JP2012516319A5 - - Google Patents

Info

Publication number

JP2012516319A5

JP2012516319A5 JP2011546988A JP2011546988A JP2012516319A5 JP 2012516319 A5 JP2012516319 A5 JP 2012516319A5 JP 2011546988 A JP2011546988 A JP 2011546988A JP 2011546988 A JP2011546988 A JP 2011546988A JP 2012516319 A5 JP2012516319 A5 JP 2012516319A5

Authority

JP

Japan

Prior art keywords

lactoferrin

collecting

angiogenin

endotoxin

lps

Prior art date

2010-01-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 15
• 108010063045 Lactoferrin Proteins 0.000 claims 14
• 102100032241 Lactotransferrin Human genes 0.000 claims 14
• CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims 14
• 229940078795 lactoferrin Drugs 0.000 claims 14
• 235000021242 lactoferrin Nutrition 0.000 claims 14
• 239000002158 endotoxin Substances 0.000 claims 10
• 239000000243 solution Substances 0.000 claims 8
• 102100022987 Angiogenin Human genes 0.000 claims 5
• 108010072788 angiogenin Proteins 0.000 claims 5
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
• 241000894006 Bacteria Species 0.000 claims 3
• 206010052428 Wound Diseases 0.000 claims 3
• 208000027418 Wounds and injury Diseases 0.000 claims 3
• 239000002994 raw material Substances 0.000 claims 3
• NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims 2
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
• 108010023244 Lactoperoxidase Proteins 0.000 claims 2
• 102000045576 Lactoperoxidases Human genes 0.000 claims 2
• 102000035195 Peptidases Human genes 0.000 claims 2
• 108091005804 Peptidases Proteins 0.000 claims 2
• 239000004365 Protease Substances 0.000 claims 2
• 239000003729 cation exchange resin Substances 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 230000002708 enhancing effect Effects 0.000 claims 2
• 229940057428 lactoperoxidase Drugs 0.000 claims 2
• 235000013336 milk Nutrition 0.000 claims 2
• 239000008267 milk Substances 0.000 claims 2
• 210000004080 milk Anatomy 0.000 claims 2
• 235000018102 proteins Nutrition 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 239000011780 sodium chloride Substances 0.000 claims 2
• 201000003883 Cystic fibrosis Diseases 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 208000005577 Gastroenteritis Diseases 0.000 claims 1
• 206010024971 Lower respiratory tract infections Diseases 0.000 claims 1
• 206010057190 Respiratory tract infections Diseases 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 claims 1
• 206010046306 Upper respiratory tract infection Diseases 0.000 claims 1
• 239000008351 acetate buffer Substances 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 210000003719 b-lymphocyte Anatomy 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 239000007853 buffer solution Substances 0.000 claims 1
• 239000000356 contaminant Substances 0.000 claims 1
• 231100000433 cytotoxic Toxicity 0.000 claims 1
• 230000001472 cytotoxic effect Effects 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 238000010828 elution Methods 0.000 claims 1
• 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
• 230000002440 hepatic effect Effects 0.000 claims 1
• 230000002757 inflammatory effect Effects 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 210000004347 intestinal mucosa Anatomy 0.000 claims 1
• 229910052742 iron Inorganic materials 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 210000002540 macrophage Anatomy 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000035800 maturation Effects 0.000 claims 1
• 210000004379 membrane Anatomy 0.000 claims 1
• 239000012528 membrane Substances 0.000 claims 1
• 210000001616 monocyte Anatomy 0.000 claims 1
• 239000002674 ointment Substances 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 238000000746 purification Methods 0.000 claims 1
• 238000011084 recovery Methods 0.000 claims 1
• 238000000926 separation method Methods 0.000 claims 1
• 208000003265 stomatitis Diseases 0.000 claims 1
• 238000003786 synthesis reaction Methods 0.000 claims 1
• 230000017423 tissue regeneration Effects 0.000 claims 1