JP5688877B2 - 癌疾患の治療用キナゾリン誘導体 - Google Patents

癌疾患の治療用キナゾリン誘導体 Download PDF

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JP5688877B2
JP5688877B2 JP2008539440A JP2008539440A JP5688877B2 JP 5688877 B2 JP5688877 B2 JP 5688877B2 JP 2008539440 A JP2008539440 A JP 2008539440A JP 2008539440 A JP2008539440 A JP 2008539440A JP 5688877 B2 JP5688877 B2 JP 5688877B2
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amino
cancer
patient
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exon
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JP2009515851A (ja
JP2009515851A5 (https=
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フラヴィオ ゾルカ
フラヴィオ ゾルカ
アンドレー アメルスベルク
アンドレー アメルスベルク
ゲルト シュテーレ
ゲルト シュテーレ
メール ヤコブス セー アー ファン
メール ヤコブス セー アー ファン
アンケ バウム
アンケ バウム
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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Application filed by ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング, ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング filed Critical ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Inorganic Chemistry (AREA)
JP2008539440A 2005-11-11 2006-11-09 癌疾患の治療用キナゾリン誘導体 Active JP5688877B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05110656 2005-11-11
EP05110656.5 2005-11-11
PCT/EP2006/068313 WO2007054550A1 (en) 2005-11-11 2006-11-09 Quinazoline derivatives for the treatment of cancer diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013006405A Division JP5695680B2 (ja) 2005-11-11 2013-01-17 癌疾患の治療用キナゾリン誘導体

Publications (3)

Publication Number Publication Date
JP2009515851A JP2009515851A (ja) 2009-04-16
JP2009515851A5 JP2009515851A5 (https=) 2010-01-07
JP5688877B2 true JP5688877B2 (ja) 2015-03-25

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ID=37700909

Family Applications (2)

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JP2008539440A Active JP5688877B2 (ja) 2005-11-11 2006-11-09 癌疾患の治療用キナゾリン誘導体
JP2013006405A Active JP5695680B2 (ja) 2005-11-11 2013-01-17 癌疾患の治療用キナゾリン誘導体

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US (5) US8404697B2 (https=)
EP (2) EP3173084B1 (https=)
JP (2) JP5688877B2 (https=)
CA (3) CA2833706C (https=)
WO (1) WO2007054550A1 (https=)

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CN105801568B (zh) 2015-01-15 2019-07-30 杭州普晒医药科技有限公司 阿法替尼一马来酸盐晶型及其制备方法和药物组合物
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KR20180086187A (ko) 2015-10-05 2018-07-30 더 트러스티이스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 자가포식 유동의 활성체 및 포스포리파제 d 및 타우를 포함하는 단백질 응집물의 클리어런스 및 단백질질환의 치료
CN107721985A (zh) * 2016-08-12 2018-02-23 山东轩竹医药科技有限公司 喹唑啉类酪氨酸激酶抑制剂的晶型
CN107721987A (zh) * 2016-08-12 2018-02-23 山东轩竹医药科技有限公司 喹唑啉类酪氨酸激酶抑制剂的晶型
CN107721986A (zh) * 2016-08-12 2018-02-23 山东轩竹医药科技有限公司 喹唑啉类酪氨酸激酶抑制剂的晶型
CN109265449B (zh) * 2018-11-07 2021-11-23 沈阳工业大学 Egfr和her2双靶点酪氨酸激酶抑制剂及制备方法和用途
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