JP2013503173A5 - - Google Patents

Info

Publication number

JP2013503173A5

JP2013503173A5 JP2012526945A JP2012526945A JP2013503173A5 JP 2013503173 A5 JP2013503173 A5 JP 2013503173A5 JP 2012526945 A JP2012526945 A JP 2012526945A JP 2012526945 A JP2012526945 A JP 2012526945A JP 2013503173 A5 JP2013503173 A5 JP 2013503173A5

Authority

JP

Japan

Prior art keywords

theta

degrees

compound

crystalline form

diffraction pattern

Prior art date

2010-08-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims description 22
• 238000000634 powder X-ray diffraction Methods 0.000 claims 10
• 238000000034 method Methods 0.000 claims 7
• 239000013078 crystal Substances 0.000 claims 5
• 239000002002 slurry Substances 0.000 claims 4
• 239000002904 solvent Substances 0.000 claims 4
• 238000006243 chemical reaction Methods 0.000 claims 3
• 238000001914 filtration Methods 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 239000012296 anti-solvent Substances 0.000 claims 2
• 238000001816 cooling Methods 0.000 claims 2
• 238000001035 drying Methods 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 239000004215 Carbon black (E152) Substances 0.000 claims 1
• 229940126062 Compound A Drugs 0.000 claims 1
• NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
• PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
• HAAOHBCJARVREN-UHFFFAOYSA-N cyclopenten-1-yl trifluoromethanesulfonate Chemical compound FC(F)(F)S(=O)(=O)OC1=CCCC1 HAAOHBCJARVREN-UHFFFAOYSA-N 0.000 claims 1
• 239000012065 filter cake Substances 0.000 claims 1
• 238000010438 heat treatment Methods 0.000 claims 1
• 229930195733 hydrocarbon Natural products 0.000 claims 1
• 150000002430 hydrocarbons Chemical class 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 239000000047 product Substances 0.000 claims 1
• LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 claims 1
• CTLOSZHDGZLOQE-UHFFFAOYSA-N CN1CCN(CN(C(c(c2c34)c(CCC5)c5c3[nH]c3c4c(OC)ccc3)=O)C2=O)CC1 Chemical compound CN1CCN(CN(C(c(c2c34)c(CCC5)c5c3[nH]c3c4c(OC)ccc3)=O)C2=O)CC1 CTLOSZHDGZLOQE-UHFFFAOYSA-N 0.000 description 1
• 239000008186 active pharmaceutical agent Substances 0.000 description 1
• 238000004090 dissolution Methods 0.000 description 1
• 230000008018 melting Effects 0.000 description 1
• 238000002844 melting Methods 0.000 description 1
• 230000000704 physical effect Effects 0.000 description 1