JP2018512880A5 - - Google Patents

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Publication number
JP2018512880A5
JP2018512880A5 JP2017555324A JP2017555324A JP2018512880A5 JP 2018512880 A5 JP2018512880 A5 JP 2018512880A5 JP 2017555324 A JP2017555324 A JP 2017555324A JP 2017555324 A JP2017555324 A JP 2017555324A JP 2018512880 A5 JP2018512880 A5 JP 2018512880A5
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JP
Japan
Prior art keywords
nucleic acid
acid species
minor
specific
chain termination
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2017555324A
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English (en)
Japanese (ja)
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JP2018512880A (ja
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Priority claimed from PCT/US2016/028971 external-priority patent/WO2016172571A1/en
Publication of JP2018512880A publication Critical patent/JP2018512880A/ja
Publication of JP2018512880A5 publication Critical patent/JP2018512880A5/ja
Priority to JP2021047479A priority Critical patent/JP2021097719A/ja
Priority to JP2021047478A priority patent/JP7325467B2/ja
Priority to JP2023189367A priority patent/JP2024012522A/ja
Withdrawn legal-status Critical Current

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JP2017555324A 2015-04-24 2016-04-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 Withdrawn JP2018512880A (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021047479A JP2021097719A (ja) 2015-04-24 2021-03-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2021047478A JP7325467B2 (ja) 2015-04-24 2021-03-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2023189367A JP2024012522A (ja) 2015-04-24 2023-11-06 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562152697P 2015-04-24 2015-04-24
US62/152,697 2015-04-24
US201662280951P 2016-01-20 2016-01-20
US62/280,951 2016-01-20
PCT/US2016/028971 WO2016172571A1 (en) 2015-04-24 2016-04-22 Multiplexed method for the identification and quantitation of minor alleles and polymorphisms

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP2019036000A Division JP2019083820A (ja) 2015-04-24 2019-02-28 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2021047479A Division JP2021097719A (ja) 2015-04-24 2021-03-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2021047478A Division JP7325467B2 (ja) 2015-04-24 2021-03-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法

Publications (2)

Publication Number Publication Date
JP2018512880A JP2018512880A (ja) 2018-05-24
JP2018512880A5 true JP2018512880A5 (enExample) 2019-04-11

Family

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Family Applications (5)

Application Number Title Priority Date Filing Date
JP2017555324A Withdrawn JP2018512880A (ja) 2015-04-24 2016-04-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2019036000A Pending JP2019083820A (ja) 2015-04-24 2019-02-28 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2021047479A Withdrawn JP2021097719A (ja) 2015-04-24 2021-03-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2021047478A Active JP7325467B2 (ja) 2015-04-24 2021-03-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2023189367A Pending JP2024012522A (ja) 2015-04-24 2023-11-06 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2019036000A Pending JP2019083820A (ja) 2015-04-24 2019-02-28 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2021047479A Withdrawn JP2021097719A (ja) 2015-04-24 2021-03-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2021047478A Active JP7325467B2 (ja) 2015-04-24 2021-03-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2023189367A Pending JP2024012522A (ja) 2015-04-24 2023-11-06 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法

Country Status (8)

Country Link
US (5) US10233489B2 (enExample)
EP (2) EP4001430A1 (enExample)
JP (5) JP2018512880A (enExample)
CN (2) CN114540470B (enExample)
AU (1) AU2016250841A1 (enExample)
CA (1) CA2983224A1 (enExample)
HK (1) HK1250747A1 (enExample)
WO (1) WO2016172571A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110564819A (zh) 2011-05-19 2019-12-13 基纳生物技术有限公司 用于多重核酸鉴定的产品和方法
JP2018512880A (ja) 2015-04-24 2018-05-24 アジーナ バイオサイエンス, インコーポレイテッド 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
CN107787371B (zh) 2015-04-24 2022-02-01 基纳生物技术有限公司 检测和定量次要变体的并行式方法
EP3802867A1 (en) 2018-06-01 2021-04-14 Agena Bioscience, Inc. Products and processes for nucleic acid detection and quantification
CN113466320B (zh) * 2021-08-06 2022-10-14 河北省食品检验研究院 一种针对乳粉中牛源性成分maldi-tof检测方法
KR102857507B1 (ko) * 2022-11-14 2025-09-10 명지대학교 산학협력단 무의 근피 색상 판별용 snp 마커 및 이의 용도
US12518859B2 (en) * 2023-07-26 2026-01-06 Helix, Inc. Systems and methods for providing test results of gene sequencing data on a recurring basis

