JP2012523821A5 - - Google Patents
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- JP2012523821A5 JP2012523821A5 JP2012502316A JP2012502316A JP2012523821A5 JP 2012523821 A5 JP2012523821 A5 JP 2012523821A5 JP 2012502316 A JP2012502316 A JP 2012502316A JP 2012502316 A JP2012502316 A JP 2012502316A JP 2012523821 A5 JP2012523821 A5 JP 2012523821A5
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- JP
- Japan
- Prior art keywords
- allele
- specific
- stage
- target sequence
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Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16423009P | 2009-03-27 | 2009-03-27 | |
| US61/164,230 | 2009-03-27 | ||
| US18677509P | 2009-06-12 | 2009-06-12 | |
| US61/186,775 | 2009-06-12 | ||
| US25162309P | 2009-10-14 | 2009-10-14 | |
| US61/251,623 | 2009-10-14 | ||
| US25350109P | 2009-10-20 | 2009-10-20 | |
| US61/253,501 | 2009-10-20 | ||
| US25858209P | 2009-11-05 | 2009-11-05 | |
| US61/258,582 | 2009-11-05 | ||
| US12/641,321 | 2009-12-17 | ||
| US12/641,321 US9534255B2 (en) | 2008-12-17 | 2009-12-17 | Methods, compositions, and kits for detecting allelic variants |
| PCT/US2010/028963 WO2010111682A2 (en) | 2009-03-27 | 2010-03-26 | Methods, compositions, and kits for detecting allelic variants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012523821A JP2012523821A (ja) | 2012-10-11 |
| JP2012523821A5 true JP2012523821A5 (enExample) | 2013-05-30 |
| JP5805064B2 JP5805064B2 (ja) | 2015-11-04 |
Family
ID=42781942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012502316A Expired - Fee Related JP5805064B2 (ja) | 2009-03-27 | 2010-03-26 | 対立遺伝子変種を検出するための方法、組成物、およびキット |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US20100285478A1 (enExample) |
| EP (2) | EP3249053A1 (enExample) |
| JP (1) | JP5805064B2 (enExample) |
| CN (2) | CN103911428B (enExample) |
| WO (1) | WO2010111682A2 (enExample) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| CN102301005A (zh) * | 2008-12-17 | 2011-12-28 | 生命技术公司 | 用于检测等位基因变体的方法、组合物和试剂盒 |
| JP5805064B2 (ja) | 2009-03-27 | 2015-11-04 | ライフ テクノロジーズ コーポレーション | 対立遺伝子変種を検出するための方法、組成物、およびキット |
| US8815515B1 (en) | 2009-09-24 | 2014-08-26 | University Of Utah Research Foundation | Methods, compositions, and kits for rare allele detection |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| AU2011255641A1 (en) | 2010-05-18 | 2012-12-06 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12545960B2 (en) | 2010-05-18 | 2026-02-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10179937B2 (en) | 2014-04-21 | 2019-01-15 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| CA2821906C (en) | 2010-12-22 | 2020-08-25 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| GB201100150D0 (en) | 2011-01-06 | 2011-02-23 | Epistem Ltd | Mutational analysis |
| CA2824387C (en) | 2011-02-09 | 2019-09-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| EP3382039B1 (en) * | 2011-05-04 | 2023-09-13 | Biocept, Inc. | Methods for detecting nucleic acid sequence variants |
| EP2744916A4 (en) | 2011-07-13 | 2015-06-17 | Primeradx Inc | MULTIMODAL PROCEDURE FOR THE SIMULTANEOUS DETECTION AND QUANTIFICATION OF MULTIPLE NUCLEIC ACIDS IN ONE SAMPLE |
| SG2014010276A (en) * | 2011-08-18 | 2014-03-28 | Nestec Sa | Compositions and methods for detecting allelic variants |
| US9260714B2 (en) * | 2011-12-02 | 2016-02-16 | Roche Molecular Systems, Inc. | Suppression of non-specific amplification with high-homology oligonucleotides |
