CN105903967A - Method of nanometer zirconia toughened titanium alloy orthopedics implant based on 3D printing - Google Patents

Method of nanometer zirconia toughened titanium alloy orthopedics implant based on 3D printing Download PDF

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CN105903967A
CN105903967A CN201610343076.3A CN201610343076A CN105903967A CN 105903967 A CN105903967 A CN 105903967A CN 201610343076 A CN201610343076 A CN 201610343076A CN 105903967 A CN105903967 A CN 105903967A
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powder
titanium alloy
implant
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沈理达
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Suzhou Cloudmplant Medical Technology Co Ltd
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Suzhou Cloudmplant Medical Technology Co Ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/10—Sintering only
    • B22F3/11—Making porous workpieces or articles
    • B22F3/1103—Making porous workpieces or articles with particular physical characteristics
    • B22F3/1118—Making porous workpieces or articles with particular physical characteristics comprising internal reinforcements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
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    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/20—Direct sintering or melting
    • B22F10/28—Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/427—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/30—Process control
    • B22F10/34—Process control of powder characteristics, e.g. density, oxidation or flowability
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C14/00—Alloys based on titanium
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C32/00—Non-ferrous alloys containing at least 5% by weight but less than 50% by weight of oxides, carbides, borides, nitrides, silicides or other metal compounds, e.g. oxynitrides, sulfides, whether added as such or formed in situ
    • C22C32/001—Non-ferrous alloys containing at least 5% by weight but less than 50% by weight of oxides, carbides, borides, nitrides, silicides or other metal compounds, e.g. oxynitrides, sulfides, whether added as such or formed in situ with only oxides
    • C22C32/0015—Non-ferrous alloys containing at least 5% by weight but less than 50% by weight of oxides, carbides, borides, nitrides, silicides or other metal compounds, e.g. oxynitrides, sulfides, whether added as such or formed in situ with only oxides with only single oxides as main non-metallic constituents
    • C22C32/0031—Matrix based on refractory metals, W, Mo, Nb, Hf, Ta, Zr, Ti, V or alloys thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/30—Process control
    • B22F10/36—Process control of energy beam parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/30—Process control
    • B22F10/36—Process control of energy beam parameters
    • B22F10/366—Scanning parameters, e.g. hatch distance or scanning strategy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/25—Process efficiency

Abstract

The invention discloses a preparation method of a nanometer zirconia particle toughened biological titanium alloy porous artificial implant. The preparation method is characterized by comprising the following steps: (1) preparation of nanometer/micron mixed powder: nanometer zirconia powder with a mass fraction of 0.5-8% is weighed and added in remained micron-grade titanium alloy powder, and the two powder is uniformly mixed by using a mechanical mixing method, wherein the particle size of the titanium alloy powder is 1-50 microns, and the purity is not lower than 99%; the size of the zirconia powder is 10-100 nm; and zirconia contains a yttrium oxide stabilizing agent with 1-5% of the mass of the zirconia powder; and (2) a matched porous artificial implant model is designed according to different personal demands by using three-dimensional design software; the designed three-dimensional data model is introduced in a computer for layering and slicing to obtain profile information of each layer; the mechanically mixed powder is paved on a forming cylinder by using a powder paving device; and the area selective melting formation is performed by using laser or electronic beams. The implant has the characteristics of good toughness and high biological compatibility.