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
DE3301833A1 (de) 1983-01-20 1984-07-26 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Verfahren zur simultanen synthese mehrerer oligonocleotide an fester phase
US5059654A (en) 1983-02-14 1991-10-22 Cuno Inc. Affinity matrices of modified polysaccharide supports
US4515781A (en) 1983-02-23 1985-05-07 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services 2',5'-Riboadenylate-morpholinoadenylate nucleotides
US4582789A (en) 1984-03-21 1986-04-15 Cetus Corporation Process for labeling nucleic acids using psoralen derivatives
US4957858A (en) 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
US5118605A (en) 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
JPH0779717B2 (ja) 1984-10-29 1995-08-30 マイクロジエニツクス コ−ポレ−シヨン タンパク質結合酵素相補性検定に関する方法
US5064754A (en) 1984-12-14 1991-11-12 Mills Randell L Genomic sequencing method
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DE3788914T2 (de) 1986-09-08 1994-08-25 Ajinomoto Kk Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere.
EP0269520A3 (fr) 1986-11-21 1988-08-24 Institut Pasteur Rétrovirus du type HIV-2 susceptible de provoquer le sida, et ses constituants antigéniques et nucléiques
US5037882A (en) 1987-03-11 1991-08-06 Steel Samuel L Synthesis of oligonucleotide analogs
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
DE68929467T3 (de) 1988-06-14 2016-12-22 Qiagen Gmbh HIV-2 Varianten
US5003059A (en) 1988-06-20 1991-03-26 Genomyx, Inc. Determining DNA sequences by mass spectrometry
US5512439A (en) 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
US5489507A (en) 1988-11-30 1996-02-06 Perkin-Elmer Corporation DNA detection by color complementation
US5237016A (en) 1989-01-05 1993-08-17 Siska Diagnostics, Inc. End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
US5242974A (en) 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5480784A (en) 1989-07-11 1996-01-02 Gen-Probe Incorporated Nucleic acid sequence amplification methods
WO1991011533A1 (en) 1990-01-26 1991-08-08 E.I. Du Pont De Nemours And Company Method for isolating primer extension products from template-directed dna polymerase reactions
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
WO1992011390A1 (en) 1990-12-17 1992-07-09 Idexx Laboratories, Inc. Nucleic acid sequence detection by triple helix formation
US5364759B2 (en) 1991-01-31 1999-07-20 Baylor College Medicine Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats
US5888819A (en) 1991-03-05 1999-03-30 Molecular Tool, Inc. Method for determining nucleotide identity through primer extension
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
DE69322266T2 (de) 1992-04-03 1999-06-02 Perkin-Elmer Corp., Foster City, Calif. Proben zusammensetzung und verfahren
US5412083A (en) 1992-04-16 1995-05-02 Northeastern University Carbohydrate heterobifunctional cross-linking reagent
WO1994000562A1 (en) 1992-06-24 1994-01-06 The Mt. Sinai School Of Medicine Of The City University Of New York A novel human immunodeficiency virus
US5710028A (en) 1992-07-02 1998-01-20 Eyal; Nurit Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor
US6194144B1 (en) 1993-01-07 2001-02-27 Sequenom, Inc. DNA sequencing by mass spectrometry
