CN101773413A - Preparation method of titanium dental implant - Google Patents
Preparation method of titanium dental implant Download PDFInfo
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- CN101773413A CN101773413A CN200910010049A CN200910010049A CN101773413A CN 101773413 A CN101773413 A CN 101773413A CN 200910010049 A CN200910010049 A CN 200910010049A CN 200910010049 A CN200910010049 A CN 200910010049A CN 101773413 A CN101773413 A CN 101773413A
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Abstract
The invention discloses a preparation method of a titanium dental implant, which includes the following steps: arranging the dental implant to be in spiral shape, increasing the initial contact area of the implant, improving the initial stability of the implant, increasing the surface area of the implant and improving the stress distribution at the bone interface; obtaining a rough surface through abrasive blasting; designing a porous structure on the surface of the implant through a laser etching method; preparing a porous TiO2 oxide film on the surface of the implant through an anodic oxidation method, wherein the oxide film has a rough surface and has round pits in different sizes at local parts; treating the anodized titanium surface through alkali liquor to form a titanium gel layer rich in Ti-OH groups which induce the production of calcium phosphate crystal nucleus to form an osteoid apatite layer. The invention processes the medical pure titanium to be in spiral shape and modifies the surface of the implant through a series of methods of abrasive blasting, laser etching and anodic oxidation so as to enhance the bonding strength of the implant and the bone and to improve the success rate of the repair of the implant.
Description
Technical field
The present invention relates to a kind of preparation method of bio-medical metal implant material, particularly relate to a kind of preparation method of novel titanium dental implant, belong to A61C8/00 (2006.01) the I technical field in the International Patent Classification (IPC).
Background technology
The tooth implant of metal material is widely used in the plantation after the anodontia, the tooth implant operation can successful key be implantation body implant behind the dental bed dental bed bone can be apace to the implant surface growth and with surperficial strong bonded.
Originally the planting material of Cai Yonging is Co-Cr alloy, corundum aluminium oxide, signle crystal alumina etc.But the biocompatibility deficiency of Co-Cr alloy is corrosive, and its mechanical property of corundum aluminium oxide can not meet the demands, easily brittle failure.The titanium and the alloy that have the title of biological metal since the later stage in last century become a kind of material of more and more paying attention to gradually in the artificial tooth reparation.Become and be used for existing a kind of economy and succedaneum good biocompatibility that can pluck with the fixed denture alloy, the applied research development in stomatology is very rapid.
Clinically the dentistry embedded material of Shi Yonging not only need and contact bone between stable interface and the mechanical property that is complementary are arranged, and the elastic modelling quantity of material is also identical with osseous tissue with toughness.If the elastic modelling quantity of embedded material is too high, will cause that material internal produces bigger stress concentration and causes the material fracture.In addition, the existence of biomaterial loose structure can improve the interfacial effect between embedded material and the host bone.If the soft or hard tissue of near interface can both be grown in the hole, thereby make fibrous tissue and the freshman bone tissue's formation bonding state that interweaves.Like this, it can not only promote the interface to carry out normal metabolic, and has greatly improved the bond strength between timbering material and the osseous tissue.Studies show that, when the aperture of porous embedded material during at 15～40m, can the grow into inside of implant of fibrous tissue; When the aperture was 40～100m, the bone sample of non-mineral can be grown into; The aperture is when 150m, for growing into of osseous tissue provides ideal place.Therefore, microcellular structure is one of focus of mouth cavity planting body biomaterial research in recent years to the Bioabsorbable of biomaterial.For example, publication number is " a kind of method at the fluorine-containing multistage pore space structure of pure-titanium tooth implantation surface preparation " that the application for a patent for invention of CN1985774 provides, it carries out sandblast with pure titanium implant, after the surface modifications such as corrosion of sulphuric acid hydrochloric acid mixed solution burn into Fluohydric acid. nitric acid mixed liquor and immersion sodium fluoride, implant surface can form the pattern of the multistage pore space structure of one deck.Publication number is " in the method for pure-titanium tooth implantation surface preparation biologically active loose structure " that the application for a patent for invention of CN1817319 provides, after it at first carries out surface modifications such as sandblast, dual acid treatment, hydrogen peroxide and heat treatment with pure titanium implant, implant surface can form the pattern of the multistage pore space structure of one deck, the TiO on surface
2Layer is the anatase phase structure.And publication number is " a kind of construction method of dental implant biological activity surface " that the application for a patent for invention of CN101292907 provides, it is characterized in that utilizing earlier sandblast technology, differential arc oxidation-electrophoretic techniques makes up the three-dimensional pore space layer that one deck is made up of titanium oxide support and apatite on pure titanium surface, back selection and bone growth and development and somatomedin fiber adhesion albumen (Fn) of regenerating relevant and bone morphogenetic protein(BMP) (BMP), design according to the organizational project biological support, make the bioactive molecule deposition of itself and titanyl laminar surface generation chemisorbed and solidify in the microenvironment of three-dimensional pore space layer, thereby make implant surface induce and to regulate and control skeletonization and participate in the bone matrix mass exchange, possess with body and coordinate coexist necessary reconstruction and self-repairing capability for a long time, form physical-chemical-biological synosteosis that tooth implant and osseous tissue both sides participate in.
The preparation method to titanium dental implant that above technical scheme provides though can both shorten implantation body's one osseous tissue healing time, has obtained certain clinical efficacy, improves the clinical success rate of tooth implant.But its treatment process is complicated, inconvenient operation and induce the limited ability of bone, shortcoming such as the plantation growth time is long.
Summary of the invention
The objective of the invention is to solve the above-mentioned technical problem that prior art exists, improve, a kind of preparation method of novel titanium dental implant is provided by research.The preparation method of this titanium dental implant that the present invention provides is processed into threaded form with the medical pure titanium, and adopt serial of methods such as sandblast, laser ablation, anodic oxidation that implantation body is carried out surface modification, to improve the bond strength of implantation body and bone, improve the success rate that implantation body repairs.
The technical scheme that the present invention provides is: the preparation method of this titanium dental implant is characterized in including the following step:
1, tooth implant is designed to threaded form, increases the initial contact surface of implantation body, improve implantation body's initial stability, it is long-pending to increase implant surface, improves the stress distribution of bone interface;
2, adopt blasting method, obtain rough surface;
3, adopt the method for laser ablation, obtain loose structure at implant surfaces, the aperture is at 45～55 μ m;
4, adopt anodised method to prepare porous TiO at implant surfaces
2Oxide-film, TiO
2The oxide-film surface ratio is more coarse, and some circular pit not of uniform size appear in regional area, observes under the high power Electronic Speculum and finds this TiO
2Oxide-film has the microstructure of three-dimensional spherical pore, and the distribution in hole is more even, and pore-size distribution is between 100-200nm, and its anodised technical conditions are 1-3M H
2SO
4Carry out electrochemical treatments;
5, the titanium surface after the anodic oxidation is covered with the stable TiO of one deck
2Film is handled through alkali liquor, and implant surfaces forms the titanium gel layer, and the Ti-OH group that wherein is rich in induces the calcium phosphate nucleus to generate, and has formed bone like apatite layer, and the technical conditions that described alkali liquor is handled are that 3-5M NaOH handles for 50-100 ℃.
In the present invention because employing is designed to threaded form with tooth implant, increased the initial contact surface of implantation body, improve implantation body's initial stability, it is long-pending to increase implant surface, improve the stress distribution of bone interface, and adopt sandblast, laser boring and anode oxidation method to increase the implant surfaces roughness, obtain porous TiO
2Oxide-film adopts the method for alkali treatment to form the titanium gel layer at implant surfaces simultaneously, and the Ti-OH group that wherein is rich in can induce the calcium phosphate nucleus to generate, and has formed bone like apatite layer, thereby has improved the clinical success rate of tooth implant greatly.
Compared with prior art, the invention has the beneficial effects as follows:
1. the threaded form of implantation body can increase the initial contact surface of implantation body, improves implantation body's initial stability, and it is long-pending to increase implant surface, improves the stress distribution of bone interface.
2. adopt methods such as sandblast, laser to increase surface roughness, coarse surface energy promotes the propagation and the differentiation of osteocyte, increases osteoplastic speed of bone regeneration around implant and bone amount, thereby obtains higher synosteosis rate and bond strength.
3. titanium surface anode oxidation process is simple, easy to operate TiO
2The oxide-film surface ratio is more coarse, and the distribution in hole is more even, and loose structure helps the conveying of growing into of human body new bone tissue and nutrient substance.
4. oxide-film can prevent that titanium is subjected to further corrosion under physiological environment, avoids producing in vivo free titanium, can increase the chemical stability and the service life of implant.
5. can form one deck titanium gel on the titanium surface behind acid-alkali treatment, the Ti-OH group that wherein is rich in can induce the calcium phosphate nucleus to generate, thereby forms bone like apatite layer.
