IL218132B - Crystal forms of 7,6,5,4-tetrahydro-11-methoxy-2-[(4-methyl-1-piperazinyl)methyl]-1h-cyclopenta[a]pyrrolo[4,3-c]carbazole-3, 1[2h]-dione and pharmaceutical preparations containing them - Google Patents
Crystal forms of 7,6,5,4-tetrahydro-11-methoxy-2-[(4-methyl-1-piperazinyl)methyl]-1h-cyclopenta[a]pyrrolo[4,3-c]carbazole-3, 1[2h]-dione and pharmaceutical preparations containing themInfo
- Publication number
- IL218132B IL218132B IL218132A IL21813212A IL218132B IL 218132 B IL218132 B IL 218132B IL 218132 A IL218132 A IL 218132A IL 21813212 A IL21813212 A IL 21813212A IL 218132 B IL218132 B IL 218132B
- Authority
- IL
- Israel
- Prior art keywords
- methyl
- cyclopenta
- pyrrolo
- carbazole
- dione
- Prior art date
Links
- CTLOSZHDGZLOQE-UHFFFAOYSA-N 14-methoxy-9-[(4-methylpiperazin-1-yl)methyl]-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaene-8,10-dione Chemical compound O=C1C2=C3C=4C(OC)=CC=CC=4NC3=C3CCCC3=C2C(=O)N1CN1CCN(C)CC1 CTLOSZHDGZLOQE-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23718009P | 2009-08-26 | 2009-08-26 | |
| PCT/US2010/046671 WO2011028580A1 (en) | 2009-08-26 | 2010-08-25 | Novel forms of a multicyclic compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL218132A0 IL218132A0 (en) | 2012-06-28 |
| IL218132B true IL218132B (en) | 2018-02-28 |
Family
ID=43033463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL218132A IL218132B (en) | 2009-08-26 | 2012-02-15 | Crystal forms of 7,6,5,4-tetrahydro-11-methoxy-2-[(4-methyl-1-piperazinyl)methyl]-1h-cyclopenta[a]pyrrolo[4,3-c]carbazole-3, 1[2h]-dione and pharmaceutical preparations containing them |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8633314B2 (enExample) |
| EP (1) | EP2470540B1 (enExample) |
| JP (3) | JP2013503173A (enExample) |
| KR (1) | KR20120092100A (enExample) |
| CN (1) | CN102482282A (enExample) |
| AU (1) | AU2010289746B2 (enExample) |
| BR (1) | BR112012004053A2 (enExample) |
| CA (1) | CA2772328C (enExample) |
| CL (1) | CL2012000478A1 (enExample) |
| DK (1) | DK2470540T3 (enExample) |
| EA (1) | EA020756B1 (enExample) |
| ES (1) | ES2572652T3 (enExample) |
| IL (1) | IL218132B (enExample) |
| MX (1) | MX2012002456A (enExample) |
| MY (1) | MY156873A (enExample) |
| NZ (1) | NZ598883A (enExample) |
| SG (1) | SG178852A1 (enExample) |
| UA (1) | UA110604C2 (enExample) |
| WO (1) | WO2011028580A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013503173A (ja) * | 2009-08-26 | 2013-01-31 | セファロン、インク． | 多環系化合物の新規形態 |
| CA2967828A1 (en) | 2014-11-26 | 2016-06-02 | Cephalon, Inc. | Crystalline forms of parp inhibitors |
| HRP20240136T1 (hr) | 2016-06-29 | 2024-04-12 | Tesaro, Inc. | Metode liječenja raka jajnika |
| AU2018246214B2 (en) | 2017-03-27 | 2021-07-08 | Merck Sharp & Dohme Llc | Niraparib compositions |
| CN111278433A (zh) | 2017-09-26 | 2020-06-12 | 特沙诺有限公司 | 尼拉帕尼制剂 |
| CN109632555B (zh) * | 2018-12-28 | 2021-07-27 | 上海新黄河制药有限公司 | 一种富马酸福莫特罗无定型含量的动态蒸汽吸附分析方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7122679B2 (en) | 2000-05-09 | 2006-10-17 | Cephalon, Inc. | Multicyclic compounds and the use thereof |
| US20060276497A1 (en) | 2000-05-09 | 2006-12-07 | Cephalon, Inc. | Novel multicyclic compounds and the use thereof |
| CN101316592A (zh) * | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
| WO2008063644A1 (en) | 2006-11-20 | 2008-05-29 | Cephalon, Inc. | Method of radio-sensitizing tumors using a radio-sensitizing agent |
| JP2013503173A (ja) * | 2009-08-26 | 2013-01-31 | セファロン、インク． | 多環系化合物の新規形態 |
-
2010
- 2010-08-25 JP JP2012526945A patent/JP2013503173A/ja active Pending
- 2010-08-25 CA CA2772328A patent/CA2772328C/en not_active Expired - Fee Related
- 2010-08-25 DK DK10750210.6T patent/DK2470540T3/en active
- 2010-08-25 EP EP10750210.6A patent/EP2470540B1/en active Active
- 2010-08-25 MY MYPI2012000710A patent/MY156873A/en unknown
- 2010-08-25 NZ NZ598883A patent/NZ598883A/en not_active IP Right Cessation
- 2010-08-25 WO PCT/US2010/046671 patent/WO2011028580A1/en not_active Ceased
- 2010-08-25 KR KR1020127007524A patent/KR20120092100A/ko not_active Ceased
- 2010-08-25 EA EA201270315A patent/EA020756B1/ru not_active IP Right Cessation
- 2010-08-25 CN CN2010800380284A patent/CN102482282A/zh active Pending
- 2010-08-25 SG SG2012012290A patent/SG178852A1/en unknown
- 2010-08-25 UA UAA201203501A patent/UA110604C2/uk unknown
- 2010-08-25 BR BR112012004053-7A patent/BR112012004053A2/pt not_active IP Right Cessation
- 2010-08-25 ES ES10750210.6T patent/ES2572652T3/es active Active
- 2010-08-25 AU AU2010289746A patent/AU2010289746B2/en not_active Ceased
- 2010-08-25 MX MX2012002456A patent/MX2012002456A/es active IP Right Grant
-
2012
- 2012-02-15 IL IL218132A patent/IL218132B/en not_active IP Right Cessation
- 2012-02-24 US US13/404,137 patent/US8633314B2/en not_active Expired - Fee Related
- 2012-02-24 CL CL2012000478A patent/CL2012000478A1/es unknown
-
2015
- 2015-07-30 JP JP2015151114A patent/JP2016014029A/ja not_active Ceased
-
2017
- 2017-09-04 JP JP2017169876A patent/JP2018035158A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CL2012000478A1 (es) | 2012-11-05 |
| EP2470540A1 (en) | 2012-07-04 |
| JP2018035158A (ja) | 2018-03-08 |
| MX2012002456A (es) | 2012-05-08 |
| CA2772328A1 (en) | 2011-03-10 |
| EA020756B1 (ru) | 2015-01-30 |
| EA201270315A1 (ru) | 2012-08-30 |
| AU2010289746B2 (en) | 2016-07-07 |
| JP2016014029A (ja) | 2016-01-28 |
| WO2011028580A1 (en) | 2011-03-10 |
| MY156873A (en) | 2016-04-15 |
| KR20120092100A (ko) | 2012-08-20 |
| NZ598883A (en) | 2014-09-26 |
| BR112012004053A2 (pt) | 2020-12-08 |
| EP2470540B1 (en) | 2016-04-20 |
| AU2010289746A1 (en) | 2012-04-12 |
| CA2772328C (en) | 2017-06-20 |
| ES2572652T3 (es) | 2016-06-01 |
| HK1171750A1 (zh) | 2013-04-05 |
| CN102482282A (zh) | 2012-05-30 |
| US8633314B2 (en) | 2014-01-21 |
| UA110604C2 (uk) | 2016-01-25 |
| JP2013503173A (ja) | 2013-01-31 |
| SG178852A1 (en) | 2012-04-27 |
| DK2470540T3 (en) | 2016-08-01 |
| US20120214998A1 (en) | 2012-08-23 |
| IL218132A0 (en) | 2012-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |