CN102497896A - 用于分离生物材料的方法和装置 - Google Patents
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Abstract
根据多种实施方式，可提供一种系统来从全组织样品中分离未分化细胞和/或基质细胞。全组织样品可以是直接从患者获得的任何适当的组织样品。组织样品可在选定的手术程序期间获得以立即或迅速应用于患者或重新应用于患者。因此，可在手术中获得自体细胞以便基本上在获得全组织样品不久之后应用于患者。
Description
领域
本公开内容涉及用于分离生物材料的方法和装置，且特别涉及用于从多组分生物材料中分离选定成分的系统。
背景
本部分提供了与本公开内容相关的背景信息，但那不一定是现有技术。
多种细胞(或生物)材料可用于辅助病人的愈合过程或康复过程。选定的细胞类型如基质细胞、多潜能干细胞或多能干细胞或完全分化的细胞可在治疗上应用于患者。例如，干细胞可被应用于患者的感染区域，如可能因损伤、化学治疗或放射治疗而损坏的区域，以通过干细胞的分化和感染细胞的再生来帮助愈合该区域。
在使用未分化细胞如干细胞或基质细胞对病人进行治疗程序时，可从多种来源获得未分化细胞，来源包括患者自身的解剖构造。因此，可将某些自体细胞应用于或注射到患者的解剖构造的不同部分中。一般地说，可在第一程序期间从患者中获得全组织样品或全血样品，可从全组织样品或全血样品分离选定的细胞，并且可在后续程序期间将该选定的、分离的细胞重新应用于或注射到患者中。
概述
本部分提供了本发明的各方面的总体概述，并且不是本发明全部范围或其全部特征的全面描述。
根据多种实施方式，可提供一种系统以从全组织样品或全血样品中分离未分化细胞，包括干细胞和/或基质细胞。样品可以是直接从患者获得的任何适当的组织样品或血液样品。可在选定的操作程序(operatingprocedure)期间获得样品，目的是从样品中分离未分化细胞以用于立即或迅速应用于患者。因此，可在手术中获得自体未分化细胞以便在获得全组织样品或全血液样品后比较快地应用于患者。
另外的适用领域将从本文提供的描述中变得明显。描述和具体实施例仅旨在用于示例的目的并且不旨在限定要求保护的发明的范围。
附图
本文描述的附图仅为了选定的实施方式而不是所有可能的实现方式的示例目的，且并非旨在限制本公开内容的范围。
图1是分离系统的正视图；
图2A是图1的分离系统的浮标系统的分解透视图；
图2B是图1的浮标系统在平面2B-2B中的横截面视图；
图3是填充图1的分离系统的方法的正视图；
图4是离心机系统的透视图；
图5A是部分地以剖面显示的图1的分离系统的浮标系统的操作的正视图；
图5B是图1的分离系统的以剖面显示的浮标系统的操作的细节视图；
图6是图1的分离系统中的被分级分离的全组织样品或全血样品的正视图；和
图7是应用全组织样品或全血样品的选定成分的环境视图。
遍及附图的几个视图，对应的参考数字指示对应的部件。
详述
现在将参考附图来更完整地描述示例性实施方式。
参考图1，图示了细胞分离系统20。细胞分离系统20可包括任何适当构型的容器22，诸如具有圆柱状外壁24且被基本上圆形的底壁26和基本上圆形的上壁或可移去的盖28封闭的基本上圆柱状的容器。容器22沿纵轴线A延伸，且顶壁28和底壁26被定位成沿纵轴线A且基本上垂直于纵轴线A而彼此分离。然而，应理解，容器22可具有任何适当的横截面，诸如多边形横截面、正方形横截面或任何其他适当的形状。
分离系统20可包括可定位在容器22内且能够相对于底壁26和顶壁28而沿纵轴线A大体轴向移动的浮标系统30。浮标系统30可被配置成以期望的、选定的方式接触壁24的内壁表面32。例如，可将浮标系统30配置成在分离系统20处于基本上静态时摩擦地接合内壁表面32，且还在分离系统20正被离心时相对于容器22比较自由地轴向移动，如以下进一步描述的。根据多个实施方式，容器22可由被选择用于使得壁24能够在选定的力下向外地且横向于纵轴线A而弯曲的材料形成。例如，如通过引用并入本文的2008年5月20日授权的美国专利7,374,678中所公开的，容器22可被定位在离心机中并旋转以使得向容器22的底壁26施加通常是重力的数倍的巨大的力，使得壁24向外弯曲并且容器22压缩。在压缩状态下，圆柱状外壁24可扩展直径，使得内壁表面32能够远离浮标系统30而径向移动。因而产生在浮标系统30和内壁表面32之间的间隙允许浮标系统30在容器22内且相对于内壁表面32轴向地移动。
如本文进一步详细讨论的，浮标系统30可包括或限定在上浮标部分或构件42与下浮标部分或构件44之间的分离或收集容积40。抽出构件(withdrawal member)或抽出管46能够使抽出口48与被关联至浮标系统30的提取口50互连。抽出口48可穿过顶壁28延伸至容器的外部，并且提取口50可与浮标30内的收集容积40连通并允许到达浮标30内的收集容积40。抽出口48可包括连接器，诸如鲁尔连接器(luer connector)52，其可用盖或塞54选择性地盖住或堵住。
引入口56也可以穿过顶壁或盖28延伸并且与容器22的内部容积57连通。引入口56也可以包括能够与引入注射器60互连的鲁尔连接器或锥形内壁58。在将材料引入容器22后，盖或塞62可被选择性地与引入口56互连，以便盖住或堵住鲁尔连接器58。第二成分或血浆的抽出口64也可以被限定成穿过顶壁或盖28，其可包括鲁尔锁(luer lock)或鲁尔连接器65，且也可用盖或塞66选择性地盖住或堵住。第二成分或血浆的抽出口64可与被限定成穿过盖28的口或钻孔连接，以在任何选定的时间，诸如在用分离系统20形成的分离步骤之后，抽出或移除被定位于浮标系统30与盖28之间的容积57内的材料。
参考图2A和图2B，浮标系统30可包括提取口50、上浮标部分42和下浮标部分44。上浮标部分42可具有腿或臂70，腿或臂70从环形图或环形构件72轴向延伸以接触下浮标部分44的横向上表面74。腿70可与容器22的纵轴线A大体平行地延伸。腿70可接触上表面74来帮助支撑上浮标部分42的环形图72。腿70可被固定或连接到上表面74或只以非固定方式接触上表面74。
腿70能够以任何适当的构型或数目形成，包括如图2A和图2B中所图示的两条腿、四条腿、任何适当数目的腿、或任何其他适当的结构、形状或构型。例如，可在第一浮标部分42与第二浮标部分44的外边缘附近形成列柱以帮助保持两个部分42和44分开。无论如何，腿70能够将第一浮标部分42支撑在离第二浮标部分44的选定距离处。在另一种构型中，腿70可被省略。
环形构件72可连接至从中心柱或中心管78径向延伸的辐条或延伸构件76。辐条76大体垂直于轴线A延伸。然而，辐条能够以相对于中心轴线A成一定角度地延伸以减少阻力等。管78限定有内孔80，内孔80可与抽出口50的通道或内孔82连通，以允许从浮标系统30的收集容积40中移除材料。中心管78包括外壁84，外壁84从环形图72中心或中央处的径向辐条76轴向地延伸以接触下浮标部分44。
中心柱或中心管78的连接部分或熔接部分86可以延伸到或被固定到下浮标部分44并位于内壁或内孔90中。柱78的连接部分86可与第二浮标部分44粘接、模制、熔接、搭扣配合、压配合或过盈配合。连接部分86可将第一浮标部分42保持至第二浮标部分44。因此，中心柱78也可以帮助腿70将环形图72保持在离下浮标部分44一定距离处以限定收集容积40。可选地，中心柱78可在不存在腿70的情况下保持环形图72与下浮标部分44分隔。
翅片或凸起部分92可从下浮标部分44的表面74向上延伸。翅片92可包括脊或凹槽部分94。中心柱78还可以被固定到翅片92，以帮助使第一浮标部分42固定或保持在离第二浮标部分44的选定距离处。
下浮标部分44可包括上表面74、环形壁或外部壁102以及下表面45。下浮标部分44的上表面74可以是锥形的并且从外周边缘100向下和向内地形成角度或倾斜，外周边缘100由环形壁或外部壁102与上表面74的相交或连接而限定。在包括中心柱78的纵轴线B并且与上表面74相交的假想平面中，轴线B和上表面74的相交线对应着一角度α。角度α可以是任何适当的角度，如大约45°到大约90°，优选大约75°。可选地，上表面74可以是凹球形而非锥形。