The specific embodiment
Earlier tooth implant is designed to threaded form, increases the initial contact surface of implantation body, improve implantation body's initial stability, it is long-pending to increase implant surface, improves the stress distribution of bone interface;
Adopt blasting method again, obtain rough surface;
Adopt the method for laser ablation again, obtain loose structure at implant surfaces, the aperture is at 50 ± 2 μ m;
Adopt anodised method to prepare porous TiO again at implant surfaces
2Oxide-film, TiO
2The oxide-film surface ratio is more coarse, and some circular pit not of uniform size appear in regional area, observes under the high power Electronic Speculum and finds this TiO
2Oxide-film has the microstructure of three-dimensional spherical pore, and the distribution in hole is more even, and pore-size distribution is between 140-160nm, and its anodised technical conditions are 1-3M H
2SO
4Carry out electrochemical treatments;
Titanium surface after the final anode oxidation is covered with the stable TiO of one deck
2Film is handled through alkali liquor, and implant surfaces forms the titanium gel layer, and the Ti-OH group that wherein is rich in induces the calcium phosphate nucleus to generate, and has formed bone like apatite layer, and wherein the technical conditions of alkali liquor processing are that 3-5M NaOH handles for 50-100 ℃.
The tooth implant kind of making has:
Tooth implant (narrow neck-1.8) specification: Z 35/18/33/8-12
Tooth implant (middle neck-1.8) specification:
B?48/18/33/8-14 B?48/18/41/6-14
B?48/18/48/6-14
Tooth implant (wide neck-1.8) specification: B 65/18/48/6-12
Tooth implant (middle neck-2.8) specification:
B?48/28/33/8-16 B?48/28/41/6-16
B?48/28/48/6-14
Tooth implant (wide neck-2.8) specification: B 65/28/48/6-12
Tooth implant (at once-1.8) specification: J 48/18/33/8-14
J?48/18/41/8-14 J?65/18/48/10-14。
Claims (1)
1. the preparation method of a titanium dental implant is characterized in that including the following step:
(1) titanium dental implant is designed to threaded form, to increase the initial contact surface of implantation body, improves implantation body's initial stability, it is long-pending to increase implant surface, improves the stress distribution of bone interface;
(2) adopt blasting method, obtain rough surface;
(3) method of employing laser ablation obtains loose structure on the titanium dental implant surface, and the aperture is at 45～55 μ m;
(4) adopt anodised method to go out porous TiO in the titanium dental implant surface preparation
2Oxide-film, TiO
2The oxide-film surface ratio is more coarse, and some circular pit not of uniform size appear in regional area, observes under the high power Electronic Speculum and finds this TiO
2Oxide-film has the microstructure of three-dimensional spherical pore, and pore-size distribution is between 100-200nm, and described anodised technical conditions are 1-3M H
2SO
4Carry out electrochemical treatments;
(5) the titanium dental implant surface after the anodic oxidation is covered with the stable TiO of one deck
2Film is handled through alkali liquor, and the titanium dental implant surface forms the titanium gel layer, and the Ti-OH group that wherein is rich in induces the calcium phosphate nucleus to generate, and has formed bone like apatite layer, and the technical conditions that described alkali liquor is handled are that 3-5M NaOH handles for 50-100 ℃.
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| CN200910010049A CN101773413A (en) | 2009-01-09 | 2009-01-09 | Preparation method of titanium dental implant |
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| CN200910010049A CN101773413A (en) | 2009-01-09 | 2009-01-09 | Preparation method of titanium dental implant |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038556A (en) * | 2010-12-15 | 2011-05-04 | 中国人民解放军第四军医大学 | Bone stretching dental implant |
| CN102345135A (en) * | 2011-09-22 | 2012-02-08 | 中国人民解放军第四军医大学 | Preparation method for silver-carrying dental implant |
| CN103536371A (en) * | 2013-10-21 | 2014-01-29 | 中国科学院上海硅酸盐研究所 | Dental implant and preparation method thereof |
| CN104921825A (en) * | 2015-05-26 | 2015-09-23 | 北京爱康宜诚医疗器材股份有限公司 | Surface treatment method of titanium implant |
| CN106086998A (en) * | 2016-08-18 | 2016-11-09 | 中国矿业大学 | A kind of electrophoretic deposition laser melting coating combined machining method of titanium porcelain artificial tooth |
| CN106149030A (en) * | 2016-08-18 | 2016-11-23 | 中国矿业大学 | A kind of electrophoretic deposition laser melting coating combined machining method of cobalt chromium porcelain artificial tooth |
