JP2018512880A - 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 - Google Patents
少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 Download PDFInfo
- Publication number
- JP2018512880A JP2018512880A JP2017555324A JP2017555324A JP2018512880A JP 2018512880 A JP2018512880 A JP 2018512880A JP 2017555324 A JP2017555324 A JP 2017555324A JP 2017555324 A JP2017555324 A JP 2017555324A JP 2018512880 A JP2018512880 A JP 2018512880A
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid species
- minor
- species
- specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021047478A JP7325467B2 (ja) | 2015-04-24 | 2021-03-22 | 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 |
| JP2021047479A JP2021097719A (ja) | 2015-04-24 | 2021-03-22 | 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 |
| JP2023189367A JP2024012522A (ja) | 2015-04-24 | 2023-11-06 | 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562152697P | 2015-04-24 | 2015-04-24 | |
| US62/152,697 | 2015-04-24 | ||
| US201662280951P | 2016-01-20 | 2016-01-20 | |
| US62/280,951 | 2016-01-20 | ||
| PCT/US2016/028971 WO2016172571A1 (en) | 2015-04-24 | 2016-04-22 | Multiplexed method for the identification and quantitation of minor alleles and polymorphisms |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019036000A Division JP2019083820A (ja) | 2015-04-24 | 2019-02-28 | 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 |
| JP2021047478A Division JP7325467B2 (ja) | 2015-04-24 | 2021-03-22 | 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 |
| JP2021047479A Division JP2021097719A (ja) | 2015-04-24 | 2021-03-22 | 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018512880A true JP2018512880A (ja) | 2018-05-24 |
| JP2018512880A5 JP2018512880A5 (enExample) | 2019-04-11 |
Family
ID=55911096
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555324A Withdrawn JP2018512880A (ja) | 2015-04-24 | 2016-04-22 | 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 |
| JP2019036000A Pending JP2019083820A (ja) | 2015-04-24 | 2019-02-28 | 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 |
| JP2021047479A Withdrawn JP2021097719A (ja) | 2015-04-24 | 2021-03-22 | 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 |
| JP2021047478A Active JP7325467B2 (ja) | 2015-04-24 | 2021-03-22 | 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 |
| JP2023189367A Pending JP2024012522A (ja) | 2015-04-24 | 2023-11-06 | 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019036000A Pending JP2019083820A (ja) | 2015-04-24 | 2019-02-28 | 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 |
| JP2021047479A Withdrawn JP2021097719A (ja) | 2015-04-24 | 2021-03-22 | 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 |
| JP2021047478A Active JP7325467B2 (ja) | 2015-04-24 | 2021-03-22 | 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 |
| JP2023189367A Pending JP2024012522A (ja) | 2015-04-24 | 2023-11-06 | 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US10233489B2 (enExample) |
| EP (2) | EP3286327B1 (enExample) |
| JP (5) | JP2018512880A (enExample) |
| CN (2) | CN107406882B (enExample) |
| AU (1) | AU2016250841A1 (enExample) |
| CA (1) | CA2983224A1 (enExample) |
| HK (1) | HK1250747A1 (enExample) |
| WO (1) | WO2016172571A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102857507B1 (ko) | 2022-11-14 | 2025-09-10 | 명지대학교 산학협력단 | 무의 근피 색상 판별용 snp 마커 및 이의 용도 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103717751A (zh) | 2011-05-19 | 2014-04-09 | 塞昆纳姆股份有限公司 | 用于多重核酸鉴定的产品和方法 |
| EP3286327B1 (en) | 2015-04-24 | 2021-11-10 | Agena Bioscience, Inc. | Multiplexed method for the identification and quantitation of minor alleles and polymorphisms |
| CN114350766A (zh) | 2015-04-24 | 2022-04-15 | 基纳生物技术有限公司 | 检测和定量次要变体的并行式方法 |
| US12188083B2 (en) | 2018-06-01 | 2025-01-07 | Agena Bioscience, Inc. | Products and processes for nucleic acid detection and quantification |
| CN113466320B (zh) * | 2021-08-06 | 2022-10-14 | 河北省食品检验研究院 | 一种针对乳粉中牛源性成分maldi-tof检测方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030027169A1 (en) * | 2000-10-27 | 2003-02-06 | Sheng Zhang | One-well assay for high throughput detection of single nucleotide polymorphisms |
| CN103602740A (zh) * | 2013-11-06 | 2014-02-26 | 毅新兴业(北京)科技有限公司 | 质谱仪鉴定血清中游离dna的方法、试剂盒及其应用 |
| JP2014515264A (ja) * | 2011-05-19 | 2014-06-30 | セクエノム, インコーポレイテッド | マルチプレックス核酸同定のための製品およびプロセス |
Family Cites Families (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| DE3301833A1 (de) | 1983-01-20 | 1984-07-26 | Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig | Verfahren zur simultanen synthese mehrerer oligonocleotide an fester phase |
| US5059654A (en) | 1983-02-14 | 1991-10-22 | Cuno Inc. | Affinity matrices of modified polysaccharide supports |
| US4515781A (en) | 1983-02-23 | 1985-05-07 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | 2',5'-Riboadenylate-morpholinoadenylate nucleotides |
| US4582789A (en) | 1984-03-21 | 1986-04-15 | Cetus Corporation | Process for labeling nucleic acids using psoralen derivatives |
| US4957858A (en) | 1986-04-16 | 1990-09-18 | The Salk Instute For Biological Studies | Replicative RNA reporter systems |
| US5118605A (en) | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
| CA1340328C (en) | 1984-10-29 | 1999-01-26 | Boehringer Mannheim Corporation | Method for protein binding enzyme complementation assays |
| US5064754A (en) | 1984-12-14 | 1991-11-12 | Mills Randell L | Genomic sequencing method |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| EP0260032B1 (en) | 1986-09-08 | 1994-01-26 | Ajinomoto Co., Inc. | Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers |
| EP0269520A3 (fr) | 1986-11-21 | 1988-08-24 | Institut Pasteur | Rétrovirus du type HIV-2 susceptible de provoquer le sida, et ses constituants antigéniques et nucléiques |
| US5037882A (en) | 1987-03-11 | 1991-08-06 | Steel Samuel L | Synthesis of oligonucleotide analogs |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| DE68927025T2 (de) | 1988-06-14 | 1997-03-27 | Chemotherapeutisches Forschung | HIV-2-Virusvarianten |
| US5003059A (en) | 1988-06-20 | 1991-03-26 | Genomyx, Inc. | Determining DNA sequences by mass spectrometry |
| US5512439A (en) | 1988-11-21 | 1996-04-30 | Dynal As | Oligonucleotide-linked magnetic particles and uses thereof |
| US5489507A (en) | 1988-11-30 | 1996-02-06 | Perkin-Elmer Corporation | DNA detection by color complementation |
| US5237016A (en) | 1989-01-05 | 1993-08-17 | Siska Diagnostics, Inc. | End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5242974A (en) | 1991-11-22 | 1993-09-07 | Affymax Technologies N.V. | Polymer reversal on solid surfaces |
| ATE282716T1 (de) | 1989-07-11 | 2004-12-15 | Gen Probe Inc | Verfahren zur amplifikation von nukleinsäuresequenzen |
| WO1991011533A1 (en) | 1990-01-26 | 1991-08-08 | E.I. Du Pont De Nemours And Company | Method for isolating primer extension products from template-directed dna polymerase reactions |
| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| WO1992011390A1 (en) | 1990-12-17 | 1992-07-09 | Idexx Laboratories, Inc. | Nucleic acid sequence detection by triple helix formation |
| US5364759B2 (en) | 1991-01-31 | 1999-07-20 | Baylor College Medicine | Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats |
| US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
| US5888819A (en) | 1991-03-05 | 1999-03-30 | Molecular Tool, Inc. | Method for determining nucleotide identity through primer extension |
| DE69322266T2 (de) | 1992-04-03 | 1999-06-02 | Perkin-Elmer Corp., Foster City, Calif. | Proben zusammensetzung und verfahren |
| US5412083A (en) | 1992-04-16 | 1995-05-02 | Northeastern University | Carbohydrate heterobifunctional cross-linking reagent |
| WO1994000562A1 (en) | 1992-06-24 | 1994-01-06 | The Mt. Sinai School Of Medicine Of The City University Of New York | A novel human immunodeficiency virus |
| US5710028A (en) | 1992-07-02 | 1998-01-20 | Eyal; Nurit | Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor |
| US6194144B1 (en) | 1993-01-07 | 2001-02-27 | Sequenom, Inc. | DNA sequencing by mass spectrometry |
| DE69433811T2 (de) | 1993-01-07 | 2005-06-23 | Sequenom, Inc., San Diego | Dns - sequenzierung durch massenspektronomie |
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| US6074823A (en) | 1993-03-19 | 2000-06-13 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
| DE69430909T2 (de) | 1993-03-19 | 2003-02-27 | Sequenom, Inc. | Dns-sequenzbestimmung durch massenspektrometrie auf dem weg des abbaus mit exonuklease |
| US5399857A (en) | 1993-05-28 | 1995-03-21 | The Johns Hopkins University | Method and apparatus for trapping ions by increasing trapping voltage during ion introduction |
| JPH07159404A (ja) | 1993-12-06 | 1995-06-23 | Doujin Kagaku Kenkyusho:Kk | スピンラベルしたビオチンを用いた物質の測定方法 |
| US5976798A (en) | 1994-03-30 | 1999-11-02 | Mitokor | Methods for detecting mitochondrial mutations diagnostic for Alzheimer's disease and methods for determining heteroplasmy of mitochondrial nucleic acid |
| GB9417211D0 (en) | 1994-08-25 | 1994-10-12 | Solicitor For The Affairs Of H | Nucleotide sequencing method |
| CA2211951A1 (en) | 1995-02-09 | 1996-08-15 | University Of Washington | Modified-affinity streptavidin |
| US6428955B1 (en) | 1995-03-17 | 2002-08-06 | Sequenom, Inc. | DNA diagnostics based on mass spectrometry |
| WO1996030545A1 (en) | 1995-03-24 | 1996-10-03 | Mitokor | Mutation detection by differential primer extension of mutant and wildtype target sequences |
| EP0830460A1 (en) | 1995-04-11 | 1998-03-25 | Trustees Of Boston University | Solid phase sequencing of biopolymers |
| US5770272A (en) | 1995-04-28 | 1998-06-23 | Massachusetts Institute Of Technology | Matrix-bearing targets for maldi mass spectrometry and methods of production thereof |
| US5700642A (en) | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
| US5869242A (en) | 1995-09-18 | 1999-02-09 | Myriad Genetics, Inc. | Mass spectrometry to assess DNA sequence polymorphisms |
| AU2217597A (en) | 1996-03-18 | 1997-10-22 | Sequenom, Inc. | Dna sequencing by mass spectrometry |
| US5965363A (en) | 1996-09-19 | 1999-10-12 | Genetrace Systems Inc. | Methods of preparing nucleic acids for mass spectrometric analysis |
| US5885775A (en) | 1996-10-04 | 1999-03-23 | Perseptive Biosystems, Inc. | Methods for determining sequences information in polynucleotides using mass spectrometry |
| CA2270132A1 (en) | 1996-11-06 | 1998-05-14 | Sequenom, Inc. | Dna diagnostics based on mass spectrometry |
| US6635452B1 (en) | 1996-12-10 | 2003-10-21 | Sequenom Inc. | Releasable nonvolatile mass label molecules |
| US6613509B1 (en) | 1999-03-22 | 2003-09-02 | Regents Of The University Of California | Determination of base (nucleotide) composition in DNA oligomers by mass spectrometry |
| US20050287592A1 (en) | 2000-08-29 | 2005-12-29 | Yeda Research And Development Co. Ltd. | Template-dependent nucleic acid polymerization using oligonucleotide triphosphates building blocks |
| GB0006141D0 (en) | 2000-03-14 | 2000-05-03 | Brax Group Ltd | Mass labels |
| EP1176212A1 (en) | 2000-07-24 | 2002-01-30 | Centre National de Genotype | Method for haplotyping by mass spectrometry |
| GB0102568D0 (en) | 2001-02-01 | 2001-03-21 | Magnetic Biosolutions Sweden A | Method |
| US7226739B2 (en) | 2001-03-02 | 2007-06-05 | Isis Pharmaceuticals, Inc | Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations |
| US20030027135A1 (en) | 2001-03-02 | 2003-02-06 | Ecker David J. | Method for rapid detection and identification of bioagents |
