KR101860830B1 - 당단백질 정제 방법 - Google Patents

당단백질 정제 방법 Download PDF

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Publication number
KR101860830B1
KR101860830B1 KR1020127016158A KR20127016158A KR101860830B1 KR 101860830 B1 KR101860830 B1 KR 101860830B1 KR 1020127016158 A KR1020127016158 A KR 1020127016158A KR 20127016158 A KR20127016158 A KR 20127016158A KR 101860830 B1 KR101860830 B1 KR 101860830B1
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KR
South Korea
Prior art keywords
chromatography
glycoprotein
size exclusion
buffer
fsh
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020127016158A
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English (en)
Korean (ko)
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KR20120089755A (ko
Inventor
슈테펜 고레츠
라르스 슈퇴클
Original Assignee
글리코토페 게엠베하
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Application filed by 글리코토페 게엠베하 filed Critical 글리코토페 게엠베하
Publication of KR20120089755A publication Critical patent/KR20120089755A/ko
Application granted granted Critical
Publication of KR101860830B1 publication Critical patent/KR101860830B1/ko
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020127016158A 2009-11-24 2010-11-24 당단백질 정제 방법 Expired - Fee Related KR101860830B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26393109P 2009-11-24 2009-11-24
US61/263,931 2009-11-24
EP09014585A EP2325194A1 (en) 2009-11-24 2009-11-24 Process for the purification of glycoproteins
EP09014585.5 2009-11-24
PCT/EP2010/007115 WO2011063943A1 (en) 2009-11-24 2010-11-24 Process for the purification of glycoproteins

Publications (2)

Publication Number Publication Date
KR20120089755A KR20120089755A (ko) 2012-08-13
KR101860830B1 true KR101860830B1 (ko) 2018-05-24

Family

ID=42173838

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127016158A Expired - Fee Related KR101860830B1 (ko) 2009-11-24 2010-11-24 당단백질 정제 방법

Country Status (12)

Country Link
US (1) US8846344B2 (https=)
EP (2) EP2325194A1 (https=)
JP (1) JP5840135B2 (https=)
KR (1) KR101860830B1 (https=)
CN (1) CN102656182B (https=)
AU (1) AU2010324104C1 (https=)
CA (1) CA2781132A1 (https=)
DK (1) DK2504350T3 (https=)
ES (1) ES2626248T3 (https=)
LT (1) LT2504350T (https=)
PL (1) PL2504350T3 (https=)
WO (1) WO2011063943A1 (https=)

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US7470672B2 (en) 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
WO2012016576A1 (en) 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
EP2968391A1 (en) 2013-03-13 2016-01-20 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
CN104101656A (zh) * 2013-04-01 2014-10-15 上海天伟生物制药有限公司 一种促性腺激素的纯度测定方法
AR100132A1 (es) 2014-04-18 2016-09-14 Glycotope Gmbh Un método para hiperestimulación ovárica controlada para estimular el desarrollo de múltiples folículos ováricos en un sujeto femenino
US20170029482A1 (en) * 2014-04-18 2017-02-02 Cadila Healthcare Limited Novel purification process of gonadotropin
ES2719748T3 (es) * 2014-05-23 2019-07-12 Inst Massone S A Proceso para obtener HMG-UP (gonadotropina menopáusica humana con grado de ultrapureza) y una composición libre de contaminantes
KR20180052128A (ko) 2015-09-17 2018-05-17 글리코토페 게엠베하 증가된 안정성을 갖는 포유동물 난포-자극 호르몬 조성물
BR112018070256A2 (pt) * 2016-03-31 2019-01-29 Spark Therapeutics, Inc. processo de fabricação de raav totalmente escalável à base de colunas
CN106008662A (zh) * 2016-05-16 2016-10-12 南京农业大学 一种以枸杞蜂花粉为原料制备富锌中性糖蛋白的方法
CN105968185A (zh) * 2016-07-20 2016-09-28 宁波人健药业集团股份有限公司 一种绒促性素纯化方法
CN106732464B (zh) * 2017-02-02 2020-11-20 复旦大学 一种亲水树枝和c18修饰的磁性石墨烯材料及其制备方法和应用
US11385238B2 (en) * 2017-06-30 2022-07-12 Amgen Inc. Methods of protein clips recovery
CN110563832B (zh) * 2019-07-31 2025-11-14 江苏璟泽生物医药有限公司 一种高纯度重组促卵泡刺激素纯化方法
JP7737374B2 (ja) * 2019-12-12 2025-09-10 イー・エム・デイー・ミリポア・コーポレイシヨン 透析濾過緩衝液を用いて増強したウイルス濾過
EP3964523A1 (en) * 2020-09-04 2022-03-09 PreviPharma Consulting GmbH Preparation of fetuin a by hydrophobic interaction chromatography
WO2022068898A1 (zh) * 2020-09-29 2022-04-07 迈威(上海)生物科技股份有限公司 一种双取代桥连抗体偶联药物的制备方法
CN114835796A (zh) * 2022-05-05 2022-08-02 江苏尤里卡生物科技有限公司 一种促性腺激素纯化方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005110015A2 (en) * 2004-04-19 2005-11-24 Ohio University Cross-linkable glycoproteins and methods of making the same

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US4840896A (en) 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein
US4923805A (en) 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
AU606099B2 (en) * 1986-12-07 1991-01-31 Japan Science And Technology Corporation Colony-stimulating factor and method for preparation thereof
IT1206302B (it) 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
RU2128227C1 (ru) 1989-12-22 1999-03-27 Апплайд Резеч Системз АРС Холдинг Н.В. (NL) (Антильские острова) Способ активации транскрипционно-молчащего гена
WO1991016922A1 (en) 1990-05-08 1991-11-14 University Of Medicine & Dentistry Of New Jersey Analogs of glycoprotein hormones having altered immunological characteristics, efficacy and/or receptor specificity
WO1992022568A1 (en) 1991-06-18 1992-12-23 University Of Medicine & Dentistry Of New Jersey Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same
IL117849A (en) 1995-04-14 2002-07-25 Lepetit Spa Chromatographic process for clearing glycoproteins
UA60311C2 (uk) * 1996-10-02 2003-10-15 Смітклайн Бічам Корпорейшн Антагоністи рецептора вітронектину, спосіб одержання цих сполук та фармацевтична композиція
IT1287138B1 (it) 1996-11-07 1998-08-04 Ibsa Inst Biochimique Sa Procedimento per la separazione e purificazione di fsh e lh
IL122732A0 (en) 1997-01-15 1998-08-16 Akzo Nobel Nv Liquid gonadotropin-containing formulation its preparation and a device containing same
SI0996629T1 (sl) 1997-06-25 2006-12-31 Applied Research Systems Analogi glikoproteinskega hormona povezanega z disulfidi, priprava in uporaba
US6414123B1 (en) 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
CN1308673A (zh) 1998-05-07 2001-08-15 变更染色体医疗公司 通过同源重组修饰FSHβ基因的表达
CN1309567A (zh) 1998-07-23 2001-08-22 伊莱利利公司 Fsh和fsh变体制剂,产品和方法
ES2284494T3 (es) 1999-04-16 2007-11-16 Instituto Massone S.A. Procedimiento para preparar composiciones de gonadotropina.
AU2001231531A1 (en) 2000-02-11 2001-08-20 Maxygen Aps Follicle stimulating hormones
SE0001660D0 (sv) 2000-05-05 2000-05-05 Gramineer Ab Separation of glyco-containing entities
CA2518903C (en) 2003-04-02 2013-02-05 Ares Trading S.A. Liquid pharmaceutical formulations of fsh and lh together with a non-ionic surfactant
CA2544333A1 (en) 2003-12-22 2005-07-14 Ares Trading S.A. Method for purifying fsh
EP1711533B1 (en) * 2004-01-14 2013-12-11 Ohio University Methods of producing peptides/proteins in plants and peptides/proteins produced thereby
AU2005303818B2 (en) 2004-11-09 2011-06-23 Ares Trading S.A. Method for purifying FSH
EP1960419B1 (en) 2005-12-09 2016-03-16 Ares Trading S.A. Method for purifying fsh or a fsh mutant
HRP20120994T1 (hr) 2006-02-07 2012-12-31 Shire Human Genetic Therapies, Inc. Stabilizirana smjesa glukocerebrozidaze
RS52976B (sr) 2007-06-28 2014-02-28 Biogenerix Ag Ćelijski klon koji proizvodi fsh
DE102008002209A1 (de) * 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur Aufreinigung von Erythropoietin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005110015A2 (en) * 2004-04-19 2005-11-24 Ohio University Cross-linkable glycoproteins and methods of making the same

Also Published As

Publication number Publication date
CA2781132A1 (en) 2011-06-03
AU2010324104A1 (en) 2012-06-07
CN102656182A (zh) 2012-09-05
ES2626248T3 (es) 2017-07-24
US20120252069A1 (en) 2012-10-04
JP2013511481A (ja) 2013-04-04
AU2010324104C1 (en) 2015-06-11
AU2010324104B2 (en) 2015-02-19
KR20120089755A (ko) 2012-08-13
WO2011063943A1 (en) 2011-06-03
PL2504350T3 (pl) 2017-08-31
EP2504350B1 (en) 2017-05-10
EP2504350A1 (en) 2012-10-03
DK2504350T3 (en) 2017-06-12
US8846344B2 (en) 2014-09-30
CN102656182B (zh) 2015-03-18
JP5840135B2 (ja) 2016-01-06
EP2325194A1 (en) 2011-05-25
LT2504350T (lt) 2017-06-12

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