CN106420119B - A kind of manufacturing process of high antibiotic property titanium alloy artificial hip joint - Google Patents

A kind of manufacturing process of high antibiotic property titanium alloy artificial hip joint Download PDF

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Publication number
CN106420119B
CN106420119B CN201611068317.4A CN201611068317A CN106420119B CN 106420119 B CN106420119 B CN 106420119B CN 201611068317 A CN201611068317 A CN 201611068317A CN 106420119 B CN106420119 B CN 106420119B
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hip joint
artificial hip
titanium alloy
titanium
manufacturing process
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CN106420119A (en
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夏木建
刘爱辉
林岳宾
李年莲
丁红燕
陈中
鱼银虎
叶玮
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Jinhu comprehensive inspection and Testing Center
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Huaiyin Institute of Technology
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/20—Direct sintering or melting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/30—Process control
    • B22F10/36—Process control of energy beam parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/30—Process control
    • B22F10/36—Process control of energy beam parameters
    • B22F10/366—Scanning parameters, e.g. hatch distance or scanning strategy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/60—Treatment of workpieces or articles after build-up
    • B22F10/62—Treatment of workpieces or articles after build-up by chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/60—Treatment of workpieces or articles after build-up
    • B22F10/64—Treatment of workpieces or articles after build-up by thermal means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/60—Treatment of workpieces or articles after build-up
    • B22F10/68—Cleaning or washing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C8/00—Solid state diffusion of only non-metal elements into metallic material surfaces; Chemical surface treatment of metallic material by reaction of the surface with a reactive gas, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals
    • C23C8/06—Solid state diffusion of only non-metal elements into metallic material surfaces; Chemical surface treatment of metallic material by reaction of the surface with a reactive gas, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using gases
    • C23C8/36—Solid state diffusion of only non-metal elements into metallic material surfaces; Chemical surface treatment of metallic material by reaction of the surface with a reactive gas, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using gases using ionised gases, e.g. ionitriding
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
    • C25D11/02—Anodisation
    • C25D11/26—Anodisation of refractory metals or alloys based thereon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30948—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using computerized tomography, i.e. CT scans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A61F2310/00407—Coating made of titanium or of Ti-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A61F2310/00419—Other metals
    • A61F2310/00467—Coating made of copper or Cu-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
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    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/25—Process efficiency

Abstract

The present invention discloses a kind of manufacturing process of high antibiotic property titanium alloy artificial hip joint, comprises the following steps that：（1）The CT scan of patient's hip joint data model, hierarchy slicing processing；（2）The design and preparation of CTB alloy powder；（3）The laser 3D printing shaping of titanium alloy artificial hip joint；（4）Titanium alloy artificial hip joint with wiener yardstick loose structure surface is constructed by anodizing technology original position；（5）Its anti-microbial property is further lifted using plasma high-temperature ammonolysis technique；（6）Cleaning, sterilizing, dry post package.It is of the invention fully to combine laser 3D printing technology, surface modification technology and the excellent anti-microbial property of copper, realize the manufacture integrated with high antibacterial functions of artificial hip joint labyrinth.Manufacturing process of the invention is simple, performance is distinguished, it is adaptable to the personalized customization of high antibiotic property titanium alloy artificial hip joint, with good social effect and economic benefit.

Description

A kind of manufacturing process of high antibiotic property titanium alloy artificial hip joint
Technical field
It is particularly a kind of to be based on laser 3D the present invention relates to a kind of manufacturing process of high antibiotic property titanium alloy artificial hip joint The manufacturing process of the high antibiotic property Ti-Cu artificial hip joints of printing, belongs to medical bone implanting appliance manufacture field.