| US20040121314A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in containers |
| JP4128453B2 (ja) | 2001-03-19 | 2008-07-30 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 新規分子機能の進化 |
| US7217510B2 (en) | 2001-06-26 | 2007-05-15 | Isis Pharmaceuticals, Inc. | Methods for providing bacterial bioagent characterizing information |
| US20030119004A1 (en) | 2001-12-05 | 2003-06-26 | Wenz H. Michael | Methods for quantitating nucleic acids using coupled ligation and amplification |
| JP3752466B2 (ja) | 2002-04-24 | 2006-03-08 | 株式会社日立製作所 | 遺伝子検査方法 |
| AU2003251424A1 (en) | 2002-06-07 | 2003-12-22 | The Regents Of The University Of California | Electrochemical detection of single nucleotide polymorphisms (snps) |
| US7074597B2 (en) | 2002-07-12 | 2006-07-11 | The Trustees Of Columbia University In The City Of New York | Multiplex genotyping using solid phase capturable dideoxynucleotides and mass spectrometry |
| DE10240746A1 (de) | 2002-09-01 | 2004-03-18 | Epigenomics Ag | Verfahren zum Nachweis von Nukleinsäuresequenzen mittels spaltbarer Sondenmoleküle |
| US20040259105A1 (en) * | 2002-10-03 | 2004-12-23 | Jian-Bing Fan | Multiplex nucleic acid analysis using archived or fixed samples |
| WO2005012578A1 (en) | 2003-07-31 | 2005-02-10 | Sequenom, Inc. | Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions for genotyping of polymorphisms |
| EP1721014B1 (en) | 2004-02-18 | 2013-07-17 | Trustees Of Boston University | Method for detecting and quantifying rare mutations/polymorphisms |
| CN100400673C (zh) * | 2004-03-18 | 2008-07-09 | 华晶基因技术有限公司 | 单核苷酸多态性(SNPs)及点突变的检测方法 |
| WO2006073436A2 (en) | 2004-04-29 | 2006-07-13 | The Trustees Of Columbia University In The City Of New York | Mass tag pcr for multiplex diagnostics |
| WO2005113804A1 (en) | 2004-05-20 | 2005-12-01 | Trillion Genomics Limited | Use of mass labelled probes to detect target nucleic acids using mass spectrometry |
| JP4735926B2 (ja) | 2004-05-27 | 2011-07-27 | アイシン精機株式会社 | 核酸の高効率回収方法 |
| US7785843B2 (en) | 2004-06-23 | 2010-08-31 | Sequenom, Inc. | Target-specific compomers and methods of use |
| EP1853732A2 (en) | 2005-02-28 | 2007-11-14 | Gen-Probe Incorporated | Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe |
| JP2006320271A (ja) | 2005-05-20 | 2006-11-30 | Tokyo Institute Of Technology | 低分子化合物とタンパク質の結合評価方法 |
| JP2008545444A (ja) * | 2005-06-13 | 2008-12-18 | エフ.ホフマン−ラ ロシュ アーゲー | 急性拒絶反応に関連するil10snp |
| US8586708B2 (en) | 2005-10-28 | 2013-11-19 | Massachusetts Institute Of Technology | Monovalent streptavidin compositions |
| US8133701B2 (en) | 2006-12-05 | 2012-03-13 | Sequenom, Inc. | Detection and quantification of biomolecules using mass spectrometry |
| US9249423B2 (en) | 2007-02-02 | 2016-02-02 | Yale University | Method of de-differentiating and re-differentiating somatic cells using RNA |
| GB2468979A (en) | 2007-10-10 | 2010-09-29 | Atanas Atanasov | Wave power station |
| WO2010056513A2 (en) | 2008-10-30 | 2010-05-20 | Sequenom, Inc. | Products and processes for multiplex nucleic acid identification |
| CN103333952B (zh) * | 2008-11-05 | 2015-07-29 | 健泰科生物技术公司 | 年龄相关的黄斑变性中的遗传多态性 |
| EP2479268B1 (en) | 2009-09-17 | 2020-11-04 | JSR Corporation | Dissociation method and dissociation agent for avidin and biotinderivatives |
| KR101890466B1 (ko) * | 2012-07-24 | 2018-08-21 | 내테라, 인코포레이티드 | 고도의 다중 pcr 방법 및 조성물 |
| CN103131787B (zh) * | 2013-03-11 | 2014-05-21 | 四川大学 | 基于y染色体snp遗传标记的法医学复合检测试剂盒 |
| CN114350766A (zh) | 2015-04-24 | 2022-04-15 | 基纳生物技术有限公司 | 检测和定量次要变体的并行式方法 |
| EP3286327B1 (en) | 2015-04-24 | 2021-11-10 | Agena Bioscience, Inc. | Multiplexed method for the identification and quantitation of minor alleles and polymorphisms |
-
2016
- 2016-04-22 EP EP16720649.9A patent/EP3286327B1/en active Active
- 2016-04-22 AU AU2016250841A patent/AU2016250841A1/en not_active Abandoned
- 2016-04-22 EP EP21196916.7A patent/EP4001430A1/en active Pending
- 2016-04-22 JP JP2017555324A patent/JP2018512880A/ja not_active Withdrawn
- 2016-04-22 CA CA2983224A patent/CA2983224A1/en not_active Abandoned
- 2016-04-22 WO PCT/US2016/028971 patent/WO2016172571A1/en not_active Ceased
- 2016-04-22 US US15/136,024 patent/US10233489B2/en active Active
- 2016-04-22 HK HK18110098.0A patent/HK1250747A1/zh unknown
- 2016-04-22 CN CN201680013462.4A patent/CN107406882B/zh active Active
- 2016-04-22 CN CN202210143725.0A patent/CN114540470A/zh active Pending
-
2019
- 2019-01-23 US US16/255,718 patent/US10513728B2/en active Active
- 2019-02-28 JP JP2019036000A patent/JP2019083820A/ja active Pending
- 2019-10-30 US US16/669,311 patent/US10865439B2/en active Active
-
2020
- 2020-11-16 US US17/098,993 patent/US11680289B2/en active Active
-
2021
- 2021-03-22 JP JP2021047479A patent/JP2021097719A/ja not_active Withdrawn
- 2021-03-22 JP JP2021047478A patent/JP7325467B2/ja active Active
-
2023
- 2023-05-02 US US18/142,512 patent/US12454722B2/en active Active
- 2023-11-06 JP JP2023189367A patent/JP2024012522A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030027169A1 (en) * | 2000-10-27 | 2003-02-06 | Sheng Zhang | One-well assay for high throughput detection of single nucleotide polymorphisms |
| JP2014515264A (ja) * | 2011-05-19 | 2014-06-30 | セクエノム, インコーポレイテッド | マルチプレックス核酸同定のための製品およびプロセス |
| CN103602740A (zh) * | 2013-11-06 | 2014-02-26 | 毅新兴业(北京)科技有限公司 | 质谱仪鉴定血清中游离dna的方法、试剂盒及其应用 |
Non-Patent Citations (2)
| Title |
|---|
| NUCLEIC ACIDS RESEARCH, vol. Vol.37, No.2, e13, JPN6019047397, 2009, pages 1 - 6, ISSN: 0004350261 * |
| SEQUENOM APPLICATION NOTE, vol. Doc. No. 8876-006, R04, JPN6019047398, 2006, pages 1 - 12, ISSN: 0004350262 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102857507B1 (ko) | 2022-11-14 | 2025-09-10 | 명지대학교 산학협력단 | 무의 근피 색상 판별용 snp 마커 및 이의 용도 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2983224A1 (en) | 2016-10-27 |
| WO2016172571A1 (en) | 2016-10-27 |
| JP2021097718A (ja) | 2021-07-01 |
| US20230383340A1 (en) | 2023-11-30 |
| US10233489B2 (en) | 2019-03-19 |
| US20190153526A1 (en) | 2019-05-23 |
| US20200123601A1 (en) | 2020-04-23 |
| AU2016250841A1 (en) | 2017-11-02 |
| US20210062254A1 (en) | 2021-03-04 |
| JP2019083820A (ja) | 2019-06-06 |
| HK1250747A1 (zh) | 2019-01-11 |
| US20160312278A1 (en) | 2016-10-27 |
| EP3286327B1 (en) | 2021-11-10 |
| CN114540470A (zh) | 2022-05-27 |
| JP7325467B2 (ja) | 2023-08-14 |
| CN107406882A (zh) | 2017-11-28 |
| US10513728B2 (en) | 2019-12-24 |
| US10865439B2 (en) | 2020-12-15 |
| EP3286327A1 (en) | 2018-02-28 |
| US11680289B2 (en) | 2023-06-20 |
| JP2021097719A (ja) | 2021-07-01 |
| EP4001430A1 (en) | 2022-05-25 |
| JP2024012522A (ja) | 2024-01-30 |
| US12454722B2 (en) | 2025-10-28 |
| CN107406882B (zh) | 2022-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6040227B2 (ja) | マルチプレックス核酸同定のための製品およびプロセス | |
| JP7325467B2 (ja) | 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 | |
| CA2742272C (en) | Products and processes for multiplex nucleic acid identification | |
| US20250340930A1 (en) | Products and processes for nucleic acid detection and quantification | |
| HK40070858A (en) | Multiplexed method for the identification and quantitation of minor alleles and polymorphisms |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190228 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190228 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20191129 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20191204 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20200207 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200403 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200923 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20201217 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20210217 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20210412 |