JP2013505288A - 方法及び触媒 - Google Patents
方法及び触媒 Download PDFInfo
- Publication number
- JP2013505288A JP2013505288A JP2012530339A JP2012530339A JP2013505288A JP 2013505288 A JP2013505288 A JP 2013505288A JP 2012530339 A JP2012530339 A JP 2012530339A JP 2012530339 A JP2012530339 A JP 2012530339A JP 2013505288 A JP2013505288 A JP 2013505288A
- Authority
- JP
- Japan
- Prior art keywords
- molybdenum
- compound
- phosphorus
- catalyst
- molar ratio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003054 catalyst Substances 0.000 title claims abstract description 40
- 238000000034 method Methods 0.000 title claims description 23
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims abstract description 62
- 229910052697 platinum Inorganic materials 0.000 claims abstract description 31
- -1 heteroaromatic nitro compounds Chemical class 0.000 claims abstract description 27
- 239000011574 phosphorus Chemical class 0.000 claims abstract description 21
- 229910052698 phosphorus Chemical class 0.000 claims abstract description 21
- 125000003118 aryl group Chemical group 0.000 claims abstract description 11
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000005078 molybdenum compound Substances 0.000 claims abstract description 9
- 150000002752 molybdenum compounds Chemical class 0.000 claims abstract description 9
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 9
- 239000011593 sulfur Substances 0.000 claims abstract description 9
- 150000001412 amines Chemical class 0.000 claims abstract description 7
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical compound O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 4
- 125000001424 substituent group Chemical group 0.000 claims abstract description 4
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 14
- 229910052750 molybdenum Inorganic materials 0.000 claims description 14
- 239000011733 molybdenum Substances 0.000 claims description 14
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 11
- 150000001875 compounds Chemical class 0.000 claims description 11
- 239000007795 chemical reaction product Substances 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 9
- 125000005843 halogen group Chemical group 0.000 claims description 8
- DDEDQHVHVPJFAC-UHFFFAOYSA-N 4,6-dichloro-5-nitro-2-propylsulfanylpyrimidine Chemical compound CCCSC1=NC(Cl)=C([N+]([O-])=O)C(Cl)=N1 DDEDQHVHVPJFAC-UHFFFAOYSA-N 0.000 claims description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 5
- 239000003610 charcoal Substances 0.000 claims description 5
- 230000003647 oxidation Effects 0.000 claims description 5
- 238000007254 oxidation reaction Methods 0.000 claims description 5
- 229910052760 oxygen Chemical group 0.000 claims description 5
- 239000001301 oxygen Chemical group 0.000 claims description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
- APUPEJJSWDHEBO-UHFFFAOYSA-P ammonium molybdate Chemical group [NH4+].[NH4+].[O-][Mo]([O-])(=O)=O APUPEJJSWDHEBO-UHFFFAOYSA-P 0.000 claims description 4
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims description 4
- 239000011701 zinc Substances 0.000 claims description 4