下浮标部分44的中心部分可限定有贮槽或下部分103，一定体积的材料的可被收集在贮槽或下部分103中，如本文进一步讨论的。贮槽103可帮助形成材料的选定部分的团块，选定部分诸如细胞成分。限定有轴向孔80的中心柱78还可包括连接孔80的穿过通道(through passage)，该穿过通道将孔80连接成与由柱78的外壁84限定的外部接收口104连通。口104可被定位在贮槽103的底部中或定位在贮槽103的底部处，以允许收集的材料穿过管78而抽出，进而穿过提取口50、抽出管46和抽出口48。
阀系统110可围绕着中心柱或中心管78被定位。阀系统110可包括由适当材料诸如硅橡胶材料制成的密封构件112。密封构件112可被配置成包括中心穿孔诸如圆孔113的圆盘或垫圈，以接收中心管78并围绕中心管78配合。保持性或阀驱动构件116可包括上穿孔圆盘或垫圈117和安装性或保持性圆柱或管118，上穿孔圆盘或垫圈117的表面积与密封构件112相似，安装性或保持性圆柱或管118从圆盘或垫圈117基本上垂直向下地延伸。保持性圆柱118和垫圈117在密封构件112下方接收中心管78并围绕中心管78配合。保持性圆柱118还可以接触表面74上方的翅片92的突出部(ledge)94并且被突出部94支撑，从而相对于翅片92和保持性圆柱118在管78周围留有圆周间隙(circumferential clearance)，以提供在翅片92之间的楔形空间中的连通。简而言之，密封构件112和圆盘117可形成抵着第一浮标部分42的挡板阀。保持性构件116的上圆盘117可折曲以允许密封构件112远离第一浮标部分42而移动，如本文进一步讨论的。
保持性圆柱118的高度可使其接触突出部94并将圆盘117支撑在适当高度处，以便在没有开启力作用于阀部分110上时保持密封构件112抵着环形构件72的底表面120。辐条76可使环形构件72与中心管或中心柱78互连，而且在辐条构件76之间还形成通道122(即开口)。通道122当被阀系统110打开时，允许材料从分离浮标系统30上方或外部的区域移动到收集容积40中。
阀系统110可以作为包括密封构件112和阀驱动构件116二者的单件而形成。例如，密封构件112可以是被涂覆或施加于驱动部分116的圆盘117的柔性材料，诸如硅橡胶。可选地，密封构件112可以是借助粘合剂或其他连接机构而固定到阀圆盘117的单独件。此外，可选地，密封构件112可与阀驱动构件116分离，并且只借助阀驱动构件116的偏置力而保持在适当位置处。换言之，密封构件112可与驱动构件116分离地来制造或被装配在一起成为阀系统110。
阀驱动构件116可由能够在施加力(如离心力或压差力)时弯曲的材料形成，如本文详细讨论的。被选择用于阀驱动构件116的材料可包括丙烯酸酯、聚碳酸酯和任何其他适当的弹性且基本上惰性的材料。阀驱动构件116可由弹性的又柔性的材料形成。因此，驱动构件116可在抵着第一浮标部分42的密封构件112上提供偏置力或闭合力。因此，阀驱动构件116可从开启位置弹回以使阀110偏置在闭合位置中。
浮标系统30可由任何适当的材料制成，并且可由根据要在分离系统20中放置和分离的生物材料而选择的材料制成。然而，浮标系统30可由具有在大约1.03g/ml到大约1.10g/ml范围内、优选在大约1.045g/ml到大约1.07g/ml范围内的平均密度的材料制成。浮标分离系统30的密度或比重可被选择成用于将收集容积40相对于被定位在分离系统20中的材料而定位在分离容器20内的区域或位置处。浮标系统40的比重可被选择成用于在分离期间移动到分离的多组分材料的两种或更多种成分的选定界面。
例如，第二浮标部分44可由单种材料或多种材料制成，并且上浮标部分42也可以由单种材料或多种材料制成。可通过选择用于制备每种构件的材料的适当部分来选择密度。选择用于制备浮标系统30的每个元件的材料的密度，连同选择元件的相对容积、位置和尺寸，可帮助实现浮标系统30在材料内的选定放置。材料还可以被选择为基本上不与系统20中正被分离的材料反应。
