JP2012523821A5 - - Google Patents
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- JP2012523821A5 JP2012523821A5 JP2012502316A JP2012502316A JP2012523821A5 JP 2012523821 A5 JP2012523821 A5 JP 2012523821A5 JP 2012502316 A JP2012502316 A JP 2012502316A JP 2012502316 A JP2012502316 A JP 2012502316A JP 2012523821 A5 JP2012523821 A5 JP 2012523821A5
- Authority
- JP
- Japan
- Prior art keywords
- allele
- specific
- stage
- target sequence
- cycles
- Prior art date
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Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16423009P | 2009-03-27 | 2009-03-27 | |
| US61/164,230 | 2009-03-27 | ||
| US18677509P | 2009-06-12 | 2009-06-12 | |
| US61/186,775 | 2009-06-12 | ||
| US25162309P | 2009-10-14 | 2009-10-14 | |
| US61/251,623 | 2009-10-14 | ||
| US25350109P | 2009-10-20 | 2009-10-20 | |
| US61/253,501 | 2009-10-20 | ||
| US25858209P | 2009-11-05 | 2009-11-05 | |
| US61/258,582 | 2009-11-05 | ||
| US12/641,321 | 2009-12-17 | ||
| US12/641,321 US9534255B2 (en) | 2008-12-17 | 2009-12-17 | Methods, compositions, and kits for detecting allelic variants |
| PCT/US2010/028963 WO2010111682A2 (en) | 2009-03-27 | 2010-03-26 | Methods, compositions, and kits for detecting allelic variants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012523821A JP2012523821A (ja) | 2012-10-11 |
| JP2012523821A5 true JP2012523821A5 (enExample) | 2013-05-30 |
| JP5805064B2 JP5805064B2 (ja) | 2015-11-04 |
Family
ID=42781942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012502316A Expired - Fee Related JP5805064B2 (ja) | 2009-03-27 | 2010-03-26 | 対立遺伝子変種を検出するための方法、組成物、およびキット |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US20100285478A1 (enExample) |
| EP (2) | EP3249053A1 (enExample) |
| JP (1) | JP5805064B2 (enExample) |
| CN (2) | CN102428190B (enExample) |
| WO (1) | WO2010111682A2 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| WO2010077324A2 (en) | 2008-12-17 | 2010-07-08 | Life Technologies Corporation | Methods, compositions, and kits for detecting allelic variants |
| JP5805064B2 (ja) | 2009-03-27 | 2015-11-04 | ライフ テクノロジーズ コーポレーション | 対立遺伝子変種を検出するための方法、組成物、およびキット |
| US8815515B1 (en) | 2009-09-24 | 2014-08-26 | University Of Utah Research Foundation | Methods, compositions, and kits for rare allele detection |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| AU2011255641A1 (en) | 2010-05-18 | 2012-12-06 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| GB201100150D0 (en) | 2011-01-06 | 2011-02-23 | Epistem Ltd | Mutational analysis |
| JP6153874B2 (ja) | 2011-02-09 | 2017-06-28 | ナテラ, インコーポレイテッド | 非侵襲的出生前倍数性呼び出しのための方法 |
| EP2705162B1 (en) | 2011-05-04 | 2018-07-11 | Biocept, Inc. | Methods for detecting nucleic acid sequence variants |
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| KR20140057343A (ko) * | 2011-08-18 | 2014-05-12 | 네스텍 소시에테아노님 | 대립형질 변이 검출을 위한 조성물 및 방법 |
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| WO2013123031A2 (en) * | 2012-02-15 | 2013-08-22 | Veridex, Llc | Highly sensitive method for detecting low frequency mutations |
| EP2839024B1 (en) | 2012-04-16 | 2017-09-06 | Life Technologies Corporation | Methods for the preparation of rna libraries |
| WO2013160563A1 (en) * | 2012-04-25 | 2013-10-31 | Ho Tho Huu | Method for competitive allele-specific cdna synthesis and differential amplification of the cdna products |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| CN103114146B (zh) * | 2013-02-28 | 2015-03-11 | 张戈 | 一种检测K-ras基因突变的试剂盒及其检测方法 |
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| KR102126031B1 (ko) * | 2013-07-23 | 2020-07-08 | 삼성전자주식회사 | 유전적 변이를 함유하는 핵산 검출 방법 |
