JP2012533304A - 生物材料を分離するための方法及び装置 - Google Patents
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Abstract
【選択図】図2A
Description
Claims (26)
- 多成分材料を少なくとも二つのフラクションに分離するための分離システムであって、
内壁、第一の端部壁、及び第二の端部壁の内側で、ボリュームを規定する分離コンテナと;
力の影響の下で、多成分材料の選択された境界面まで移動するように構成された、前記ボリュームの中のブイ分離システムと;
を有し、
このブイ分離システムは、
第一のブイ部分と、第二のブイ部分と、弁装置と、を含んでいて;
第一のブイ部分は、第一のブイ部分の第一の側と第二の側との間の、経路を有し;
第二のブイ部分は、第一のブイ部分の第二の側から選択された距離にあって、この選択された距離は、第一のブイ部分の第二の側と第二のブイ部分との間の収集ボリュームを規定し;
前記弁装置は、封止部分及びフレキシブルな部分を有し、フレキシブルな部分は、第一のブイ部分に対して、封止部分を保持し、第一のブイ部分の中の前記経路をシールして、第一のブイ部分の第一の側の前記収集ボリュームの外側のボリュームから前記収集ボリュームを分離し;
前記弁装置は、力の適用により、第一のブイ部分からシールが開かれ、それにより、選択されたフラクションが前記収集ボリュームの中へ移動することを可能にするように構成されていること、
を特徴とする分離システム。 - 下記特徴を有する請求項1に記載の分離システム:
遠心分離バケットを有する遠心分離システムを更に有し、
この遠心分離バケットは、前記分離コンテナを保持し、遠心分離バケットの中心軸の周りで前記分離コンテナを回転させて、前記分離コンテナの長手方向軸に沿って遠心力を加えるように構成されている。 - 下記特徴を有する請求項2に記載の分離システム:
前記分離コンテナの第一の端部壁の中を通って伸びる抜き出しポートと;
第一のブイ部分と第二のブイ部分との間で、抜き出しポートと前記収集ボリュームを相互に接続し、前記弁装置が封止されたときに、間質細胞の抜き出しを可能にする接続チューブと;
を更に有し:
前記ブイ分離システムは、前記分離コンテナが前記遠心分離システムの中で遠心分離されたときに、多成分材料により前記ブイ分離システムに加えられる力に基づいて、前記分離コンテナに対して移動ように構成されている。 - 下記特徴を有する請求項1に記載の分離システム:
前記封止部分及び前記フレキシブルな部分は、互いに対して移動可能な別個の封止部材及びフレキシブルな部材であり;
この封止部材及びこのフレキシブルな部材のそれぞれは、第一のブイ部分から前記収集ボリュームの中に伸びる中央のチューブの周りで、前記弁装置を嵌め込む経路を規定する内側の壁を有し;
前記フレキシブルな部材の少なくとも一部は、第一のブイ部分に対して固定されている。 - 下記特徴を有する請求項4に記載の分離システム:
前記中央のチューブの外側の壁の中を通って形成された抽出ポートが、前記収集ボリュームへの抜き出しのためのアクセスを可能にする。 - 下記特徴を有する請求項5に記載の分離システム:
第二のブイ部分は、上部壁を有していて、この上部壁が、間質細胞のペレットを集める中央のサンプを規定する。 - 下記特徴を有する請求項4に記載の分離システム:
前記フレキシブルな部材の周辺のエッジは、移動して、前記封止部材が第一のブイ部分からシールを開くことを可能にする。 - 下記特徴を有する請求項7に記載の分離システム:
前記フレキシブルな部材は、前記フレキシブルな部材の第二の部分に対して片持ち梁式に取り付けられて湾曲する第一の部分を含んでいる。 - 下記特徴を有する請求項1に記載の分離システム:
前記分離コンテナの内壁は、円筒状のボリュームを実質的に規定し;
第一のブイ部分は、中央のポストの周りを伸びる環状の部材と、この中央のポストから前記環状の部材まで伸びるスポーク部材と、を含み;
前記スポーク部材及び前記環状の部材は、前記経路を規定し;
前記弁装置は、前記収集ボリュームに実質的に隣接する第一のブイ部分の第一の側と接触して、第一のブイ部分の中を通る前記経路をシールする。 - 多成分材料を分離して少なくとも第一のフラクションを得るためのブイ分離システムを含む分離システムであって、