| CN106245095A (en) * | 2016-07-29 | 2016-12-21 | 中国矿业大学 | A kind of electrophoretic deposition microwave sintering combined machining method of cobalt chromium porcelain artificial tooth |
| CN106283156A (en) * | 2016-07-29 | 2017-01-04 | 中国矿业大学 | A kind of electrophoretic deposition microwave sintering combined machining method of nickel chromium triangle porcelain artificial tooth |
| CN106535860A (en) * | 2014-04-11 | 2017-03-22 | 拜奥美特3i有限责任公司 | Implant with high primary stability and accelerated secondary stability |
| CN106902384A (en) * | 2017-03-07 | 2017-06-30 | 珠海乔丹科技股份有限公司 | A kind of method for preparing class bone structure film layer on titanium surface |
| CN107115566A (en) * | 2017-05-17 | 2017-09-01 | 南宁越洋科技有限公司 | The preparation method of titanium-based artificial tooth with PLLA/nHA surface active coatings |
| CN107736943A (en) * | 2017-10-24 | 2018-02-27 | 绍兴华晶科技有限公司 | Zirconium oxide implant surface multi-processing methods |
| WO2019037059A1 (en) * | 2017-08-25 | 2019-02-28 | 广州市健齿生物科技有限公司 | Dental implant having micro-pattern design on surface and construction method therefor |
| CN114344560A (en) * | 2021-12-30 | 2022-04-15 | 北京市春立正达医疗器械股份有限公司 | Roughening treatment technology for surface of bone implant prosthesis |
-
2009
- 2009-01-09 CN CN200910010049A patent/CN101773413A/en active Pending
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038556A (en) * | 2010-12-15 | 2011-05-04 | 中国人民解放军第四军医大学 | Bone stretching dental implant |
| CN102345135A (en) * | 2011-09-22 | 2012-02-08 | 中国人民解放军第四军医大学 | Preparation method for silver-carrying dental implant |
| CN102345135B (en) * | 2011-09-22 | 2013-05-15 | 中国人民解放军第四军医大学 | Preparation method for silver-carrying dental implant |
| CN103536371B (en) * | 2013-10-21 | 2016-03-23 | 中国科学院上海硅酸盐研究所 | A kind of dentistry implant and preparation method thereof |
| CN103536371A (en) * | 2013-10-21 | 2014-01-29 | 中国科学院上海硅酸盐研究所 | Dental implant and preparation method thereof |
| CN106535860A (en) * | 2014-04-11 | 2017-03-22 | 拜奥美特3i有限责任公司 | Implant with high primary stability and accelerated secondary stability |
| CN106535860B (en) * | 2014-04-11 | 2020-01-07 | 拜奥美特3i有限责任公司 | Implant with high primary stability and enhanced secondary stability |
| CN104921825A (en) * | 2015-05-26 | 2015-09-23 | 北京爱康宜诚医疗器材股份有限公司 | Surface treatment method of titanium implant |
| CN106283156B (en) * | 2016-07-29 | 2018-05-15 | 中国矿业大学 | A kind of electrophoretic deposition of nickel chromium triangle porcelain artificial tooth-microwave sintering combined machining method |
| CN106245095A (en) * | 2016-07-29 | 2016-12-21 | 中国矿业大学 | A kind of electrophoretic deposition microwave sintering combined machining method of cobalt chromium porcelain artificial tooth |
| CN106283156A (en) * | 2016-07-29 | 2017-01-04 | 中国矿业大学 | A kind of electrophoretic deposition microwave sintering combined machining method of nickel chromium triangle porcelain artificial tooth |
| CN106086998B (en) * | 2016-08-18 | 2018-08-24 | 中国矿业大学 | A kind of electrophoretic deposition of titanium porcelain artificial tooth-laser melting coating combined machining method |
| CN106086998A (en) * | 2016-08-18 | 2016-11-09 | 中国矿业大学 | A kind of electrophoretic deposition laser melting coating combined machining method of titanium porcelain artificial tooth |
| CN106149030B (en) * | 2016-08-18 | 2018-12-14 | 中国矿业大学 | A kind of electrophoretic deposition-laser melting coating combined machining method of cobalt chromium porcelain artificial tooth |
| CN106149030A (en) * | 2016-08-18 | 2016-11-23 | 中国矿业大学 | A kind of electrophoretic deposition laser melting coating combined machining method of cobalt chromium porcelain artificial tooth |
| CN106902384A (en) * | 2017-03-07 | 2017-06-30 | 珠海乔丹科技股份有限公司 | A kind of method for preparing class bone structure film layer on titanium surface |
| CN107115566A (en) * | 2017-05-17 | 2017-09-01 | 南宁越洋科技有限公司 | The preparation method of titanium-based artificial tooth with PLLA/nHA surface active coatings |
| CN107115566B (en) * | 2017-05-17 | 2020-01-31 | 南宁越洋科技有限公司 | Preparation method of titanium-based artificial tooth with PLLA/nHA surface active coating |
| WO2019037059A1 (en) * | 2017-08-25 | 2019-02-28 | 广州市健齿生物科技有限公司 | Dental implant having micro-pattern design on surface and construction method therefor |
| CN107736943A (en) * | 2017-10-24 | 2018-02-27 | 绍兴华晶科技有限公司 | Zirconium oxide implant surface multi-processing methods |
| CN114344560A (en) * | 2021-12-30 | 2022-04-15 | 北京市春立正达医疗器械股份有限公司 | Roughening treatment technology for surface of bone implant prosthesis |
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Application publication date: 20100714 |