Description

Based on 3D The method of the nano zircite Strengthening and Toughening titanium alloy orthopedic implant printed
Technical field
The present invention relates to the preparation method of a kind of orthopaedics implant, the preparation method of a kind of orthopaedics implant having increasing action, a kind of method of nano zircite Strengthening and Toughening titanium alloy orthopedic implant printed based on 3D.
Background technology
Artificial implantation has reintegrated into society for the patient's situations of making the life better suffering from orthopaedic disease up to a million since coming out and provides guarantee.Artificial implantation must have good biocompatibility, suitable mechanical property and enough service life.But the Traditional Man implant manufacture method manufacturing cycle is long, it is impossible to carrying out personalized customization, its biocompatibility can not be met well with mechanical property.It is thus desirable to develop more particularly suitable artificial implantation material and preparation method.
Density is low, specific strength is high, the characteristic of good mechanical property owing to having for titanium alloy material, has the corrosion resistance of excellence and splendid biocompatibility simultaneously, is widely used in biologic medical field.But the artificial bone surgical implant strength and toughness prepared with titanium alloy material can not meet long-term (more than general ten years) well uses requirement, and its elastic modelling quantity does not also mate with human body, it is therefore necessary to improve the mechanical property of titanium alloy further.
Adding nano zirconia ceramic material is the effective way improving titanium alloy mechanical property.Owing in yittrium oxide PSZ powder, part crystal of zirconium oxide is tetragonal phase structure, have a kind of try hard to expand and become the spontaneous trend of monoclinic phase.The zirconium oxide of Tetragonal is in compressive stress state, and matrix prolongs granule line direction and is stressed.When External Force Acting, occur tetragonal phase zirconium oxide to be changed into the martensitic phase transformation of monoclinic phase, cause volumetric expansion, absorb energy, thus improve fracture toughness (transformation toughening).Creating part micro-crack during changing simultaneously, can absorb energy in crack propagation process, the stress reducing lead crack is concentrated, and also can play the effect (microcrack evolution equation) improving fracture toughness.Additionally, add the second phase zircite particle in titanium alloy substrate, this granule stops lateral cross section to be shunk when host material Tensile, will reach the cross-direction shrinkage identical with matrix, is necessary for increasing longitudinal tension stress, thus plays invigoration effect (dispersion-strengtherning).When only the diameter of zirconia dispersion particle is less than room temperature phase-change critical particle diameter (generally less than 1 μm), just can make titanium alloy-based internal storage phase change elastomeric strain energy, cause its toughness and intensity all to have raising in various degree.Therefore the titanium alloy material after adding nanometer zirconium oxide ceramic has more preferable strength and toughness.
Surface has the implantation of the artificial implantation of suitable microcellular structure, beneficially cell, the growth of tissue, the input of nutrition, the discharge etc. of metabolite, can improve the biocompatibility of artificial implantation.The artificial implantation of inner hole structure and skeleton have close elastic modelling quantity, can reduce stress shielding effect, prevent osteoporosis from causing second fracture.3D printing technique (selective laser fusing, electron beam selective melting etc.) is utilized to be capable of complex three-dimensional forms and micropore, the accurate control of inner hole structure, so that artificial implantation has more preferable biocompatibility and less stress shielding effect.
In sum, the activeness and quietness principle utilizing nano zircite can significantly improve the obdurability of biological titanium alloy porous artificial implantation, loose structure can reduce the elastic modelling quantity of artificial implantation, 3D printing technique can disclosure satisfy that the making requirement of implant inner hole structure and surface microporous structure, finally prepares the artificial implantation close with people's flexible bone modulus with high-strength tenacity.
Summary of the invention
It is an object of the invention to for existing titanium alloy orthopedic implant intensity the highest, the problem that subject range is little, the method inventing the nano zircite Strengthening and Toughening titanium alloy orthopedic implant printed based on 3D that a kind of intensity is high, biocompatibility is good.
The technical scheme is that
The preparation method of a kind of nano zircite granule Strengthening and Toughening biological titanium alloy porous artificial implantation, is characterized in that it comprises the following steps:
(1) preparation of Nano/micron mixed-powder: weigh in the micron order titanium alloy powder that the nano zirconium oxide powder that mass fraction is 0.5-8% joins surplus, utilizes the method for mechanical mixture to make two kinds of powder mix homogeneously；Wherein, the particle size of titanium alloy powder is 1-50 μm, and purity is not less than 99%；Zirconium oxide powder a size of 10-100nm, contains the stabilized with yttrium oxide agent of Zirconium oxide powder quality 1-5% in zirconium oxide；
