JP2013509395A5 - - Google Patents
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- Publication number
- JP2013509395A5 JP2013509395A5 JP2012535998A JP2012535998A JP2013509395A5 JP 2013509395 A5 JP2013509395 A5 JP 2013509395A5 JP 2012535998 A JP2012535998 A JP 2012535998A JP 2012535998 A JP2012535998 A JP 2012535998A JP 2013509395 A5 JP2013509395 A5 JP 2013509395A5
- Authority
- JP
- Japan
- Prior art keywords
- preparation
- extract
- preparation according
- medicament
- ginseng
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 9
- 235000001014 amino acid Nutrition 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000009429 Ginkgo biloba extract Substances 0.000 claims 4
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 4
- SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 claims 4
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 4
- 229960002173 citrulline Drugs 0.000 claims 4
- 235000013477 citrulline Nutrition 0.000 claims 4
- 239000000284 extract Substances 0.000 claims 4
- 229940068052 ginkgo biloba extract Drugs 0.000 claims 4
- 235000020686 ginkgo biloba extract Nutrition 0.000 claims 4
- 235000020710 ginseng extract Nutrition 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 claims 4
- 229950000628 silibinin Drugs 0.000 claims 4
- 235000014899 silybin Nutrition 0.000 claims 4
- GGTYBZJRPHEQDG-WCCKRBBISA-N (2s)-2,5-diaminopentanoic acid hydrochloride Chemical compound Cl.NCCC[C@H](N)C(O)=O GGTYBZJRPHEQDG-WCCKRBBISA-N 0.000 claims 3
- 241000208340 Araliaceae Species 0.000 claims 3
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims 3
- 235000003140 Panax quinquefolius Nutrition 0.000 claims 3
- 244000269722 Thea sinensis Species 0.000 claims 3
- 229940105039 coconut extract Drugs 0.000 claims 3
- 235000015872 dietary supplement Nutrition 0.000 claims 3
- 235000008434 ginseng Nutrition 0.000 claims 3
- 229960003244 ornithine hydrochloride Drugs 0.000 claims 3
- 150000008442 polyphenolic compounds Chemical class 0.000 claims 3
- 235000013824 polyphenols Nutrition 0.000 claims 3
- 208000007848 Alcoholism Diseases 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 2
- 240000000724 Berberis vulgaris Species 0.000 claims 2
- 235000016068 Berberis vulgaris Nutrition 0.000 claims 2
- 206010021143 Hypoxia Diseases 0.000 claims 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
- 206010067125 Liver injury Diseases 0.000 claims 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 2
- 239000004473 Threonine Substances 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- 102100040653 Tryptophan 2,3-dioxygenase Human genes 0.000 claims 2
- 101710136122 Tryptophan 2,3-dioxygenase Proteins 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 229960003104 ornithine Drugs 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 230000035899 viability Effects 0.000 claims 2
- OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 201000007930 alcohol dependence Diseases 0.000 claims 1
- 235000013361 beverage Nutrition 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 235000013376 functional food Nutrition 0.000 claims 1
- 229940049654 glyceryl behenate Drugs 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 231100000234 hepatic damage Toxicity 0.000 claims 1
- 231100000753 hepatic injury Toxicity 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 230000007954 hypoxia Effects 0.000 claims 1
- 230000001146 hypoxic effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 230000008818 liver damage Effects 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 235000019426 modified starch Nutrition 0.000 claims 1