- 229910052725 zinc Inorganic materials 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 2
- UQOKRDJILZMZKU-UHFFFAOYSA-N 2-nitropyrimidine Chemical compound [O-][N+](=O)C1=NC=CC=N1 UQOKRDJILZMZKU-UHFFFAOYSA-N 0.000 claims description 2
- 229940010552 ammonium molybdate Drugs 0.000 claims 1
- 239000011609 ammonium molybdate Substances 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract description 11
- 150000002828 nitro derivatives Chemical class 0.000 abstract description 3
- 150000002367 halogens Chemical class 0.000 abstract description 2
- 150000003017 phosphorus Chemical class 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 13
- 238000003756 stirring Methods 0.000 description 9
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- 229910052757 nitrogen Inorganic materials 0.000 description 7
- 239000000047 product Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- 239000000543 intermediate Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical compound [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 229940126062 Compound A Drugs 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 2
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000004414 alkyl thio group Chemical group 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 description 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 239000012065 filter cake Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 150000002431 hydrogen Chemical class 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- 238000007086 side reaction Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 description 1
- HLTDBMHJSBSAOM-UHFFFAOYSA-N 2-nitropyridine Chemical compound [O-][N+](=O)C1=CC=CC=N1 HLTDBMHJSBSAOM-UHFFFAOYSA-N 0.000 description 1
- CJJLJBFJNXMANZ-UHFFFAOYSA-N 4,6-dichloro-2-propylsulfanylpyrimidin-5-amine Chemical compound CCCSC1=NC(Cl)=C(N)C(Cl)=N1 CJJLJBFJNXMANZ-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910001382 calcium hypophosphite Inorganic materials 0.000 description 1
- 229940064002 calcium hypophosphite Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 150000004292 cyclic ethers Chemical class 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229960004592 isopropanol Drugs 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 125000000018 nitroso group Chemical group N(=O)* 0.000 description 1
- 150000003018 phosphorus compounds Chemical class 0.000 description 1
- 230000010118 platelet activation Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- FVLAYJRLBLHIPV-UHFFFAOYSA-N pyrimidin-5-amine Chemical compound NC1=CN=CN=C1 FVLAYJRLBLHIPV-UHFFFAOYSA-N 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910001379 sodium hypophosphite Inorganic materials 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
- CNALVHVMBXLLIY-IUCAKERBSA-N tert-butyl n-[(3s,5s)-5-methylpiperidin-3-yl]carbamate Chemical compound C[C@@H]1CNC[C@@H](NC(=O)OC(C)(C)C)C1 CNALVHVMBXLLIY-IUCAKERBSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000000101 thioether group Chemical group 0.000 description 1
- 150000003568 thioethers Chemical group 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- B01J27/14—Phosphorus; Compounds thereof
- B01J27/185—Phosphorus; Compounds thereof with iron group metals or platinum group metals
- B01J27/1856—Phosphorus; Compounds thereof with iron group metals or platinum group metals with platinum group metals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J21/00—Catalysts comprising the elements, oxides, or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium, or hafnium
- B01J21/18—Carbon
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/54—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals combined with metals, oxides or hydroxides provided for in groups B01J23/02 - B01J23/36
- B01J23/56—Platinum group metals
- B01J23/64—Platinum group metals with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
- B01J23/652—Chromium, molybdenum or tungsten
- B01J23/6525—Molybdenum
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- B01J27/14—Phosphorus; Compounds thereof
- B01J27/186—Phosphorus; Compounds thereof with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
- B01J27/188—Phosphorus; Compounds thereof with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium with chromium, molybdenum, tungsten or polonium
- B01J27/19—Molybdenum
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J37/00—Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
- B01J37/28—Phosphorising
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
- C07C209/36—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
化合物[1S−(1α,2α,3β(1S*,2R*),5β)]−3−[7−[2−(3,4−ジフルオロフェニル)−シクロプロピル]アミノ]−5−(プロピルチオ)−3H−1,2,3−トリアゾロ[4,5−d]ピリミジン−3−イル)−5−(2−ヒドロキシエトキシ)−シクロペンタン−1,2−ジオール(化合物A)、及び同様なこのような化合物は、WO00/34283及びWO99/05143中で、医薬的に活性なP2T(これは、今や通常P2Y12と呼ばれる)受容体アンタゴニストとして開示されている。このようなアンタゴニストは、特に血小板活性化、凝集又は脱顆粒の阻害剤として使用することができる。
特に、本発明は、以下の式(I):
白金触媒の支持体(担体)は、制約されるものではないが、アルミナ、シリカ及び木炭(活性炭)を含むいずれもの通常の担体であることができ、木炭が好ましい。
具体的に好ましい複素芳香族ニトロ化合物は、4,6−ジクロロ−5−ニトロ−2−(プロピルスルファニル)ピリミジンであり、これは、5−アミノ−4,6−ジクロロ−2−(プロピル−スルファニル)ピリミジンに還元することができる。
なおもう一つの側面において、式(II)の化合物の水素化は、1から10バールの圧力で行われる。
4.6gの市販の木炭上の白金触媒(5%のPt、Engelhard タイプ18、40.5湿潤重量%、ロット番号12410)の水(38g)中のスラリーに、次亜リン酸の水溶液(50%、0.44g、3.4mmol)を加え、そして15分間20℃で撹拌した。この後、オルトモリブデン酸アンモニウム((NH4)2MoO4、0.27g、1.4mmol;H3PO2/(NH4)2MoO4モル比=2.4:1;(NH4)2MoO4/Ptモル比=2:1)をスラリーに加え、これを激しく15分間撹拌し、そして次いで水素化オートクレーブに移した。フラスコ及び移動管路をtert−ブチルメチルエーテル(31g)で洗い流した。水相の測定されたpHは2.3であり、そしてモリブデン含有率は123ppmであった。
tert−ブチルメチルエーテル(370g)を、温度制御ジャケット、Ekato InterMIG(登録商標)撹拌機、内部温度センサー及び封管を備えた1Lのステンレス鋼のオートクレーブに窒素下で入れ、そして4,6−ジクロロ−5−ニトロ−2−プロピルスルファニル−ピリミジン(94.5g、0.35mol)を加え、そして200分−1の撹拌速度で溶解した。
1H NMR(CDCl3,400MHz):δ 4.24(br.s,2H),3.08(t,J=7.2Hz,2H),1.74(六重線,J=7.2Hz,2H),1.02(t,J=7.2Hz,3H)。
tert−ブチルメチルエーテル(370g)を、温度制御ジャケット、InterMIG(登録商標)撹拌機、内部温度センサー及び封管を備えた1Lのステンレス鋼のオートクレーブに窒素下で入れた。4,6−ジクロロ−5−ニトロ−2−プロピルスルファニル−ピリミジン(94.5g、0.35mol)を加え、そして200分−1の撹拌速度で溶解した。オートクレーブを窒素で4回置換した(撹拌速度:600分−1)。
Claims (14)
- 支持体上の元素白金を含む白金触媒の存在下での、芳香族又は複素芳香族ニトロ化合物の対応するアミンへの接触水素化のための方法であって、前記白金触媒が、モリブデン化合物及びリンが+5より少ない酸化状態を有するリン化合物で改変されていることを特徴とする方法。
- 前記リン化合物が、次亜リン酸又は塩或いはこれらの反応生成物である、請求項1に記載の方法。
- 前記モリブデン化合物が、オルト−モリブデン酸塩又はその反応生成物である、請求項1又は2のいずれか1項に記載の方法。
- 前記モリブデン化合物が、オルト−モリブデン酸アンモニウム又はオルトモリブデン酸亜鉛或いはこれらの反応生成物である、請求項3に記載の方法。
- 前記支持体が、木炭である、請求項1から4のいずれか1項に記載の方法。
- 前記触媒が、1:1から100:1のモリブデン/白金モル比及び1:1から100:1のリン/モリブデンモル比を有する、請求項1から5のいずれか1項に記載の方法。
- 前記触媒が、1:1から10:1のモリブデン/白金モル比及び1:1から10:1のリン/モリブデンモル比を有する、請求項6に記載の方法。
- 前記芳香族又は複素芳香族ニトロ化合物が、ハロゲン原子及び酸素含有又は硫黄含有基からなる群から選択される一つ又はそれより多い置換基で置換されている、請求項1から7のいずれか1項に記載の方法。
- 前記複素芳香族ニトロ化合物が、ニトロピリミジンである、請求項1から8のいずれか1項に記載の方法。
- 前記複素芳香族ニトロ化合物が、4,6−ジクロロ−5−ニトロ−2−(プロピルスルファニル)ピリミジンである、請求項10に記載の方法。
- 改変され支持された白金触媒であって、モリブデン及びリン化合物を含有し、リンが+5より小さい酸化状態を有し、次亜リン酸又はその塩及びオルトモリブデン酸塩の水溶液で、1:1から100:1のモリブデン/白金モル比及び1:1から100:1のリン/モリブデンモル比で、支持された白金触媒を処理することによって得ることが可能な、前記白金触媒。
- 前記モリブデン/白金モル比が、1:1から10:1であり、そしてリン/モリブデンモル比が1:1から10:1である、請求項12に記載の改変され支持された白金触媒。
- 前記オルトモリブデン酸塩が、オルトモリブデン酸アンモニウム又はオルトモリブデン酸亜鉛から選択される、請求項12又は13のいずれか1項に記載の改変され支持された白金触媒。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09012080.9 | 2009-09-23 | ||
EP09012080A EP2305376A1 (en) | 2009-09-23 | 2009-09-23 | Process and catalyst for the catalytic hydrogenation of aromatic and heteroaromatic nitro compounds |
PCT/GB2010/051583 WO2011036479A2 (en) | 2009-09-23 | 2010-09-21 | Process and catalyst |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013505288A true JP2013505288A (ja) | 2013-02-14 |
JP5931731B2 JP5931731B2 (ja) | 2016-06-08 |
Family
ID=41604325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012530339A Active JP5931731B2 (ja) | 2009-09-23 | 2010-09-21 | 方法及び触媒 |
Country Status (18)
Country | Link |
---|---|
US (1) | US8242044B2 (ja) |
EP (2) | EP2305376A1 (ja) |
JP (1) | JP5931731B2 (ja) |
KR (1) | KR20120092108A (ja) |
CN (2) | CN102574105A (ja) |
AR (1) | AR078429A1 (ja) |
AU (1) | AU2010299665B2 (ja) |
BR (1) | BR112012006491B1 (ja) |
CA (1) | CA2773617C (ja) |
ES (1) | ES2881677T3 (ja) |
IL (1) | IL218348A (ja) |
IN (1) | IN2012DN01942A (ja) |
MX (1) | MX2012003567A (ja) |
MY (1) | MY159144A (ja) |
RU (1) | RU2538277C2 (ja) |
SG (1) | SG178601A1 (ja) |
TW (1) | TWI518054B (ja) |
WO (1) | WO2011036479A2 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104520278A (zh) * | 2012-08-06 | 2015-04-15 | 埃南蒂亚有限公司 | 三唑并嘧啶碳核苷的中间体的制备方法 |
EP2705902B1 (de) | 2012-09-06 | 2015-05-06 | Allessa Chemie GmbH | Verfahren zur Hydrierung von Nitroaromaten mit ausgewählten Platinkatalysatoren |
WO2014206187A1 (zh) | 2013-06-24 | 2014-12-31 | 苏州明锐医药科技有限公司 | 替卡格雷及其中间体的制备方法 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2932620A (en) * | 1954-03-20 | 1960-04-12 | Basf Ag | Process for preparing catalysts utilizing alumina in the carriers |
JPS51122029A (en) * | 1975-04-07 | 1976-10-25 | Du Pont | Catalytic reduction of halonitroaromatic compound |
JPS55149651A (en) * | 1979-02-22 | 1980-11-21 | Johnson Matthey Co Ltd | Hydrogenating catalyst |
JPH05140008A (ja) * | 1991-11-21 | 1993-06-08 | Daikin Ind Ltd | 1,3−ジクロロ−1,2,2,3,3−ペンタフルオロプロパンの製造方法 |
JP2001198469A (ja) * | 1999-11-05 | 2001-07-24 | Sekisui Chem Co Ltd | 水素貯蔵・供給用金属担持触媒及びこれを利用した水素貯蔵・供給システム |
JP2004516922A (ja) * | 2000-10-02 | 2004-06-10 | ビーエーエスエフ アクチェンゲゼルシャフト | 制御された無電解メッキにより得られる白金族金属の担持触媒 |
JP2007530650A (ja) * | 2004-03-31 | 2007-11-01 | アストラゼネカ アクチボラグ | 化学的工程 |
JP2008273778A (ja) * | 2007-04-27 | 2008-11-13 | Masaru Ichikawa | 水素化/脱水素化反応用担持触媒、その製造方法、およびその触媒を用いた水素貯蔵/供給方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2932626A (en) * | 1956-06-01 | 1960-04-12 | Union Carbide Corp | Diepoxide polymers |