(2) utilize the porous Artificial Intervention object model that Three-dimensional Design Software matches according to Different Individual Demand Design, the three-dimensional data model designed importing computer is carried out hierarchy slicing process, obtains the profile information of each layer；Utilize power spreading device to be layered on formation cylinder by the powder after mechanical mixture, spread powder thickness 30-50 μm, the method printed with 3D, carry out having regioselectivity fusing to shape with laser or electron beam, Single Slice Mode, successively superposition, realize part forming, prepare personalized customization porous orthopaedics implant.
The titanium alloy porous orthopaedics implant relative density utilizing 3D printing technique to prepare may be up to 99%, the labyrinth of band endoporus can be prepared, the elastic modelling quantity making porous orthopaedics implant is close with human body, thus reduce stress shielding effect, reduce and around implant, occur that bone resorption causes implant to loosen and the danger of fracture.
Utilize the toughened and strengthened mechanism of part nano zircite, nano zircite is added in titanium alloy powder, improve intensity and the toughness of porous orthopaedics implant.
The method of the present invention can be used for the knee joint in personalized customization orthopaedics implant, hip joint and spinal implant.
Specifically, the present invention includes:
(1) preparation of Nano/micron mixed-powder: weigh the nano yttrium oxide PSZ powder that mass fraction is 0.5-8% and join in biology titanium alloy powder, utilize the method for mechanical mixture to make two kinds of powder mix homogeneously.Wherein, the particle size of titanium alloy powder is 1-50 μm, and purity is not less than 99%；Yittrium oxide PSZ powder size is 10-100nm, stabilizer yittrium oxide (Y2O3) content is 1-5%, the two comprehensive purity is not less than 99.8%, and it is 1100 DEG C that monoclinic phase is changed into the temperature of Tetragonal, tetragonal phase converting be the temperature of Emission in Cubic be 1900 DEG C, fusing point is 2715 DEG C.
(2) design of personalized customization porous orthopaedics implant and preparation: the porous Artificial Intervention object model matched according to Different Individual Demand Design first with Three-dimensional Design Software, the three-dimensional data model designed importing computer is carried out hierarchy slicing process, obtains the profile information of each layer.
(3) utilize power spreading device to be layered on formation cylinder by the powder after mechanical mixture, spread powder thickness 30-50 μm, carry out having regioselectivity fusing to shape with laser or electron beam, Single Slice Mode, successively superposition, it is achieved part forming.Powder 3D for mixing prints, and needs, by technological parameters such as regulation power, scanning speed, scanning strategys, to carry out the optimization of technological parameter, prepare personalized customization porous orthopaedics implant.
(4) titanium alloy powder is melted by the method (selective laser fusing or electron beam selective melting) utilizing 3D to print, laser or electron beam produce the high temperature of more than 1800 DEG C, make monoclinic phase unstable in nano zircite granule in mixed-powder change into Tetragonal or Emission in Cubic, and stable zirconium oxide (generating solid solution or complex with stabilizer yittrium oxide) will not undergo phase transition.During by high temperature cooling to room temperature, the zirconium oxide undergone phase transition is converted into monoclinic phase by Tetragonal or Emission in Cubic again.So stabilizing zirconia realizes solution strengthening and dispersion-strengtherning, and the zirconium oxide undergone phase transition realizes transformation toughening and microcrack evolution equation.
(5) the obdurability performance test of orthopaedics implant: after post-treated for the implant sample that printed, carry out intensity detection with metal yield strength-testing machine, carries out impacting the detection of (fracture) toughness on shock machine.
Beneficial effects of the present invention:
(1) the titanium alloy artificial implant prepared by has good biocompatibility, owing to titanium alloy has suitable mechanical property and excellent corrosion resistance, can increase service life, reduce the misery of patient's second operation.
(2) utilizing nano zircite to improve intensity and the toughness of biological titanium alloy mutually as activeness and quietness, the transformation toughening mechanism of nano zircite, microcrack evolution equation mechanism and dispersion strengthening mechanism can significantly improve the mechanical property of biological titanium alloy.
(3) utilizing 3D printing technique, prepare the biological titanium alloy artificial implantation with surface porosity, the regeneration for osteocyte provides suitable microenvironment.
(4) utilize 3D printing technique, prepare the biological titanium alloy artificial implantation with inner hole structure, make implant close with people's flexible bone modulus, thus reduce stress shielding effect, prevent osteoporosis from causing second fracture.
(5) artificial implantation utilizing 3D printing technique to prepare can carry out personalized customization according to the different situations of user, meets different demands and the particular/special requirement of client, improves the matching of orthopaedics implant and patient, thus reaches the requirement of precisely medical treatment.
(6) one nano zircite (ZrO is related to2) granule Strengthening and Toughening biological titanium alloy material, use the method that 3D printing technique prepares porous artificial implantation, the method has that preparation technology is simple, technical parameter is easily controlled, easy to operate, properties of product are good, the feature such as with short production cycle, it is possible to meet the bone implant research of biologic medical field and the demand of application.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment one.
A kind of preparation method of nano zircite granule Strengthening and Toughening biological titanium alloy porous artificial implantation, it comprises the following steps:
(1) (stabilizer yttria levels is 2% to utilize the nano yttrium oxide PSZ powder that electronic balance precise quality is 2.5g, the i.e. weight of yittrium oxide is 0.05 gram) and titanium alloy powder TC4 that 47.5g particle size is 20-50 μm, two kinds of powder are used the method mix homogeneously of mechanical mixture, finally prepares zirconium oxide/titanium alloy TC 4 composite powder that zirconium oxide mass fraction is 5%.
(2) utilize Solidworks Three-dimensional Design Software that artificial implantation is carried out structure design, the three-dimensional data model designed importing computer is carried out hierarchy slicing process, then on the melting unit of selective laser, mixed-powder is layered on formation cylinder, spreads powder thickness 30-50 μm, carry out having regioselectivity fusing to shape with laser, Single Slice Mode, successively superposition, it is achieved part forming, finally gives designed artificial implantation.
(3) by after post-treated for the implant sample that printed, carry out intensity detection with metal yield strength-testing machine, shock machine is carried out impact the detection of (fracture) toughness.In preliminary experiment, compared with the intensity of general T C4, add 187MPa by the titanium composite material intensity of the Nano grade size zirconia particles strengthening that mass fraction is 5%；Compared with the intensity of porous TC4 of 75% porosity, the POROUS TITANIUM composite material strength with the Nano grade size zirconia particles strengthening that mass fraction is 5% of 75% porosity increases 46MPa.Add the intensity of artificial implantation of nano zircite and toughness to be all significantly improved than not adding zirconic artificial implantation.
Embodiment two.
A kind of preparation method of nano zircite granule Strengthening and Toughening biological titanium alloy porous artificial implantation, it comprises the following steps:
(1) (stabilizer yttria levels is 1% to utilize the nano yttrium oxide PSZ powder that electronic balance precise quality is 0.25g, the i.e. weight of yittrium oxide is 0.0025 gram) and titanium alloy powder TC4 that 49.75g particle size is 1-30 μm, two kinds of powder are used the method mix homogeneously of mechanical mixture, finally prepares zirconium oxide/titanium alloy TC 4 composite powder that zirconium oxide mass fraction is 0.5%.
(2) utilize Solidworks Three-dimensional Design Software that artificial implantation is carried out structure design, the three-dimensional data model designed importing computer is carried out hierarchy slicing process, then on the melting unit of selective laser, mixed-powder is layered on formation cylinder, spreads powder thickness 30-50 μm, carry out having regioselectivity fusing to shape with laser, Single Slice Mode, successively superposition, it is achieved part forming, finally gives designed artificial implantation.
(3) by after post-treated for the implant sample that printed, carry out intensity detection with metal yield strength-testing machine, shock machine is carried out impact the detection of (fracture) toughness.In preliminary experiment, compared with the intensity of general T C4, add 85MPa by the titanium composite material intensity of the Nano grade size zirconia particles strengthening that mass fraction is 0.5%；Compared with the intensity of porous TC4 of 75% porosity, the POROUS TITANIUM composite material strength with the Nano grade size zirconia particles strengthening that mass fraction is 0.5% of 75% porosity increases 30MPa.Add the intensity of artificial implantation of nano zircite and toughness to be all significantly improved than not adding zirconic artificial implantation.
Embodiment three.
A kind of preparation method of nano zircite granule Strengthening and Toughening biological titanium alloy porous artificial implantation, it comprises the following steps:
(1) (stabilizer yttria levels is 5% to utilize the nano yttrium oxide PSZ powder that electronic balance precise quality is 4g, the i.e. weight of yittrium oxide is 0.2 gram) and titanium alloy powder TC4 that 46g particle size is 30-50 μm, two kinds of powder are used the method mix homogeneously of mechanical mixture, finally prepares zirconium oxide/titanium alloy TC 4 composite powder that zirconium oxide mass fraction is 8%.
(2) utilize Solidworks Three-dimensional Design Software that artificial implantation is carried out structure design, the three-dimensional data model designed importing computer is carried out hierarchy slicing process, then on the melting unit of selective laser, mixed-powder is layered on formation cylinder, spreads powder thickness 30-50 μm, carry out having regioselectivity fusing to shape with laser, Single Slice Mode, successively superposition, it is achieved part forming, finally gives designed artificial implantation.
(3) by after post-treated for the implant sample that printed, carry out intensity detection with metal yield strength-testing machine, shock machine is carried out impact the detection of (fracture) toughness.In preliminary experiment, compared with the intensity of general T C4, add 162MPa by the titanium composite material intensity of the Nano grade size zirconia particles strengthening that mass fraction is 8%；Compared with the intensity of porous TC4 of 75% porosity, the POROUS TITANIUM composite material strength with the Nano grade size zirconia particles strengthening that mass fraction is 8% of 75% porosity increases 40MPa.Add the intensity of artificial implantation of nano zircite and toughness to be all significantly improved than not adding zirconic artificial implantation.
Part that the present invention does not relate to is the most same as the prior art maybe can use prior art to be realized.

Claims (4)

1. a preparation method for nano zircite granule Strengthening and Toughening biological titanium alloy porous artificial implantation, is characterized in that it comprises the following steps:
(1) preparation of Nano/micron mixed-powder: weigh in the micron order titanium alloy powder that the nano zirconium oxide powder that mass fraction is 0.5-8% joins surplus, utilizes the method for mechanical mixture to make two kinds of powder mix homogeneously；Wherein, the particle size of titanium alloy powder is 1-50 μm, and purity is not less than 99%；Zirconium oxide powder a size of 10-100nm, contains the stabilized with yttrium oxide agent of Zirconium oxide powder quality 1-5% in zirconium oxide；
(2) utilize the porous Artificial Intervention object model that Three-dimensional Design Software matches according to Different Individual Demand Design, the three-dimensional data model designed importing computer is carried out hierarchy slicing process, obtains the profile information of each layer；Utilize power spreading device to be layered on formation cylinder by the powder after mechanical mixture, spread powder thickness 30-50 μm, the method printed with 3D, carry out having regioselectivity fusing to shape with laser or electron beam, Single Slice Mode, successively superposition, realize part forming, prepare personalized customization porous orthopaedics implant.
Method the most according to claim 1, it is characterized in that: the titanium alloy porous orthopaedics implant relative density utilizing 3D printing technique to prepare may be up to 99%, the labyrinth of band endoporus can be prepared, the elastic modelling quantity making porous orthopaedics implant is close with human body, thus reduce stress shielding effect, reduce and around implant, occur that bone resorption causes implant to loosen and the danger of fracture.
Method the most according to claim 1, it is characterised in that: utilize the toughened and strengthened mechanism of part nano zircite, nano zircite is added in titanium alloy powder, improve intensity and the toughness of porous orthopaedics implant.
4. the method described in claim 1, is characterized in that the knee joint in personalized customization orthopaedics implant, hip joint and spinal implant.
CN201610343076.3A 2016-05-23 2016-05-23 Method of nanometer zirconia toughened titanium alloy orthopedics implant based on 3D printing Pending CN105903967A (en)

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Cited By (10)

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CN106420119A (en) * 2016-11-29 2017-02-22 淮阴工学院 Method for forming high-anti-bacterial-performance titanium-alloy artificial hip joint
CN107029284A (en) * 2017-06-03 2017-08-11 张文平 A kind of artificial joint material
CN107225242A (en) * 2017-05-19 2017-10-03 淮阴工学院 The method and implant of 3D printing in-situ authigenic multi-stage nano ceramic phase reinforcing titanium alloy bone implant
CN107469142A (en) * 2017-08-23 2017-12-15 杨蕾 A kind of antibacterial modified nano composite material for promoting osteogenic growth and preparation method thereof
WO2018100251A1 (en) * 2016-11-30 2018-06-07 Abdelmadjid Djemai Titanium-zirconium alloy and method for the production thereof by means of additive manufacturing
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CN113061779A (en) * 2021-03-17 2021-07-02 东北大学 Additive manufacturing method of nanoparticle reinforced titanium-based composite material based on selective electron beam melting
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