| EP2607495A1 (en) * | 2011-12-23 | 2013-06-26 | Genomica S.A.U. | Method for detection of KRAS mutations |
| JP2015517798A (ja) * | 2012-02-15 | 2015-06-25 | ジャンセン ダイアグノスティックス,エルエルシー | 低頻度変異を検出するための高感度な方法 |
| EP3301188B1 (en) | 2012-04-16 | 2020-10-07 | Life Technologies Corporation | Methods for the preparation of rna libraries |
| WO2013160563A1 (en) * | 2012-04-25 | 2013-10-31 | Ho Tho Huu | Method for competitive allele-specific cdna synthesis and differential amplification of the cdna products |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| CN103114146B (zh) * | 2013-02-28 | 2015-03-11 | 张戈 | 一种检测K-ras基因突变的试剂盒及其检测方法 |
| WO2014164874A2 (en) * | 2013-03-13 | 2014-10-09 | Becton, Dickinson And Company | Methods and compositions for modulation of amplification efficiency |
| CN103215361A (zh) * | 2013-04-18 | 2013-07-24 | 深圳联合医学科技有限公司 | 等位基因变体检测方法、试剂盒及组合物 |
| KR102126031B1 (ko) * | 2013-07-23 | 2020-07-08 | 삼성전자주식회사 | 유전적 변이를 함유하는 핵산 검출 방법 |
| EP3083960B1 (en) | 2013-12-16 | 2021-02-03 | Syddansk Universitet | Ras exon 2 skipping for cancer treatment |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| WO2015179339A1 (en) * | 2014-05-19 | 2015-11-26 | William Marsh Rice University | Allele-specific amplification using a composition of overlapping non-allele-specific primer and allele-specific blocker oligonucleotides |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| US20190194757A1 (en) * | 2014-07-14 | 2019-06-27 | Universitat Zurich Prorektorat Mnw | Means and methods for identifying a patient having a BRAF-positive cancer as a non-responder to a BRAF inhibitor as a responder to an MAPK/ERK inhibitor |
| CN105671137A (zh) * | 2014-11-17 | 2016-06-15 | 武汉白原科技有限公司 | 运动心率反应的检测试剂盒和计算方法 |
| DK3294906T3 (en) | 2015-05-11 | 2024-08-05 | Natera Inc | Methods for determining ploidy |
| CN104862401B (zh) * | 2015-05-29 | 2017-10-31 | 沈阳优吉诺生物科技有限公司 | 检测kras基因热点突变位点的引物、试剂盒及其pcr方法 |
| WO2017070281A1 (en) * | 2015-10-21 | 2017-04-27 | Admera Health LLC | Blocker-based enrichment system and uses thereof |
| CN116064747A (zh) * | 2015-11-25 | 2023-05-05 | 综合基因技术公司 | 用于变体检测的方法 |
| WO2017181202A2 (en) | 2016-04-15 | 2017-10-19 | Natera, Inc. | Methods for lung cancer detection |
| WO2017193025A1 (en) | 2016-05-06 | 2017-11-09 | William Marsh Rice University | Stoichiometric nucleic acid purification using randomer capture probe libraries |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| JP7279633B2 (ja) * | 2017-03-29 | 2023-05-23 | 東洋紡株式会社 | 核酸の検出方法 |
| CN109306374A (zh) * | 2017-09-08 | 2019-02-05 | 广州健天基因技术有限公司 | 用于检测人类pik3ca基因e545k突变的引物、检测方法及试剂盒 |
| US12131803B2 (en) | 2017-10-17 | 2024-10-29 | The Broad Institute, Inc. | Methods and systems for detection of somatic structural variants |
| CA3085933A1 (en) | 2017-12-14 | 2019-06-20 | Tai Diagnostics, Inc. | Assessing graft suitability for transplantation |
| US12331350B2 (en) | 2018-02-20 | 2025-06-17 | William Marsh Rice University | Systems and methods for allele enrichment using multiplexed blocker displacement amplification |
| EP3766992A4 (en) * | 2018-03-15 | 2021-12-01 | Eiken Kagaku Kabushiki Kaisha | OLIGONUCLEOTIDE PROBE FOR DETECTION OF MONONUCLEOTIDIC POLYMORPHISM, AND PROCESS FOR DIFFERENTIATION OF CIS FORM AND TRANS FORM |
| EP3781714B1 (en) | 2018-04-14 | 2026-01-07 | Natera, Inc. | Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| CN110106063B (zh) * | 2019-05-06 | 2022-07-08 | 臻和精准医学检验实验室无锡有限公司 | 基于二代测序的用于神经胶质瘤1p/19q联合缺失检测的系统 |