Background technology
In recent years, because of the continuous aggravation and the increase of unexpected injury of population in the world aging degree, the need of artificial hip joint The amount of asking is increased sharply.Titanium and its alloy are because modulus of elasticity is low, specific strength is high, corrosion resistance and the excellent feature of biocompatibility and selected extensively It is used as manufacturing artificial joint material, the pure titanium of such as Clinical practice, Ti6Al4V（TC4）.At this stage, used on domestic market Artificial hip joint implant majority is using casting and machining group technology processing and manufacturing.However, because of human hip macroscopic view Structure is more complicated, and Conventional processing methods machining accuracy is low, easily cause that individual suitability is poor after implantation human body, postoperative event trace with Stress is abnormal, the point-face way of contact abrasion of implant and the risk increase of Aseptic Loosening is ultimately resulted in, so as to cause postoperative The increase of skeleton animation rate.
With developing rapidly for laser technology and intelligent Manufacturing Technology, the laser metal 3D printing based on increasing material manufacturing principle It is many that technology is widely used in biologic medical, Aero-Space and automobile making etc. because of the advantages of forming speed is fast, precision is high Field.Particularly can disposably formingspace is complicated, thin-wall member, manufacturing procedure is greatly decreased, shortens the process-cycle. CN104498940A complies fully with the standard of medical titanium alloy joint prosthesis using increasing material manufacturing direct forming microstructure and property The titanium alloy artificial joint of propertyization customization.
However, titanium alloy artificial joint is often more sensitive to bacterial adhesion, it is easier to trigger bacterium infection.In order to assign Material surface anti-microbial property, needs the mechanism according to bacterium infection, targetedly carries out the structure of antimicrobial surface, assigns it Anti-microbial property, to reduce the adhesion and breeding of bacterium, and then the generation avoided infection.Strengthen titanium alloy artificial joint antibacterial energy Power, reduction surface bacteria infect the extensive concern by domestic and foreign scholars.CN103110981A is used to be induced by ultraviolet lighting Doping deposition antibacterial silver particles, the oxygen of bioactivity is prepared on medical titanium alloy surface inside active oxidation titanium nano-tube array Change titanium nano-tube array antimicrobial coating.CN101766840A is obtained using centrifugal load technology on titanium alloy artificial joint surface The sodium titanate nanotube array layer of silver is mixed, to lift its anti-microbial property.CN102676985A is using glow ion percolation technology in doctor Antibacterial, which is prepared, with titanium alloy surface oozes layers of copper.Wu Haibo etc. is thin in medical pure titanium surface sputtering Ti-Cu using magnetron sputtering technique Film, with reference to differential arc oxidation and ion at high temperature Nitriding Technology, prepares Cu-TiO2With Ti-Cu-N antimicrobial coatings.But it is loaded with antimicrobial coating Titanium alloy artificial joint implantation human body after, load with corrosion friction reciprocation under, antimicrobial coating and substrate combinating strength It is low, be also easy to produce stress deformation and crackle, or even fracture failure, and then reduce its service life.What is more important, fracture it is anti- Bacterium coating easy damaged implant surrounding tissue, increases patient suffering.Therefore, a kind of high antibiotic property, the titanium of service life length are developed Alloy joint prosthesis is particularly important, and can significantly reduce the slight illness and second operation expense of patient, with good society's effect Should be with economic benefit.
The content of the invention
Goal of the invention：To overcome the deficiencies in the prior art, the present invention provides a kind of high antibiotic property titanium alloy artificial The manufacturing process of hip joint, this method is based on the excellent clinical anti-microbial property of copper, using advanced laser 3D printing technology The baroque titanium alloy artificial hip joint of precision form is carried out, is modified by surfaces such as anodic oxidation and plasma high-temperature ammonolysis The Ti-Cu-N surfaces of wiener yardstick loose structure are constructed in technology original position, finally obtain high antibiotic property titanium alloy artificial hip joint, with Further lift its military service performance requirement under human body complex physiologic environment.
Technical scheme：To solve above-mentioned technical barrier, the present invention can be realized using following technical scheme：A kind of high antibacterial The manufacturing process of property titanium alloy artificial hip joint, it is characterised in that：High antibacterial is shaped using laser 3D printing, surface modification technology Property titanium alloy artificial hip joint, specifically includes following steps：
Step（1）：Patient's hip joint is scanned by CT machines, 3D data models are obtained, and model is carried out at hierarchy slicing Reason；
Step（2）：After Titanium Powder, copper powder are weighed in proportion, Titanium Powder and copper powder are entered using high energy ball mill Row ball milling mixing, obtains titanium-copper alloy powder；
Step（3）：By step（1）The middle hip joint 3D data models through processing import laser 3D printing system, to step （2）Described titanium-copper alloy powder carries out 3D printing precision form hip joint；
Step（4）：By step（3）In titanium-copper alloy hip joint formed thereby carry out anodized in the electrolytic solution, Construct the titanium alloy artificial hip joint on the loose structure surface with wiener yardstick；
Step（5）：By step（4）Described in the hip joint on loose structure surface of wiener yardstick be placed in plasma high temperature In nitriding furnace, high-temperature ammonolysis processing is carried out, the high antibacterial artificial hip joints of Ti-Cu-N are obtained；
Step（6）：By step（5）Described in high antibacterial artificial hip joint cleaned, sterilized and done in clean room After dry processing, it is packaged and saves backup.
Further, above-mentioned steps（1）In, the thickness that the model carries out hierarchy slicing processing is 30 μm.
Further, above-mentioned steps（2）In, the titanium alloy is medical pure titanium, Ti6Al4V, Ti6Al7Nb, Ti-Zr conjunction One kind in gold, average grain diameter is 30 μm, and the copper powder average grain diameter is 50 nm.
Further, above-mentioned steps（2）In, the Titanium Powder, copper powder ratio are：Copper powder weight ratio is 1~5 %, titanium Weight alloy ratio is 99~95 %.
Further, above-mentioned steps（2）In, the process conditions of the high energy ball mill are：Rotating speed is 400 rpm, ball milling Time is 2 h, and the argon gas that purity is 99.99% is protective atmosphere.
Further, above-mentioned steps（3）In, the laser 3D printing forming parameters are set as：Laser power is 100 ~250 W, sweep speed is 200~2000 mm/s, and sweep span is 60 μm, and laser facula is 70 μm.
Further, above-mentioned steps（4）In, the volume fraction composition of the electrolyte is：The % of hydrofluoric acid 5, ethylene glycol 92 %, the % of hydrogen peroxide 3.
Further, above-mentioned steps（4）In, the anode oxidation process condition is：Operating voltage 8V, the A of operating current 1, Oxidization time is 5~20 min.
Further, above-mentioned steps（5）In, the high-temperature ammonolysis treatment process condition is：Nitrogen gas purity is 99.9 %, nitrogen Throughput is 50 ml/min, and 550 °C of high-temperature ammonolysis temperature, the high-temperature ammonolysis time is 4 h.
At this stage, plurality titanium alloy artificial hip joint realizes that its manufacture shapes by traditional casting+machining. Because of the special space structure of human hip, cause manufacturing process complex, the production cycle is higher with cost.However, traditional Process does not account for the personalized difference of different patient's knee joint shapes and size, will directly contribute artificial hip joint with not Best match can not be carried out with patient, causes its individual suitability poor, postoperative joint prosthesis event trace is abnormal with stress, finally Cause the risk of implant corrosive wear, sterile loosening to increase severely, and then cause postoperative patient to bear painful ratio and revision rate Increase.
