JP2013064024A5 - - Google Patents

Info

Publication number

JP2013064024A5

JP2013064024A5 JP2013006405A JP2013006405A JP2013064024A5 JP 2013064024 A5 JP2013064024 A5 JP 2013064024A5 JP 2013006405 A JP2013006405 A JP 2013006405A JP 2013006405 A JP2013006405 A JP 2013006405A JP 2013064024 A5 JP2013064024 A5 JP 2013064024A5

Authority

JP

Japan

Prior art keywords

carcinoma

mutation

patient

amino

cancer

Prior art date

2013-01-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 230000035772 mutation Effects 0.000 claims 15
• 206010028980 Neoplasm Diseases 0.000 claims 14
• 201000009030 Carcinoma Diseases 0.000 claims 9
• 201000011510 cancer Diseases 0.000 claims 8
• 239000003814 drug Substances 0.000 claims 8
• 206010027476 Metastases Diseases 0.000 claims 6
• 230000009401 metastasis Effects 0.000 claims 6
• 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 5
• 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 5
• YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 5
• -1 3-Chloro-4-fluorophenyl Chemical group 0.000 claims 4
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 4
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 4
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
• 206010006187 Breast cancer Diseases 0.000 claims 3
• 208000026310 Breast neoplasm Diseases 0.000 claims 3
• 208000000265 Lobular Carcinoma Diseases 0.000 claims 3
• 201000010983 breast ductal carcinoma Diseases 0.000 claims 3
• 201000003714 breast lobular carcinoma Diseases 0.000 claims 3
• 208000014829 head and neck neoplasm Diseases 0.000 claims 3
• 238000011065 in-situ storage Methods 0.000 claims 3
• 230000002757 inflammatory effect Effects 0.000 claims 3
• 206010073096 invasive lobular breast carcinoma Diseases 0.000 claims 3
• 206010041823 squamous cell carcinoma Diseases 0.000 claims 3
• 206010044412 transitional cell carcinoma Diseases 0.000 claims 3
• 208000010576 undifferentiated carcinoma Diseases 0.000 claims 3
• ULXXDDBFHOBEHA-ONEGZZNKSA-N Afatinib Chemical compound N1=CN=C2C=C(OC3COCC3)C(NC(=O)/C=C/CN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 ULXXDDBFHOBEHA-ONEGZZNKSA-N 0.000 claims 2
• 239000002253 acid Substances 0.000 claims 2
• USNRYVNRPYXCSP-JUGPPOIOSA-N afatinib dimaleate Chemical compound OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.N1=CN=C2C=C(O[C@@H]3COCC3)C(NC(=O)/C=C/CN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 USNRYVNRPYXCSP-JUGPPOIOSA-N 0.000 claims 2
• 230000037430 deletion Effects 0.000 claims 2
• 238000012217 deletion Methods 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 210000004907 gland Anatomy 0.000 claims 2
• 230000037431 insertion Effects 0.000 claims 2
• 238000003780 insertion Methods 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 239000012453 solvate Substances 0.000 claims 2
• USNRYVNRPYXCSP-MHBOEXQVSA-N (Z)-but-2-enedioic acid N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide Chemical compound OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.N1=CN=C2C=C(O[C@@H]3COCC3)C(NC(=O)C=CCN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 USNRYVNRPYXCSP-MHBOEXQVSA-N 0.000 claims 1
• ULXXDDBFHOBEHA-INIZCTEOSA-N N-[4-(3-chloro-4-fluoroanilino)-7-[[(3S)-3-oxolanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide Chemical compound N1=CN=C2C=C(O[C@@H]3COCC3)C(NC(=O)C=CCN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 ULXXDDBFHOBEHA-INIZCTEOSA-N 0.000 claims 1
• 150000004677 hydrates Chemical class 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• ULXXDDBFHOBEHA-CWDCEQMOSA-N CN(C)C/C=C/C(Nc(c(O[C@@H]1COCC1)c1)cc2c1ncnc2Nc(cc1Cl)ccc1F)=O Chemical compound CN(C)C/C=C/C(Nc(c(O[C@@H]1COCC1)c1)cc2c1ncnc2Nc(cc1Cl)ccc1F)=O ULXXDDBFHOBEHA-CWDCEQMOSA-N 0.000 description 1