JP2013511481A5 - - Google Patents
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- Publication number
- JP2013511481A5 JP2013511481A5 JP2012539237A JP2012539237A JP2013511481A5 JP 2013511481 A5 JP2013511481 A5 JP 2013511481A5 JP 2012539237 A JP2012539237 A JP 2012539237A JP 2012539237 A JP2012539237 A JP 2012539237A JP 2013511481 A5 JP2013511481 A5 JP 2013511481A5
- Authority
- JP
- Japan
- Prior art keywords
- chromatography
- process according
- glycoprotein
- steps
- size exclusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 37
- 102000003886 Glycoproteins Human genes 0.000 claims description 23
- 108090000288 Glycoproteins Proteins 0.000 claims description 23
- 238000001542 size-exclusion chromatography Methods 0.000 claims description 11
- 238000004366 reverse phase liquid chromatography Methods 0.000 claims description 9
- 238000005571 anion exchange chromatography Methods 0.000 claims description 8
- 238000000108 ultra-filtration Methods 0.000 claims description 8
- 238000004191 hydrophobic interaction chromatography Methods 0.000 claims description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 4
- 238000011026 diafiltration Methods 0.000 claims description 4
- 239000012149 elution buffer Substances 0.000 claims description 4
- 230000002779 inactivation Effects 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000001728 nano-filtration Methods 0.000 claims description 4
- 238000000746 purification Methods 0.000 claims description 4
- 102000001708 Protein Isoforms Human genes 0.000 claims description 2
- 108010029485 Protein Isoforms Proteins 0.000 claims description 2
- 238000001042 affinity chromatography Methods 0.000 claims description 2
- 239000000872 buffer Substances 0.000 claims description 2
- 238000011210 chromatographic step Methods 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000004255 ion exchange chromatography Methods 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 238000005215 recombination Methods 0.000 claims description 2
- 230000006798 recombination Effects 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 230000003612 virological effect Effects 0.000 claims 2
- 101710088235 Envelope glycoprotein C homolog Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 description 2
- 102000006771 Gonadotropins Human genes 0.000 description 1
- 108010086677 Gonadotropins Proteins 0.000 description 1
- 239000002622 gonadotropin Substances 0.000 description 1
- 229940094892 gonadotropins Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26393109P | 2009-11-24 | 2009-11-24 | |
| EP09014585A EP2325194A1 (en) | 2009-11-24 | 2009-11-24 | Process for the purification of glycoproteins |
| US61/263,931 | 2009-11-24 | ||
| EP09014585.5 | 2009-11-24 | ||
| PCT/EP2010/007115 WO2011063943A1 (en) | 2009-11-24 | 2010-11-24 | Process for the purification of glycoproteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013511481A JP2013511481A (ja) | 2013-04-04 |
| JP2013511481A5 true JP2013511481A5 (https=) | 2013-11-28 |
| JP5840135B2 JP5840135B2 (ja) | 2016-01-06 |
Family
ID=42173838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012539237A Expired - Fee Related JP5840135B2 (ja) | 2009-11-24 | 2010-11-24 | 糖タンパク質の精製のためのプロセス |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8846344B2 (https=) |
| EP (2) | EP2325194A1 (https=) |
| JP (1) | JP5840135B2 (https=) |
| KR (1) | KR101860830B1 (https=) |
| CN (1) | CN102656182B (https=) |
| AU (1) | AU2010324104C1 (https=) |
| CA (1) | CA2781132A1 (https=) |
| DK (1) | DK2504350T3 (https=) |
| ES (1) | ES2626248T3 (https=) |
| LT (1) | LT2504350T (https=) |
| PL (1) | PL2504350T3 (https=) |
| WO (1) | WO2011063943A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7470672B2 (en) | 2006-07-31 | 2008-12-30 | Savvipharm Inc. | Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives |
| WO2012016576A1 (en) | 2010-08-04 | 2012-02-09 | Glycotope Gmbh | Improved recombinant human follicle-stimulating hormone |
| EP2968391A1 (en) | 2013-03-13 | 2016-01-20 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| CN104101656A (zh) * | 2013-04-01 | 2014-10-15 | 上海天伟生物制药有限公司 | 一种促性腺激素的纯度测定方法 |
| KR20160131113A (ko) * | 2014-04-18 | 2016-11-15 | 카딜라 핼쓰캐어 리미티드 | 고나도트로핀의 신규한 정제 방법 |
| MX2016013449A (es) | 2014-04-18 | 2017-05-04 | Glycotope Gmbh | Hiperestimulacion ovarica controlada con la hormona estimuladora folicular humana recombinante mejorada. |
| ES2719748T3 (es) * | 2014-05-23 | 2019-07-12 | Inst Massone S A | Proceso para obtener HMG-UP (gonadotropina menopáusica humana con grado de ultrapureza) y una composición libre de contaminantes |
| CN108348465B (zh) | 2015-09-17 | 2020-11-10 | 葛莱高托普有限公司 | 具有提高的稳定性的哺乳动物促卵泡激素组合物 |
| LT3436051T (lt) * | 2016-03-31 | 2021-11-25 | Spark Therapeutics, Inc. | Kolonėlėmis pagrįstas visiškai keičiamo masto raav gavimo būdas |
| CN106008662A (zh) * | 2016-05-16 | 2016-10-12 | 南京农业大学 | 一种以枸杞蜂花粉为原料制备富锌中性糖蛋白的方法 |
| CN105968185A (zh) * | 2016-07-20 | 2016-09-28 | 宁波人健药业集团股份有限公司 | 一种绒促性素纯化方法 |
| CN106732464B (zh) * | 2017-02-02 | 2020-11-20 | 复旦大学 | 一种亲水树枝和c18修饰的磁性石墨烯材料及其制备方法和应用 |
| US11385238B2 (en) * | 2017-06-30 | 2022-07-12 | Amgen Inc. | Methods of protein clips recovery |
| CN110563832B (zh) * | 2019-07-31 | 2025-11-14 | 江苏璟泽生物医药有限公司 | 一种高纯度重组促卵泡刺激素纯化方法 |
| CN114829371A (zh) * | 2019-12-12 | 2022-07-29 | Emd密理博公司 | 使用透析过滤缓冲液强化的病毒过滤 |
| EP3964523A1 (en) * | 2020-09-04 | 2022-03-09 | PreviPharma Consulting GmbH | Preparation of fetuin a by hydrophobic interaction chromatography |
| EP4223741A4 (en) * | 2020-09-29 | 2026-01-07 | Mabwell Shanghai Bioscience Co Ltd | METHOD FOR PREPARING A BIS-SUPTITUTED ANTIBODY-DRUG CONJUGATE |
| CN114835796A (zh) * | 2022-05-05 | 2022-08-02 | 江苏尤里卡生物科技有限公司 | 一种促性腺激素纯化方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4840896A (en) | 1983-11-02 | 1989-06-20 | Integrated Genetics, Inc. | Heteropolymeric protein |
| US4923805A (en) | 1983-11-02 | 1990-05-08 | Integrated Genetics, Inc. | Fsh |
| AU606099B2 (en) * | 1986-12-07 | 1991-01-31 | Japan Science And Technology Corporation | Colony-stimulating factor and method for preparation thereof |
| IT1206302B (it) | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
| ES2151463T5 (es) | 1989-12-22 | 2012-10-29 | Merck Serono Sa | Constructos de ADN para la activación y la modificación de la expresión de genes endógenos |
| WO1991016922A1 (en) | 1990-05-08 | 1991-11-14 | University Of Medicine & Dentistry Of New Jersey | Analogs of glycoprotein hormones having altered immunological characteristics, efficacy and/or receptor specificity |
| WO1992022568A1 (en) | 1991-06-18 | 1992-12-23 | University Of Medicine & Dentistry Of New Jersey | Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same |
| IL117849A (en) | 1995-04-14 | 2002-07-25 | Lepetit Spa | Chromatographic process for clearing glycoproteins |
| UA60311C2 (uk) * | 1996-10-02 | 2003-10-15 | Смітклайн Бічам Корпорейшн | Антагоністи рецептора вітронектину, спосіб одержання цих сполук та фармацевтична композиція |
| IT1287138B1 (it) | 1996-11-07 | 1998-08-04 | Ibsa Inst Biochimique Sa | Procedimento per la separazione e purificazione di fsh e lh |
| IL122732A0 (en) | 1997-01-15 | 1998-08-16 | Akzo Nobel Nv | Liquid gonadotropin-containing formulation its preparation and a device containing same |
| ES2332931T3 (es) | 1997-06-25 | 2010-02-15 | Merck Serono Sa | Analogos de hormonas glicoproteinicas entrelazadas por disulfuro, su preparacion y uso. |
| US6414123B1 (en) | 1997-10-21 | 2002-07-02 | Vitro Diagnostics, Inc. | Method for purifying FSH |
| RU2229309C2 (ru) | 1998-05-07 | 2004-05-27 | Транскариотик Терапиз, Инк. | МОДИФИЦИРОВАНИЕ ЭКСПРЕССИИ ГЕНА FSHβ С ПОМОЩЬЮ ГОМОЛОГИЧНОЙ РЕКОМБИНАЦИИ |
| IL140984A0 (en) | 1998-07-23 | 2002-02-10 | Lilly Co Eli | Fsh and fsh variant formulations, products and methods |
| BRPI0010677B8 (pt) | 1999-04-16 | 2021-05-25 | Inst Massone S A | processo de purificação de gonadotropinas urinárias humanas a partir de gonadotropinas brutas. |
| WO2001058493A1 (en) | 2000-02-11 | 2001-08-16 | Maxygen Aps | Conjugates of follicle stimulating hormones |
| SE0001660D0 (sv) | 2000-05-05 | 2000-05-05 | Gramineer Ab | Separation of glyco-containing entities |
| DK1610822T4 (en) | 2003-04-02 | 2019-01-14 | Ares Trading Sa | Liquid pharmaceutical FSH and LH formulations together with a nonionic surfactant |
| EP1697412B1 (en) | 2003-12-22 | 2009-10-21 | Ares Trading S.A. | Method for purifying fsh |
| MXPA06008126A (es) * | 2004-01-14 | 2008-02-14 | Univ Ohio | Metodos para la produccion de peptidos/proteinas en plantas y peptidos/proteinas producidos de este modo. |
| US8623812B2 (en) * | 2004-04-19 | 2014-01-07 | Ohio University | Cross-linkable glycoproteins and methods of making the same |
| DE602005009856D1 (de) * | 2004-11-09 | 2008-10-30 | Ares Trading Sa | Verfahren zur reinigung von fsh |
| EP1960419B1 (en) | 2005-12-09 | 2016-03-16 | Ares Trading S.A. | Method for purifying fsh or a fsh mutant |
| HRP20120994T1 (hr) | 2006-02-07 | 2012-12-31 | Shire Human Genetic Therapies, Inc. | Stabilizirana smjesa glukocerebrozidaze |
| DK2170942T3 (da) | 2007-06-28 | 2013-11-04 | Biogenerix Ag | Fsh-producerende celleklon |
| DE102008002209A1 (de) * | 2008-06-04 | 2009-12-10 | Evonik Degussa Gmbh | Verfahren zur Aufreinigung von Erythropoietin |
-
2009
- 2009-11-24 EP EP09014585A patent/EP2325194A1/en not_active Withdrawn
-
2010
- 2010-11-24 DK DK10788242.5T patent/DK2504350T3/en active
- 2010-11-24 US US13/511,285 patent/US8846344B2/en not_active Expired - Fee Related
- 2010-11-24 WO PCT/EP2010/007115 patent/WO2011063943A1/en not_active Ceased
- 2010-11-24 AU AU2010324104A patent/AU2010324104C1/en not_active Ceased
- 2010-11-24 EP EP10788242.5A patent/EP2504350B1/en not_active Revoked
- 2010-11-24 ES ES10788242.5T patent/ES2626248T3/es active Active
- 2010-11-24 CN CN201080056651.2A patent/CN102656182B/zh active Active
- 2010-11-24 KR KR1020127016158A patent/KR101860830B1/ko not_active Expired - Fee Related
- 2010-11-24 PL PL10788242T patent/PL2504350T3/pl unknown
- 2010-11-24 LT LTEP10788242.5T patent/LT2504350T/lt unknown
- 2010-11-24 CA CA2781132A patent/CA2781132A1/en not_active Abandoned
- 2010-11-24 JP JP2012539237A patent/JP5840135B2/ja not_active Expired - Fee Related
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