| US12305235B2 (en) | 2019-06-06 | 2025-05-20 | Natera, Inc. | Methods for detecting immune cell DNA and monitoring immune system |
| AU2020359655B2 (en) * | 2019-10-02 | 2024-06-27 | Rutgers, The State University Of New Jersey | Assay methods and kits for detecting rare sequence variants |
| CN111607652B (zh) * | 2020-05-29 | 2022-02-11 | 中国科学院南海海洋研究所 | 一种与马氏珠母贝生长性状关联的InDel标记、检测引物组及开发方法 |
| CN114645077B (zh) * | 2020-12-17 | 2025-06-03 | 厦门大学 | 一种检测受体样品中供体的存在或比例的方法和试剂盒 |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1008183A (en) | 1911-07-17 | 1911-11-07 | P & M Co | Rail-anchor. |
| US5585481A (en) | 1987-09-21 | 1996-12-17 | Gen-Probe Incorporated | Linking reagents for nucleotide probes |
| EP0472648A4 (en) | 1989-05-18 | 1992-09-16 | Microprobe Corporation | Crosslinking oligonucleotides |
| US5451463A (en) * | 1989-08-28 | 1995-09-19 | Clontech Laboratories, Inc. | Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides |
| US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
| US5419966A (en) | 1991-06-10 | 1995-05-30 | Microprobe Corporation | Solid support for synthesis of 3'-tailed oligonucleotides |
| EP0593572B1 (en) * | 1991-07-01 | 1998-06-17 | The Blood Center Of Southeastern Wisconsin | PEN POLYMORPHISM OF HUMAN PLATELET MEMBRANE GLYCOPROTEIN IIIa AND DIAGNOSTIC AND THERAPEUTIC APPLICATION THEREOF |
| US5512677A (en) | 1991-08-13 | 1996-04-30 | National Science Council | 3-substituted methyl-2,3-dihydroimidazo 1,2-c!quinazoline derivatives, the preparation and use thereof |
| GB9211979D0 (en) | 1992-06-05 | 1992-07-15 | Buchard Ole | Uses of nucleic acid analogues |
| US5767259A (en) | 1994-12-27 | 1998-06-16 | Naxcor | Oligonucleotides containing base-free linking groups with photoactivatable side chains |
| US5925517A (en) * | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| EP0706649B1 (en) * | 1994-04-29 | 2001-01-03 | Perkin-Elmer Corporation | Method and apparatus for real time detection of nucleic acid amplification products |
| US5512441A (en) * | 1994-11-15 | 1996-04-30 | American Health Foundation | Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method |
| US5801155A (en) * | 1995-04-03 | 1998-09-01 | Epoch Pharmaceuticals, Inc. | Covalently linked oligonucleotide minor grove binder conjugates |
| US6312894B1 (en) | 1995-04-03 | 2001-11-06 | Epoch Pharmaceuticals, Inc. | Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders |
| US5736626A (en) | 1996-01-29 | 1998-04-07 | The Perkin-Elmer Corporation | Solid support reagents for the direct synthesis of 3'-labeled polynucleotides |
| US6852487B1 (en) * | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| AU713667B2 (en) | 1996-04-12 | 1999-12-09 | Phri Properties, Inc. | Detection probes, kits and assays |
| JP4468488B2 (ja) * | 1996-05-29 | 2010-05-26 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | 組み合せたリガーゼ検出およびポリメラーゼ連鎖反応を用いる核酸配列相違の検出 |
| US6174670B1 (en) * | 1996-06-04 | 2001-01-16 | University Of Utah Research Foundation | Monitoring amplification of DNA during PCR |
| US5861295A (en) * | 1997-01-02 | 1999-01-19 | Life Technologies, Inc. | Nucleic acid-free thermostable enzymes and methods of production thereof |
| US6043070A (en) | 1997-08-29 | 2000-03-28 | The Perkin-Elmer Corporation | Phosphoramidate-phosphodiester oligonucleotide chimera as primers |
| EP1025120B1 (en) | 1997-10-27 | 2010-08-18 | Boston Probes, Inc. | Methods, kits and compositions pertaining to pna molecular beacons |
| US6485901B1 (en) | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
| US6303305B1 (en) * | 1999-03-30 | 2001-10-16 | Roche Diagnostics, Gmbh | Method for quantification of an analyte |
| US6383752B1 (en) | 1999-03-31 | 2002-05-07 | Hybridon, Inc. | Pseudo-cyclic oligonucleobases |
| US6528254B1 (en) | 1999-10-29 | 2003-03-04 | Stratagene | Methods for detection of a target nucleic acid sequence |
| US6727356B1 (en) * | 1999-12-08 | 2004-04-27 | Epoch Pharmaceuticals, Inc. | Fluorescent quenching detection reagents and methods |
| US7495070B2 (en) * | 2000-04-24 | 2009-02-24 | Yale University | Protein binding miniature proteins |
| US6783934B1 (en) * | 2000-05-01 | 2004-08-31 | Cepheid, Inc. | Methods for quantitative analysis of nucleic acid amplification reaction |
| US6605451B1 (en) * | 2000-06-06 | 2003-08-12 | Xtrana, Inc. | Methods and devices for multiplexing amplification reactions |
| US7087414B2 (en) | 2000-06-06 | 2006-08-08 | Applera Corporation | Methods and devices for multiplexing amplification reactions |
| US6596490B2 (en) | 2000-07-14 | 2003-07-22 | Applied Gene Technologies, Inc. | Nucleic acid hairpin probes and uses thereof |
| JP2004520812A (ja) * | 2000-08-30 | 2004-07-15 | ハプロゲン・エルエルシー | 対立遺伝子を決定するための方法 |
| US20030082549A1 (en) * | 2000-08-30 | 2003-05-01 | Xiangjun Liu | Method for determining alleles |
| US6350580B1 (en) | 2000-10-11 | 2002-02-26 | Stratagene | Methods for detection of a target nucleic acid using a probe comprising secondary structure |
| US6391592B1 (en) * | 2000-12-14 | 2002-05-21 | Affymetrix, Inc. | Blocker-aided target amplification of nucleic acids |
| DE10112515B4 (de) | 2001-03-09 | 2004-02-12 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität |
| JP4502168B2 (ja) * | 2001-07-06 | 2010-07-14 | ルネサスエレクトロニクス株式会社 | 化学機械研磨装置および化学機械研磨方法 |
| CA2459347C (en) | 2001-09-04 | 2012-10-09 | Exiqon A/S | Locked nucleic acid (lna) compositions and uses thereof |
| US6593091B2 (en) | 2001-09-24 | 2003-07-15 | Beckman Coulter, Inc. | Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer |
| US6589250B2 (en) * | 2001-11-20 | 2003-07-08 | Stephen A. Schendel | Maxillary distraction device |
| US7253007B2 (en) * | 2001-11-30 | 2007-08-07 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
| AU2002222737A1 (en) * | 2001-12-08 | 2003-06-23 | Seegene, Inc | Annealing control primer system for regulating primer annealing specificity and its applications |
| CN1578841B (zh) | 2001-12-08 | 2013-03-27 | 视基因公司 | 退火控制引物及该退火控制引物的使用 |
| US7228237B2 (en) * | 2002-02-07 | 2007-06-05 | Applera Corporation | Automatic threshold setting and baseline determination for real-time PCR |
| US6818420B2 (en) * | 2002-02-27 | 2004-11-16 | Biosource International, Inc. | Methods of using FET labeled oligonucleotides that include a 3′-5′ exonuclease resistant quencher domain and compositions for practicing the same |
| EP1594975A4 (en) | 2002-12-04 | 2006-08-02 | Applera Corp | MULTIPLEX AMPLIFICATION OF POLYNUCLEOTIDES |
| US7348146B2 (en) | 2003-10-02 | 2008-03-25 | Epoch Biosciences, Inc. | Single nucleotide polymorphism analysis of highly polymorphic target sequences |
| EP1733054A2 (en) | 2004-04-06 | 2006-12-20 | Epigenomics AG | Method for the quantification of methylated dna |
| US7517978B1 (en) | 2004-04-14 | 2009-04-14 | Applied Biosystems, Llc | Modified oligonucleotides and applications thereof |