Antimicrobial coating prepared by prior art mainly by numerous surface modifying methods, is loaded with titanium alloy surface deposition and contained Cu the or Ag coatings of antibiotic property, improve the anti-microbial property of titanium alloy artificial hip joint.But above-mentioned antimicrobial coating exists with matrix Composition, the difference of structure organization, bond strength are weak, load and corrode under friction reciprocal effect effect in human body, in antimicrobial coating Portion is also easy to produce stress, causes its underbead crack to germinate, finally causes antimicrobial coating fracture failure, bring even more serious to patient Pain and financial burden.In the manufacturing process of the present invention, based on the good antibacterial functions of copper, beaten by advanced laser 3D Manufacturing technology is printed, the precision form of the Ti-Cu artificial hip joints of space three-dimensional structure complex is realized；Utilize anodic oxidation skill Art constructs micro/nano-scale loose structure in above-mentioned titanium alloy artificial hip joint surface in situ, further promotes bone and its cells planting Enter body surface face depends on growth, strengthens its bond strength, while the loose structure of growth in situ provides for the release of copper ion Passage；In addition using plasma high-temperature ammonolysis technology, constructs above-mentioned micro/nano-scale loose structure through high-temperature ammonolysis and handles shape Into Ti-Cu-N layers, its anti-microbial property is further lifted.The present invention is innovatively by advanced manufacturing technology, simple and feasible table Surface modification process, and the excellent antibacterial functions of copper are merged, shape high anti-microbial property, the titanium alloy artificial hip of service life is closed Section, not only shortens the production cycle, saves production cost, also improve the combination property of titanium alloy artificial hip joint, realize it Customization of individual character, meets the use demand of different patients, is that patient brings Gospel.
In summary, compared with prior art, the present invention has advantages below and beneficial effect：
1st, the present invention is based on the excellent anti-microbial property of copper, using advanced laser 3D printing manufacturing technology formingspace The complicated Ti-Cu alloy antibacterial artificial hip joints of three-dimensional structure, realize the integral forming of structure and function, with shaping essence The characteristics such as height, efficiency height are spent, the hip joint performance requirement needed for different patient's displacements is met.
2nd, micro-nano is constructed in the titanium alloy artificial hip joint surface in situ of shaping using the anodizing technology of technical maturity Yardstick loose structure, promotes body bone tissue cell in the growth of depending on of implant surfaces, promotes bone tissue and artificial hip joint Embedded connection, its bond strength is significantly increased, while the loose structure of growth in situ carries for the release of antibiotic property copper ion Passage is supplied.
3rd, the present invention utilizes using plasma high-temperature ammonolysis technology, will construct micro/nano-scale loose structure through high-temperature ammonolysis Processing forms the Ti-Cu-N antibiotic layers with rock-steady structure tissue, further lifts its anti-microbial property and military service performance.
4th, antibiotic property copper is dispersed in titanium alloy artificial hip joint in the present invention, makes it that integrally there is antibacterial Function, through going through abrasion after implantation human body, still with lasting antibacterial functions.
Brief description of the drawings
Fig. 1 is high antibiotic property Ti-Cu-N artificial hip joint surface topography maps made from embodiment 1；
Fig. 2 is high antibiotic property Ti-Cu-N artificial hip joint surface topography maps made from embodiment 3；
Fig. 3 is high antibiotic property Ti-Cu-N artificial hip joint surface topography maps made from embodiment 5.
Embodiment
With reference to specific embodiment, the present invention is described in detail.Following examples are only used for clearly illustrating Technical scheme, and can not be limited the scope of the invention with this.
