JP2013511280A5 - - Google Patents
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- Publication number
- JP2013511280A5 JP2013511280A5 JP2012540120A JP2012540120A JP2013511280A5 JP 2013511280 A5 JP2013511280 A5 JP 2013511280A5 JP 2012540120 A JP2012540120 A JP 2012540120A JP 2012540120 A JP2012540120 A JP 2012540120A JP 2013511280 A5 JP2013511280 A5 JP 2013511280A5
- Authority
- JP
- Japan
- Prior art keywords
- substitution
- variant
- bgl1
- bgl1 variant
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000006467 substitution reaction Methods 0.000 claims 34
- 101100437484 Arabidopsis thaliana BGLU18 gene Proteins 0.000 claims 31
- 101100342633 Bos taurus LLGL1 gene Proteins 0.000 claims 31
- 101100065855 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) EXG1 gene Proteins 0.000 claims 31
- 101100058298 Saccharomycopsis fibuligera BGL1 gene Proteins 0.000 claims 31
- 101150100570 bglA gene Proteins 0.000 claims 31
- 230000000694 effects Effects 0.000 claims 16
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000006995 beta-Glucosidase Human genes 0.000 claims 3
- 108010047754 beta-Glucosidase Proteins 0.000 claims 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Substances [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 3
- 230000007062 hydrolysis Effects 0.000 claims 3
- 238000006460 hydrolysis reaction Methods 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- 101710099628 Beta-glucosidase 1 Proteins 0.000 claims 2
- 239000002028 Biomass Substances 0.000 claims 2
- 241000209149 Zea Species 0.000 claims 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 235000005822 corn Nutrition 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 239000010907 stover Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26324009P | 2009-11-20 | 2009-11-20 | |
| US61/263,240 | 2009-11-20 | ||
| PCT/US2010/057531 WO2011063308A2 (en) | 2009-11-20 | 2010-11-19 | Beta-glucosidase i variants with improved properties |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015120937A Division JP2015211678A (ja) | 2009-11-20 | 2015-06-16 | 改良された特性を有するβ−グルコシダーゼＩ変異体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013511280A JP2013511280A (ja) | 2013-04-04 |
| JP2013511280A5 true JP2013511280A5 (cg-RX-API-DMAC7.html) | 2014-01-09 |
Family
ID=43608030
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012540120A Pending JP2013511280A (ja) | 2009-11-20 | 2010-11-19 | 改良された特性を有するβ−グルコシダーゼＩ変異体 |
| JP2015120937A Withdrawn JP2015211678A (ja) | 2009-11-20 | 2015-06-16 | 改良された特性を有するβ−グルコシダーゼＩ変異体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015120937A Withdrawn JP2015211678A (ja) | 2009-11-20 | 2015-06-16 | 改良された特性を有するβ−グルコシダーゼＩ変異体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9447400B2 (cg-RX-API-DMAC7.html) |
| EP (6) | EP2602317B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2013511280A (cg-RX-API-DMAC7.html) |
| CN (2) | CN102844429B (cg-RX-API-DMAC7.html) |
| BR (1) | BR112012011711A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2780767A1 (cg-RX-API-DMAC7.html) |
| DK (6) | DK2599863T3 (cg-RX-API-DMAC7.html) |
| IN (1) | IN2012DN03825A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2012125624A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011063308A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX353237B (es) | 2009-09-23 | 2018-01-08 | Danisco Us Inc | Enzimas de glicosil hidrolasa novedosas y usos de las mismas. |
| EP2504017B1 (en) | 2009-11-25 | 2014-01-08 | Codexis, Inc. | Recombinant beta-glucosidase variants for production of soluble sugars from cellulosic biomass |
| US10138499B2 (en) | 2009-12-23 | 2018-11-27 | Danisco Us Inc. | Methods for improving the efficiency of simultaneous saccharification and fermentation reactions |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| EP2622069B1 (en) * | 2010-10-01 | 2015-11-25 | Novozymes, Inc. | Beta-glucosidase variants and polynucleotides encoding same |
| KR20130132789A (ko) * | 2010-11-05 | 2013-12-05 | 아사히 가라스 가부시키가이샤 | 스키조사카로미세스속 효모의 형질 전환체 및 그 제조 방법 |
| MX2013010512A (es) | 2011-03-17 | 2013-10-07 | Danisco Inc | Metodo para reducir la viscosidad en un proceso de sacarificacion. |
| CN102816748B (zh) * | 2011-06-09 | 2014-07-16 | 中国科学院上海生命科学研究院 | 一种新型β-葡萄糖苷酶及其编码基因和应用 |
| EP2747778B1 (en) | 2011-08-26 | 2017-12-06 | Wisconsin Alumni Research Foundation | Influenza viruses with mutant pb2 gene segment as live attenuated vaccines |
| CA2892054A1 (en) | 2012-12-07 | 2014-06-12 | Ling Hua | Compositions and methods of use |
| ES2521940B1 (es) | 2013-05-10 | 2015-09-09 | Abengoa Bioenergía Nuevas Tecnologías, S.A. | Variantes de beta-glucosidasa con actividad de transglicosilación reducida |
| WO2015017255A1 (en) | 2013-07-29 | 2015-02-05 | Danisco Us Inc. | Variant enzymes |
| WO2015042064A1 (en) * | 2013-09-17 | 2015-03-26 | Edeniq, Inc. | Improved beta-glucosidase enzymes for increased biomass saccharification |
| JP7098270B2 (ja) * | 2014-02-26 | 2022-07-11 | セーホーエル．ハンセン アクティーゼルスカブ | 改善された凝乳特性を有するキモシンの変異体 |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| BR112017002391A2 (pt) | 2014-08-08 | 2017-11-28 | Xyleco Inc | enzima aglicosilada e usos da mesma |
| US20170362621A1 (en) | 2014-12-18 | 2017-12-21 | Danisco Us Inc. | Engineered multifunctional enzymes and methods of use |
| WO2016100825A1 (en) | 2014-12-18 | 2016-06-23 | Danisco Us Inc | Engineered multifunctional enzymes and methods of use |
| US10612058B2 (en) * | 2014-12-19 | 2020-04-07 | Danisco Us Inc | Methods for saccharifying a starch substrate |
| MX2017016625A (es) | 2015-07-07 | 2018-05-15 | Danisco Us Inc | Induccion de la expresion genica usando una mezcla de azucar de alta concentracion. |
| EP3702469A1 (en) * | 2015-12-10 | 2020-09-02 | DSM IP Assets B.V. | Beta-glucosidase and uses thereof |
| US20190002860A1 (en) * | 2015-12-10 | 2019-01-03 | Dsm Ip Assets B.V. | Beta-glucosidase and uses thereof |
| US20190002859A1 (en) * | 2015-12-10 | 2019-01-03 | Dsm Ip Assets B.V. | Beta-glucosidase and uses thereof |
| EP3417056A1 (en) | 2016-02-19 | 2018-12-26 | Wisconsin Alumni Research Foundation (WARF) | Improved influenza b virus replication for vaccine development |
| EP3336180A1 (en) * | 2016-07-04 | 2018-06-20 | Evonik Degussa GmbH | Mutant alkb gene |
| WO2018053058A1 (en) | 2016-09-14 | 2018-03-22 | Danisco Us Inc. | Lignocellulosic biomass fermentation-based processes |
| KR102593668B1 (ko) | 2016-10-04 | 2023-10-24 | 다니스코 유에스 인크. | 유도 기질 부재 하의 사상 진균 세포에서의 단백질 생산 |
| WO2018106656A1 (en) | 2016-12-06 | 2018-06-14 | Danisco Us Inc | Truncated lpmo enzymes and use thereof |
| US20190330577A1 (en) | 2016-12-21 | 2019-10-31 | Dupont Nutrition Biosciences Aps | Methods of using thermostable serine proteases |
| US20200071685A1 (en) | 2017-03-06 | 2020-03-05 | Dupont Nutrition Biosciences Aps | Novel fungal fucosidases and their use in preventing and/or treating a pathogenic infection in an animal |
| WO2018213482A1 (en) * | 2017-05-16 | 2018-11-22 | The Curators Of The University Of Missouri | Immobilized enzyme complexes and related methods |
| WO2019074828A1 (en) | 2017-10-09 | 2019-04-18 | Danisco Us Inc | CELLOBIOSE DEHYDROGENASE VARIANTS AND METHODS OF USE |
| JP7051491B2 (ja) * | 2018-02-26 | 2022-04-11 | 花王株式会社 | 変異β－グルコシダーゼ |
| JP2021516058A (ja) | 2018-03-09 | 2021-07-01 | ダニスコ・ユーエス・インク | グルコアミラーゼ及びその使用方法 |
| WO2020010101A2 (en) | 2018-07-04 | 2020-01-09 | Danisco Us Inc | Glucoamylases and methods of use, thereof |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| US11389523B2 (en) | 2018-08-20 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein |
| CA3118924A1 (en) | 2018-11-09 | 2020-05-14 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| JP7569523B2 (ja) | 2018-11-20 | 2024-10-18 | インターナショナル エヌアンドエイチ デンマーク エーピーエス | 改変ロバスト高Ｔｍ－フィターゼ分岐群ポリペプチド及びその断片 |
| JP2022527235A (ja) * | 2019-01-23 | 2022-06-01 | 義裕 河岡 | インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異 |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| CN114929269A (zh) | 2019-05-01 | 2022-08-19 | 威斯康星校友研究基金会(Warf) | 用于疫苗开发的改进的流感病毒复制 |
| WO2021041624A2 (en) | 2019-08-27 | 2021-03-04 | Yoshihiro Kawaoka | Recombinant influenza viruses with stabilized ha for replication in eggs |
| US11739303B2 (en) | 2020-01-24 | 2023-08-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized NA |
| CN115915956A (zh) | 2020-02-28 | 2023-04-04 | 杜邦营养生物科学有限公司 | 饲料组合物 |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| CN115478060B (zh) * | 2021-06-16 | 2023-11-28 | 弈柯莱生物科技(集团)股份有限公司 | 一种糖基转移酶及其应用 |
| CN113842454A (zh) * | 2021-09-30 | 2021-12-28 | 中国人民解放军空军军医大学 | 一种基于vsv载体的htnv疫苗及其制备方法和应用 |
| EP4416280A1 (en) | 2021-10-15 | 2024-08-21 | Danisco Us Inc | Glucoamylase variants and methods for use thereof |
| WO2023092018A1 (en) | 2021-11-17 | 2023-05-25 | Dupont Nutrition Biosciences Aps | Improved enzymatic modification of galactolipids in food |
| CN116426506B (zh) * | 2023-03-10 | 2024-01-30 | 云南师范大学 | 低温活性提高的β-木糖苷酶突变体D259G及其应用 |
| CN118006590B (zh) * | 2024-02-23 | 2024-12-27 | 南京师范大学常州合成生物学产业研究院有限公司 | 一种Microbacterium dextranolyticumβ-葡萄糖苷酶的突变体及方法和应用 |
| CN118956830B (zh) * | 2024-09-27 | 2025-09-09 | 安徽大学 | 一种β-葡萄糖苷酶突变体及其在水解丙二酰染料木苷中的应用 |
| CN118853624B (zh) * | 2024-09-29 | 2025-04-25 | 青岛奔月生物技术有限公司 | 催化莱鲍迪苷d生产莱鲍迪苷m的葡萄糖基转移酶突变体及其应用 |
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-
2010
- 2010-11-19 JP JP2012540120A patent/JP2013511280A/ja active Pending
- 2010-11-19 BR BR112012011711A patent/BR112012011711A2/pt not_active IP Right Cessation
- 2010-11-19 IN IN3825DEN2012 patent/IN2012DN03825A/en unknown
- 2010-11-19 EP EP12199328.1A patent/EP2602317B1/en not_active Not-in-force
- 2010-11-19 CN CN201080061975.5A patent/CN102844429B/zh not_active Expired - Fee Related
- 2010-11-19 CA CA2780767A patent/CA2780767A1/en not_active Abandoned
- 2010-11-19 US US13/510,902 patent/US9447400B2/en not_active Expired - Fee Related
- 2010-11-19 EP EP12199332.3A patent/EP2599864B1/en not_active Not-in-force
- 2010-11-19 CN CN201510672711.8A patent/CN105316303B/zh not_active Expired - Fee Related
- 2010-11-19 EP EP12199330.7A patent/EP2599863B1/en not_active Not-in-force
- 2010-11-19 DK DK12199330.7T patent/DK2599863T3/da active
- 2010-11-19 RU RU2012125624/10A patent/RU2012125624A/ru not_active Application Discontinuation
- 2010-11-19 EP EP12199329.9A patent/EP2599862B1/en not_active Not-in-force
- 2010-11-19 DK DK10782511.9T patent/DK2501806T3/da active
- 2010-11-19 DK DK12199329.9T patent/DK2599862T3/da active
- 2010-11-19 EP EP12199327.3A patent/EP2599861B1/en not_active Not-in-force
- 2010-11-19 DK DK12199328.1T patent/DK2602317T3/da active
- 2010-11-19 DK DK12199327.3T patent/DK2599861T3/da active
- 2010-11-19 EP EP10782511.9A patent/EP2501806B1/en not_active Not-in-force
- 2010-11-19 DK DK12199332.3T patent/DK2599864T3/da active
- 2010-11-19 WO PCT/US2010/057531 patent/WO2011063308A2/en not_active Ceased
-
2015
- 2015-06-16 JP JP2015120937A patent/JP2015211678A/ja not_active Withdrawn
-
2016
- 2016-08-29 US US15/250,626 patent/US20170145396A1/en not_active Abandoned
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