JP2018512880A - 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 - Google Patents

少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 Download PDF

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JP2018512880A
JP2018512880A JP2017555324A JP2017555324A JP2018512880A JP 2018512880 A JP2018512880 A JP 2018512880A JP 2017555324 A JP2017555324 A JP 2017555324A JP 2017555324 A JP2017555324 A JP 2017555324A JP 2018512880 A JP2018512880 A JP 2018512880A
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アンダーズ オロフ ヘルマン ニーグレン,
アンダーズ オロフ ヘルマン ニーグレン,
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アジーナ バイオサイエンス, インコーポレイテッド
アジーナ バイオサイエンス, インコーポレイテッド
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    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
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    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]

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JP2017555324A 2015-04-24 2016-04-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法 Withdrawn JP2018512880A (ja)

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JP2021047478A JP7325467B2 (ja) 2015-04-24 2021-03-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2021047479A JP2021097719A (ja) 2015-04-24 2021-03-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2023189367A JP2024012522A (ja) 2015-04-24 2023-11-06 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法

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US201562152697P 2015-04-24 2015-04-24
US62/152,697 2015-04-24
US201662280951P 2016-01-20 2016-01-20
US62/280,951 2016-01-20
PCT/US2016/028971 WO2016172571A1 (en) 2015-04-24 2016-04-22 Multiplexed method for the identification and quantitation of minor alleles and polymorphisms

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JP2019036000A Division JP2019083820A (ja) 2015-04-24 2019-02-28 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2021047478A Division JP7325467B2 (ja) 2015-04-24 2021-03-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2021047479A Division JP2021097719A (ja) 2015-04-24 2021-03-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法

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JP2019036000A Pending JP2019083820A (ja) 2015-04-24 2019-02-28 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2021047479A Withdrawn JP2021097719A (ja) 2015-04-24 2021-03-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
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JP2023189367A Pending JP2024012522A (ja) 2015-04-24 2023-11-06 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法

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JP2021047479A Withdrawn JP2021097719A (ja) 2015-04-24 2021-03-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2021047478A Active JP7325467B2 (ja) 2015-04-24 2021-03-22 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法
JP2023189367A Pending JP2024012522A (ja) 2015-04-24 2023-11-06 少量の対立遺伝子および多型の同定ならびに定量のためのマルチプレックス法

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CN (2) CN107406882B (enExample)
AU (1) AU2016250841A1 (enExample)
CA (1) CA2983224A1 (enExample)
HK (1) HK1250747A1 (enExample)
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Cited By (1)

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KR102857507B1 (ko) 2022-11-14 2025-09-10 명지대학교 산학협력단 무의 근피 색상 판별용 snp 마커 및 이의 용도

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CN103717751A (zh) 2011-05-19 2014-04-09 塞昆纳姆股份有限公司 用于多重核酸鉴定的产品和方法
EP3286327B1 (en) 2015-04-24 2021-11-10 Agena Bioscience, Inc. Multiplexed method for the identification and quantitation of minor alleles and polymorphisms
CN114350766A (zh) 2015-04-24 2022-04-15 基纳生物技术有限公司 检测和定量次要变体的并行式方法
US12188083B2 (en) 2018-06-01 2025-01-07 Agena Bioscience, Inc. Products and processes for nucleic acid detection and quantification
CN113466320B (zh) * 2021-08-06 2022-10-14 河北省食品检验研究院 一种针对乳粉中牛源性成分maldi-tof检测方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030027169A1 (en) * 2000-10-27 2003-02-06 Sheng Zhang One-well assay for high throughput detection of single nucleotide polymorphisms
CN103602740A (zh) * 2013-11-06 2014-02-26 毅新兴业(北京)科技有限公司 质谱仪鉴定血清中游离dna的方法、试剂盒及其应用
JP2014515264A (ja) * 2011-05-19 2014-06-30 セクエノム, インコーポレイテッド マルチプレックス核酸同定のための製品およびプロセス

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
DE3301833A1 (de) 1983-01-20 1984-07-26 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Verfahren zur simultanen synthese mehrerer oligonocleotide an fester phase
US5059654A (en) 1983-02-14 1991-10-22 Cuno Inc. Affinity matrices of modified polysaccharide supports
US4515781A (en) 1983-02-23 1985-05-07 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services 2',5'-Riboadenylate-morpholinoadenylate nucleotides
US4582789A (en) 1984-03-21 1986-04-15 Cetus Corporation Process for labeling nucleic acids using psoralen derivatives
US4957858A (en) 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
US5118605A (en) 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
CA1340328C (en) 1984-10-29 1999-01-26 Boehringer Mannheim Corporation Method for protein binding enzyme complementation assays
US5064754A (en) 1984-12-14 1991-11-12 Mills Randell L Genomic sequencing method
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
EP0260032B1 (en) 1986-09-08 1994-01-26 Ajinomoto Co., Inc. Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers
EP0269520A3 (fr) 1986-11-21 1988-08-24 Institut Pasteur Rétrovirus du type HIV-2 susceptible de provoquer le sida, et ses constituants antigéniques et nucléiques
US5037882A (en) 1987-03-11 1991-08-06 Steel Samuel L Synthesis of oligonucleotide analogs
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
DE68927025T2 (de) 1988-06-14 1997-03-27 Chemotherapeutisches Forschung HIV-2-Virusvarianten
US5003059A (en) 1988-06-20 1991-03-26 Genomyx, Inc. Determining DNA sequences by mass spectrometry
US5512439A (en) 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
US5489507A (en) 1988-11-30 1996-02-06 Perkin-Elmer Corporation DNA detection by color complementation
US5237016A (en) 1989-01-05 1993-08-17 Siska Diagnostics, Inc. End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5242974A (en) 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
ATE282716T1 (de) 1989-07-11 2004-12-15 Gen Probe Inc Verfahren zur amplifikation von nukleinsäuresequenzen
WO1991011533A1 (en) 1990-01-26 1991-08-08 E.I. Du Pont De Nemours And Company Method for isolating primer extension products from template-directed dna polymerase reactions
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
WO1992011390A1 (en) 1990-12-17 1992-07-09 Idexx Laboratories, Inc. Nucleic acid sequence detection by triple helix formation
US5364759B2 (en) 1991-01-31 1999-07-20 Baylor College Medicine Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
US5888819A (en) 1991-03-05 1999-03-30 Molecular Tool, Inc. Method for determining nucleotide identity through primer extension
DE69322266T2 (de) 1992-04-03 1999-06-02 Perkin-Elmer Corp., Foster City, Calif. Proben zusammensetzung und verfahren
US5412083A (en) 1992-04-16 1995-05-02 Northeastern University Carbohydrate heterobifunctional cross-linking reagent
WO1994000562A1 (en) 1992-06-24 1994-01-06 The Mt. Sinai School Of Medicine Of The City University Of New York A novel human immunodeficiency virus
US5710028A (en) 1992-07-02 1998-01-20 Eyal; Nurit Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor
US6194144B1 (en) 1993-01-07 2001-02-27 Sequenom, Inc. DNA sequencing by mass spectrometry
DE69433811T2 (de) 1993-01-07 2005-06-23 Sequenom, Inc., San Diego Dns - sequenzierung durch massenspektronomie
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US6074823A (en) 1993-03-19 2000-06-13 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
DE69430909T2 (de) 1993-03-19 2003-02-27 Sequenom, Inc. Dns-sequenzbestimmung durch massenspektrometrie auf dem weg des abbaus mit exonuklease
US5399857A (en) 1993-05-28 1995-03-21 The Johns Hopkins University Method and apparatus for trapping ions by increasing trapping voltage during ion introduction
JPH07159404A (ja) 1993-12-06 1995-06-23 Doujin Kagaku Kenkyusho:Kk スピンラベルしたビオチンを用いた物質の測定方法
US5976798A (en) 1994-03-30 1999-11-02 Mitokor Methods for detecting mitochondrial mutations diagnostic for Alzheimer's disease and methods for determining heteroplasmy of mitochondrial nucleic acid
GB9417211D0 (en) 1994-08-25 1994-10-12 Solicitor For The Affairs Of H Nucleotide sequencing method
CA2211951A1 (en) 1995-02-09 1996-08-15 University Of Washington Modified-affinity streptavidin
US6428955B1 (en) 1995-03-17 2002-08-06 Sequenom, Inc. DNA diagnostics based on mass spectrometry
WO1996030545A1 (en) 1995-03-24 1996-10-03 Mitokor Mutation detection by differential primer extension of mutant and wildtype target sequences
EP0830460A1 (en) 1995-04-11 1998-03-25 Trustees Of Boston University Solid phase sequencing of biopolymers
US5770272A (en) 1995-04-28 1998-06-23 Massachusetts Institute Of Technology Matrix-bearing targets for maldi mass spectrometry and methods of production thereof
US5700642A (en) 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers
US5869242A (en) 1995-09-18 1999-02-09 Myriad Genetics, Inc. Mass spectrometry to assess DNA sequence polymorphisms
AU2217597A (en) 1996-03-18 1997-10-22 Sequenom, Inc. Dna sequencing by mass spectrometry
US5965363A (en) 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
US5885775A (en) 1996-10-04 1999-03-23 Perseptive Biosystems, Inc. Methods for determining sequences information in polynucleotides using mass spectrometry
CA2270132A1 (en) 1996-11-06 1998-05-14 Sequenom, Inc. Dna diagnostics based on mass spectrometry
US6635452B1 (en) 1996-12-10 2003-10-21 Sequenom Inc. Releasable nonvolatile mass label molecules
US6613509B1 (en) 1999-03-22 2003-09-02 Regents Of The University Of California Determination of base (nucleotide) composition in DNA oligomers by mass spectrometry
US20050287592A1 (en) 2000-08-29 2005-12-29 Yeda Research And Development Co. Ltd. Template-dependent nucleic acid polymerization using oligonucleotide triphosphates building blocks
GB0006141D0 (en) 2000-03-14 2000-05-03 Brax Group Ltd Mass labels
EP1176212A1 (en) 2000-07-24 2002-01-30 Centre National de Genotype Method for haplotyping by mass spectrometry
GB0102568D0 (en) 2001-02-01 2001-03-21 Magnetic Biosolutions Sweden A Method
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US20040121314A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in containers
JP4128453B2 (ja) 2001-03-19 2008-07-30 プレジデント アンド フェロウズ オブ ハーバード カレッジ 新規分子機能の進化
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US20030119004A1 (en) 2001-12-05 2003-06-26 Wenz H. Michael Methods for quantitating nucleic acids using coupled ligation and amplification
JP3752466B2 (ja) 2002-04-24 2006-03-08 株式会社日立製作所 遺伝子検査方法
AU2003251424A1 (en) 2002-06-07 2003-12-22 The Regents Of The University Of California Electrochemical detection of single nucleotide polymorphisms (snps)
US7074597B2 (en) 2002-07-12 2006-07-11 The Trustees Of Columbia University In The City Of New York Multiplex genotyping using solid phase capturable dideoxynucleotides and mass spectrometry
DE10240746A1 (de) 2002-09-01 2004-03-18 Epigenomics Ag Verfahren zum Nachweis von Nukleinsäuresequenzen mittels spaltbarer Sondenmoleküle
US20040259105A1 (en) * 2002-10-03 2004-12-23 Jian-Bing Fan Multiplex nucleic acid analysis using archived or fixed samples
WO2005012578A1 (en) 2003-07-31 2005-02-10 Sequenom, Inc. Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions for genotyping of polymorphisms
EP1721014B1 (en) 2004-02-18 2013-07-17 Trustees Of Boston University Method for detecting and quantifying rare mutations/polymorphisms
CN100400673C (zh) * 2004-03-18 2008-07-09 华晶基因技术有限公司 单核苷酸多态性(SNPs)及点突变的检测方法
WO2006073436A2 (en) 2004-04-29 2006-07-13 The Trustees Of Columbia University In The City Of New York Mass tag pcr for multiplex diagnostics
WO2005113804A1 (en) 2004-05-20 2005-12-01 Trillion Genomics Limited Use of mass labelled probes to detect target nucleic acids using mass spectrometry
JP4735926B2 (ja) 2004-05-27 2011-07-27 アイシン精機株式会社 核酸の高効率回収方法
US7785843B2 (en) 2004-06-23 2010-08-31 Sequenom, Inc. Target-specific compomers and methods of use
EP1853732A2 (en) 2005-02-28 2007-11-14 Gen-Probe Incorporated Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe
JP2006320271A (ja) 2005-05-20 2006-11-30 Tokyo Institute Of Technology 低分子化合物とタンパク質の結合評価方法
JP2008545444A (ja) * 2005-06-13 2008-12-18 エフ.ホフマン−ラ ロシュ アーゲー 急性拒絶反応に関連するil10snp
US8586708B2 (en) 2005-10-28 2013-11-19 Massachusetts Institute Of Technology Monovalent streptavidin compositions
US8133701B2 (en) 2006-12-05 2012-03-13 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US9249423B2 (en) 2007-02-02 2016-02-02 Yale University Method of de-differentiating and re-differentiating somatic cells using RNA
GB2468979A (en) 2007-10-10 2010-09-29 Atanas Atanasov Wave power station
WO2010056513A2 (en) 2008-10-30 2010-05-20 Sequenom, Inc. Products and processes for multiplex nucleic acid identification
CN103333952B (zh) * 2008-11-05 2015-07-29 健泰科生物技术公司 年龄相关的黄斑变性中的遗传多态性
EP2479268B1 (en) 2009-09-17 2020-11-04 JSR Corporation Dissociation method and dissociation agent for avidin and biotinderivatives
KR101890466B1 (ko) * 2012-07-24 2018-08-21 내테라, 인코포레이티드 고도의 다중 pcr 방법 및 조성물
CN103131787B (zh) * 2013-03-11 2014-05-21 四川大学 基于y染色体snp遗传标记的法医学复合检测试剂盒
CN114350766A (zh) 2015-04-24 2022-04-15 基纳生物技术有限公司 检测和定量次要变体的并行式方法
EP3286327B1 (en) 2015-04-24 2021-11-10 Agena Bioscience, Inc. Multiplexed method for the identification and quantitation of minor alleles and polymorphisms

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030027169A1 (en) * 2000-10-27 2003-02-06 Sheng Zhang One-well assay for high throughput detection of single nucleotide polymorphisms
JP2014515264A (ja) * 2011-05-19 2014-06-30 セクエノム, インコーポレイテッド マルチプレックス核酸同定のための製品およびプロセス
CN103602740A (zh) * 2013-11-06 2014-02-26 毅新兴业(北京)科技有限公司 质谱仪鉴定血清中游离dna的方法、试剂盒及其应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NUCLEIC ACIDS RESEARCH, vol. Vol.37, No.2, e13, JPN6019047397, 2009, pages 1 - 6, ISSN: 0004350261 *
SEQUENOM APPLICATION NOTE, vol. Doc. No. 8876-006, R04, JPN6019047398, 2006, pages 1 - 12, ISSN: 0004350262 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102857507B1 (ko) 2022-11-14 2025-09-10 명지대학교 산학협력단 무의 근피 색상 판별용 snp 마커 및 이의 용도

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CA2983224A1 (en) 2016-10-27
WO2016172571A1 (en) 2016-10-27
JP2021097718A (ja) 2021-07-01
US20230383340A1 (en) 2023-11-30
US10233489B2 (en) 2019-03-19
US20190153526A1 (en) 2019-05-23
US20200123601A1 (en) 2020-04-23
AU2016250841A1 (en) 2017-11-02
US20210062254A1 (en) 2021-03-04
JP2019083820A (ja) 2019-06-06
HK1250747A1 (zh) 2019-01-11
US20160312278A1 (en) 2016-10-27
EP3286327B1 (en) 2021-11-10
CN114540470A (zh) 2022-05-27
JP7325467B2 (ja) 2023-08-14
CN107406882A (zh) 2017-11-28
US10513728B2 (en) 2019-12-24
US10865439B2 (en) 2020-12-15
EP3286327A1 (en) 2018-02-28
US11680289B2 (en) 2023-06-20
JP2021097719A (ja) 2021-07-01
EP4001430A1 (en) 2022-05-25
JP2024012522A (ja) 2024-01-30
US12454722B2 (en) 2025-10-28
CN107406882B (zh) 2022-03-01

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