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
CA2153387A1 (en) 1993-01-07 1994-07-21 Hubert Koester Dna sequencing by mass spectrometry
CA2158642A1 (en) 1993-03-19 1994-09-29 Hubert Koster Dna sequencing by mass spectrometry via exonuclease degradation
US6074823A (en) 1993-03-19 2000-06-13 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
US5399857A (en) 1993-05-28 1995-03-21 The Johns Hopkins University Method and apparatus for trapping ions by increasing trapping voltage during ion introduction
JPH07159404A (ja) 1993-12-06 1995-06-23 Doujin Kagaku Kenkyusho:Kk スピンラベルしたビオチンを用いた物質の測定方法
US5976798A (en) 1994-03-30 1999-11-02 Mitokor Methods for detecting mitochondrial mutations diagnostic for Alzheimer's disease and methods for determining heteroplasmy of mitochondrial nucleic acid
GB9417211D0 (en) 1994-08-25 1994-10-12 Solicitor For The Affairs Of H Nucleotide sequencing method
WO1996024606A1 (en) 1995-02-09 1996-08-15 University Of Washington Modified-affinity streptavidin
US6428955B1 (en) 1995-03-17 2002-08-06 Sequenom, Inc. DNA diagnostics based on mass spectrometry
WO1996030545A1 (en) 1995-03-24 1996-10-03 Mitokor Mutation detection by differential primer extension of mutant and wildtype target sequences
JPH11503611A (ja) 1995-04-11 1999-03-30 トラスティーズ・オブ・ボストン・ユニバーシティ 生体高分子の固相配列決定法
US5770272A (en) 1995-04-28 1998-06-23 Massachusetts Institute Of Technology Matrix-bearing targets for maldi mass spectrometry and methods of production thereof
US5700642A (en) 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers
US5869242A (en) 1995-09-18 1999-02-09 Myriad Genetics, Inc. Mass spectrometry to assess DNA sequence polymorphisms
WO1997037041A2 (en) 1996-03-18 1997-10-09 Sequenom, Inc. Dna sequencing by mass spectrometry
US5965363A (en) 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
US5885775A (en) 1996-10-04 1999-03-23 Perseptive Biosystems, Inc. Methods for determining sequences information in polynucleotides using mass spectrometry
EP0954612A2 (en) 1996-11-06 1999-11-10 Sequenom, Inc. Dna diagnostics based on mass spectrometry
CA2274587A1 (en) 1996-12-10 1998-06-18 Genetrace Systems Inc. Releasable nonvolatile mass-label molecules
US6613509B1 (en) 1999-03-22 2003-09-02 Regents Of The University Of California Determination of base (nucleotide) composition in DNA oligomers by mass spectrometry
US20050287592A1 (en) 2000-08-29 2005-12-29 Yeda Research And Development Co. Ltd. Template-dependent nucleic acid polymerization using oligonucleotide triphosphates building blocks
GB0006141D0 (en) 2000-03-14 2000-05-03 Brax Group Ltd Mass labels
EP1176212A1 (en) 2000-07-24 2002-01-30 Centre National de Genotype Method for haplotyping by mass spectrometry
US20030027169A1 (en) * 2000-10-27 2003-02-06 Sheng Zhang One-well assay for high throughput detection of single nucleotide polymorphisms
GB0102568D0 (en) 2001-02-01 2001-03-21 Magnetic Biosolutions Sweden A Method
US20040121314A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in containers
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US7070928B2 (en) 2001-03-19 2006-07-04 President And Fellows Of Harvard College Evolving new molecular function