前記ブイ分離システムは、第一のブイ部分と、第二のブイ部分と、弁装置と、を有し;
第一のブイ部分は、第一のブイ部分の第一の側と第二の側との間の経路を有し;
第二のブイ部分は、第一のブイ部分の第二の側から選択された距離にあり、ここで、この選択された距離は、第一のブイ部分の第二の側と第二のブイ部分との間の収集ボリュームを規定し;
弁装置は、封止部材及びフレキシブルな部材を有し、このフレキシブルな部材は、第二のブイ部分と接触したとき、全体の選択された距離を、実質的に伸ばすために十分な寸法を有し、
前記フレキシブルな部材は、第一のブイ部分に対して前記封止部材を保持して、第一のブイ部分の中の前記経路をシールし、それにより、第一のブイ部分の第一の側の外側のボリュームからの、前記収集ボリュームの分離状態を維持すること;
前記弁装置は、力を作用させることにより、第一のブイ部分からシールが開かれ、それにより、第一のフラクションが前記収集ボリュームの中に移動することを可能にするように構成されていること、
を特徴とする分離システム。 - 下記特徴を有する請求項10に記載の分離システム:
内壁、第一の端部壁、及び第二の端部壁により規定されるボリュームを有する分離コンテナを、更に有している。 - 下記特徴を有する請求項10に記載の分離システム:
前記封止部材は、前記フレキシブルな部材に固定されている。 - 下記特徴を有する請求項11に記載の分離システム:
第一の端部壁の中を通って伸びる引き抜きポートと;
第一のブイ部分から伸びる抽出ポートと;
前記引き抜き部分と前記抽出部分を相互に接続するチューブと;
前記抽出部分から前記収集ボリュームの中に伸びるチューブと;
を更に有している。 - 下記特徴を有する請求項13に記載の分離システム:
前記チューブは、外側の壁を有していて、この外側の壁は、第一のブイ部分を、前記選択された距離で、第二のブイ部分に対して少なくとも部分的に固定して、第一のブイ部分と第二のブイ部分との間の前記収集ボリュームを規定し;
前記チューブの第一の端部は、第一のブイ部分まで伸び、
前記チューブの第二の端部は、第二のブイ部分の上部壁により規定されるサンプまで伸びている。 - 下記特徴を有する請求項13に記載の分離システム:
第二のブイ部分の前記上部壁は、チューブの軸に対して角度を付けて形成され;
その角度は、約45度から約90度までである。 - 下記特徴を有する請求項10に記載の分離システム:
前記フレキシブルな部材は、中央のハブ部分から径方向に伸びる第一のディスク部分を含んでいて、
この中央のハブ部分は、全体の選択された距離を実質的に伸ばし;
前記封止部材は、前記フレキシブルな部材により、第一のブイ部分に対して押圧されるように構成された環状の部材である。 - 下記特徴を有する請求項16に記載の分離システム:
前記フレキシブルな部材は、第二のブイ部分と前記封止部材との間に力を作用させて、第一のブイ部分の前記経路をシールするように構成されている。 - 下記特徴を有する請求項17に記載の分離システム:
第一のブイ部分は、チューブから環状の部分の内側の壁まで伸びるスポークを含んでいて;
前記経路は、前記スポークの外側の壁及び前記環状の部分の内側の壁により、少なくとも部分的に規定される。 - 全組織サンプルから細胞を分離する方法であって:
分離コンテナ・システムの中に集められた全組織サンプルを配置し;
前記分離コンテナの中に配置された、集められた全組織サンプルに遠心力を作用させ;
遠心力を作用させている間に、且つ集められた全組織サンプルの材料の力で、ブイ分離システムを移動させ;
前記ブイ分離システムの第一のブイ部分を通る弁を開けて、第一のブイ部分と第二のブイ部分との間で、細胞フラクション収集ボリュームの中に入ることを可能にし;
遠心力を作用させることを停止したときに、前記弁を閉じて、前記収集ボリュームと第一のブイ部分の外側のボリュームとの間に物理的なバリアを形成し;
ここで、前記弁を開けることは、外部の力を作用させ、前記弁のフレキシブルな部分曲げて、前記弁の封止部分を、第一のブイ部分との接触状態から移動させることを含んでいること;
前記弁を閉じることは、前記フレキシブルな部分から外部の力を取り除き、前記フレキシブルな部分を回復させて、前記封止部分を、第一のブイ部分との接触状態に移動させることを含んでいること、を特徴とする方法。 - 下記特徴を有する請求項19に記載の方法:
前記外部の力は、少なくとも部分的に、遠心力であって;
前記弁を開けることは、前記収集ボリュームの外側のボリュームと、前記収集ボリュームの内側の圧力との間の圧力差に起因して生じ;
遠心力を作用させている間、前記弁を開放位置に維持することは、前記弁の密度が、前記収集ボリュームの中で、全組織サンプルの密度と比べて高いことに起因して生ずる。 - 下記特徴を有する請求項19に記載の方法:
分離コンテナ・システムの中に集められた全組織サンプルを配置することは、分離コンテナ・システムの中に骨髄を配置することを含んでいる。 - 下記特徴を有する請求項19に記載の方法:
分離コンテナ・システムの中に、集められた全組織サンプルを配置することは、分離コンテナ・システムの中に全血液を配置することを含んでいる。 - 下記特徴を有する請求項19に記載の方法:
前記弁を開けることは、外部の力を、前記ブイ分離システムの少なくとも一部に対して固定されたフレキシブルな部分を作用させることを含んでいて、
ここで、外部の力を前記フレキシブルな部分に作用させることにより、前記フレキシブルな部分を湾曲させて、前記フレキシブルな部分を、前記ブイ分離システムの少なくとも一部により規定される経路から引き離し;
前記フレキシブルな部分を更に曲げることにより、第一のブイ部分を通る経路をシールする前記封止部分に対して加えられる力を取り除く。 - 下記特徴を有する請求項23に記載の方法:
外部の力を前記フレキシブルな部分に作用させることは、外部の力をフレキシブルな部材に作用させて、前記フレキシブルな部材の第一の部分を、前記フレキシブルな部材の第二の部分に対して曲げることを含み;
第一の部分が、曲げられた形態にあるとき、前記封止部分が、開放位置に移動する。 - 下記特徴を有する請求項19に記載の方法:
分離コンテナの中に、集められた全組織サンプルを配置することは、前記弁が閉鎖位置に偏らされた状態で、前記ブイ分離システムを含むコンテナの中に、集められた全組織サンプルを配置することを含んでいて、
前記弁を開けることは、力を作用させて、閉鎖位置にある前記弁のバイアス力に打ち勝つことを含んでいる。 - 下記特徴を有する請求項25に記載の方法:
前記弁を閉じることは、外部の力を取り除いて、前記バイアス力が、前記弁を閉じるための主要な力になることを可能にすることを含んでいる。
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US12/504,413 US9011800B2 (en) | 2009-07-16 | 2009-07-16 | Method and apparatus for separating biological materials |
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WO2015025912A1 (ja) * | 2013-08-22 | 2015-02-26 | 株式会社ジェイ・エム・エス | 血液成分分離用装置 |
JPWO2015025912A1 (ja) * | 2013-08-22 | 2017-03-02 | 株式会社ジェイ・エム・エス | 血液成分分離用装置 |
Also Published As
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EP2464397B1 (en) | 2018-02-14 |
AU2010273449A2 (en) | 2012-04-19 |
EP2464397A1 (en) | 2012-06-20 |
US20110014705A1 (en) | 2011-01-20 |
WO2011008836A1 (en) | 2011-01-20 |
AU2010273449B2 (en) | 2015-07-16 |
CN102497896B (zh) | 2016-04-13 |
US9011800B2 (en) | 2015-04-21 |
AU2010273449A1 (en) | 2012-02-09 |
BR112012001675A2 (pt) | 2016-04-12 |
CN102497896A (zh) | 2012-06-13 |
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