US3953509A (en) * | 1972-10-10 | 1976-04-27 | Koppers Company, Inc. | Hydrogenation of nitrobenzene to p-aminophenol |
ATE237577T1 (de) * | 1996-09-23 | 2003-05-15 | Syngenta Participations Ag | Verfahren zur herstellung von substituierten aromatischen aminoverbindungen |
AR017014A1 (es) | 1997-07-22 | 2001-08-22 | Astrazeneca Ab | Compuestos de triazolo [4,5-d]pirimidina, composiciones farmaceuticas, uso de los mismos para preparar medicamentos y procesos para la preparacionde dichos compuestos |
TWI229674B (en) | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
GB0013488D0 (en) | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Chemical compound |
JP2005144432A (ja) * | 2003-11-18 | 2005-06-09 | Rohm & Haas Co | アルカンをアルケン、およびそれらの対応する酸素化生成物に転化するための触媒系 |
DE102006035203A1 (de) * | 2006-07-29 | 2008-01-31 | Bayer Materialscience Ag | Verfahren zur Herstellung von aromatischen Aminen |
PT2155386E (pt) * | 2007-05-10 | 2012-04-16 | Basf Se | Processo para a produção de aminas |
-
2009
- 2009-09-23 EP EP09012080A patent/EP2305376A1/en not_active Ceased
-
2010
- 2010-09-21 SG SG2012014122A patent/SG178601A1/en unknown
- 2010-09-21 JP JP2012530339A patent/JP5931731B2/ja active Active
- 2010-09-21 ES ES10759961T patent/ES2881677T3/es active Active
- 2010-09-21 CN CN2010800415391A patent/CN102574105A/zh active Pending
- 2010-09-21 EP EP10759961.5A patent/EP2480330B1/en active Active
- 2010-09-21 RU RU2012116047/04A patent/RU2538277C2/ru active
- 2010-09-21 BR BR112012006491A patent/BR112012006491B1/pt active IP Right Grant
- 2010-09-21 AU AU2010299665A patent/AU2010299665B2/en active Active
- 2010-09-21 CN CN201510346197.9A patent/CN104941676B/zh active Active
- 2010-09-21 IN IN1942DEN2012 patent/IN2012DN01942A/en unknown
- 2010-09-21 MY MYPI2012001277A patent/MY159144A/en unknown
- 2010-09-21 TW TW099132060A patent/TWI518054B/zh active
- 2010-09-21 KR KR1020127008697A patent/KR20120092108A/ko not_active Application Discontinuation
- 2010-09-21 WO PCT/GB2010/051583 patent/WO2011036479A2/en active Application Filing
- 2010-09-21 CA CA2773617A patent/CA2773617C/en not_active Expired - Fee Related
- 2010-09-21 MX MX2012003567A patent/MX2012003567A/es unknown
- 2010-09-22 US US12/887,623 patent/US8242044B2/en active Active
- 2010-09-22 AR ARP100103451A patent/AR078429A1/es active IP Right Grant
-
2012
- 2012-02-27 IL IL218348A patent/IL218348A/en active IP Right Grant
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2932620A (en) * | 1954-03-20 | 1960-04-12 | Basf Ag | Process for preparing catalysts utilizing alumina in the carriers |
JPS51122029A (en) * | 1975-04-07 | 1976-10-25 | Du Pont | Catalytic reduction of halonitroaromatic compound |
JPS55149651A (en) * | 1979-02-22 | 1980-11-21 | Johnson Matthey Co Ltd | Hydrogenating catalyst |
JPH05140008A (ja) * | 1991-11-21 | 1993-06-08 | Daikin Ind Ltd | 1,3−ジクロロ−1,2,2,3,3−ペンタフルオロプロパンの製造方法 |
JP2001198469A (ja) * | 1999-11-05 | 2001-07-24 | Sekisui Chem Co Ltd | 水素貯蔵・供給用金属担持触媒及びこれを利用した水素貯蔵・供給システム |
JP2004516922A (ja) * | 2000-10-02 | 2004-06-10 | ビーエーエスエフ アクチェンゲゼルシャフト | 制御された無電解メッキにより得られる白金族金属の担持触媒 |
