL2008002960A1 (es) * | 2007-10-04 | 2009-05-08 | Bio Arch Lab Inc | Método para producir 2-ceto-3-desoxi d-gluconato (kdg), basado en proporciopnar acido-desoxi l-eritro hexocelulosa uronico (dehu), y contactar dicha molecula con un microorganismo recombinante que codofica una dehu-hidrogenasa. |
| EP2198039A4 (en) | 2007-10-12 | 2012-05-09 | Univ California | MODIFIED MICROORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL |
| US20100261241A1 (en) | 2007-10-26 | 2010-10-14 | Nikolai Khramtsov | Methods for the production of n-butanol |
| WO2009085278A1 (en) * | 2007-12-21 | 2009-07-09 | Ls9, Inc. | Methods and compositions for producing olefins |
| US8455239B2 (en) * | 2007-12-23 | 2013-06-04 | Gevo, Inc. | Yeast organism producing isobutanol at a high yield |
| KR20100119877A (ko) * | 2008-01-28 | 2010-11-11 | 바이오 아키텍쳐 랩, 인크. | 단리된 알코올 디하이드로게나제 효소 및 이의 용도 |
| EP2706111A1 (en) | 2008-03-03 | 2014-03-12 | Joule Unlimited Technologies, Inc. | Engineered CO2 fixing microorganisms producing carbon-based products of interest |
| BRPI0909690A2 (pt) | 2008-03-05 | 2019-02-26 | Genomatica Inc | organismos produtores de alcoóis primários |
| NO2265709T3 (OSRAM) | 2008-03-27 | 2018-04-07 | ||
| US20090286294A1 (en) | 2008-04-04 | 2009-11-19 | University Of Massachusetts | Methods and Compositions for Improving the Production of Fuels in Microorganisms |
| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| WO2009135074A2 (en) | 2008-05-01 | 2009-11-05 | Genomatica, Inc. | Microorganisms for the production of methacrylic acid |
| US8129154B2 (en) | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| US20100021978A1 (en) | 2008-07-23 | 2010-01-28 | Genomatica, Inc. | Methods and organisms for production of 3-hydroxypropionic acid |
| WO2010022763A1 (en) | 2008-08-25 | 2010-03-04 | Metabolic Explorer | Method for the preparation of 2-hydroxy-isobutyrate |
| CA2735883C (en) | 2008-09-10 | 2020-05-05 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol |
| CA2738574A1 (en) * | 2008-09-26 | 2010-04-01 | Kesen Ma | Thermostable alcohol dehydrogenase derived from thermococcus guaymasensis |
| US8354563B2 (en) | 2008-10-16 | 2013-01-15 | Maverick Biofuels, Inc. | Methods and apparatus for synthesis of alcohols from syngas |
| WO2010057022A1 (en) | 2008-11-14 | 2010-05-20 | Genomatica, Inc. | Microorganisms for the production of methyl ethyl ketone and 2-butanol |
| WO2010068953A2 (en) * | 2008-12-12 | 2010-06-17 | Metabolix Inc. | Green process and compositions for producing poly(5hv) and 5 carbon chemicals |
| BRPI0922276A2 (pt) | 2008-12-16 | 2015-08-04 | Genomatica Inc | "organismo microbiano de ocorrência não-natural, e , método para produzir isopropanol, 4-hidroxibutirato,e, 1,4-butanodiol." |
| US8455225B2 (en) * | 2008-12-29 | 2013-06-04 | Butamax Advanced Biofuels Llc | Yeast with increased butanol tolerance involving high osmolarity/glycerol response pathway |
| US8557562B2 (en) * | 2008-12-29 | 2013-10-15 | Butamax(Tm) Advanced Biofuels Llc | Yeast with increased butanol tolerance involving filamentous growth response |
| US8795992B2 (en) * | 2008-12-29 | 2014-08-05 | Butamax Advanced Biofuels Llc | Yeast with increased butanol tolerance involving cell wall integrity pathway |
| US20100086981A1 (en) * | 2009-06-29 | 2010-04-08 | Qteros, Inc. | Compositions and methods for improved saccharification of biomass |
| US9034616B2 (en) | 2009-04-06 | 2015-05-19 | Syracuse University | Butanal production using engineered Streptomyces coelicolor |
| WO2010127319A2 (en) | 2009-04-30 | 2010-11-04 | Genomatica, Inc. | Organisms for the production of 1,3-butanediol |
| JP2012525156A (ja) | 2009-04-30 | 2012-10-22 | ゲノマチカ, インク. | イソプロパノール、n−ブタノール、及びイソブタノールの産生のための微生物 |
| KR102036265B1 (ko) | 2009-05-07 | 2019-10-24 | 게노마티카 인코포레이티드 | 아디페이트, 헥사메틸렌디아민 및 6-아미노카프로산의 생합성을 위한 미생물 및 방법 |
| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
| AU2010248831A1 (en) | 2009-05-15 | 2011-11-24 | Genomatica, Inc. | Organisms for the production of cyclohexanone |
| CN113528417A (zh) | 2009-06-04 | 2021-10-22 | 基因组股份公司 | 生产1,4-丁二醇的微生物和相关方法 |
| SG176654A1 (en) | 2009-06-04 | 2012-01-30 | Genomatica Inc | Process of separating components of a fermentation broth |
| EP2440669A4 (en) | 2009-06-10 | 2013-08-28 | Genomatica Inc | MICROOGANISMS AND PROCEDURES FOR THE CARBON EFFECTIVE BIOSYNTHESIS MEK AND 2-BUTANOL |
| CA2773694A1 (en) | 2009-09-09 | 2011-03-17 | Genomatica, Inc. | Microorganisms and methods for the co-production of isopropanol with primary alcohols, diols and acids |
| BR112012006939A2 (pt) * | 2009-09-29 | 2015-09-08 | Butamax Tm Advanced Biofuels | célula hospedeira de produção de levedura recombinante e método para a produção de um produto selecionado do grupo que consiste em 2,3-butanodiol, isobutanol, 2-butanol, 1-butanol, 2-butanona, valina, leucina, ácido lático, ácido málico, álcool, isoampilico e isoprenoides |
| CN105441374A (zh) | 2009-10-13 | 2016-03-30 | 基因组股份公司 | 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法 |
| PH12012500766A1 (en) | 2009-10-23 | 2012-11-26 | Genomatica Inc | Microorganisms for the production of aniline |
| US20120276606A1 (en) * | 2009-10-30 | 2012-11-01 | Daicel Corporation | Recombinant microorganisms with 1,3-butanediol-producing function and uses thereof |
| US8530210B2 (en) | 2009-11-25 | 2013-09-10 | Genomatica, Inc. | Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone |
| US20110137088A1 (en) * | 2009-12-03 | 2011-06-09 | Bp Corporation North America Inc. | Methods and Apparatuses for Producing Renewable Materials From Inhibiting Compounds |
| KR20120120493A (ko) * | 2009-12-10 | 2012-11-01 | 게노마티카 인코포레이티드 | 합성 가스 또는 기타 가스상 탄소원 및 메탄올을 1,3-부탄디올로 변환하는 방법 및 변환용 유기체 |
| WO2011081658A2 (en) * | 2009-12-15 | 2011-07-07 | Qteros, Inc. | Methods and compositions for producing chemical products from c. phytofermentants |
| WO2011094131A1 (en) | 2010-01-29 | 2011-08-04 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of p-toluate and terephthalate |
| EP2534240B1 (en) * | 2010-02-12 | 2019-06-05 | GEVO, Inc. | Yeast microorganisms with reduced by-product accumulation for improved production of fuels, chemicals, and amino acids |
| US8445244B2 (en) | 2010-02-23 | 2013-05-21 | Genomatica, Inc. | Methods for increasing product yields |
| US8048661B2 (en) | 2010-02-23 | 2011-11-01 | Genomatica, Inc. | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes |
| SG184848A1 (en) | 2010-04-13 | 2012-11-29 | Genomatica Inc | Microorganisms and methods for the production of ethylene glycol |
| US9023636B2 (en) | 2010-04-30 | 2015-05-05 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of propylene |
| JP5911847B2 (ja) | 2010-05-05 | 2016-04-27 | ジェノマティカ, インコーポレイテッド | ブタジエンの生合成のための微生物および方法 |
| MX2013001071A (es) | 2010-07-26 | 2013-06-28 | Genomatica Inc | Microorganismos y metodos para la biosintesis de aromaticos, 2, 4-pentadienoato y 1, 3-butadieno. |
| EP2652141A4 (en) | 2010-12-17 | 2014-05-14 | Genomatica Inc | MICROORGANISMS AND METHOD FOR PRODUCING 1,4-CYCLOHEXANDIMETHANOL |
| BR112013019811A2 (pt) | 2011-02-02 | 2017-02-21 | Genomatica Inc | processo para a produção de butadieno e organismo microbiano que não ocorre naturalmente. |
| JP6272757B2 (ja) * | 2011-08-19 | 2018-01-31 | ジェノマティカ, インコーポレイテッド | 2,4−ペンタジエノエート、ブタジエン、プロピレン、1,3−ブタンジオールおよび関連アルコールを生成するための微生物および方法 |
| WO2018183640A1 (en) * | 2017-03-31 | 2018-10-04 | Genomatica, Inc. | 3-hydroxybutyryl-coa dehydrogenase variants and methods of use |
| CA3058219A1 (en) * | 2017-03-31 | 2018-10-04 | Genomatica, Inc. | Aldehyde dehydrogenase variants and methods of use |
-
2010
- 2010-11-19 KR KR1020127017813A patent/KR20120120493A/ko not_active Withdrawn
- 2010-11-19 EP EP10836412.6A patent/EP2510102A4/en not_active Withdrawn
- 2010-11-19 CN CN201811072486.4A patent/CN109136161A/zh active Pending
- 2010-11-19 CA CA2783096A patent/CA2783096A1/en not_active Abandoned
- 2010-11-19 JP JP2012543135A patent/JP2013513384A/ja active Pending
- 2010-11-19 SG SG2012042537A patent/SG181607A1/en unknown
- 2010-11-19 CN CN201910187957.4A patent/CN109880782A/zh active Pending
- 2010-11-19 BR BR112012014062A patent/BR112012014062A2/pt not_active IP Right Cessation
- 2010-11-19 US US12/950,954 patent/US8268607B2/en active Active
- 2010-11-19 CN CN2010800635936A patent/CN102753698A/zh active Pending
- 2010-11-19 WO PCT/US2010/057525 patent/WO2011071682A1/en not_active Ceased
- 2010-11-19 MX MX2012006602A patent/MX2012006602A/es not_active Application Discontinuation
- 2010-11-19 RU RU2012128843/10A patent/RU2012128843A/ru not_active Application Discontinuation
-
2012
- 2012-06-08 ZA ZA2012/04217A patent/ZA201204217B/en unknown
- 2012-08-28 US US13/597,095 patent/US9284581B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002345479A (ja) * | 2001-05-28 | 2002-12-03 | Daicel Chem Ind Ltd | 新規な(r)−2,3−ブタンジオール脱水素酵素、その製造方法、及びこれを利用した光学活性アルコールの製造方法 |
| WO2009031766A2 (en) * | 2007-09-07 | 2009-03-12 | Lg Chem, Ltd. | Mutants having capability to produce 1,4-butanediol and method for preparing 1,4-butanediol using the same |
| WO2009094485A1 (en) * | 2008-01-22 | 2009-07-30 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
Non-Patent Citations (2)
| Title |
|---|
| JPN6015005055; Applied Microbiology and Biotechnology Vol.75, 2007, p.1249-1256 * |
| JPN6015005059; Journal of Molecular Catalysis B: Enzymatic Vol.11, 2001, p.513-521 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017534268A (ja) * | 2014-09-30 | 2017-11-24 | ズヴァシンサ リミテッド | 有用産物の生産のための改変微生物および方法 |
| JP2018530342A (ja) * | 2015-10-13 | 2018-10-18 | ランザテク・ニュージーランド・リミテッド | エネルギー発生発酵経路を含む遺伝子操作細菌 |
| JP2020512351A (ja) * | 2017-03-31 | 2020-04-23 | ジェノマティカ, インコーポレイテッド | 発酵ブロスから1,3−ブタンジオールを取得するためのプロセスおよびシステム |
| JP2022173383A (ja) * | 2017-03-31 | 2022-11-18 | ジェノマティカ, インコーポレイテッド | 発酵ブロスから1,3-ブタンジオールを取得するためのプロセスおよびシステム |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109136161A (zh) | 2019-01-04 |
| SG181607A1 (en) | 2012-07-30 |
| KR20120120493A (ko) | 2012-11-01 |
| US9284581B2 (en) | 2016-03-15 |
| BR112012014062A2 (pt) | 2017-04-04 |
| US20110129904A1 (en) | 2011-06-02 |
| MX2012006602A (es) | 2012-08-01 |
| CN102753698A (zh) | 2012-10-24 |
| CA2783096A1 (en) | 2011-06-16 |
| EP2510102A4 (en) | 2014-01-22 |
| ZA201204217B (en) | 2013-08-28 |
| WO2011071682A1 (en) | 2011-06-16 |
| CN109880782A (zh) | 2019-06-14 |
| US20130131262A1 (en) | 2013-05-23 |
| EP2510102A1 (en) | 2012-10-17 |
| RU2012128843A (ru) | 2014-01-20 |
| US8268607B2 (en) | 2012-09-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9284581B2 (en) | Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol | |
| US11708589B2 (en) | Microorganisms for producing 1,3-butanediol and methods related thereto | |
| US20250320531A1 (en) | Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,4-butanediol related thereto | |
| US10087470B2 (en) | Methods for increasing product yields | |
| US9109236B2 (en) | Microorganisms and methods for conversion of syngas and other carbon sources to useful products | |
| US8048661B2 (en) | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes | |
| US20230287464A1 (en) | Microorganisms and methods for the production of butadiene using acetyl-coa | |
| KR20140058691A (ko) | 1,3-부탄디올을 생산하기 위한 진핵 유기체 및 방법 | |
| CN107586753A (zh) | 协同产生异丙醇与伯醇,二元醇和酸的微生物和方法 | |
| WO2012177599A2 (en) | Microorganisms for producing n-propanol 1, 3-propanediol, 1,2-propanediol or glycerol and methods related thereto | |
| EP2734627A1 (en) | Methods for increasing product yields | |
| AU2013203770B2 (en) | Eukaryotic organisms and methods for producing 1,3-butanediol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131118 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20131118 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150210 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150508 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150629 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150807 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160112 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20160406 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20160927 |