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US20030119004A1 (en) 2001-12-05 2003-06-26 Wenz H. Michael Methods for quantitating nucleic acids using coupled ligation and amplification
JP3752466B2 (ja) 2002-04-24 2006-03-08 株式会社日立製作所 遺伝子検査方法
AU2003251424A1 (en) 2002-06-07 2003-12-22 The Regents Of The University Of California Electrochemical detection of single nucleotide polymorphisms (snps)
US7074597B2 (en) 2002-07-12 2006-07-11 The Trustees Of Columbia University In The City Of New York Multiplex genotyping using solid phase capturable dideoxynucleotides and mass spectrometry
DE10240746A1 (de) 2002-09-01 2004-03-18 Epigenomics Ag Verfahren zum Nachweis von Nukleinsäuresequenzen mittels spaltbarer Sondenmoleküle
US20040259105A1 (en) * 2002-10-03 2004-12-23 Jian-Bing Fan Multiplex nucleic acid analysis using archived or fixed samples
EP2107129B1 (en) 2003-07-31 2012-08-22 Sequenom, Inc. Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions for genotyping of polymorhisms
WO2006019407A2 (en) 2004-02-18 2006-02-23 The Trustees Of Boston University Method for detecting and quantifying rare mutations/polymorphisms
CN100400673C (zh) * 2004-03-18 2008-07-09 华晶基因技术有限公司 单核苷酸多态性(SNPs)及点突变的检测方法
WO2006073436A2 (en) 2004-04-29 2006-07-13 The Trustees Of Columbia University In The City Of New York Mass tag pcr for multiplex diagnostics
US7618780B2 (en) 2004-05-20 2009-11-17 Trillion Genomics Limited Use of mass labelled probes to detect target nucleic acids using mass spectrometry
JP4735926B2 (ja) 2004-05-27 2011-07-27 アイシン精機株式会社 核酸の高効率回収方法
US7785843B2 (en) 2004-06-23 2010-08-31 Sequenom, Inc. Target-specific compomers and methods of use
CA2599013A1 (en) 2005-02-28 2006-09-08 Gen-Probe Incorporated Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe
JP2006320271A (ja) 2005-05-20 2006-11-30 Tokyo Institute Of Technology 低分子化合物とタンパク質の結合評価方法
CN101194023A (zh) * 2005-06-13 2008-06-04 弗·哈夫曼-拉罗切有限公司 与急性排斥有关的il 10 snp
US8586708B2 (en) 2005-10-28 2013-11-19 Massachusetts Institute Of Technology Monovalent streptavidin compositions
US8133701B2 (en) 2006-12-05 2012-03-13 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US9249423B2 (en) 2007-02-02 2016-02-02 Yale University Method of de-differentiating and re-differentiating somatic cells using RNA
WO2009046507A1 (en) 2007-10-10 2009-04-16 Atanas Atanasov Wave power station
EP2356259A4 (en) 2008-10-30 2012-11-14 Sequenom Inc PRODUCTS AND METHOD FOR MULTIPLEX IDENTIFICATION OF NUCLEIC ACIDS
CA2740242A1 (en) * 2008-11-05 2010-05-14 Genentech, Inc. Genetic polymorphisms in age-related macular degeneration
EP2479268B1 (en) 2009-09-17 2020-11-04 JSR Corporation Dissociation method and dissociation agent for avidin and biotinderivatives
CN110564819A (zh) 2011-05-19 2019-12-13 基纳生物技术有限公司 用于多重核酸鉴定的产品和方法
AU2012385961B9 (en) * 2012-07-24 2017-05-18 Natera, Inc. Highly multiplex PCR methods and compositions
CN103131787B (zh) * 2013-03-11 2014-05-21 四川大学 基于y染色体snp遗传标记的法医学复合检测试剂盒
CN103602740A (zh) * 2013-11-06 2014-02-26 毅新兴业(北京)科技有限公司 质谱仪鉴定血清中游离dna的方法、试剂盒及其应用
CN107787371B (zh) 2015-04-24 2022-02-01 基纳生物技术有限公司 检测和定量次要变体的并行式方法
JP2018512880A (ja) 2015-04-24 2018-05-24 アジーナ バイオサイエンス, インコーポレイテッド 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法

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