JP2007530650A (ja) * | 2004-03-31 | 2007-11-01 | アストラゼネカ アクチボラグ | 化学的工程 |
JP2008273778A (ja) * | 2007-04-27 | 2008-11-13 | Masaru Ichikawa | 水素化/脱水素化反応用担持触媒、その製造方法、およびその触媒を用いた水素貯蔵/供給方法 |
Also Published As
Publication number | Publication date |
---|---|
IL218348A0 (en) | 2012-04-30 |
CA2773617A1 (en) | 2011-03-31 |
AR078429A1 (es) | 2011-11-09 |
CN104941676B (zh) | 2018-06-08 |
BR112012006491B1 (pt) | 2018-10-09 |
EP2480330A2 (en) | 2012-08-01 |
MX2012003567A (es) | 2012-04-30 |
RU2012116047A (ru) | 2013-10-27 |
WO2011036479A3 (en) | 2012-02-02 |
RU2538277C2 (ru) | 2015-01-10 |
EP2305376A1 (en) | 2011-04-06 |
CN102574105A (zh) | 2012-07-11 |
IL218348A (en) | 2015-10-29 |
MY159144A (en) | 2016-12-15 |
IN2012DN01942A (ja) | 2015-08-21 |
US8242044B2 (en) | 2012-08-14 |
SG178601A1 (en) | 2012-04-27 |
AU2010299665A1 (en) | 2012-03-15 |
AU2010299665B2 (en) | 2013-02-07 |
TW201127786A (en) | 2011-08-16 |
KR20120092108A (ko) | 2012-08-20 |
CN104941676A (zh) | 2015-09-30 |
CA2773617C (en) | 2017-10-10 |
WO2011036479A2 (en) | 2011-03-31 |
TWI518054B (zh) | 2016-01-21 |
ES2881677T3 (es) | 2021-11-30 |
EP2480330B1 (en) | 2021-05-26 |
US20110071290A1 (en) | 2011-03-24 |
BR112012006491A2 (pt) | 2016-04-26 |
JP5931731B2 (ja) | 2016-06-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6084963B2 (ja) | 1,3−ブタジエンの製造方法 | |
EA021623B1 (ru) | Катализатор на носителе и способ получения амина | |
NL8001507A (nl) | Bereidingswijze van methacrylzuur. | |
JP5931731B2 (ja) | 方法及び触媒 | |
JP2007530650A (ja) | 化学的工程 | |
US9914693B2 (en) | Process for preparing EDA using SO2-free hydrocyanic acid | |
JP2018171587A (ja) | エタノールからの1,3−ブタジエン製造触媒およびプロセス | |
JPWO2014129248A1 (ja) | エタノールから1,3−ブタジエンを選択的に製造する方法 | |
KR20100075514A (ko) | 메타크롤레인 및/또는 메타크릴산의 제조 방법 | |
JP4938125B2 (ja) | 3級アミンの製造方法 | |
JP5152895B2 (ja) | 環状アルキレンイミンの製造方法 | |
JP2011251951A (ja) | 水素化芳香族化合物の製造方法及び有機化合物の製造方法 | |
WO2002036559A2 (en) | Process for the production of amides | |
CN107774259B (zh) | 一种费托合成催化剂及其应用 | |
JP7227209B2 (ja) | 1,3-ブタジエン製造触媒 | |
JP2000119258A (ja) | シアノピリミジン類の製造法 | |
JP4834217B2 (ja) | 複素環式ニトリルの製造法 | |
JPS59186928A (ja) | 第1アミン類の製法 | |
JP2013119522A (ja) | 1−メチルイミダゾール化合物の製造方法 | |
JP2002003438A (ja) | 脂肪族アルデヒド酸アセタール及び/又は脂肪族ジカルボン酸の製造方法 | |
WO2019012920A1 (ja) | 触媒の製造方法及び不飽和ニトリルの製造方法 | |
JP2002255907A (ja) | 3−アリールプロピルアミンの製造法 | |
PL198548B1 (pl) | Sposób otrzymywania 3-glicydoksypropylotrialkoksysilanów | |
JPH11315050A (ja) | 3−アシロキシシクロヘキセンの製造法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130912 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20141008 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20141215 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20141222 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150206 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150807 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20151105 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20160329 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160427 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5931731 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |