JP2012516936A - グアールを精製するためのプロセス - Google Patents
グアールを精製するためのプロセス Download PDFInfo
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- JP2012516936A JP2012516936A JP2011549292A JP2011549292A JP2012516936A JP 2012516936 A JP2012516936 A JP 2012516936A JP 2011549292 A JP2011549292 A JP 2011549292A JP 2011549292 A JP2011549292 A JP 2011549292A JP 2012516936 A JP2012516936 A JP 2012516936A
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- guar
- borate
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- aqueous solution
- solution
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Images
Classifications
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- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
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- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
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Abstract
Description
本願は、米国特許法§119に基づき、2009年2月5日に出願された米国仮特許出願第61/150,215号に対する優先権を主張する。この仮特許出願の全内容は、参照により本明細書中に援用される。
本発明は、グアールおよびグアール誘導体に関し、より具体的には、精製グアールおよびグアール誘導体を生成するためのプロセスに関する。
グアールガムは、グアール(クラスタマメとしても公知)植物Cyamopsis tetragonoloba(L.) Taubの内胚乳から得られる。グアールガム粉末は、代表的には、グアール種子から内胚乳(グアール「スプリット(split)」としても公知)を機械的に分離する工程および塩基性溶液中で上記内胚乳材料を水和し、続いて、機械的に製粉および乾燥させて、上記グアール粉末を形成する工程によって生成される。特許文献1(Yehら)は、グアールガム粉末をグアールスプリットから形成するために使用され得る技術を開示する。
本発明は、一般に、グアールおよびグアール誘導体を生成するためのプロセスに関する。本発明のプロセスを介して生成される材料は、眼用の水性薬学的製品の成分として特に有用である。
グアール粉末および水は、水溶液もしくはスラリーを形成するために合わされる。上記グアールおよび水のスラリーは、次いで、上記グアールを分散させるために混合される。水中のグアール濃度は変動し得るが、代表的には、0.1%〜1.5% w/vである。好ましい実施形態において、上記グアールは、最終濃度1.0% w/v未満、および好ましくは、約0.5%〜0.8% w/vを提供するに十分な量で添加され、pH約6.0〜7.0で2時間以上にわたって水中で水和させられる。水和のための異なる時間およびpH条件が、他の実施形態において使用され得る。種々の温度もまた、水和に使用され得る。一実施形態において、70℃での水和が好ましい。
本発明の好ましいプロセスは、TIC Gum,Incから得たUSPグレードのグアール粉末を利用する。上記未加工グアール粉末を使用して、0.8% グアール水溶液を形成する。上記溶液を、pH6〜7で4時間にわたって、水中でグアール(8g)を混合することによって調製する。次いで、上記グアール水溶液を、40μm 孔サイズのデプスフィルタ、続いて、20μmおよび10μmの孔サイズのデプスフィルタ(Pall SealKleen(登録商標))を通して、25℃で加圧濾過(5psi)する。次いで、ホウ酸(2g)を添加し、上記濾過した0.8% グアール溶液中に溶解させる。上記ホウ酸が溶解した後、必要であれば、そのpHを6〜6.5に調節する。
以下の表1および表2は、(i)エタノール/アセトン沈殿物および洗浄工程のみを使用して精製したグアール、および(ii)ボレート添加およびエタノール/アセトンを使用して精製したグアールを比較して、水溶液中の非加工処理グアール(USPグレード;TIC Gum,Inc.)を比較する実験の結果を示す。透過性測定のために選択した500nm波長は、可視スペクトル領域に存在し、上記溶液の視覚的透明性に対応する一方で、280nm波長は、タンパク質不純物の吸収領域にあり、よって、保持された不純物の間接的測定になる。
本発明に従って生成したグアールの熱安定性を、非加工処理グアールおよび他の技術を使用して加工処理したグアールの熱安定性と比較した。この実験において、グアールサンプルを、121℃で35分間、オートクレーブにかけた。上記実験の結果を、図1に示す。
本発明の一実施形態に従うグアール処方物のpH感受性を、市販のHP8Aグアールおよびヒドロキシプロピル化グアール誘導体HPGG−75のものと比較した。上記処方物は、グアールと、ホウ酸、塩化ナトリウム、ソルビトールおよびポリクオタニウム−1とから構成された。その粘性を、40℃で1週間後に測定した。図2に示されるように、本発明のプロセスを使用して精製したグアールは、生理的pH(7〜8)で良好な粘性保持を示し、HP8AもしくはHPGG−75よりもpH変化に対する感受性が有意に高かった。そしてpH8.0で粘性の増大を示す。
Claims (16)
- グアールを製造するためのプロセスであって、該プロセスは、
ボレートと水溶液中のグアールとを合わせる工程;および
有機溶媒を該水溶液に添加することによって、グアールを沈殿させる工程、
を包含するプロセス。 - 前記有機溶媒は、アセトンである、請求項1に記載のプロセス。
- 沈殿したグアールを濾過する工程、
をさらに包含する、請求項1に記載のプロセス。 - 前記濾過する工程は、沈殿したグアールを、孔サイズ40μm以下を有する1つ以上のフィルタを使用して濾過する工程を包含する、請求項3に記載のプロセス。
- 前記フィルタは、40μm、20μm、および10μmからなる群より選択される孔サイズを有する、請求項4に記載のプロセス。
- 前記合わせる工程は、ボレートを、グアール水溶液に添加する工程を包含する、請求項1に記載のプロセス。
- 前記グアール水溶液は、前記ボレートを添加する工程の前に濾過される、請求項6に記載のプロセス。
- 前記ボレートは、ホウ酸ナトリウム、ホウ酸カリウム、ホウ酸、ホウ酸アルキル、ホウ酸トリメチル、ホウ酸フェニル、およびこれらの組み合わせからなる群より選択される、請求項1に記載のプロセス。
- 前記ボレートは、前記合わせる工程の間に添加されて、前記水溶液中、0.05%〜0.05% w/vの濃度を形成する、請求項1に記載のプロセス。
- 前記グアールは、前記水溶液中、1.0% w/v未満の濃度である、請求項1に記載のプロセス。
- 請求項1に記載のプロセスによって生成される、グアール。
- 前記グアールは、ヒドロキシエチルグアール、ヒドロキシプロピルグアールガラクトマンナン、もしくはカルボキシメチルヒドロキシプロピルグアールである、請求項11に記載のグアール。
- 眼用処方物であって、
請求項1に記載のプロセスによって生成されるグアール、および1種以上の賦形剤を含む、
処方物。 - 前記グアールは、ヒドロキシエチルグアール、ヒドロキシプロピルグアールガラクトマンナン、カルボキシメチルヒドロキシプロピルグアール、およびこれらの組み合わせからなる群より選択される、請求項13に記載の眼用処方物。
- 前記グアールは、ヒドロキシプロピルグアールガラクトマンナンである、請求項13に記載の眼用処方物。
- 前記グアールは、0.1%〜0.25% w/vの濃度で存在する、請求項13に記載の眼用処方物。
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TW201336527A (zh) | 2012-02-10 | 2013-09-16 | Alcon Res Ltd | 具增強的穩定性之水性藥學組成物 |
PE20142350A1 (es) * | 2012-03-28 | 2015-01-18 | Halosource Inc | Composicion para el tratamiento de aguas y metodos de uso |
WO2019123266A1 (en) | 2017-12-20 | 2019-06-27 | Novartis Ag | Ophthalmic composition having a prostaglandin and a beta-blocker |
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MX2011007714A (es) | 2011-12-06 |
ZA201105048B (en) | 2012-09-26 |
KR20110113199A (ko) | 2011-10-14 |
CN102356094B (zh) | 2014-05-21 |
US20100196415A1 (en) | 2010-08-05 |
JP2015180754A (ja) | 2015-10-15 |
AU2010210497A1 (en) | 2011-08-04 |
AU2010210497B2 (en) | 2015-07-23 |
CA2749809A1 (en) | 2010-08-12 |
SG173581A1 (en) | 2011-09-29 |
US8536325B2 (en) | 2013-09-17 |
CA2749809C (en) | 2017-03-14 |
NZ594419A (en) | 2013-07-26 |
EP2393837A1 (en) | 2011-12-14 |
CN102356094A (zh) | 2012-02-15 |
US20120142630A1 (en) | 2012-06-07 |
US20130330430A1 (en) | 2013-12-12 |
BRPI1008654A2 (pt) | 2016-03-08 |
WO2010091287A1 (en) | 2010-08-12 |
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