| US7563572B2 (en) * | 2004-08-02 | 2009-07-21 | University Of Utah Research Foundation | Method for long range allele-specific PCR |
| DE102005011398A1 (de) * | 2005-03-03 | 2006-09-14 | Epigenomics Ag | Verfahren zur Untersuchung von Cytosin-Methylierungen in DNA |
| EP2477029A1 (en) | 2005-06-02 | 2012-07-18 | Fluidigm Corporation | Analysis using microfluidic partitioning devices |
| US20070087360A1 (en) * | 2005-06-20 | 2007-04-19 | Boyd Victoria L | Methods and compositions for detecting nucleotides |
| WO2007062212A1 (en) * | 2005-11-23 | 2007-05-31 | University Of Southern California | High throughput method of dna methylation haplotyping |
| US20100009355A1 (en) * | 2006-03-14 | 2010-01-14 | Kolodney Michael S | Selective amplification of minority mutations using primer blocking high-affinity oligonucleotides |
| WO2007147018A1 (en) * | 2006-06-14 | 2007-12-21 | Cellpoint Diagnostics, Inc. | Analysis of rare cell-enriched samples |
| EP1905842A1 (en) | 2006-09-26 | 2008-04-02 | DiaSorin S.p.A. | Method for detection of mutant alleles combining Real Time PCR and REMS-PCR |
| GB0703996D0 (en) | 2007-03-01 | 2007-04-11 | Oxitec Ltd | Nucleic acid detection |
| US20090053719A1 (en) * | 2007-08-03 | 2009-02-26 | The Chinese University Of Hong Kong | Analysis of nucleic acids by digital pcr |
| DK2644707T3 (en) | 2008-04-30 | 2015-06-29 | Integrated Dna Tech Inc | RNase-H-based assays using modified RNA monomers. |
| US20100041048A1 (en) | 2008-07-31 | 2010-02-18 | The Johns Hopkins University | Circulating Mutant DNA to Assess Tumor Dynamics |
| CN102301005A (zh) | 2008-12-17 | 2011-12-28 | 生命技术公司 | 用于检测等位基因变体的方法、组合物和试剂盒 |
| JP5805064B2 (ja) | 2009-03-27 | 2015-11-04 | ライフ テクノロジーズ コーポレーション | 対立遺伝子変種を検出するための方法、組成物、およびキット |
| WO2011139920A2 (en) | 2010-04-29 | 2011-11-10 | Life Technologies Corporation | Methylation-specific competitive allele-specific taqman polymerase chain reaction (cast-pcr) |
| DK2576832T3 (en) | 2010-05-25 | 2016-06-20 | Univ Johns Hopkins | CONFIGURATIONS AND METHODS FOR DETECTION OF neoplasia |
| EP2400035A1 (en) | 2010-06-28 | 2011-12-28 | Technische Universität München | Methods and compositions for diagnosing gastrointestinal stromal tumors |
| WO2012097353A1 (en) | 2011-01-14 | 2012-07-19 | Life Technologies Corporation | Methods, compositions, and kits for detecting rare cells |
| EP3382039B1 (en) | 2011-05-04 | 2023-09-13 | Biocept, Inc. | Methods for detecting nucleic acid sequence variants |
| WO2014004726A1 (en) | 2012-06-26 | 2014-01-03 | Caifu Chen | Methods, compositions and kits for the diagnosis, prognosis and monitoring of cancer |
-
2010
- 2010-03-26 JP JP2012502316A patent/JP5805064B2/ja not_active Expired - Fee Related
- 2010-03-26 CN CN201410051965.3A patent/CN103911428B/zh active Active
- 2010-03-26 EP EP17166862.7A patent/EP3249053A1/en not_active Ceased
- 2010-03-26 EP EP10756973.3A patent/EP2411543B1/en active Active
- 2010-03-26 US US12/748,329 patent/US20100285478A1/en not_active Abandoned
- 2010-03-26 WO PCT/US2010/028963 patent/WO2010111682A2/en not_active Ceased
- 2010-03-26 CN CN201080021402.XA patent/CN102428190B/zh active Active
-
2014
- 2014-07-28 US US14/445,046 patent/US9512473B2/en active Active
-
2015
- 2015-09-16 US US14/856,448 patent/US10081833B2/en active Active
-
2018
- 2018-08-22 US US16/109,191 patent/US10689694B2/en active Active
-
2020
- 2020-05-12 US US15/930,101 patent/US11572585B2/en active Active
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