参考图3-7，图示了一种使用分离系统20的方法。起初，将全组织样品140(例如，骨髓抽吸物、全血、血与骨髓的组合)经由从填充注射器60引入而被定位在分离系统20内。浮标系统30可在填充期间被定位在分离容器22的底壁26附近。浮标系统30可在离心阶段移动，如本文进一步讨论的。
被定位在分离系统20中的全组织样品140可以是任何适当的全组织样品。例如，全组织样品可包括全血、骨髓抽吸物或全血与骨髓抽吸物的混合物。全组织样品可包括在美国专利第7,374,678号中描述的全组织样品，该专利在上文通过引用并入本文。然而，被定位在分离系统20内的全组织样品140可被分离成选定的部分或成分，并且选定的成分可从分离系统20中抽出。
然后分离系统20可被定位在离心机设备150中，如图4所图示的。离心机设备150可包括离心机构件或离心机转子152，离心机构件或离心机转子152具有能够保持住分离系统20和适当的坯体或其他分离系统的分离井道。分离离心机150可包括与Biomet有限公司出售的带有GPS
血小板分离系统的离心机相似的离心机。分离系统20可在离心机中旋转，以使离心力沿着分离系统20的纵轴线A朝着底壁26定向。在离心期间，多组分材料的材料可基于各组分的比重和密度而分离。如本领域技术人员所理解的，密度较高的材料将朝向分离系统20的底壁移动且较轻材料朝向顶壁28移动。
如图5A和图5B所图示的，在离心期间，当高密度材料朝向底壁26移动时，浮标系统30可朝向分离系统20的顶壁28移动。当浮标系统30大体上在箭头X的方向上朝向分离容器的顶部28移动时，离心力和施压在阀系统110上的材料的力可使边缘诸如阀系统110的外侧边缘或外围边缘112a和117a折曲。当边缘或外侧部分112a、117a远离下表面120折曲或移动时，阀是开启的或解密封的。密封构件112从相对于环形构件72的开启位置解密封或移动至相对于环形构件72的开启位置，诸如相对于环形构件72的底部120。如在图5A和详细地在图5B中所图示的，当阀系统110的边缘112a、117a被折曲时，材料可在箭头Y的方向上移动穿过辐条76之间的空隙或通道122并且进入到收集容积40中。
起初，阀系统110可通过离心力和全组织样品140朝向收集容积40的移动而折曲。然后，在离心期间由于圆盘112和117的密度较高的柔性材料与密度较低的生物材料如血浆之间的密度差，阀110可保持在开启位置中、折曲。
此外，如以上所讨论的，分离容器22可向外弯曲，允许离心期间浮标系统30在该容器22内移动。具有选定密度或比重的浮标系统30可在分离容器22内移动至正被离心力分离的全样品140的适当材料或成分的选定界面。由于容器22的弯曲，可在浮标系统30与内部壁32之间形成空隙。因此，材料还可以在Y′方向上在浮标系统30周围移动。下浮标部分44可包括锥形下表面45，以帮助浮标系统30远离下壁26的移动。
如图6所图示的，一旦离心足够慢或停止，在不存在开启力或外力(例如，离心力)的情况下，阀系统110可通过驱动构件116的偏置力而闭合。浮标系统30，由于其选定的密度，可允许收集容积40被定位在分离的样品140内的选定界面处。分离的全组织样品140可至少包括第一成分140a和第二成分140b，第一成分140a能够最接近于分离容器22的顶壁28，第二成分140b能够处于浮标分离系统30的收集容积40内。当容器22弯曲时，第二成分140b可在浮标系统30周围流动。全样品140还可被分离成包括能够最接近于分离容器22的底壁26的第三成分140c。
在离心停止后，阀系统110能够闭合或密封收集容积40以与第一成分140a隔离。因此，在分离或收集容积40内的提取或移除第二成分140b的期间，第一成分140a将不会干扰第二成分140b或与第二成分140b混合。因为阀系统110能够帮助使选定成分或第二成分140b保持与其他成分的物理分离，所以分离的材料可保持基本上是纯的且具有高产率。
一旦分离结束，提取抽出注射器或系统160可用于借助于抽出口48经由管46、提取口50、中心柱或中心管78以及抽出孔104的互连，将材料或选定成分140b从分离容积40中抽出。一旦材料从分离系统20中抽出，使用者170诸如外科医生可将材料以任何适当的方式应用于患者180。例如，提取抽出注射器160可与针182配合或互连，以允许将选定成分注入患者180中。如以上所讨论的，选定成分140b可包括未分化细胞和/或基质细胞，未分化细胞和/或基质细胞可为了选定的目的，诸如组织再生长、愈合或其他适当目的，而应用于患者180。
因此，分离系统20可允许将自体细胞引入患者180中。在单次手术程序期间，可用输送注射器60从患者180中取出全组织样品140。离心机系统150可被定位在手术室或手术室附近，以适时分离全组织样品以允许选定成分140b的提取抽出。
前述的实施方式的描述是为了示例和描述的目的而提供。其并不旨在为穷举或限制本发明。具体实施方式的单个要素或特征一般不限于该具体实施方式，然而适用时是可互换的且能够用在选定的实施方式中，即使没有被特定地显示或描述。相同的要素或特征也可以以许多方式改变。不应认为这些变化偏离本发明，并且旨在将所有这些改进包括在本发明的范围内。
Claims (26)
1.一种分离系统，其将多组分材料分离成至少两种成分，所述分离系统包括：
分离容器，其在内部壁、第一端壁和第二端壁内限定容积；
浮标分离系统，其在所述容积中可操作成在力的影响下移动至所述多组分材料的选定界面，所述浮标分离系统包括：
第一浮标部分，其具有在所述第一浮标部分的第一侧与第二侧之间的通道；
第二浮标部分，其位于离所述第一浮标部分的第二侧的选定距离处，其中所述选定距离限定了在所述第一浮标部分的第二侧与所述第二浮标部分之间的收集容积；
阀组件，其具有密封部分和柔性部分，其中所述柔性部分保持所述密封部分抵着所述第一浮标部分来密封所述第一浮标部分中的通道，以使所述收集容积与位于所述第一浮标部分的第一侧上所述收集容积的外部的容积分离；
其中所述阀组件可操作成根据力的施加而从所述第一浮标部分解密封，从而允许选定成分移动到所述收集容积中。
2.如权利要求1所述的分离系统，还包括：
具有离心筒的离心机系统，所述离心机系统可操作成保持所述分离容器并使所述分离容器绕所述离心筒的中心轴线旋转并沿所述分离容器的纵轴线施加离心力。
3.如权利要求2所述的分离系统，还包括：
抽出口，其延伸穿过所述分离容器的第一端壁；和
连接管，其使所述抽出口与在所述第一浮标部分和所述第二浮标部分之间的所述收集容积互连，以允许在所述阀组件被密封时抽出基质细胞；
其中所述浮标分离系统可操作成当所述分离容器在所述离心机系统中被离心时，基于由所述多组分材料赋予所述浮标分离系统的力而相对于所述分离容器移动。
4.如权利要求1所述的分离系统，其中所述密封部分和所述柔性部分是相对于彼此可移动的分离的且不同的密封构件和柔性构件；
其中所述密封构件和所述柔性构件中的每一个具有内壁，该内壁限定用于使所述阀组件围绕从所述第一浮标部分延伸到所述收集容积中的中心管而配合的通道；
其中所述柔性构件的至少一部分相对于所述第一浮标部分而固定。
5.如权利要求4所述的分离系统，穿过所述中心管的外壁形成有提取口以允许进入所述收集容积的抽出。
6.如权利要求5所述的分离系统，其中所述第二浮标部分具有上壁，所述上壁限定有中心贮槽以收集基质细胞的团块。
7.如权利要求4所述的分离系统，其中所述柔性构件的外围边缘移动以允许所述密封构件从所述第一浮标部分解密封。
8.如权利要求7所述的分离系统，其中所述柔性构件包括第一部分，所述第一部分是悬臂式的且相对于所述柔性构件的第二部分弯曲。
9.如权利要求1所述的分离系统，其中所述分离容器的内部壁基本上限定圆柱状容积；
其中所述第一浮标部分包括围绕中心柱延伸的环形构件和从所述中心柱延伸至所述环形构件的辐条构件；
其中所述辐条和所述环形构件限定所述通道；
其中所述阀组件接触所述第一浮标部分的与所述收集容积基本上相邻的第一侧以密封穿过所述第一浮标部分的所述通道。
