JP2011513340A5 - - Google Patents
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- Publication number
- JP2011513340A5 JP2011513340A5 JP2010549002A JP2010549002A JP2011513340A5 JP 2011513340 A5 JP2011513340 A5 JP 2011513340A5 JP 2010549002 A JP2010549002 A JP 2010549002A JP 2010549002 A JP2010549002 A JP 2010549002A JP 2011513340 A5 JP2011513340 A5 JP 2011513340A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- cells
- epigallocatechin
- tea
- tea polyphenol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 244000269722 Thea sinensis Species 0.000 claims 13
- 235000013616 tea Nutrition 0.000 claims 11
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 claims 10
- 150000008442 polyphenolic compounds Chemical class 0.000 claims 10
- 235000013824 polyphenols Nutrition 0.000 claims 10
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims 5
- LSHVYAFMTMFKBA-TZIWHRDSSA-N (-)-epicatechin-3-O-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-TZIWHRDSSA-N 0.000 claims 5
- LSHVYAFMTMFKBA-UHFFFAOYSA-N ECG Natural products C=1C=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-UHFFFAOYSA-N 0.000 claims 5
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 claims 5
- XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 claims 5
- 239000002775 capsule Substances 0.000 claims 5
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims 5
- 235000005487 catechin Nutrition 0.000 claims 5
- 229950001002 cianidanol Drugs 0.000 claims 5
- DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 claims 4
- 229940030275 epigallocatechin gallate Drugs 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000003826 tablet Substances 0.000 claims 3
- 206010000871 Acute monocytic leukaemia Diseases 0.000 claims 2
- 208000035489 Monocytic Acute Leukemia Diseases 0.000 claims 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 2
- 235000009569 green tea Nutrition 0.000 claims 2
- WMBWREPUVVBILR-GHTZIAJQSA-N (+)-gallocatechin gallate Chemical compound O([C@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-GHTZIAJQSA-N 0.000 claims 1
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 239000001263 FEMA 3042 Substances 0.000 claims 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 claims 1
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 239000006189 buccal tablet Substances 0.000 claims 1
- 229940046011 buccal tablet Drugs 0.000 claims 1
- 229960001948 caffeine Drugs 0.000 claims 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000001055 chewing effect Effects 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 239000007919 dispersible tablet Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- LVJJFMLUMNSUFN-UHFFFAOYSA-N gallocatechin gallate Natural products C1=C(O)C=C2OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C1OC(=O)C1=CC(O)=C(O)C(O)=C1 LVJJFMLUMNSUFN-UHFFFAOYSA-N 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 230000009033 hematopoietic malignancy Effects 0.000 claims 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 239000006191 orally-disintegrating tablet Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 claims 1
- 229940033123 tannic acid Drugs 0.000 claims 1
- 235000015523 tannic acid Nutrition 0.000 claims 1
- 229920002258 tannic acid Polymers 0.000 claims 1
- 229940092665 tea leaf extract Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810034350A CN101524348A (zh) | 2008-03-06 | 2008-03-06 | 茶多酚在制备治疗肿瘤药剂中的应用 |
| PCT/CN2009/000233 WO2009109109A1 (zh) | 2008-03-06 | 2009-03-05 | 茶多酚在制备预防或治疗肿瘤药物中的应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011513340A JP2011513340A (ja) | 2011-04-28 |
| JP2011513340A5 true JP2011513340A5 (enExample) | 2012-04-12 |
Family
ID=41055542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010549002A Pending JP2011513340A (ja) | 2008-03-06 | 2009-03-05 | 腫瘍の予防または治療用医薬の製造における茶ポリフェノールの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110021620A1 (enExample) |
| EP (1) | EP2263668B1 (enExample) |
| JP (1) | JP2011513340A (enExample) |
| CN (2) | CN101524348A (enExample) |
| WO (1) | WO2009109109A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102580112A (zh) * | 2012-02-28 | 2012-07-18 | 南京农业大学 | Egcg磷脂复合物的制备方法 |
| JP6592010B2 (ja) * | 2014-12-22 | 2019-10-16 | シーシーアイホールディングス株式会社 | 癌細胞増殖抑制組成物および癌細胞増殖の抑制方法 |
| CN104957034B (zh) * | 2015-07-15 | 2016-06-08 | 福建农林大学 | 一种抑瘤功能茶树良种的选育方法 |
| US10380765B2 (en) * | 2016-08-17 | 2019-08-13 | Magna Electronics Inc. | Vehicle vision system with camera calibration |
| CN107115337A (zh) * | 2017-07-06 | 2017-09-01 | 中国科学院上海有机化学研究所 | 一种儿茶素类化合物的应用 |
| CN111944771B (zh) * | 2019-10-29 | 2022-06-14 | 华南农业大学 | 茶多酚或其组分在制备粪肠球菌噬菌体钝化剂中的应用 |
| CN115887443A (zh) * | 2023-02-27 | 2023-04-04 | 深圳市第二人民医院(深圳市转化医学研究院) | 表没食子儿茶素在制备结直肠癌治疗药物中的应用 |
| CN119386097A (zh) * | 2024-10-31 | 2025-02-07 | 重庆市优胜科技发展有限公司 | 茶多酚在防治三阴性乳腺癌中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6428818B1 (en) * | 1999-03-30 | 2002-08-06 | Purdue Research Foundation | Tea catechin formulations and processes for making same |
| US6410052B1 (en) * | 1999-03-30 | 2002-06-25 | Purdue Research Foundation | Tea catechins in sustained release formulations as cancer specific proliferation inhibitors |
| JP3525182B2 (ja) * | 2000-02-16 | 2004-05-10 | 独立行政法人産業技術総合研究所 | 新規抗白血病細胞剤 |
| US7192612B2 (en) * | 2001-02-22 | 2007-03-20 | Purdue Research Foundation | Compositions and methods based on synergies between capsicum extracts and tea catechins for prevention and treatment of cancer |
| JP2005075790A (ja) * | 2003-09-02 | 2005-03-24 | Fumio Hashimoto | Ａｐｏｐｔｏｓｉｓ誘導剤 |
-
2008
- 2008-03-06 CN CN200810034350A patent/CN101524348A/zh active Pending
-
2009
- 2009-03-05 EP EP09716802.5A patent/EP2263668B1/en active Active
- 2009-03-05 JP JP2010549002A patent/JP2011513340A/ja active Pending
- 2009-03-05 CN CN2009801045844A patent/CN101965185A/zh active Pending
- 2009-03-05 US US12/921,353 patent/US20110021620A1/en not_active Abandoned
- 2009-03-05 WO PCT/CN2009/000233 patent/WO2009109109A1/zh not_active Ceased
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