- 239000000419 plant extract Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2009/007253 WO2011051742A1 (en) | 2009-10-28 | 2009-10-28 | Preparation comprising amino acids and plants and its activity in the alcohol detoxification |
| IBPCT/IB2009/007253 | 2009-10-28 | ||
| PCT/IB2010/054885 WO2011051900A1 (en) | 2009-10-28 | 2010-10-28 | Preparation comprising amino acids and plants and its activity in the alcohol detoxification |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013509395A JP2013509395A (ja) | 2013-03-14 |
| JP2013509395A5 true JP2013509395A5 (enExample) | 2014-08-14 |
| JP6077305B2 JP6077305B2 (ja) | 2017-02-08 |
Family
ID=42200965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012535998A Expired - Fee Related JP6077305B2 (ja) | 2009-10-28 | 2010-10-28 | アミノ酸および植物を含む調製物およびアルコール解毒におけるその活性 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9526753B2 (enExample) |
| EP (1) | EP2493488B1 (enExample) |
| JP (1) | JP6077305B2 (enExample) |
| CN (1) | CN102711780B (enExample) |
| AR (1) | AR078812A1 (enExample) |
| BR (1) | BR112012009806B1 (enExample) |
| CA (1) | CA2778884A1 (enExample) |
| ES (1) | ES2458353T3 (enExample) |
| MX (1) | MX2012004876A (enExample) |
| PL (1) | PL2493488T3 (enExample) |
| RU (1) | RU2573990C2 (enExample) |
| WO (2) | WO2011051742A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103054040B (zh) * | 2013-01-13 | 2014-05-21 | 浙江奥默生物医药有限公司 | 一种提高缺氧耐受力的药用组合物 |
| WO2015066799A1 (en) * | 2013-11-06 | 2015-05-14 | Jarrouj Salim | Composition and method for increasing the rate of alcohol metabolism and preventing hangover symptoms |
| CN103655929B (zh) * | 2013-12-06 | 2017-01-18 | 江苏德和生物科技有限公司 | 一种具有护肝作用药物组合物及其制备方法 |
| WO2015137387A1 (ja) * | 2014-03-11 | 2015-09-17 | 協和発酵バイオ株式会社 | 筋肉増強剤 |
| CN104474135B (zh) * | 2014-04-29 | 2018-04-17 | 遵义陆圣康源科技开发有限责任公司 | 一种对化学性肝损伤具有辅助保护功能的药物组合物 |
| CN105267267A (zh) * | 2014-06-05 | 2016-01-27 | 樊伟 | L-半胱氨酸组合物在预防、清除（或消除）吸烟、饮酒时所产生的致癌因素乙醛的应用 |
| KR101621356B1 (ko) * | 2014-09-05 | 2016-05-17 | 한국과학기술원 | 진세노사이드 f2의 간 질환 예방 또는 치료 용도 |
| WO2016121925A1 (ja) * | 2015-01-30 | 2016-08-04 | 協和発酵バイオ株式会社 | 機能性物質を高含有する錠剤及びその製造方法 |
| CN105105123B (zh) * | 2015-09-06 | 2017-11-21 | 青海之也科技咨询服务有限公司 | 一种黑果枸杞保健片及其制备方法 |
| CN105533348A (zh) * | 2016-02-22 | 2016-05-04 | 叶芳 | 一种具有提高人体缺氧耐受力的复合果蔬饮料 |
| WO2019147914A1 (en) | 2018-01-29 | 2019-08-01 | Fisher Joseph M | Compositions and methods for delaying and reducing blood alcohol concentration |
| CN108175807A (zh) * | 2018-02-22 | 2018-06-19 | 可贝熊（武汉）健康科技股份有限公司 | 一种治疗化学性肝损伤的药片 |
| AT16233U1 (de) * | 2018-03-28 | 2019-04-15 | Neurofelix Handels GmbH | Mittel zur Behandlung von neurodegenerativen Erkrankungen |
| EP4000626A1 (en) * | 2020-11-16 | 2022-05-25 | concrete flowers GmbH | Pharmaceutical preparation |
| RU2769242C1 (ru) * | 2021-06-16 | 2022-03-29 | Александр Владимирович Чемоданов | Кетогенная композиция |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3537656A1 (de) * | 1984-11-22 | 1986-05-22 | Dr. Madaus GmbH & Co, 5000 Köln | Verfahren zur herstellung von isosilybinfreiem silibinin und arzneimittel, enthaltend silibinin |
| JP2891738B2 (ja) * | 1990-03-15 | 1999-05-17 | ロート製薬株式会社 | アルコール吸収抑制剤 |
| JP3228534B2 (ja) * | 1991-08-30 | 2001-11-12 | 日東電工株式会社 | 血中アルコール濃度低下用組成物 |
| CN1091604C (zh) * | 1995-06-07 | 2002-10-02 | 第一制糖株式会社 | 具有提高了药理作用的加工人参提取物及其制备方法 |
| CN1188800A (zh) | 1997-01-22 | 1998-07-29 | 山东省达瀚实业总公司 | 护肝酒及其生产方法 |
| US6028107A (en) * | 1997-02-27 | 2000-02-22 | Waugh; William Howard | Orthomolecular medical use of L-citrulline for vasoprotection, relaxative smooth muscle tone and cell protection |
| CN1265799C (zh) | 1997-03-17 | 2006-07-26 | 夏小琳 | 含锌化合物和谷氨酰胺类的组合物 |
| JPH10298093A (ja) * | 1997-04-24 | 1998-11-10 | Chugai Pharmaceut Co Ltd | 内用液剤 |
| US6030621A (en) * | 1998-03-19 | 2000-02-29 | De Long; Xie | Ginkgo biloba composition, method to prepare the same and uses thereof |
| WO1999061038A1 (en) * | 1998-05-29 | 1999-12-02 | Adams Food Ltd. | Composition having therapeutic and/or nutritionally active substituent |
| US9486429B2 (en) * | 1999-06-01 | 2016-11-08 | Vanderbilt University | Therapeutic methods employing nitric oxide precursors |
| DE19929993C2 (de) * | 1999-06-30 | 2001-07-05 | Sueddeutsche Kalkstickstoff | Kreatin-alpha-ketoglutarate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| EP1318825A2 (de) | 2000-07-26 | 2003-06-18 | Vitaplant AG | Piper methysticum pflanzenextrakt |
| AU2001276537A1 (en) * | 2000-08-08 | 2002-02-18 | Paula Frances Buchanan-Baillie-Hamilton | Slimming system |
| JP4988085B2 (ja) * | 2000-09-04 | 2012-08-01 | ハウスウェルネスフーズ株式会社 | 肝機能賦活剤 |
| JP2003095966A (ja) * | 2001-09-27 | 2003-04-03 | Tokiwa Shokubutsu Kagaku Kenkyusho:Kk | 脳梗塞後遺症治療剤 |
| CN1262208C (zh) | 2003-04-08 | 2006-07-05 | 刘义国 | 橡籽冻 |
| CN1257736C (zh) * | 2003-05-08 | 2006-05-31 | 深圳太太药业有限公司 | 一种预防化学性肝损伤的解酒护肝药物组合物及制备方法 |
| CN100418548C (zh) * | 2003-05-18 | 2008-09-17 | 漆又毛 | 一种药用组合物及其用途 |
| US6936283B2 (en) * | 2003-07-25 | 2005-08-30 | Langeland Bjoern T. | Composition for stimulation of specific metallo-enzymes |
| CN1569123A (zh) | 2004-04-30 | 2005-01-26 | 成进学 | 用蛇、蜂、宏、微量元素强化中药方剂的内服功能性药剂及其生产工艺 |
| JP5040060B2 (ja) * | 2004-10-14 | 2012-10-03 | 大正製薬株式会社 | メチオニン配合内服液剤 |
| CN1660188A (zh) * | 2004-12-27 | 2005-08-31 | 陆友新 | 一种益肝滋肾、解毒祛湿的中药胶囊及其制备方法 |
| CN1876024A (zh) * | 2005-02-01 | 2006-12-13 | 王衡新 | 一种治疗肝肾疾病的中药制剂的质量控制方法 |
| US20080160001A1 (en) * | 2005-03-28 | 2008-07-03 | Pficker Pharmaceuticals Ltd. | Antihypercholesterolemic Formulation with Less Side-Effects |
| CN1698879B (zh) * | 2005-06-21 | 2010-08-11 | 蔺益民 | 具有解酒护肝功能的产品及制备方法和用途 |
| JP5188181B2 (ja) * | 2005-08-25 | 2013-04-24 | 協和発酵バイオ株式会社 | 血中アルコール濃度上昇抑制用組成物 |
| JPWO2008105384A1 (ja) * | 2007-02-26 | 2010-06-03 | 協和発酵バイオ株式会社 | シトルリン含有錠剤 |
| CN101053407A (zh) * | 2007-05-18 | 2007-10-17 | 河南京豫药业有限公司 | 大枣枸杞茶及其生产工艺 |
| JP5247120B2 (ja) * | 2007-11-02 | 2013-07-24 | 雪印メグミルク株式会社 | Ｌ−オルニチン含有物の製造方法 |
| AU2008323156B2 (en) * | 2007-11-15 | 2012-05-31 | Madaus Gmbh | Silibinin component for the treatment of hepatitis |
-
2009
- 2009-10-28 WO PCT/IB2009/007253 patent/WO2011051742A1/en not_active Ceased
-
2010
- 2010-10-28 MX MX2012004876A patent/MX2012004876A/es active IP Right Grant
- 2010-10-28 ES ES10782700.8T patent/ES2458353T3/es active Active
- 2010-10-28 CA CA2778884A patent/CA2778884A1/en not_active Abandoned
- 2010-10-28 CN CN201080059352.4A patent/CN102711780B/zh not_active Expired - Fee Related
- 2010-10-28 US US13/504,756 patent/US9526753B2/en not_active Expired - Fee Related
- 2010-10-28 WO PCT/IB2010/054885 patent/WO2011051900A1/en not_active Ceased
- 2010-10-28 AR ARP100103969A patent/AR078812A1/es not_active Application Discontinuation
- 2010-10-28 JP JP2012535998A patent/JP6077305B2/ja not_active Expired - Fee Related
- 2010-10-28 BR BR112012009806-3A patent/BR112012009806B1/pt not_active IP Right Cessation
- 2010-10-28 EP EP10782700.8A patent/EP2493488B1/en active Active
- 2010-10-28 PL PL10782700T patent/PL2493488T3/pl unknown
- 2010-10-28 RU RU2012119714/15A patent/RU2573990C2/ru active
-
2014
- 2014-04-04 US US14/245,355 patent/US9192638B2/en active Active
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