10.一种分离系统，其包括将多组分材料分离成至少第一成分的浮标分离系统，所述浮标分离系统包括：
第一浮标部分，其具有在所述第一浮标部分的第一侧与第二侧之间的通道；
第二浮标部分，其位于离所述第一浮标部分的第二侧的选定距离处，其中所述选定距离限定了在所述第一浮标部分的第二侧与所述第二浮标部分之间的收集容积；
阀组件，其具有密封构件和柔性构件，所述柔性构件具有大到足以在接触所述第二浮标部分时基本上延伸整个选定距离的尺寸；
其中所述柔性构件保持所述密封构件抵着所述第一浮标部分以密封所述第一浮标部分中的通道，从而维持所述收集容积与位于所述第一浮标部分的第一侧上的外部的容积分离；
其中所述阀组件可操作成根据力的施加而从所述第一浮标部分解密封，从而允许所述第一成分移动到所述收集容积中。
11.如权利要求10所述的分离系统，还包括：
分离容器，其具有由内部壁、第一端壁和第二端壁限定的容积。
12.如权利要求10所述的分离系统，
其中所述密封构件被固定至所述柔性构件。
13.如权利要求11所述的分离系统，还包括：
延伸穿过所述第一端壁的抽出口；
从所述第一浮标部分延伸的提取口；
使所述抽出部分与所述提取部分互连的管；和
从所述提取部分延伸到所述收集容积中的管。
14.如权利要求13所述的分离系统，其中所述管具有外部壁，所述外部壁至少部分地将所述第一浮标部分相对于所述第二浮标部分固定所述选定距离以限定所述第一浮标部分与所述第二浮标部分之间的收集容积；
其中所述管的第一端延伸至所述第一浮标部分并且所述管的第二端延伸至由所述第二浮标部分的上壁限定的贮槽。
15.如权利要求13所述的分离系统，其中所述第二浮标部分的上壁以相对于所述管的轴线成一定角度而形成；
其中所述角度为大约45度到大约90度。
16.如权利要求10所述的分离系统，其中所述柔性构件包括从中心毂部分径向延伸的第一圆盘部分，其中所述中心毂部分基本上延伸整个选定距离；
其中所述密封构件是环形构件，所述环形构件可操作成被所述柔性构件压紧在所述第一浮标部分上。
17.如权利要求16所述的分离系统，其中所述柔性构件可操作成在所述第二浮标部分与所述密封构件之间施加力以密封所述第一浮标部分的通道。
18.如权利要求17所述的分离系统，其中所述第一浮标部分包括辐条，所述辐条从管延伸至环形部分的内壁；
其中所述通道至少部分地由所述辐条的外壁和所述环形部分的内壁限定。
19.一种从全组织样品中分离细胞的方法，所述方法包括：
将采集的全组织样品定位在分离容器系统中；
向被定位在所述分离容器中的所述采集的全组织样品施加离心力；
在施加离心力期间并借助所述采集的全组织样品的材料力来移动浮标分离系统；
通过所述浮标分离系统的第一浮标部分开启阀，以允许细胞成分进入所述第一浮标部分与第二浮标部分之间的收集容积；和
在停止施加离心力时闭合所述阀，以便在所述收集容积与所述第一浮标部分的外部的容积之间形成物理障碍；
其中开启阀包括施加外力并且折曲所述阀的柔性部分以使所述阀的密封部分移动而脱离与所述第一浮标部分接触；
其中闭合所述阀包括从所述柔性部分除去所述外力并且使所述柔性部分弹回以使所述密封部分移动而与所述第一浮标部分接触。
20.如权利要求19所述的方法，其中所述外力至少部分是离心力；
其中开启阀是由于在所述收集容积的外部的容积与所述收集容积内的压力之间的压差而发生；并且
在施加离心力的期间由于在所述收集容积中所述阀的密度比所述全组织样品的密度高而将所述阀维持在开启位置中。
21.如权利要求19所述的方法，其中将采集的全组织样品定位在分离容器系统中包括将骨髓定位在所述分离容器系统中。
22.如权利要求19所述的方法，其中将采集的全组织样品定位在分离容器系统中包括将全血定位在所述分离容器系统中。
23.如权利要求19所述的方法，其中开启阀包括，
向相对于所述浮标分离系统的至少一部分而固定的柔性部分施加外力；
其中向柔性部分施加外力使所述柔性部分折曲以使所述柔性部分远离于通过所述浮标分离系统的至少一部分而限定的通道来移动；
其中使所述柔性部分折曲还移除了被抵着所述密封部分而施加的力，所述密封部分密封穿过所述第一浮标部分的通道。
24.如权利要求23所述的方法，其中向柔性部分施加外力包括向柔性构件施加外力以使所述柔性构件的第一部分相对于所述柔性构件的第二部分折曲；
其中当所述第一部分处于折曲构型时，所述密封部分移动至开启位置。
25.如权利要求19所述的方法，其中将采集的全组织样品定位在分离容器中包括将所述采集的全组织样品定位在包含有使所述阀偏置在闭合位置中的所述浮标分离系统的容器中，其中开启阀包括施加力以克服所述阀在所述闭合位置中的偏置力。
26.如权利要求25所述的方法，其中闭合所述阀包括移除外力以允许所述偏置力成为用于闭合所述阀的主要力。
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| US9642956B2 (en) * | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5354483A (en) * | 1992-10-01 | 1994-10-11 | Andronic Technologies, Inc. | Double-ended tube for separating phases of blood |
| US6516953B1 (en) * | 1998-12-05 | 2003-02-11 | Becton, Dickinson And Company | Device for separating components of a fluid sample |
| US20050109716A1 (en) * | 2002-05-24 | 2005-05-26 | Michael Leach | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20060273050A1 (en) * | 2002-05-24 | 2006-12-07 | Higgins Joel C | Apparatus and method for separating and concentrating fluids containing multiple components |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111032858A (zh) * | 2017-08-07 | 2020-04-17 | 李喜永 | 不使用酶地从活体组织分离基质细胞的方法及装置 |
| CN111032858B (zh) * | 2017-08-07 | 2024-05-10 | 李喜永 | 不使用酶地从活体组织分离基质细胞的方法及装置 |
| CN108654142A (zh) * | 2018-07-31 | 2018-10-16 | 宁波爱德康生物科技有限公司 | 一种富血小板血浆分离装置及其分离方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2464397B1 (en) | 2018-02-14 |
| US20110014705A1 (en) | 2011-01-20 |
| WO2011008836A1 (en) | 2011-01-20 |
| AU2010273449B2 (en) | 2015-07-16 |
| CN102497896B (zh) | 2016-04-13 |
| JP2012533304A (ja) | 2012-12-27 |
| EP2464397A1 (en) | 2012-06-20 |
| US9011800B2 (en) | 2015-04-21 |
| AU2010273449A1 (en) | 2012-02-09 |
| AU2010273449A2 (en) | 2012-04-19 |
| BR112012001675A2 (pt) | 2016-04-12 |
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