JP2012514483A - インプラント上の抗感染性コーティングの製造方法 - Google Patents
インプラント上の抗感染性コーティングの製造方法 Download PDFInfo
- Publication number
- JP2012514483A JP2012514483A JP2011544053A JP2011544053A JP2012514483A JP 2012514483 A JP2012514483 A JP 2012514483A JP 2011544053 A JP2011544053 A JP 2011544053A JP 2011544053 A JP2011544053 A JP 2011544053A JP 2012514483 A JP2012514483 A JP 2012514483A
- Authority
- JP
- Japan
- Prior art keywords
- oxide layer
- metal
- implant
- titanium
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007943 implant Substances 0.000 title claims abstract description 18
- 238000000576 coating method Methods 0.000 title claims abstract description 16
- 230000002924 anti-infective effect Effects 0.000 title claims abstract description 13
- 239000011248 coating agent Substances 0.000 title claims abstract description 12
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 5
- 229910052751 metal Inorganic materials 0.000 claims abstract description 23
- 239000002184 metal Substances 0.000 claims abstract description 23
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000010936 titanium Substances 0.000 claims abstract description 12
- 229910052719 titanium Inorganic materials 0.000 claims abstract description 12
- 238000000151 deposition Methods 0.000 claims abstract description 9
- 238000005728 strengthening Methods 0.000 claims abstract description 6
- 239000012670 alkaline solution Substances 0.000 claims abstract description 5
- 230000008021 deposition Effects 0.000 claims abstract description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 16
- 239000010949 copper Substances 0.000 claims description 16
- 229910052802 copper Inorganic materials 0.000 claims description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- 238000005422 blasting Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 230000003647 oxidation Effects 0.000 claims description 7
- 238000007254 oxidation reaction Methods 0.000 claims description 7
- 239000011324 bead Substances 0.000 claims description 6
- 239000011521 glass Substances 0.000 claims description 6
- 229910052709 silver Inorganic materials 0.000 claims description 6
- 239000004332 silver Substances 0.000 claims description 6
- 239000008151 electrolyte solution Substances 0.000 claims description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- 239000011148 porous material Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 239000004115 Sodium Silicate Substances 0.000 claims description 2
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052911 sodium silicate Inorganic materials 0.000 claims description 2
- 238000002048 anodisation reaction Methods 0.000 claims 2
- 238000007743 anodising Methods 0.000 abstract description 3
- 238000005457 optimization Methods 0.000 abstract description 2
- 239000010410 layer Substances 0.000 description 24
- 239000000243 solution Substances 0.000 description 8
- 238000010438 heat treatment Methods 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 3
- 239000003792 electrolyte Substances 0.000 description 3
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- OPQARKPSCNTWTJ-UHFFFAOYSA-L copper(ii) acetate Chemical class [Cu+2].CC([O-])=O.CC([O-])=O OPQARKPSCNTWTJ-UHFFFAOYSA-L 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000002923 metal particle Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 238000007739 conversion coating Methods 0.000 description 1
- 238000000280 densification Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 230000007998 vessel formation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
【解決手段】本発明に従い、インプラントをアルカリ性溶液内で陽極酸化し、引き続きこの表面において、抗感染性特性を有する金属を電解析出し、その後、金属含有酸化物層を強化する。
【選択図】図2
Description
特許文献1から、チタン又はチタン合金から成るインプラントに、ゾルゲル法を使用して、銀や銅のような金属イオンが均質に分散されている酸化チタンコーティングを設けることが公知である。コーティング(被膜)の機械的安定性と高密度化のために乾燥後に熱処理が行われる。ほぼ500℃への加熱によりコーティングのセラミック化(Keramisierung)が行われる。しかし熱処理は、インプラントにとって強度の損失をもたらすという短所をもつ。それ故、熱処理は、高い耐久強度をもつべきインプラントには適していない。
即ち、本発明の一視点により、チタンを含む又はチタンから成るインプラント上の抗感染性コーティングの製造方法であって、以下のステップ、即ち、
− 多孔質酸化物層を、アルカリ性溶液内の陽極酸化により、多孔内の導電率が電解析出を可能にするように形成するステップ、
− 抗感染性特性を有する金属を電解析出するステップ、
− ブラストにより、金属含有酸化物層を強化するステップ、
を含むこと。
(形態1)上記一視点のとおり。
(形態2)前記陽極酸化のための電解液が水酸化ナトリウムを含むことが好ましい。
(形態3)前記陽極酸化のための電解液が珪酸ナトリウムを含むことが好ましい。
(形態4)前記多孔質酸化物層内へ銅、銀、及び/又は亜鉛を取り入れることが好ましい。
(形態5)前記金属含有酸化物層をガラスビードでブラストすることが好ましい。
(形態6)前記酸化物層の厚さが8〜15μmであることが好ましい。
Claims (6)
- チタンを含む又はチタンから成るインプラント上の抗感染性コーティングの製造方法であって、以下のステップ、即ち、
− 多孔質酸化物層を、アルカリ性溶液内の陽極酸化により、多孔内の導電率が電解析出を可能にするように形成するステップ、
− 抗感染性特性を有する金属を電解析出するステップ、
− ブラストにより、金属含有酸化物層を強化するステップ、
を含むことを特徴とする方法。 - 前記陽極酸化のための電解液が水酸化ナトリウムを含むこと
を特徴とする、請求項1に記載の方法。 - 前記陽極酸化のための電解液が珪酸ナトリウムを含むこと
を特徴とする、請求項1又は2に記載の方法。 - 前記多孔質酸化物層内へ銅、銀、及び/又は亜鉛を取り入れること
を特徴とする、請求項1に記載の方法。 - 前記金属含有酸化物層をガラスビードでブラストすること
を特徴とする、請求項1に記載の方法。 - 前記酸化物層の厚さが8〜15μmであること
を特徴とする、請求項1に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09100006.7 | 2009-01-05 | ||
EP09100006A EP2204199B1 (de) | 2009-01-05 | 2009-01-05 | Verfahren zur Herstellung einer antiinfektiösen Beschichtung auf Implantaten |
PCT/EP2010/050010 WO2010076338A1 (de) | 2009-01-05 | 2010-01-04 | Verfahren zur herstellung einer antiinfektiösen beschichtung auf implantaten |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2012514483A true JP2012514483A (ja) | 2012-06-28 |
JP2012514483A5 JP2012514483A5 (ja) | 2012-10-18 |
JP5647145B2 JP5647145B2 (ja) | 2014-12-24 |
Family
ID=40677900
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011544053A Expired - Fee Related JP5647145B2 (ja) | 2009-01-05 | 2010-01-04 | インプラント上の抗感染性コーティングの製造方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US8828552B2 (ja) |
EP (1) | EP2204199B1 (ja) |
JP (1) | JP5647145B2 (ja) |
CN (1) | CN102271721B (ja) |
AT (1) | ATE530205T1 (ja) |
AU (1) | AU2010203260B9 (ja) |
CA (1) | CA2748760C (ja) |
ES (1) | ES2376539T3 (ja) |
WO (1) | WO2010076338A1 (ja) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102009023459B4 (de) * | 2009-06-02 | 2017-08-31 | Aap Implantate Ag | Osteosynthese mit Nanosilber |
DE102009046743A1 (de) * | 2009-11-17 | 2011-05-19 | Primus Oberflächentechnik GmbH & Co. KG | Verfahren zur Herstellung einer antimikrobiellen Oberfläche eines Gegenstandes und Gegenstand mit einer antimikrobiellen Oberfläche |
TWI400100B (zh) * | 2010-09-29 | 2013-07-01 | Metal Ind Res & Dev Ct | Medical equipment and manufacturing methods thereof |
EP2693978B1 (en) * | 2011-04-01 | 2018-11-07 | Washington State University Research Foundation | Materials with modified surfaces and methods of manufacturing |
KR101278740B1 (ko) | 2012-02-17 | 2013-06-25 | 영남대학교 산학협력단 | 물유리 코팅층을 포함하는 임플란트 및 이의 제조 방법 |
DE102012210804B4 (de) * | 2012-06-26 | 2014-07-10 | Innovent E.V. | Verfahren zur Erzeugung einer bakteriziden Schicht auf einem Grundkörper aus Titan oder einer Titanbasislegierung |
CA2949664A1 (en) | 2014-05-18 | 2015-11-26 | Carlos M. Lacerda | Antibacterial composition, antibacterial cases and accessories for handheld electronics, and method of making antibacterial cases for handheld electronics |
WO2016160983A1 (en) | 2015-03-30 | 2016-10-06 | C. R. Bard, Inc. | Application of antimicrobial agents to medical devices |
US10064273B2 (en) | 2015-10-20 | 2018-08-28 | MR Label Company | Antimicrobial copper sheet overlays and related methods for making and using |
CN108472414A (zh) | 2016-01-25 | 2018-08-31 | 史密夫和内修有限公司 | 矫形外科植入物 |
PL232314B1 (pl) * | 2016-05-06 | 2019-06-28 | Gen Electric | Maszyna przepływowa zawierająca system regulacji luzu |
CN106420119B (zh) * | 2016-11-29 | 2017-10-31 | 淮阴工学院 | 一种高抗菌性钛合金人工髋关节的成形方法 |
WO2018187782A1 (en) * | 2017-04-07 | 2018-10-11 | The Board Of Trustees Of The University Of Illinois | Nanostructured polymer-based compositions and methods to fabricate the same |
CN107893252A (zh) * | 2017-11-22 | 2018-04-10 | 四川大学 | 钛基材料表面具有软组织密封性的生物活性涂层的原位制备方法及其应用 |
WO2019199292A1 (en) | 2018-04-11 | 2019-10-17 | Hewlett-Packard Development Company, L.P. | Device housings with glass beads |
DE102019108327A1 (de) * | 2019-03-29 | 2020-10-01 | Karl Leibinger Medizintechnik Gmbh & Co. Kg | Implantat mit intrinsischer antimikrobieller Wirksamkeit und Verfahren zu dessen Herstellung |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2009A (en) * | 1841-03-18 | Improvement in machines for boring war-rockets | ||
JPH06125979A (ja) * | 1992-03-31 | 1994-05-10 | Nisshin Steel Co Ltd | インプラント用金属焼結体及びその製造方法 |
JPH08289927A (ja) * | 1995-04-21 | 1996-11-05 | Nikon Corp | 骨内インプラント及びその製造方法 |
JP2005287985A (ja) * | 2004-04-05 | 2005-10-20 | Gha:Kk | 炎症/臭い抑制部材及びその製造方法並びにこれを用いた義体及びギブス |
WO2007144667A2 (en) * | 2006-06-12 | 2007-12-21 | Accentus Plc | Metal implants |
WO2008091835A2 (en) * | 2007-01-26 | 2008-07-31 | Boston Scientific Limited | Implantable medical endoprostheses |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5833463A (en) * | 1996-12-09 | 1998-11-10 | Hurson; Steven M. | Titanium surface treated dental screw for attaching a prosthetic component to an implant |
DE20020649U1 (de) | 2000-12-06 | 2002-04-11 | stryker Trauma GmbH, 24232 Schönkirchen | Vorrichtung für den chirurgischen oder therapeutischen Gebrauch, insbesondere Implantate und chirurgische Instrumente sowie deren Zubehör |
DE10241137B4 (de) * | 2002-09-03 | 2008-05-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Metallisierung von Kunststoffen |
DE10243132B4 (de) | 2002-09-17 | 2006-09-14 | Biocer Entwicklungs Gmbh | Antiinfektiöse, biokompatible Titanoxid-Beschichtungen für Implantate sowie Verfahren zu deren Herstellung |
US7488343B2 (en) * | 2003-09-16 | 2009-02-10 | Boston Scientific Scimed, Inc. | Medical devices |
US20060229715A1 (en) * | 2005-03-29 | 2006-10-12 | Sdgi Holdings, Inc. | Implants incorporating nanotubes and methods for producing the same |
EP1879522A2 (en) * | 2005-04-28 | 2008-01-23 | The Regents of The University of California | Compositions comprising nanostructures for cell, tissue and artificial organ growth, and methods for making and using same |
CN100430099C (zh) * | 2005-12-23 | 2008-11-05 | 中国科学院金属研究所 | 一种钛或钛合金表面生物活性涂层及其制备方法 |
US9095391B2 (en) * | 2007-06-11 | 2015-08-04 | Aeolin Llc | Osseointegration and biointegration coatings for bone screw implants |
-
2009
- 2009-01-05 EP EP09100006A patent/EP2204199B1/de active Active
- 2009-01-05 AT AT09100006T patent/ATE530205T1/de active
- 2009-01-05 ES ES09100006T patent/ES2376539T3/es active Active
-
2010
- 2010-01-04 AU AU2010203260A patent/AU2010203260B9/en not_active Ceased
- 2010-01-04 WO PCT/EP2010/050010 patent/WO2010076338A1/de active Application Filing
- 2010-01-04 CN CN201080003993.8A patent/CN102271721B/zh active Active
- 2010-01-04 JP JP2011544053A patent/JP5647145B2/ja not_active Expired - Fee Related
- 2010-01-04 US US13/130,431 patent/US8828552B2/en active Active
- 2010-01-04 CA CA2748760A patent/CA2748760C/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2009A (en) * | 1841-03-18 | Improvement in machines for boring war-rockets | ||
JPH06125979A (ja) * | 1992-03-31 | 1994-05-10 | Nisshin Steel Co Ltd | インプラント用金属焼結体及びその製造方法 |
JPH08289927A (ja) * | 1995-04-21 | 1996-11-05 | Nikon Corp | 骨内インプラント及びその製造方法 |
JP2005287985A (ja) * | 2004-04-05 | 2005-10-20 | Gha:Kk | 炎症/臭い抑制部材及びその製造方法並びにこれを用いた義体及びギブス |
WO2007144667A2 (en) * | 2006-06-12 | 2007-12-21 | Accentus Plc | Metal implants |
WO2008091835A2 (en) * | 2007-01-26 | 2008-07-31 | Boston Scientific Limited | Implantable medical endoprostheses |
Also Published As
Publication number | Publication date |
---|---|
AU2010203260B2 (en) | 2013-10-17 |
EP2204199A1 (de) | 2010-07-07 |
US20120024712A1 (en) | 2012-02-02 |
CA2748760C (en) | 2015-07-21 |
CA2748760A1 (en) | 2010-07-08 |
AU2010203260A1 (en) | 2011-07-14 |
US8828552B2 (en) | 2014-09-09 |
AU2010203260B9 (en) | 2013-10-31 |
CN102271721A (zh) | 2011-12-07 |
ES2376539T3 (es) | 2012-03-14 |
EP2204199B1 (de) | 2011-10-26 |
WO2010076338A1 (de) | 2010-07-08 |
CN102271721B (zh) | 2014-12-10 |
JP5647145B2 (ja) | 2014-12-24 |
ATE530205T1 (de) | 2011-11-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5647145B2 (ja) | インプラント上の抗感染性コーティングの製造方法 | |
CN103110981B (zh) | 一种抗菌、活性氧化钛纳米管阵列复合涂层材料的制备 | |
CN103088348B (zh) | 钛表面多孔结构层低弹性模量生物活性陶瓷膜的制备方法 | |
CN101570874B (zh) | 原位生成含TiO2/HA/CaCO3梯度膜层的方法 | |
JP2012514483A5 (ja) | ||
CN101575726B (zh) | 含氟羟基磷灰石梯度生物活性膜层的制备方法 | |
CN105903076A (zh) | 一种牙科种植体及其复合表面的制备方法 | |
CN109706450B (zh) | 一种钛基表面纳米分级结构智能化抑菌生物涂层的制备方法 | |
CN106835130B (zh) | 一种以镁/镁合金为基体的多涂层复合材料及其制备方法 | |
CN105274603A (zh) | 镁或镁合金表面含碳纳米管的复合改性涂层及其制备方法 | |
CN100430099C (zh) | 一种钛或钛合金表面生物活性涂层及其制备方法 | |
WO2011093414A1 (ja) | 金属酸化物、金属材料、生体親和材料、および金属酸化物の製造方法 | |
Kang et al. | Evaluation of antibacterial property and biocompatibility of Cu doped TiO2 coated implant prepared by micro-arc oxidation | |
CN107998445A (zh) | 一种表面修饰多孔钽生物材料及其制备方法 | |
CN101491692A (zh) | 一种钛酸钙纳米管阵列生物活性涂层的制备方法 | |
CN110393821B (zh) | 多孔氧化锌和氧化钽涂层共修饰的人工植入体及其制备方法 | |
CN102389588B (zh) | 一种用于生物植入的镁或镁合金材料及其制备方法 | |
CN102181904A (zh) | 一种钛表面活化处理的方法 | |
JP6588816B2 (ja) | 塩素発生用電極 | |
Luo et al. | Fabrication, properties and biological activity of a titanium surface modified with zinc via plasma electrolytic oxidation | |
CN110904490A (zh) | 一种羧基化纤维素纳米纤维水凝胶的制备方法 | |
CN114164475B (zh) | 镁或镁合金表面电化学处理的方法 | |
CN113969421B (zh) | 一种借助电化学在钛钽合金表面构建多孔钽的方法 | |
CN109161955A (zh) | 一种医用镁合金表面羟基磷灰石和氧化石墨烯复合生物涂层的电沉积制备方法 | |
KR20220125395A (ko) | 플라즈마 전해산화 방법 및 그 방법을 위한 전해액 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120829 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20120829 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140114 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140404 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20141104 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20141106 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5647145 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |