JP2013508456A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013508456A5 JP2013508456A5 JP2012536897A JP2012536897A JP2013508456A5 JP 2013508456 A5 JP2013508456 A5 JP 2013508456A5 JP 2012536897 A JP2012536897 A JP 2012536897A JP 2012536897 A JP2012536897 A JP 2012536897A JP 2013508456 A5 JP2013508456 A5 JP 2013508456A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydropyrazino
- pyrazin
- methyl
- triazol
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25491709P | 2009-10-26 | 2009-10-26 | |
| US61/254,917 | 2009-10-26 | ||
| US32848010P | 2010-04-27 | 2010-04-27 | |
| US61/328,480 | 2010-04-27 | ||
| PCT/US2010/053678 WO2011053518A1 (en) | 2009-10-26 | 2010-10-22 | Methods of synthesis and purification of heteroaryl compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016148782A Division JP6338622B2 (ja) | 2009-10-26 | 2016-07-28 | ヘテロアリール化合物の合成方法および精製方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013508456A JP2013508456A (ja) | 2013-03-07 |
| JP2013508456A5 true JP2013508456A5 (enExample) | 2013-11-07 |
Family
ID=43922466
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012536897A Pending JP2013508456A (ja) | 2009-10-26 | 2010-10-22 | ヘテロアリール化合物の合成方法および精製方法 |
| JP2016148782A Active JP6338622B2 (ja) | 2009-10-26 | 2016-07-28 | ヘテロアリール化合物の合成方法および精製方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016148782A Active JP6338622B2 (ja) | 2009-10-26 | 2016-07-28 | ヘテロアリール化合物の合成方法および精製方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US8569494B2 (enExample) |
| EP (2) | EP3091021B1 (enExample) |
| JP (2) | JP2013508456A (enExample) |
| KR (2) | KR101903925B1 (enExample) |
| CN (2) | CN106117213B (enExample) |
| AR (1) | AR078788A1 (enExample) |
| AU (1) | AU2010313585B2 (enExample) |
| BR (1) | BR112012009751A2 (enExample) |
| CA (1) | CA2778615C (enExample) |
| CO (1) | CO6541598A2 (enExample) |
| CR (1) | CR20120211A (enExample) |
| EC (1) | ECSP12011831A (enExample) |
| ES (2) | ES2613664T3 (enExample) |
| IL (1) | IL219368A (enExample) |
| MX (1) | MX341704B (enExample) |
| MY (1) | MY177695A (enExample) |
| NI (1) | NI201200066A (enExample) |
| NZ (2) | NZ599549A (enExample) |
| PH (2) | PH12012500825A1 (enExample) |
| RU (1) | RU2557242C2 (enExample) |
| SG (1) | SG10201500511TA (enExample) |
| WO (1) | WO2011053518A1 (enExample) |
| ZA (1) | ZA201202959B (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| JP2011523646A (ja) | 2008-05-21 | 2011-08-18 | アリアド・ファーマシューティカルズ・インコーポレイテッド | キナーゼ阻害剤としてのリン誘導体 |
| US8110578B2 (en) * | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
| JP5590040B2 (ja) | 2008-11-12 | 2014-09-17 | アリアド・ファーマシューティカルズ・インコーポレイテッド | キナーゼ阻害剤としてのピラジノピラジンおよび誘導体 |
| AU2012250517B2 (en) | 2011-05-04 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| CN103998036B (zh) * | 2011-10-19 | 2017-05-31 | 西格诺药品有限公司 | 利用tor激酶抑制剂治疗癌症 |
| AU2015201807B2 (en) * | 2011-12-02 | 2016-12-08 | Signal Pharmaceuticals, Llc | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methocyclohexyl)-3,4-dihydropyrazino[2,3-b] pyrazin-2(1H)-one, a solid form thereof and methods of their use |
| BR112014013332B1 (pt) | 2011-12-02 | 2022-09-06 | Signal Pharmaceuticals, Llc | Composições farmacêuticas de 7-(6-(2-hidroxi-propan-2-il)piridin-3-il)-1-((trans)-4- metoxicicloexil)-3,4-diidropirazino [2,3-b]pirazin-2(1h)-ona, uma forma sólida dessa e métodos de seu uso |
| CN104271159B (zh) | 2012-02-24 | 2017-11-28 | 西格诺药品有限公司 | 利用tor激酶抑制剂联合治疗来治疗非小细胞肺癌的方法 |
| EP2825169B1 (en) | 2012-03-15 | 2018-05-09 | Signal Pharmaceuticals, LLC | Treatment of cancer with tor kinase inhibitors |
| EP2825168B1 (en) | 2012-03-15 | 2018-05-09 | Signal Pharmaceuticals, LLC | Treatment of cancer with tor kinase inhibitors |
| EA028414B1 (ru) | 2012-03-15 | 2017-11-30 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Лечение рака ингибиторами tor киназы |
| ES2668279T3 (es) | 2012-03-15 | 2018-05-17 | Signal Pharmaceuticals, Llc | Tratamiento del cáncer con inhibidores de la cinasa TOR |
| JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Egfr発動性がんの細胞増殖阻害用化合物 |
| CA2876689C (en) | 2012-06-13 | 2022-04-26 | Incyte Corporation | Substituted tricyclic compounds as fgfr inhibitors |
| AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
| AU2015213397B2 (en) * | 2012-10-18 | 2017-07-27 | Signal Pharmaceuticals, Llc | Treatment of cancer with TOR kinase inhibitors |
| AU2013202768B2 (en) * | 2012-10-18 | 2015-11-05 | Signal Pharmaceuticals, Llc | Treatment of cancer with TOR kinase inhibitors |
| SG11201505446WA (en) | 2013-01-16 | 2015-08-28 | Signal Pharm Llc | Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith |
| AU2014223501A1 (en) * | 2013-02-28 | 2015-09-17 | Signal Pharmaceuticals, Llc | Treatment of cancer with TOR kinase inhibitors |
| WO2014158650A1 (en) * | 2013-03-13 | 2014-10-02 | Dow Agrosciences Llc | Preparation of triaryl rhamnose carbamates |
| US9273399B2 (en) | 2013-03-15 | 2016-03-01 | Ppg Industries Ohio, Inc. | Pretreatment compositions and methods for coating a battery electrode |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| US20140314673A1 (en) * | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Treatment of cancer with dihydropyrazino-pyrazines |
| JP6382946B2 (ja) | 2013-04-17 | 2018-08-29 | シグナル ファーマシューティカルズ,エルエルシー | ジヒドロピラジノ−ピラジンによる癌治療 |
| EP3549940A1 (en) * | 2013-04-17 | 2019-10-09 | Signal Pharmaceuticals, LLC | Pharmaceutical formulations, of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one |
| WO2014172436A1 (en) * | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer |
| CA2908742C (en) * | 2013-04-17 | 2021-06-01 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer |
| MY189663A (en) * | 2013-04-17 | 2022-02-23 | Signal Pharm Llc | Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer |
| WO2014172425A1 (en) * | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Treatment of cancer with dihydropyrazino-pyrazines |
| HK1221168A1 (zh) | 2013-04-17 | 2017-05-26 | 西格诺药品有限公司 | 用於治疗癌症的包括tor激酶抑制剂和n-(3-(5-氟-2-(4-(2-甲氧基乙氧基)苯基氨基)嘧啶-4-基氨基)苯基)丙烯醯胺的组合疗法 |
| CA2908954C (en) * | 2013-04-17 | 2021-08-03 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and an imid compound for treating cancer |
| PH12015502383B1 (en) | 2013-04-19 | 2023-02-03 | Incyte Holdings Corp | Bicyclic heterocycles as fgfr inhibitors |
| CN107474051B (zh) * | 2013-05-29 | 2020-10-30 | 西格诺药品有限公司 | 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途 |
| CN105792816A (zh) | 2013-10-04 | 2016-07-20 | 西格诺药品有限公司 | 以基因突变为特征的癌症的预防或治疗中的tor激酶抑制剂 |
| NZ714742A (en) * | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
| WO2015160880A1 (en) * | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
| US9718824B2 (en) | 2014-04-16 | 2017-08-01 | Signal Pharmaceuticals, Llc | Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof |
| EP3131552B1 (en) | 2014-04-16 | 2020-07-15 | Signal Pharmaceuticals, LLC | Methods for treating cancer using tor kinase inhibitor combination therapy |
| NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
| WO2016010886A1 (en) | 2014-07-14 | 2016-01-21 | Signal Pharmaceuticals, Llc | Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| CA2976790C (en) | 2015-02-20 | 2024-02-27 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| IL271491B2 (en) | 2017-06-22 | 2023-09-01 | Celgene Corp | Treatment of carcinoma of the liver characterized by hepatitis b virus infection |
| KR102956194B1 (ko) | 2018-05-04 | 2026-04-23 | 인사이트 코포레이션 | Fgfr 억제제의 염 |
| RS66310B1 (sr) | 2018-05-04 | 2025-01-31 | Incyte Corp | Čvrsti oblici inhibitora fgfr i procesi za njegovu pripremu |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| GEP20247679B (en) | 2019-10-14 | 2024-10-10 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| MX2022006691A (es) | 2019-12-04 | 2022-09-19 | Incyte Corp | Derivados de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr). |
| WO2021113479A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CN115151532B (zh) * | 2020-04-29 | 2023-06-06 | 北京泰德制药股份有限公司 | 喹喔啉二酮衍生物作为kras g12c突变蛋白的不可逆抑制剂 |
| WO2022166866A1 (zh) * | 2021-02-08 | 2022-08-11 | 南京明德新药研发有限公司 | 二氢吡嗪并吡嗪类大环化合物 |
| EP4323405A1 (en) | 2021-04-12 | 2024-02-21 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| TW202313610A (zh) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | 作為fgfr抑制劑之三環雜環 |
| CA3220274A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3507866A (en) | 1967-08-08 | 1970-04-21 | Merck & Co Inc | 1h - imidazo(4,5-b)pyrazin - 2 - one and processes for their preparation |
| US3567725A (en) | 1968-11-20 | 1971-03-02 | Merck & Co Inc | Process for preparation of 1h-imidazo-(4,5-b)pyrazin-2-ones |
| US4294837A (en) | 1980-03-28 | 1981-10-13 | Sterling Drug Inc. | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use |
| US4317909A (en) | 1980-03-24 | 1982-03-02 | Sterling Drug Inc. | Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones |
| US4294836A (en) | 1980-03-24 | 1981-10-13 | Sterling Drug Inc. | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use |
| US4309537A (en) | 1980-03-28 | 1982-01-05 | Sterling Drug Inc. | Production of imidazo[4,5-b]pyridin-2-ones or thiones |
| GB8709448D0 (en) | 1987-04-21 | 1987-05-28 | Pfizer Ltd | Heterobicyclic quinoline derivatives |
| JPS63275582A (ja) | 1987-05-02 | 1988-11-14 | Naade Kenkyusho:Kk | 2−アミノイミダゾ〔4,5−b〕ピリジン誘導体の製造方法 |
| DD262026A1 (de) | 1987-07-10 | 1988-11-16 | Akad Wissenschaften Ddr | Verfahren zur herstellung von 4-substituierten 6-(pyrid-4-yl)-2,4-dihydro-1h-imidazo[4,5-b]pyrid-2-onen |
| FR2643903A1 (fr) | 1989-03-03 | 1990-09-07 | Union Pharma Scient Appl | Nouveaux derives de benzimidazole, leurs procedes de preparation, intermediaires de synthese, compositions pharmaceutiques les contenant, utiles notamment pour le traitement des maladies cardiovasculaires, et des ulceres duodenaux |
| US4963561A (en) | 1990-02-28 | 1990-10-16 | Sterling Drug Inc. | Imidazopyridines, their preparation and use |
| TW274550B (enExample) * | 1992-09-26 | 1996-04-21 | Hoechst Ag | |
| AU6999996A (en) * | 1995-09-22 | 1997-04-09 | Sumitomo Chemical Company, Limited | Pyrazin-2-one derivatives, their use, and intermediates for their production |
| DE19601627A1 (de) | 1996-01-18 | 1997-07-24 | Bayer Ag | Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone |
| US6031105A (en) * | 1996-04-09 | 2000-02-29 | Pfizer Inc | Substituted pyridines |
| RU2230553C2 (ru) | 1997-09-26 | 2004-06-20 | Центарис АГ | Способ модулирования функции серин/треонин протеинкиназы соединением на основе азабензимидазола, способ идентификации соединений, модулирующих функцию серин/треонин протеинкиназы, способ профилактики или лечения патологических состояний в организме, соединение на основе азабензимидазола, способ его синтеза и фармацевтическая композиция |
| ZA9810490B (en) | 1997-12-03 | 1999-05-20 | Dainippon Pharmaceutical Co | 2-Aryl-8-oxodihydropurine derivative process for the preparation thereof pharmaceutical composition containing the same and intermediate therefor |
| JP2003146987A (ja) | 1999-05-31 | 2003-05-21 | Dainippon Pharmaceut Co Ltd | 2−アリールプリン−9−アセトアミド誘導体 |
| JP3814125B2 (ja) | 1999-06-02 | 2006-08-23 | 大日本住友製薬株式会社 | 2−アリール−8−オキソジヒドロプリン誘導体からなる医薬 |
| JP2002100363A (ja) | 2000-09-25 | 2002-04-05 | Mitsubishi Chemicals Corp | リチウム二次電池用正極材料、リチウム二次電池用正極及びリチウム二次電池 |
| JP2002167387A (ja) | 2000-11-29 | 2002-06-11 | Dainippon Pharmaceut Co Ltd | 2−(7,8−ジヒドロ−8−オキソ−9h−プリン−9−イル)酢酸誘導体 |
| JP2004520299A (ja) | 2000-12-12 | 2004-07-08 | ニューロジェン・コーポレーション | スピロ[イソベンゾフラン−1,4’−ピペリジン]−3−オン類及び3h−スピロイソベンゾフラン−1,4’−ピペリジン類 |
| WO2002076954A1 (en) | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
| UY27427A1 (es) | 2001-09-04 | 2003-03-31 | Boehringer Ingelheim Pharma | Nuevas dihidro-pteridinonas, procedimientos para su preparación y su utilización como medicamentos |
| WO2003032989A1 (en) | 2001-10-18 | 2003-04-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1,4-disubstituted benzo-fused urea compounds as cytokine inhibitors |
| US7247621B2 (en) | 2002-04-30 | 2007-07-24 | Valeant Research & Development | Antiviral phosphonate compounds and methods therefor |
| BR0309581A (pt) | 2002-05-06 | 2005-03-29 | Genelabs Tech Inc | Derivados de nucleosìdeo para tratamento de infecção por vìrus de hepatite c |
| AU2003299531A1 (en) | 2002-08-05 | 2004-06-07 | University Of Massachusetts | Compounds for modulating rna interference |
| EP1556053A4 (en) | 2002-10-31 | 2006-04-19 | Amgen Inc | ANTI-INFLAMMATORY AGENTS |
| RU2005118401A (ru) * | 2002-11-12 | 2006-01-10 | Байер Фармасьютикалс Корпорейшн (US) | Производные индолилпиразинона, применимые для лечения гиперпролиферативных нарушений и заболеваний, связанных с ангиогенезом |
| EP1590341B1 (en) | 2003-01-17 | 2009-06-17 | Warner-Lambert Company LLC | 2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation |
| DE50307267D1 (de) | 2003-02-26 | 2007-06-21 | Boehringer Ingelheim Pharma | Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| GB2400101A (en) | 2003-03-28 | 2004-10-06 | Biofocus Discovery Ltd | Compounds capable of binding to the active site of protein kinases |
| RU2358979C2 (ru) | 2003-05-30 | 2009-06-20 | Фармассет, Инк. | Модифицированные фторированные аналоги нуклеозида |
| US7476665B2 (en) | 2003-06-26 | 2009-01-13 | Merck & Co., Inc. | Benzodiazepine CGRP receptor antagonists |
| JP2008501707A (ja) | 2004-06-04 | 2008-01-24 | アイコス、コーポレーション | マスト細胞障害を処置するための方法 |
| DE102004029784A1 (de) | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
| WO2006001266A1 (ja) | 2004-06-23 | 2006-01-05 | Banyu Pharmaceutical Co., Ltd. | 2-アリールプリン誘導体の製造方法 |
| GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| AU2005289644A1 (en) | 2004-09-24 | 2006-04-06 | Janssen Pharmaceutica, N.V. | Imidazo{4,5-b}pyrazinone inhibitors of protein kinases |
| WO2006050076A1 (en) | 2004-10-29 | 2006-05-11 | Janssen Pharmaceutica, N.V. | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders |
| BRPI0517272A (pt) | 2004-10-29 | 2008-10-07 | Tibotec Pharm Ltd | derivados de pirimidina bicìclicos de inibição de hiv |
| SE0403006D0 (sv) * | 2004-12-09 | 2004-12-09 | Biovitrum Ab | New compounds |
| US7767687B2 (en) | 2004-12-13 | 2010-08-03 | Biogen Idec Ma Inc. | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors |
| KR101362621B1 (ko) | 2005-02-16 | 2014-02-13 | 아스트라제네카 아베 | 화합물 |
| WO2006091737A1 (en) | 2005-02-24 | 2006-08-31 | Kemia, Inc. | Modulators of gsk-3 activity |
| CN101142217B (zh) * | 2005-03-21 | 2010-12-08 | 伊莱利利公司 | 咪唑并哒嗪化合物 |
| BRPI0610514A2 (pt) | 2005-04-05 | 2016-11-16 | Pharmacopeia Inc | composto, composição farmacêutica, e, método de tratamento de um distúrbio |
| GB0519245D0 (en) * | 2005-09-20 | 2005-10-26 | Vernalis R&D Ltd | Purine compounds |
| TW200732331A (en) * | 2005-12-28 | 2007-09-01 | Takeda Pharmaceuticals Co | Fused heterocyclic compound and use thereof |
| JP5040036B2 (ja) * | 2005-12-30 | 2012-10-03 | メルク・シャープ・エンド・ドーム・コーポレイション | Cetp阻害剤として有用な1,3−オキサゾリジン−2−オン誘導体 |
| US20090281075A1 (en) | 2006-02-17 | 2009-11-12 | Pharmacopeia, Inc. | Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors |
| DK2013208T3 (da) * | 2006-04-21 | 2011-08-15 | Pfizer Prod Inc | Pyridin[3,4-B]pyrazinoner |
| BRPI0714725B1 (pt) | 2006-08-02 | 2021-05-25 | Cytokinetics, Inc | Entidade química, composição farmaceuticamente aceitável, e, uso de uma entidade química |
| WO2008030744A2 (en) | 2006-09-05 | 2008-03-13 | Board Of Regents, The University Of Texas System | Inhibitors of c-met and uses thereof |
| US8268809B2 (en) | 2006-09-05 | 2012-09-18 | Emory University | Kinase inhibitors for preventing or treating pathogen infection and method of use thereof |
| TW200831104A (en) | 2006-10-04 | 2008-08-01 | Pharmacopeia Inc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| US7902187B2 (en) | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| RU2474582C2 (ru) | 2006-10-19 | 2013-02-10 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Гетероарильные соединения, их композиции и их применение в качестве ингибиторов протеинкиназы |
| ES2627352T3 (es) | 2006-10-19 | 2017-07-27 | Signal Pharmaceuticals, Llc | Compuestos heteroarilo, sus composiciones y su uso como inhibidores de proteínas quinasas |
| SA08290245B1 (ar) * | 2007-04-23 | 2012-02-12 | استرازينيكا ايه بي | مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم |
| AR067027A1 (es) * | 2007-06-19 | 2009-09-30 | Astrazeneca Ab | Derivados de 2, 3-dihidro-1h-pirrol[3, 4b]quinolin-1-ona, una composicion farmaceutica que los comprende y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la modulacion de la actividad del receptor gaba a. |
| JP2009046435A (ja) * | 2007-08-21 | 2009-03-05 | Mitsubishi Tanabe Pharma Corp | グルココルチコイド受容体モジュレーター |
| WO2009051752A1 (en) * | 2007-10-16 | 2009-04-23 | Arqule, Inc. | Novel lapachone compounds and methods of use thereof |
| AU2008345225A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| US8110578B2 (en) * | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
| CN102264743B (zh) | 2008-11-25 | 2015-02-11 | 罗彻斯特大学 | Mlk抑制剂及其使用方法 |
-
2010
- 2010-10-22 NZ NZ599549A patent/NZ599549A/xx unknown
- 2010-10-22 PH PH1/2012/500825A patent/PH12012500825A1/en unknown
- 2010-10-22 KR KR1020177030006A patent/KR101903925B1/ko active Active
- 2010-10-22 CN CN201610474699.4A patent/CN106117213B/zh active Active
- 2010-10-22 MY MYPI2012001849A patent/MY177695A/en unknown
- 2010-10-22 EP EP16172434.9A patent/EP3091021B1/en active Active
- 2010-10-22 NZ NZ618135A patent/NZ618135A/en unknown
- 2010-10-22 SG SG10201500511TA patent/SG10201500511TA/en unknown
- 2010-10-22 ES ES10827343T patent/ES2613664T3/es active Active
- 2010-10-22 ES ES16172434T patent/ES2751705T3/es active Active
- 2010-10-22 CA CA2778615A patent/CA2778615C/en active Active
- 2010-10-22 WO PCT/US2010/053678 patent/WO2011053518A1/en not_active Ceased
- 2010-10-22 RU RU2012121806/04A patent/RU2557242C2/ru active
- 2010-10-22 JP JP2012536897A patent/JP2013508456A/ja active Pending
- 2010-10-22 EP EP10827343.4A patent/EP2493472B1/en active Active
- 2010-10-22 MX MX2012004887A patent/MX341704B/es active IP Right Grant
- 2010-10-22 KR KR1020127013441A patent/KR20120091240A/ko not_active Ceased
- 2010-10-22 CN CN2010800594724A patent/CN102686225A/zh active Pending
- 2010-10-22 BR BR112012009751-2A patent/BR112012009751A2/pt not_active IP Right Cessation
- 2010-10-22 AU AU2010313585A patent/AU2010313585B2/en active Active
- 2010-10-25 US US12/910,920 patent/US8569494B2/en active Active
- 2010-10-26 AR ARP100103939A patent/AR078788A1/es unknown
-
2012
- 2012-04-23 IL IL219368A patent/IL219368A/en active IP Right Grant
- 2012-04-23 ZA ZA2012/02959A patent/ZA201202959B/en unknown
- 2012-04-25 NI NI201200066A patent/NI201200066A/es unknown
- 2012-04-26 CR CR20120211A patent/CR20120211A/es unknown
- 2012-04-26 EC ECSP12011831 patent/ECSP12011831A/es unknown
- 2012-05-14 CO CO12079058A patent/CO6541598A2/es unknown
-
2013
- 2013-04-30 US US13/873,662 patent/US8686135B2/en active Active
-
2014
- 2014-02-07 US US14/174,896 patent/US9079900B2/en active Active
- 2014-02-19 PH PH12014500392A patent/PH12014500392A1/en unknown
-
2016
- 2016-07-28 JP JP2016148782A patent/JP6338622B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2012121806A (ru) | Способы получения и очистки гетероарильных соединений | |
| RU2011121353A (ru) | Ингибиторы mtor киназы для онкологических показаний и заболеваний, связанных с mtor/pi3k/akt путем метаболизма | |
| TWI899285B (zh) | Rock抑制劑及其製備方法和用途 | |
| RU2013108840A (ru) | Биомаркерный анализ для детектирования или измерения ингибирования активности tor-киназы | |
| DK2760865T3 (en) | New heterocyclic derivatives and their applications | |
| JP2016516820A5 (enExample) | ||
| JP2022543689A (ja) | Shp2阻害剤 | |
| JP2016516817A5 (enExample) | ||
| Da Settimo et al. | GABAA/Bz receptor subtypes as targets for selective drugs | |
| JP2013518890A5 (enExample) | ||
| JP2016516819A5 (enExample) | ||
| JP2015534981A5 (enExample) | ||
| KR20160037198A (ko) | Syk 억제제 | |
| KR20190076976A (ko) | Ret 키나제 억제제로서의 치환된 피라졸로[1,5-a]피리딘 화합물 | |
| TW201127385A (en) | N-containing heteroaryl derivatives as JAK3 kinase inhibitors | |
| WO2019158731A1 (en) | Pharmaceutical 6,5 heterobicyclic ring derivatives | |
| JP2025538097A (ja) | がんを処置するための方法 | |
| JP6960064B2 (ja) | 7H−ピロロ[2,3−d]ピリミジン−4−アミン誘導体 | |
| US20230339900A1 (en) | Casein kinase 1 delta modulators | |
| TW202523321A (zh) | 作為麩醯胺醯基肽環轉移酶及麩醯胺醯基肽環轉移酶樣蛋白之抑制劑的哌啶基吡啶基甲腈衍生物 | |
| EP3597642A1 (en) | Pharmaceutical 6,5 heterobicyclic ring derivatives | |
| WO2026006796A1 (en) | Compositions comprising werner syndrome helicase inhibitors and methods of using the same |