Embodiment 1
The present invention provides a kind of manufacturing process of high antibiotic property titanium alloy artificial hip joint, utilizes laser 3D printing, surface Modified technique shapes high antibiotic property Ti-Cu-N artificial hip joints, specifically includes following steps：
Step（1）：Patient's hip joint is scanned by CT machines, 3D data models are obtained, and model is carried out at hierarchy slicing Reason, thickness is 30 μm；
Step（2）：It is 50 nm copper powders by quality point by the % of medical pure titanium valve 99 that average grain diameter is 30 μm, average grain diameter After number is weighed for 1 %, it is 99.99% for 400 rpm, in purity in rotating speed to Titanium Powder and copper powder to use high energy ball mill The h of ball milling mixing 2 is carried out under argon gas protective condition, titanium-copper alloy powder is obtained；
Step（3）：By step（1）Described in hip joint 3D data models through processing import laser 3D printing system, and Select suitable laser forming technological parameter：Laser power is 100 W, and sweep speed is 200 mm/s, and sweep span is 60 μ M, laser facula is 70 μm, to step（2）Described titanium-copper alloy powder carries out 3D printing precision form hip joint；
Step（4）：By step（3）In titanium-copper alloy hip joint formed thereby in volume fraction be the % of hydrofluoric acid 5, second two Anodized is carried out in the % of alcohol 92, the % of hydrogen peroxide 3 electrolyte, wherein, operating voltage 8V, the A of operating current 1, during oxidation Between be 10 min, construct the titanium alloy artificial hip joint with micro/nano-scale loose structure surface；
Step（5）：By step（4）Described in the hip joint on micro/nano-scale loose structure surface be placed in plasma high temperature nitrogen Change in stove, adjust suitable technological parameter and carry out high-temperature ammonolysis processing, wherein, nitrogen gas purity is 99.9 %, and nitrogen flow is 50 Ml/min, 550 °C of high-temperature ammonolysis temperature, the high-temperature ammonolysis time is 4 h, obtains the high antibacterial artificial hip joints of Ti-Cu-N；
Step（6）：By step（5）Described in high antibacterial artificial hip joint cleaned, sterilized and done in clean room After dry processing, it is packaged and saves backup.
Anti-microbial Performance Tests are carried out to the high antibiotic property Ti-Cu-N artificial hip joints that the present embodiment shapes, selection is golden yellow Staphylococcus is subjects, according to QB/T2591-2003《Antibiotic plastic-Anti-microbial Performance Tests method and antibacterial effect》Detection The anti-microbial property of artificial hip joint, as a result shows, after testing one day, bacteriostasis rate of the titanium alloy hip joint to staphylococcus aureus 95 % are reached, bacteriostasis rate still reaches 94 % after testing 4 days, with good lasting bacteriostasis property.
Embodiment 2
Present embodiment is as different from Example 1 in step（2）Middle titanium alloy is set as Ti6Al4V powder, its quality point Number is 97 %, and copper powder mass fraction is 3 %；In step（3）Middle is 175 W, other and the phase of embodiment 1 by laser power settings Together.
Anti-microbial Performance Tests are carried out to the high antibiotic property Ti-Cu-N artificial hip joints that the present embodiment shapes, selection is golden yellow Staphylococcus is subjects, according to QB/T2591-2003《Antibiotic plastic-Anti-microbial Performance Tests method and antibacterial effect》Detection The anti-microbial property of artificial hip joint, as a result shows, after testing one day, bacteriostasis rate of the titanium alloy hip joint to staphylococcus aureus 97 % are reached, bacteriostasis rate still reaches 96 % after testing 4 days, with good lasting bacteriostasis property.
Embodiment 3
Present embodiment is as different from Example 2 in step（3）It is middle that laser scanning speed is set to 1100 mm/s； In step（3）Middle that the anodized time is set into 12 min, other are same as Example 2.
Anti-microbial Performance Tests are carried out to the high antibiotic property Ti-Cu-N artificial hip joints that the present embodiment shapes, selection is golden yellow Staphylococcus is subjects, according to QB/T2591-2003《Antibiotic plastic-Anti-microbial Performance Tests method and antibacterial effect》Detection The anti-microbial property of artificial hip joint, as a result shows, after testing one day, bacteriostasis rate of the titanium alloy hip joint to staphylococcus aureus 96 % are reached, bacteriostasis rate still reaches 95 % after testing 4 days, with good lasting bacteriostasis property.
Embodiment 4
Present embodiment is as different from Example 3 in step（2）Middle titanium alloy is set as Ti6Al7Nb alloyed powders, its matter Amount fraction is 95 %, and copper powder mass fraction is 5 %；In step（3）It is middle that laser scanning speed is set as 2000 mm/s, other It is same as Example 3.
Anti-microbial Performance Tests are carried out to the high antibiotic property Ti-Cu-N artificial hip joints that the present embodiment shapes, selection is golden yellow Staphylococcus is subjects, according to QB/T2591-2003《Antibiotic plastic-Anti-microbial Performance Tests method and antibacterial effect》Detection The anti-microbial property of artificial hip joint, as a result shows, after testing one day, bacteriostasis rate of the titanium alloy hip joint to staphylococcus aureus 98 % are reached, bacteriostasis rate still reaches 97 % after testing 4 days, with good lasting bacteriostasis property.
Embodiment 5
Present embodiment is as different from Example 4 in step（3）Middle laser power settings are 250 W；In step（4）In It is 20 min by anodized set of time, other are same as Example 4.
Anti-microbial Performance Tests are carried out to the high antibiotic property Ti-Cu-N artificial hip joints that the present embodiment shapes, selection is golden yellow Staphylococcus is subjects, according to QB/T2591-2003《Antibiotic plastic-Anti-microbial Performance Tests method and antibacterial effect》Detection The anti-microbial property of artificial hip joint, as a result shows, after testing one day, bacteriostasis rate of the titanium alloy hip joint to staphylococcus aureus 99 % are reached, bacteriostasis rate still reaches 98 % after testing 4 days, with good lasting bacteriostasis property.
The present invention is shaped high based on the good anti-microbial property of copper ion using laser 3D printing technology, surface modifying method The Ti-Cu-N artificial hip joints of anti-microbial property, and its anti-microbial property is measured and evaluated, to prove that the technology of the present invention is excellent Gesture.It can be found that the Ti-Cu-N artificial hip joints prepared under differing formed technique are respectively provided with higher antibacterial after experiment 1 day Performance, meanwhile, after testing 4 days, good anti-microbial property is still kept, the Ti-Cu- for the anti-microbial property that the present invention shapes is further illustrated N artificial hip joints have excellent durable antibiotic function.
Under the conditions of technological parameter after optimization, the excellent Ti-Cu-N artificial hip joints of antibiotic property can be obtained, it is improved Antibacterial functions, meanwhile, the persistence of antibacterial functions is also enhanced, its performance requirement under the complicated physiological condition of human body is met, Extend its service life.Process is simple, with low cost simultaneously, and this is domestic for high antibiotic property titanium alloy artificial hip joint Solid foundation has been established in change.
Foregoing description is only embodiments of the invention, is easy to the understanding of the R＆D personnel of the technical field and makes With invention.Therefore, the present invention is not limited to above-described embodiment, and those skilled in the art do not depart from this according to the announcement of the present invention Improvement, modification and the equivalent replacement that invention category is made should be all included within protection scope of the present invention.

Claims (7)

1. a kind of manufacturing process of high antibiotic property titanium alloy artificial hip joint, it is characterised in that：Changed using laser 3D printing, surface The property high antibiotic property titanium alloy artificial hip joint of process forming, specifically includes following steps：
Step（1）：Patient's hip joint is scanned by CT machines, 3D data models are obtained, and hierarchy slicing processing is carried out to model；
Step（2）：After Titanium Powder, copper powder are weighed in proportion, ball is carried out to Titanium Powder and copper powder using high energy ball mill Mill mixing, obtains titanium-copper alloy powder；
Step（3）：By step（1）The middle hip joint 3D data models through processing import laser 3D printing system, to step（2）Institute The titanium stated-copper alloy powder carries out 3D printing precision form hip joint；
Step（4）：By step（3）In titanium-copper alloy hip joint formed thereby carry out anodized in the electrolytic solution, construct The titanium alloy artificial hip joint on the loose structure surface with wiener yardstick, the volume fraction of the electrolyte, which is constituted, is：Hydrogen fluorine Acid 5 %, the % of ethylene glycol 92, the % of hydrogen peroxide 3；
Step（5）：By step（4）Described in the hip joint on loose structure surface of wiener yardstick be placed in plasma high-temperature ammonolysis In stove, high-temperature ammonolysis processing is carried out, the high antibacterial artificial hip joints of Ti-Cu-N, the high-temperature ammonolysis treatment process condition is obtained For：Nitrogen gas purity is 99.9 %, and nitrogen flow is 50 ml/min, and 550 °C of high-temperature ammonolysis temperature, the high-temperature ammonolysis time is 4 h；
Step（6）：By step（5）Described in high antibacterial artificial hip joint cleaned in clean room, sterilize and drying at After reason, it is packaged and saves backup.
2. a kind of manufacturing process of high antibiotic property titanium alloy artificial hip joint according to claim 1, it is characterised in that： Above-mentioned steps（1）In, the thickness that the model carries out hierarchy slicing processing is 30 μm.
3. a kind of manufacturing process of high antibiotic property titanium alloy artificial hip joint according to claim 1, it is characterised in that： Above-mentioned steps（2）In, the titanium alloy is one kind in medical pure titanium, Ti6Al4V, Ti6Al7Nb, Ti-Zr alloy, average grain Footpath is 30 μm, and the copper powder average grain diameter is 50 nm.
4. a kind of manufacturing process of high antibiotic property titanium alloy artificial hip joint according to claim 1, it is characterised in that： Above-mentioned steps（2）In, the Titanium Powder, copper powder ratio are：Copper powder weight ratio is 1~5 %, and titanium alloy weight ratio is 99~95 %。
5. a kind of manufacturing process of high antibiotic property titanium alloy artificial hip joint according to claim 1, it is characterised in that： Above-mentioned steps（2）In, the process conditions of the high energy ball mill are：Rotating speed is 400 rpm, and Ball-milling Time is 2 h, and purity is 99.99% argon gas is protective atmosphere.
6. a kind of manufacturing process of high antibiotic property titanium alloy artificial hip joint according to claim 1, it is characterised in that： Above-mentioned steps（3）In, the laser 3D printing forming parameters are set as：Laser power is 100~250 W, sweep speed For 200~2000 mm/s, sweep span is 60 μm, and laser facula is 70 μm.
7. a kind of manufacturing process of high antibiotic property titanium alloy artificial hip joint according to claim 1, it is characterised in that： Above-mentioned steps（4）In, the anode oxidation process condition is：Operating voltage 8V, the A of operating current 1, oxidization time are 5~20 min。
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018157071A1 (en) * 2017-02-24 2018-08-30 Ohio State Innovation Foundation Titanium alloys for additive manufacturing
CN106926461A (en) * 2017-04-27 2017-07-07 重庆英泰帝克科技有限公司 A kind of aseptic printing production lines of medical 3D
CN107225242A (en) * 2017-05-19 2017-10-03 淮阴工学院 The method and implant of 3D printing in-situ authigenic multi-stage nano ceramic phase reinforcing titanium alloy bone implant
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CN110373709A (en) * 2018-04-13 2019-10-25 中国科学院金属研究所 A kind of CTB alloy surface modifying method
EP3666932A1 (en) * 2018-12-14 2020-06-17 Nano-implant Sp. z o.o. Production method of a personalised, biocompatible and bioactive orthopaedic implant
CN112386745A (en) * 2019-08-13 2021-02-23 中国科学院福建物质结构研究所 Artificial joint material, artificial joint prosthesis containing same and application thereof
CN111134905B (en) * 2019-12-30 2021-12-07 云南省第一人民医院 Artificial hip joint and preparation method thereof
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CN113172237A (en) * 2021-04-26 2021-07-27 广州柔岩科技有限公司 Antibacterial material additive, preparation method and application thereof
CN113732307B (en) * 2021-07-20 2023-03-24 暨南大学 Method for manufacturing medical metal by mixing selective laser melting and laser surface texture
CN115519135A (en) * 2022-10-18 2022-12-27 沈阳海纳鑫科技有限公司 Antibacterial titanium alloy and preparation method and application thereof

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101991876A (en) * 2009-08-14 2011-03-30 机械科学研究总院先进制造技术研究中心 Manufacture method of prosthesis with self-antibacterial action
CN102212717A (en) * 2011-05-24 2011-10-12 佳木斯大学 Copper-bearing antibacterial titanium alloy and preparation method thereof
CN103695706A (en) * 2013-10-18 2014-04-02 中国医科大学 Titanium copper alloy nanotube for surgery fixing apparatus and preparation method thereof
KR20140090962A (en) * 2013-01-10 2014-07-18 한양대학교 에리카산학협력단 Manufacturing method for antibacterial titanium implant and antibacterial titanium implant by thesame
TW201503877A (en) * 2013-07-22 2015-02-01 Univ Nat Central Porous amorphous alloy artificial joint and manufacturing method thereof
CN104498940A (en) * 2014-12-03 2015-04-08 中国航空工业集团公司北京航空材料研究院 Method of manufacturing titanium-alloy artificial joints by virtue of laser material increase
CN104529474A (en) * 2014-12-01 2015-04-22 青岛麦特瑞欧新材料技术有限公司 Copper-doped inorganic nano-grade composite material used in 3D printing, and preparation method thereof
CN105803254A (en) * 2016-03-29 2016-07-27 昆明理工大学 Preparation method for blocky titanium-copper-calcium biological materials
CN105838926A (en) * 2016-03-28 2016-08-10 中国科学院金属研究所 3D printing based method for preparing antibacterial cobalt based dental crown
CN105903967A (en) * 2016-05-23 2016-08-31 苏州云植医学技术有限公司 Method of nanometer zirconia toughened titanium alloy orthopedics implant based on 3D printing

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE530205T1 (en) * 2009-01-05 2011-11-15 Dot Gmbh METHOD FOR PRODUCING AN ANTINIFECTIVE COATING ON IMPLANTS

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101991876A (en) * 2009-08-14 2011-03-30 机械科学研究总院先进制造技术研究中心 Manufacture method of prosthesis with self-antibacterial action
CN102212717A (en) * 2011-05-24 2011-10-12 佳木斯大学 Copper-bearing antibacterial titanium alloy and preparation method thereof
KR20140090962A (en) * 2013-01-10 2014-07-18 한양대학교 에리카산학협력단 Manufacturing method for antibacterial titanium implant and antibacterial titanium implant by thesame
TW201503877A (en) * 2013-07-22 2015-02-01 Univ Nat Central Porous amorphous alloy artificial joint and manufacturing method thereof
CN103695706A (en) * 2013-10-18 2014-04-02 中国医科大学 Titanium copper alloy nanotube for surgery fixing apparatus and preparation method thereof
CN104529474A (en) * 2014-12-01 2015-04-22 青岛麦特瑞欧新材料技术有限公司 Copper-doped inorganic nano-grade composite material used in 3D printing, and preparation method thereof
CN104498940A (en) * 2014-12-03 2015-04-08 中国航空工业集团公司北京航空材料研究院 Method of manufacturing titanium-alloy artificial joints by virtue of laser material increase
CN105838926A (en) * 2016-03-28 2016-08-10 中国科学院金属研究所 3D printing based method for preparing antibacterial cobalt based dental crown
CN105803254A (en) * 2016-03-29 2016-07-27 昆明理工大学 Preparation method for blocky titanium-copper-calcium biological materials
CN105903967A (en) * 2016-05-23 2016-08-31 苏州云植医学技术有限公司 Method of nanometer zirconia toughened titanium alloy orthopedics implant based on 3D printing

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Ti6Al4V表面Ti_Cu_N纳米薄膜溅射沉积及其抗菌性能研究;张慧桥，黄晓波，田伟红，郭杨阳，李娟，范爱兰，唐宾;《表面技术》;20140831;第43卷(第4期);全文 *
含铜量不同的钛合金生物相容性的研究;郑兰兰，马志玲，刘杰;《黑龙江医药科学》;20151031;第38卷(第5期);全文 *

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