| EP3083960B1 (en) | 2013-12-16 | 2021-02-03 | Syddansk Universitet | Ras exon 2 skipping for cancer treatment |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| JP6659575B2 (ja) | 2014-04-21 | 2020-03-04 | ナテラ, インコーポレイテッド | 変異の検出および染色体分節の倍数性 |
| RU2708992C2 (ru) * | 2014-05-19 | 2019-12-12 | Уильям Марш Райс Юниверсити | Аллель-специфическая амплификация с использованием композиции перекрывающихся олигонуклеотидов в качестве не являющегося аллель-специфическим праймера и аллель-специфического блокатора |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| CA2953732C (en) * | 2014-07-14 | 2023-09-26 | Universitat Zurich Prorektorat Mnw | Means and methods for identifying a patient having a braf-positive cancer as a non-responder to a braf inhibitor and as a responder to an mapk/erk inhibitor |
| CN105671137A (zh) * | 2014-11-17 | 2016-06-15 | 武汉白原科技有限公司 | 运动心率反应的检测试剂盒和计算方法 |
| DK3294906T3 (en) | 2015-05-11 | 2024-08-05 | Natera Inc | Methods for determining ploidy |
| CN104862401B (zh) * | 2015-05-29 | 2017-10-31 | 沈阳优吉诺生物科技有限公司 | 检测kras基因热点突变位点的引物、试剂盒及其pcr方法 |
| WO2017070281A1 (en) * | 2015-10-21 | 2017-04-27 | Admera Health LLC | Blocker-based enrichment system and uses thereof |
| JP6744917B2 (ja) * | 2015-11-25 | 2020-08-19 | インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド | バリアント検出のための方法 |
| CN109477138A (zh) | 2016-04-15 | 2019-03-15 | 纳特拉公司 | 肺癌检测方法 |
| US11414686B2 (en) | 2016-05-06 | 2022-08-16 | William Marsh Rice University | Stoichiometric nucleic acid purification using randomer capture probe libraries |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| WO2018180987A1 (ja) * | 2017-03-29 | 2018-10-04 | 東洋紡株式会社 | 核酸の検出方法 |
| CN109306374A (zh) * | 2017-09-08 | 2019-02-05 | 广州健天基因技术有限公司 | 用于检测人类pik3ca基因e545k突变的引物、检测方法及试剂盒 |
| CN111587302B (zh) * | 2017-10-17 | 2023-09-01 | 哈佛学院院长等 | 用于检测体细胞结构变体的方法和系统 |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| WO2019164885A1 (en) | 2018-02-20 | 2019-08-29 | William Marsh Rice University | Systems and methods for allele enrichment using multiplexed blocker displacement amplification |
| CN111615561B (zh) * | 2018-03-15 | 2024-06-04 | 荣研化学株式会社 | 单核苷酸多态性检测用寡核苷酸探针和顺式-反式判别方法 |
| CN112236535A (zh) | 2018-04-14 | 2021-01-15 | 纳特拉公司 | 用于借助于循环肿瘤dna的个人化检测的癌症检测和监测的方法 |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| CN110106063B (zh) * | 2019-05-06 | 2022-07-08 | 臻和精准医学检验实验室无锡有限公司 | 基于二代测序的用于神经胶质瘤1p/19q联合缺失检测的系统 |
| EP3980559A1 (en) | 2019-06-06 | 2022-04-13 | Natera, Inc. | Methods for detecting immune cell dna and monitoring immune system |
| IL291819A (en) * | 2019-10-02 | 2022-06-01 | Univ Rutgers | Assay methods and kits for detecting rare sequence variants |
| CN111607652B (zh) * | 2020-05-29 | 2022-02-11 | 中国科学院南海海洋研究所 | 一种与马氏珠母贝生长性状关联的InDel标记、检测引物组及开发方法 |
| CN114645077B (zh) * | 2020-12-17 | 2025-06-03 | 厦门大学 | 一种检测受体样品中供体的存在或比例的方法和试剂盒 |
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-
2010
- 2010-03-26 JP JP2012502316A patent/JP5805064B2/ja not_active Expired - Fee Related
- 2010-03-26 CN CN201080021402.XA patent/CN102428190B/zh active Active
- 2010-03-26 US US12/748,329 patent/US20100285478A1/en not_active Abandoned
- 2010-03-26 WO PCT/US2010/028963 patent/WO2010111682A2/en not_active Ceased
- 2010-03-26 CN CN201410051965.3A patent/CN103911428B/zh active Active
- 2010-03-26 EP EP17166862.7A patent/EP3249053A1/en not_active Ceased
- 2010-03-26 EP EP10756973.3A patent/EP2411543B1/en active Active
-
2014
- 2014-07-28 US US14/445,046 patent/US9512473B2/en active Active
-
2015
- 2015-09-16 US US14/856,448 patent/US10081833B2/en active Active
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2018
- 2018-08-22 US US16/109,191 patent/US10689694B2/en active Active
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2020
- 2020-05-12 US US15/930,101 patent/US11572585B2/en active Active
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