JP2012511927A5 - - Google Patents
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- JP2012511927A5 JP2012511927A5 JP2011542142A JP2011542142A JP2012511927A5 JP 2012511927 A5 JP2012511927 A5 JP 2012511927A5 JP 2011542142 A JP2011542142 A JP 2011542142A JP 2011542142 A JP2011542142 A JP 2011542142A JP 2012511927 A5 JP2012511927 A5 JP 2012511927A5
- Authority
- JP
- Japan
- Prior art keywords
- allele
- specific
- specific primer
- reaction mixture
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13852108P | 2008-12-17 | 2008-12-17 | |
| US61/138,521 | 2008-12-17 | ||
| US16423009P | 2009-03-27 | 2009-03-27 | |
| US61/164,230 | 2009-03-27 | ||
| US18677509P | 2009-06-12 | 2009-06-12 | |
| US61/186,775 | 2009-06-12 | ||
| US25162309P | 2009-10-14 | 2009-10-14 | |
| US61/251,623 | 2009-10-14 | ||
| US25350109P | 2009-10-20 | 2009-10-20 | |
| US61/253,501 | 2009-10-20 | ||
| US25858209P | 2009-11-05 | 2009-11-05 | |
| US61/258,582 | 2009-11-05 | ||
| PCT/US2009/006652 WO2010077324A2 (en) | 2008-12-17 | 2009-12-17 | Methods, compositions, and kits for detecting allelic variants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012511927A JP2012511927A (ja) | 2012-05-31 |
| JP2012511927A5 true JP2012511927A5 (enExample) | 2013-08-15 |
Family
ID=42310453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011542142A Pending JP2012511927A (ja) | 2008-12-17 | 2009-12-17 | 対立遺伝子変種を検出するための方法、組成物、およびキット |
Country Status (6)
| Country | Link |
|---|---|
| US (6) | US9534255B2 (enExample) |
| EP (1) | EP2376659B1 (enExample) |
| JP (1) | JP2012511927A (enExample) |
| CN (1) | CN102301005A (enExample) |
| CA (1) | CA2747026A1 (enExample) |
| WO (2) | WO2010077324A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8583380B2 (en) | 2008-09-05 | 2013-11-12 | Aueon, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| CN102301005A (zh) | 2008-12-17 | 2011-12-28 | 生命技术公司 | 用于检测等位基因变体的方法、组合物和试剂盒 |
| US8606527B2 (en) * | 2009-02-27 | 2013-12-10 | Bio-Rad Laboratories, Inc. | SNP detection by melt curve clustering |
| JP5805064B2 (ja) * | 2009-03-27 | 2015-11-04 | ライフ テクノロジーズ コーポレーション | 対立遺伝子変種を検出するための方法、組成物、およびキット |
| JP6147502B2 (ja) * | 2009-10-27 | 2017-06-14 | スウィフト バイオサイエンシーズ, インコーポレイテッド | ポリヌクレオチドプライマー及びプローブ |
| CN102115782B (zh) * | 2009-12-30 | 2014-06-18 | 北京雅康博生物科技有限公司 | 用于定量检测K-ras突变的试剂盒 |
| JP5842811B2 (ja) * | 2010-03-24 | 2016-01-13 | 凸版印刷株式会社 | 競合プライマーによる標的塩基配列の検出方法 |
| CN103228798B (zh) | 2010-09-24 | 2015-12-09 | 斯坦福大学托管董事会 | 使用固定的引物直接捕获、扩增及测序靶标dna |
| US9169514B2 (en) * | 2010-12-03 | 2015-10-27 | Brandeis University | Detecting nucleic acid variations within populations of genomes |
| GB201100150D0 (en) * | 2011-01-06 | 2011-02-23 | Epistem Ltd | Mutational analysis |
| GB2487632B (en) * | 2011-01-14 | 2014-03-12 | Genefirst Ltd | Methods,compositions,and kits for determining the presence/absence of a variant nucleic acid sequence |
| WO2012097353A1 (en) * | 2011-01-14 | 2012-07-19 | Life Technologies Corporation | Methods, compositions, and kits for detecting rare cells |
| EP3382039B1 (en) | 2011-05-04 | 2023-09-13 | Biocept, Inc. | Methods for detecting nucleic acid sequence variants |
| CN102367478B (zh) * | 2011-10-25 | 2013-07-31 | 浙江大学 | 用于KRAS基因突变分型的ARMS-qPCR检测试剂盒及检测方法 |
| US9738935B2 (en) | 2011-11-10 | 2017-08-22 | Roche Molecular Systems, Inc. | Complex mutations in the epidermal growth factor receptor kinase domain |
| BR112014019168B1 (pt) | 2012-02-03 | 2021-10-05 | California Institute Of Technology | Método capaz de detectar de forma não degenerada presença ou ausência de analitos em um único volume de amostra e método de detecção da presença ou ausência de cada analito dentre uma pluralidade de analitos |
| JP6108407B2 (ja) * | 2012-03-15 | 2017-04-05 | 公益財団法人ヒューマンサイエンス振興財団 | マクロライド系抗生物質耐性変異菌の検出方法及び検出キット |
| KR20150010939A (ko) * | 2012-03-16 | 2015-01-29 | 라이프 테크놀로지스 코포레이션 | 생물학적 샘플을 평가하기 위한 시스템 및 방법 |
| CN102618646B (zh) * | 2012-03-30 | 2014-08-20 | 南方医科大学 | 一种基因拷贝数的定量检测方法 |
| CN104662172B (zh) | 2012-08-03 | 2018-07-06 | 加州理工学院 | Pcr中具有减少的硬件和要求的多重化和定量 |
| EP2749654A1 (en) * | 2012-12-28 | 2014-07-02 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method of analysis of composition of nucleic acid mixtures |
| AU2014200958B2 (en) * | 2013-02-25 | 2016-01-14 | Seegene, Inc. | Detection of nucleotide variation on target nucleic acid sequence |
| CA2917920A1 (en) * | 2013-08-14 | 2015-02-19 | Qiagen Mansfield, Inc. | Compositions and methods for multiplex analysis of nras and braf nucleic acids |
| PL3102704T3 (pl) | 2014-02-07 | 2021-01-11 | University Of Iowa Research Foundation | Sondy oparte na oligonukleotydach i sposoby wykrywania drobnoustrojów |
| CN104232750A (zh) * | 2014-05-30 | 2014-12-24 | 嘉兴雅康博医学检验所有限公司 | Nras基因突变检测试剂盒 |
| CN107849606A (zh) * | 2015-04-20 | 2018-03-27 | 尼欧基因组学实验室股份有限公司 | 提高下一代测序灵敏度的方法 |
| CN104762410A (zh) * | 2015-04-29 | 2015-07-08 | 上海允英医疗科技有限公司 | 用于全ras突变检测的引物、探针及检测试剂盒 |
| CN104862401B (zh) * | 2015-05-29 | 2017-10-31 | 沈阳优吉诺生物科技有限公司 | 检测kras基因热点突变位点的引物、试剂盒及其pcr方法 |
| US9657353B2 (en) | 2015-06-26 | 2017-05-23 | Great Basin Scientific, Inc. | Specific detection of organisms derived from a sample |
| CN106520919A (zh) * | 2016-09-30 | 2017-03-22 | 苏州新海生物科技股份有限公司 | 一种检测目标核酸序列变异体的组合物和方法及试剂盒 |
| CN107022607B (zh) * | 2017-03-16 | 2019-01-22 | 北京博奥晶典生物技术有限公司 | 通过碱基错配解决多重pcr时等位基因扩增不平衡的方法 |
| WO2018212247A1 (ja) * | 2017-05-16 | 2018-11-22 | 公立大学法人和歌山県立医科大学 | Egfr変異非小細胞肺がんにおけるegfrチロシンキナーゼ阻害剤の治療奏功性の予測方法 |
| CN107577921A (zh) * | 2017-08-25 | 2018-01-12 | 云壹生物技术(大连)有限公司 | 一种肿瘤靶向基因测序数据解析方法 |
| US12378591B2 (en) | 2017-09-29 | 2025-08-05 | University Of Iowa Research Foundation | Digital nuclease detection compositions and methods |
| CN112424377A (zh) | 2018-04-17 | 2021-02-26 | 克罗玛科德公司 | 用于多重分析的方法和系统 |
| CN110438223B (zh) * | 2018-05-03 | 2023-03-14 | 同济大学苏州研究院 | 检测Kras基因点突变的引物、探针及其试剂盒与检测方法 |
| US12203129B2 (en) | 2018-07-03 | 2025-01-21 | ChromaCode, Inc. | Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays |
| US20210189473A1 (en) * | 2018-09-06 | 2021-06-24 | ChromaCode,Inc. | Universal tail primers with multiple binding motifs for multiplexed detection of single nucleotide polymorphisms |
| CN117025765B (zh) * | 2023-02-01 | 2024-11-29 | 珠海圣美生物诊断技术有限公司 | 多重数字pcr检测试剂盒及其检测方法 |
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| JP5805064B2 (ja) | 2009-03-27 | 2015-11-04 | ライフ テクノロジーズ コーポレーション | 対立遺伝子変種を検出するための方法、組成物、およびキット |
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| DK2576832T3 (en) | 2010-05-25 | 2016-06-20 | Univ Johns Hopkins | CONFIGURATIONS AND METHODS FOR DETECTION OF neoplasia |
| EP2400035A1 (en) | 2010-06-28 | 2011-12-28 | Technische Universität München | Methods and compositions for diagnosing gastrointestinal stromal tumors |
| WO2012097353A1 (en) | 2011-01-14 | 2012-07-19 | Life Technologies Corporation | Methods, compositions, and kits for detecting rare cells |
| EP3382039B1 (en) | 2011-05-04 | 2023-09-13 | Biocept, Inc. | Methods for detecting nucleic acid sequence variants |
| WO2014004726A1 (en) | 2012-06-26 | 2014-01-03 | Caifu Chen | Methods, compositions and kits for the diagnosis, prognosis and monitoring of cancer |
-
2009
- 2009-12-17 CN CN2009801557753A patent/CN102301005A/zh active Pending
- 2009-12-17 JP JP2011542142A patent/JP2012511927A/ja active Pending
- 2009-12-17 CA CA2747026A patent/CA2747026A1/en not_active Withdrawn
- 2009-12-17 WO PCT/US2009/006652 patent/WO2010077324A2/en not_active Ceased
- 2009-12-17 US US12/641,321 patent/US9534255B2/en active Active
- 2009-12-17 EP EP09836510.9A patent/EP2376659B1/en not_active Not-in-force
- 2009-12-18 WO PCT/US2009/068610 patent/WO2010080559A2/en not_active Ceased
-
2015
- 2015-10-09 US US14/879,156 patent/US20160040256A1/en not_active Abandoned
-
2018
- 2018-03-16 US US15/923,954 patent/US10570459B2/en active Active
-
2020
- 2020-01-16 US US16/745,296 patent/US11530450B2/en active Active
-
2022
- 2022-12-06 US US18/075,729 patent/US20230323472A1/en active Pending
- 2022-12-22 US US18/087,259 patent/US20240132946A1/en not_active Abandoned
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