CA2748760A1 - Method for producing an anti-infective coating on implants - Google Patents
Method for producing an anti-infective coating on implants Download PDFInfo
- Publication number
- CA2748760A1 CA2748760A1 CA2748760A CA2748760A CA2748760A1 CA 2748760 A1 CA2748760 A1 CA 2748760A1 CA 2748760 A CA2748760 A CA 2748760A CA 2748760 A CA2748760 A CA 2748760A CA 2748760 A1 CA2748760 A1 CA 2748760A1
- Authority
- CA
- Canada
- Prior art keywords
- oxide layer
- implants
- metal
- titanium
- infective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
The invention relates to a method for producing an anti-infective coating on implants that contain titanium or are composed of titanium. The aim of the invention is to provide a coating method with which it is possible, for implants made of titanium or that contain titanium, to combine the optimization of the mechanical properties achieved with the anodic oxidation type II
with the optimization of the anti-infective properties. According to the invention, the implants are anodically oxidized in an alkali-ne solution, then metal having anti-infective properties is electrodeposited on said surface, and afterwards the oxide layer containing metal is solidified.
with the optimization of the anti-infective properties. According to the invention, the implants are anodically oxidized in an alkali-ne solution, then metal having anti-infective properties is electrodeposited on said surface, and afterwards the oxide layer containing metal is solidified.
Description
Method for producing an anti-infective coating on implants Description [0001] The invention relates to a method for producing an anti-infective coating on implants, that contain titanium or are composed of titanium.
State of the art [0002] From DE 10243132 B4 is known to provide implants made of titanium or titanium alloys with a titanium oxide coating, in which metal ions such as silver and copper are homogeneously distributed, by using a sol-gel method. For the mechanical stabilization and densification of said coating a heat treatment is applied after drying. By means of heating to about 500 C a ceramization of the coating takes place. For the implants the heat treatment has the disadvantage that it results in a loss of strength. Therefore, it is not suitable for implants which must have high fatigue strength.
State of the art [0002] From DE 10243132 B4 is known to provide implants made of titanium or titanium alloys with a titanium oxide coating, in which metal ions such as silver and copper are homogeneously distributed, by using a sol-gel method. For the mechanical stabilization and densification of said coating a heat treatment is applied after drying. By means of heating to about 500 C a ceramization of the coating takes place. For the implants the heat treatment has the disadvantage that it results in a loss of strength. Therefore, it is not suitable for implants which must have high fatigue strength.
[0003] It is known that an anodic oxidation type II of titanium results in a greater hardness and higher fatigue strength. In DE 20020649 U1 this coating is also described as an anti-infective coating because of its smooth surface, besides silver and copper. However, it is not possible to produce a sufficiently adherent coating of silver or copper on an anodic oxidation type II coating.
Disclosure of the invention [0004] The invention is based on the object to provide a coating method by means of which it is possible for implants made of titanium or which contain titanium to combine the optimization of the mechanical properties achieved by the anodic oxidation type II with the optimization of the anti-infective properties.
Disclosure of the invention [0004] The invention is based on the object to provide a coating method by means of which it is possible for implants made of titanium or which contain titanium to combine the optimization of the mechanical properties achieved by the anodic oxidation type II with the optimization of the anti-infective properties.
[0005] This object is solved in that the implants are oxidized anodically in an alkaline solution, then metal having anti-infective properties is electrodeposited on the surface, and afterwards the metal-containing oxide layer is solidified.
[0006] In the anodic oxidation a conversion layer containing oxygen and optionally other atoms, and a porous titanium oxide layer having a sufficient conductivity, which is electrically conductive in the pores, such that metal can be electrode posited in it, can be formed. By blasting, e.g. with glass beads, the metal-containing oxide layer is solidified, and more weakly bound oxide and metal particles are removed or more intensely connected with each other and with the surface of the implant.
[0007] There is provided a method for the combined modification of implants containing titanium or consisting of titanium, wherein in the first step a porous oxide layer is formed by anodic spark discharge in strongly alkaline electrolytes, in the second step the galvanic charge of metal into the porous layer takes place, and in a third step the metal-enriched oxide layer is solidified by blasting and can be more or less eliminated by removing more weakly bound oxide or metal particles or by connecting said particles more intensely with each other and the implant.
[0008] The elution of the metal starting under physiological conditions may be adjusted in regard to its concentration by variation of the mean metal coating of the implant surface, so that an antimicrobial or rather antibacterial action without any substantial damage to the cells of the surrounding body tissue is achieved. In particular copper, silver and zinc are suitable as metals. In the case of the metal copper there can be additionally expected an improved blood flow of the newly formed body tissue due to the catalytic effect on the angiogenesis. The thickness of the metal-containing layer is advantageously 8 -15 m, preferably 10 m.
[0009] Solidifying the metal-containing oxide layer is advantageously carried out by blasting with glass beads.
Brief Description of the Figures [0010] Figure 1 Partially copper-coated TiAIV-surface [0011] Figure 2 Development of cell number of staphylococcus aureus ATCC
25923 after culture on a partially copper-coated TiAIV-surface Carrying out the invention [0012] In the following the invention is explained in more detail by way of an example.
Brief Description of the Figures [0010] Figure 1 Partially copper-coated TiAIV-surface [0011] Figure 2 Development of cell number of staphylococcus aureus ATCC
25923 after culture on a partially copper-coated TiAIV-surface Carrying out the invention [0012] In the following the invention is explained in more detail by way of an example.
[0013] Example 1: Coating [0014] TiAI6V4-samples are coated with a porous oxide layer according to the principle of anodic spark discharge in a strongly alkaline electrolyte. For that, 50 g NaOH are dissolved in 500 ml of distilled water. In the solution heated to 40 C, the anodic spark oxidation of the titanium sample is conducted by slowly increasing the voltage to 40 volt. Then, copper from a saturated copper acetate solution is added into the porous oxide layer by means of cathode deposition. The resulting copper-enriched oxide layer is partially removed by glass bead blasting, and the copper contained in it is almost completely incorporated in an island-like manner into the sample surface (Figure 1).
[0015] Example 2: Description of the antibacterial mechanism [0016] For testing the antibacterial action investigations were performed on clinically relevant bacterial strain staphylococcus aureus ATCC25923. For that, TiAIV-cylinders with a diameter of 8 mm and a length of 20 mm were coated with copper according to Example 1, and outsourced at 37 C for various times in 6 ml of a PBS buffer solution which had been vaccinated with 150 l of bacterial suspension. Thereafter, the concentration of the living bacteria on the cylinders and in the solution was determined by plating on agar culture media and by outsourcing (48 h) at 30 C.
Even after only 4 hours no living bacteria were found on the cylinders and after 24 hours only very few living bacteria were found in the buffer solution (Figure 2).
Even after only 4 hours no living bacteria were found on the cylinders and after 24 hours only very few living bacteria were found in the buffer solution (Figure 2).
Claims (6)
1. A method for producing an anti-infective coating on implants, which contain titanium or are composed of titanium, characterized by the following steps - formation of a porous oxide layer by anodic oxidation in an alkaline solution, such that the conductivity in the pores enables an electrodeposition, - electrodeposition of a metal with anti-infective properties, - solidification of said metal-containing oxide layer by blasting.
2. The method according to claim 1, characterized in that the electrolyte for said anodic oxidation contains sodium hydroxide solution.
3. Method according to claim 1 or 2, characterized in that said electrolyte contains soda water glass.
4. The method according to claim 1, characterized in that copper, silver and/or zinc are added into said porous oxide layer.
5. The method according to claim 1, characterized in that said metal-containing oxide layer is blasted with glass beads.
6. The method according to claim 1, characterized in that the thickness of said oxide layer is 8 - 15 µm.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09100006A EP2204199B1 (en) | 2009-01-05 | 2009-01-05 | Method for manufacturing an anti-infection coating on implants |
EP09100006.7 | 2009-01-05 | ||
PCT/EP2010/050010 WO2010076338A1 (en) | 2009-01-05 | 2010-01-04 | Method for producing an anti-infective coating on implants |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2748760A1 true CA2748760A1 (en) | 2010-07-08 |
CA2748760C CA2748760C (en) | 2015-07-21 |
Family
ID=40677900
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2748760A Expired - Fee Related CA2748760C (en) | 2009-01-05 | 2010-01-04 | Method for producing an anti-infective coating on implants |
Country Status (9)
Country | Link |
---|---|
US (1) | US8828552B2 (en) |
EP (1) | EP2204199B1 (en) |
JP (1) | JP5647145B2 (en) |
CN (1) | CN102271721B (en) |
AT (1) | ATE530205T1 (en) |
AU (1) | AU2010203260B9 (en) |
CA (1) | CA2748760C (en) |
ES (1) | ES2376539T3 (en) |
WO (1) | WO2010076338A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2693978A2 (en) * | 2011-04-01 | 2014-02-12 | Washington State University Researchfoundation | Materials with modified surfaces and methods of manufacturing |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102009023459B4 (en) * | 2009-06-02 | 2017-08-31 | Aap Implantate Ag | Osteosynthesis with nanosilver |
DE102009046743A1 (en) * | 2009-11-17 | 2011-05-19 | Primus Oberflächentechnik GmbH & Co. KG | Method for producing antimicrobial surface of an object, comprises producing a porous surface, storing an antimicrobial effective first and second metal in the resulting pore, closing the pores, and removing parts of the surface |
TWI400100B (en) * | 2010-09-29 | 2013-07-01 | Metal Ind Res & Dev Ct | Medical equipment and manufacturing methods thereof |
KR101278740B1 (en) | 2012-02-17 | 2013-06-25 | 영남대학교 산학협력단 | Implants comprising water glass coating layer and preparation method thereof |
DE102012210804B4 (en) * | 2012-06-26 | 2014-07-10 | Innovent E.V. | A method for producing a bactericidal layer on a base made of titanium or a titanium-based alloy |
US9717238B2 (en) | 2014-05-18 | 2017-08-01 | Carlos M. Lacerda | Antibacterial composition, antibacterial cases and accessories for handheld electronics, and method of making antibacterial cases for handheld electronics |
WO2016160983A1 (en) | 2015-03-30 | 2016-10-06 | C. R. Bard, Inc. | Application of antimicrobial agents to medical devices |
US10064273B2 (en) | 2015-10-20 | 2018-08-28 | MR Label Company | Antimicrobial copper sheet overlays and related methods for making and using |
AU2017211214A1 (en) | 2016-01-25 | 2018-07-12 | Smith & Nephew, Inc. | Orthopaedic implant |
PL232314B1 (en) * | 2016-05-06 | 2019-06-28 | Gen Electric | Fluid-flow machine equipped with the clearance adjustment system |
CN106420119B (en) * | 2016-11-29 | 2017-10-31 | 淮阴工学院 | A kind of manufacturing process of high antibiotic property titanium alloy artificial hip joint |
WO2018187758A1 (en) * | 2017-04-07 | 2018-10-11 | The Board Of Trustees Of The University Of Illinois | Directed plasma nanosynthesis (dpns) methods, uses and systems |
CN107893252A (en) * | 2017-11-22 | 2018-04-10 | 四川大学 | Titanium base material surface has in-situ preparation method and its application of the bioactivity coatings of soft tissue seal |
WO2019199292A1 (en) | 2018-04-11 | 2019-10-17 | Hewlett-Packard Development Company, L.P. | Device housings with glass beads |
DE102019108327A1 (en) | 2019-03-29 | 2020-10-01 | Karl Leibinger Medizintechnik Gmbh & Co. Kg | Implant with intrinsic antimicrobial activity and process for its manufacture |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2009A (en) * | 1841-03-18 | Improvement in machines for boring war-rockets | ||
JP2740071B2 (en) * | 1992-03-31 | 1998-04-15 | 日新製鋼株式会社 | Method for producing sintered metal body for implant |
JPH08289927A (en) * | 1995-04-21 | 1996-11-05 | Nikon Corp | Inplant in bone and its manufacture |
US5833463A (en) * | 1996-12-09 | 1998-11-10 | Hurson; Steven M. | Titanium surface treated dental screw for attaching a prosthetic component to an implant |
DE20020649U1 (en) | 2000-12-06 | 2002-04-11 | Stryker Trauma Gmbh | Device for surgical or therapeutic use, in particular implants and surgical instruments and their accessories |
DE10241137B4 (en) * | 2002-09-03 | 2008-05-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Process for the metallization of plastics |
DE10243132B4 (en) * | 2002-09-17 | 2006-09-14 | Biocer Entwicklungs Gmbh | Anti-infective, biocompatible titanium oxide coatings for implants and methods of making them |
US7488343B2 (en) * | 2003-09-16 | 2009-02-10 | Boston Scientific Scimed, Inc. | Medical devices |
JP2005287985A (en) * | 2004-04-05 | 2005-10-20 | Gha:Kk | Inflammation/odor suppressing member, manufacturing method thereof, and prosthesis and cast using it |
US20060229715A1 (en) * | 2005-03-29 | 2006-10-12 | Sdgi Holdings, Inc. | Implants incorporating nanotubes and methods for producing the same |
EP1879522A2 (en) * | 2005-04-28 | 2008-01-23 | The Regents of The University of California | Compositions comprising nanostructures for cell, tissue and artificial organ growth, and methods for making and using same |
CN100430099C (en) * | 2005-12-23 | 2008-11-05 | 中国科学院金属研究所 | Bioactive coating on surface of Titanium or titanium alloy and its preparing method |
JP5268894B2 (en) | 2006-06-12 | 2013-08-21 | アクセンタス ピーエルシー | Metal implant |
CA2675633A1 (en) * | 2007-01-26 | 2008-07-31 | Boston Scientific Limited | Implantable medical endoprostheses |
US9095391B2 (en) * | 2007-06-11 | 2015-08-04 | Aeolin Llc | Osseointegration and biointegration coatings for bone screw implants |
-
2009
- 2009-01-05 EP EP09100006A patent/EP2204199B1/en active Active
- 2009-01-05 AT AT09100006T patent/ATE530205T1/en active
- 2009-01-05 ES ES09100006T patent/ES2376539T3/en active Active
-
2010
- 2010-01-04 JP JP2011544053A patent/JP5647145B2/en not_active Expired - Fee Related
- 2010-01-04 CN CN201080003993.8A patent/CN102271721B/en active Active
- 2010-01-04 WO PCT/EP2010/050010 patent/WO2010076338A1/en active Application Filing
- 2010-01-04 CA CA2748760A patent/CA2748760C/en not_active Expired - Fee Related
- 2010-01-04 US US13/130,431 patent/US8828552B2/en active Active
- 2010-01-04 AU AU2010203260A patent/AU2010203260B9/en not_active Ceased
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2693978A2 (en) * | 2011-04-01 | 2014-02-12 | Washington State University Researchfoundation | Materials with modified surfaces and methods of manufacturing |
EP2693978A4 (en) * | 2011-04-01 | 2014-11-05 | Univ Washington State Res Fdn | Materials with modified surfaces and methods of manufacturing |
US9440002B2 (en) | 2011-04-01 | 2016-09-13 | Washington State University | Materials with modified surfaces and methods of manufacturing |
Also Published As
Publication number | Publication date |
---|---|
ATE530205T1 (en) | 2011-11-15 |
CA2748760C (en) | 2015-07-21 |
WO2010076338A1 (en) | 2010-07-08 |
EP2204199B1 (en) | 2011-10-26 |
AU2010203260B2 (en) | 2013-10-17 |
AU2010203260A1 (en) | 2011-07-14 |
JP2012514483A (en) | 2012-06-28 |
CN102271721A (en) | 2011-12-07 |
JP5647145B2 (en) | 2014-12-24 |
US8828552B2 (en) | 2014-09-09 |
CN102271721B (en) | 2014-12-10 |
EP2204199A1 (en) | 2010-07-07 |
US20120024712A1 (en) | 2012-02-02 |
ES2376539T3 (en) | 2012-03-14 |
AU2010203260B9 (en) | 2013-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2748760C (en) | Method for producing an anti-infective coating on implants | |
CN103110981B (en) | Method for preparing antibacterial active titanium oxide nanotube array composite coating material | |
Yao et al. | Antibacterial activity and inflammation inhibition of ZnO nanoparticles embedded TiO2 nanotubes | |
Zhang et al. | Synthesis and antibacterial property of Ag-containing TiO2 coatings by combining magnetron sputtering with micro-arc oxidation | |
JPWO2007108450A1 (en) | Degradation time control method for medical biodegradable device | |
CN104562145B (en) | A kind of method that combined oxidation prepares bioceramic film | |
JP4457230B2 (en) | Surface treatment method for medical implant material | |
CN104674215A (en) | Preparation method of nano silver particle loaded antimicrobial titanium dioxide coating | |
US20230293765A1 (en) | Medical material for promoting cell growth and inhibiting bacterial adhesion and machining method thereof | |
US9353453B2 (en) | Metal substrate modified with silicon based biomimetic treatment having antibacterial property for the osteointegration thereof | |
Jamali et al. | Effects of co-incorporated ternary elements on biocorrosion stability, antibacterial efficacy, and cytotoxicity of plasma electrolytic oxidized titanium for implant dentistry | |
CN110331426B (en) | Magnesium alloy silver-containing micro-arc oxidation electrolyte, biological ceramic film and preparation method | |
CN106902384B (en) | Method for preparing bone-like structure film on titanium surface | |
Lan et al. | Evaluation of antibacterial property and biocompatibility of Cu doped TiO2 coated implant prepared by micro-arc oxidation | |
CN112843330B (en) | Composite material for implant and method for producing same | |
TWI532883B (en) | Titanium or titanium alloy having antibacterial surface and method for manufacturing the same | |
CN101491692A (en) | Preparation method of calcium titanate nano-tube array biological coatings | |
CN112121227A (en) | Preparation method of medical composite coating of strontium titanate/strontium hydroxyapatite on titanium metal surface | |
CN1490058A (en) | Preparing method for biological active peptide and titanium alloy hard tissue implanting material | |
CN110448798B (en) | Graphene artificial cochlea electrode and manufacturing method thereof | |
CN111850553A (en) | Preparation method of silver-loaded tannin nano apatite composite coating on surface of titanium-based nanotube | |
CN102011164A (en) | Electrochemical method for preparing chitosan tetracycline coating on surface of metallic implant | |
CN102389588A (en) | Magnesium or magnesium alloy material used for biological implantation and preparation method thereof | |
US9492588B2 (en) | Antibacterial and osteoinductive implant coating, method of producing such coating, and implant coated with same | |
CN103120805A (en) | Bioactive surface coating of biomedical degradable magnesium alloy and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20210104 |