CN107802886A - A kind of 3D printing titanium alloy artificial bone material and preparation method - Google Patents

A kind of 3D printing titanium alloy artificial bone material and preparation method Download PDF

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Publication number
CN107802886A
CN107802886A CN201711322896.5A CN201711322896A CN107802886A CN 107802886 A CN107802886 A CN 107802886A CN 201711322896 A CN201711322896 A CN 201711322896A CN 107802886 A CN107802886 A CN 107802886A
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titanium alloy
bone
printing
artificial bone
alloy artificial
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汪梅花
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Chengdu Yuya Science and Technology Co Ltd
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Chengdu Yuya Science and Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30943—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using mathematical models
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention relates to a kind of 3D printing titanium alloy artificial bone material, is made up of following mass fraction material：Al：5%—13%、Zn：1.1%—6.5%、Mg：6%—18%、Cu：15%—35%、Ni：1.5%—3.5%、Zr：2.5%—6.1%、Nb：0—4.5%、Si：0-3.5%, surplus Ti.Artificial bone preparation method models including bone, 3D printing equipment debugging, material mixing, machine-shaping, six steps such as blank surface processing and nitrogen treatment.One aspect of the present invention can effectively improve the precision of processing operation, improve the connection reliability between the biological tissue such as titanium alloy artificial bone and skeleton and muscle and biological compatible degree, on the other hand reliability and flexibility of the titanium alloy artificial bone by 3D printing machine-shaping operation can be effectively improved, and reaches the effective structural strength for improving titanium alloy artificial bone and reduce the purpose of titanium alloy artificial bone weight.

Description

A kind of 3D printing titanium alloy artificial bone material and preparation method
Technical field
The present invention relates to a kind of 3D printing titanium alloy artificial bone material artificial bone preparation method, belongs to 3D printing technique Field.
Background technology
With the rapid development and progress of 3D printing technique, also obtained in medical titanium alloy artificial bone is processed and is prepared Extremely wide application, but currently often adopted in titanium alloy artificial bone process is carried out by 3D printing system Prepared by conventional machining process, although can meet the needs prepared to the processing of titanium alloy artificial bone, process Titanium alloy artificial bone structure precision and skeleton between structural deviation in various degree be present, so as to cause titanium alloy people When work bone is installed into the human body, installation positioning difficulty is relatively large, and matching is relatively poor, while also causes current titanium to close Biological compatible degree between golden artificial bone and tissue is relatively poor, uses so as to having had a strong impact on titanium alloy artificial bone Reliability and stability, it is impossible to it is effective to meet the needs of actual use, therefore this problem is directed to, there is an urgent need to develop one kind The titanium alloy artificial bone material and processing technology of 3D printing processing can effectively be met, to meet the needs of actual use.
The content of the invention
The object of the invention, which is that, overcomes above-mentioned deficiency, there is provided a kind of 3D printing titanium alloy artificial bone material and its system Preparation Method.
To achieve the above object, the present invention is to be achieved through the following technical solutions：
A kind of 3D printing titanium alloy artificial bone material, it is made up of following mass fraction material：Al：5%—13%、Zn： 1.1%—6.5%、Mg：6%—18%、Cu：15%—35%、Ni：1.5%—3.5%、Zr：2.5%—6.1%、Nb：0—4.5%、Si： 0-3.5%, surplus Ti.
Further, described Al, Zn, Mg, Cu, Ni, Zr, Nb, Si and Ti are elemental metals particle and alloying pellet In any one, and particle diameter is 30-50nm.
A kind of 3D printing titanium alloy artificial bone preparation method, comprises the following steps：
The first step, bone modeling, first by CT scan equipment, human body is needed to carry out the bone of titanium alloy bone alternative site Institutional framework is scanned, and establishes the three-dimensional structure data model of the position organization structure of skeleton, then by the three-dimensional of foundation The encoded translated programming voice coding for 3D printing processing and forming operation of structured data model；
Second step, 3D printing equipment debugging, the programming vocoded data that the first step is compiled and edit is downloaded into laser 3D printing system In and preserve, simulation run then is carried out to programming vocoded data by laser 3D printing system runs program, and according to imitative True operation result, with reference to the operation deviation of laser 3D printing system, parameter compensation is carried out to programming vocoded data, obtains bone Bone processing and forming program, is then saved backup；
3rd step, material mixing, according to using needs, Al, Zn, Mg, Cu, Ni, Zr, Nb, Si and Ti raw material are added in proportion Into mixing equipment, it is stirred by mixing equipment and mixes and preheat, material mixing was completed in 10-30 minutes, and simultaneously By material temperature constant-speed heating to 80 DEG C -150 DEG C, and it is incubated standby；
4th step, machine-shaping, the mixed material that the 3rd step is prepared is added in laser 3D printing system, by laser 3D Mixed material machine-shaping is bone blank according to the skeleton shaping procedure that second step preserves by print system；
5th step, blank surface processing, bone blank veining defect prepared by the 4th step is cleared up, then by blank It is immersed in electrolyte and carries out anodized, the porous surface knot with wiener yardstick is formed on bone blank surface Structure, then the bone blank after completing anodized clear up by deionized water and cold air drying is standby；
6th step, nitrogen treatment, the bone blank by the processing of the 5th step is placed in plasma high-temperature nitriding furnace and carries out nitrogen Change is handled, and bone blank is naturally cooled into normal temperature can obtain finished product titanium alloy bone after then completing nitrogen treatment Part.
Further, described second step to the 6th step is processed in operation, is entered in inert gas shielding environment OK.
Further, described inert gas is any one in nitrogen, argon gas, helium.
Further, in the 3rd described step, stirring operation is using ultrasonic wave stirring, high pressure draught stirring, magnetic stirring In any one；Thermal source is preheated as irradiation thermal source.
Further, in the 4th described step, laser power during laser 3D printing system operation is 100-300W, is swept It is 200-2000mm/s to retouch speed, and sweep span is 30-80 μm, and laser facula is 40-90 μm.
Further, in the 5th described step, electrolyte is made up of following mass fraction material：Hydrofluoric acid 5% -10%, it is double Oxygen water 3% -8%, surplus are ethylene glycol.
Further, in the 5th described step, it is 8V to carry out anodized voltage, operating current 1A, the working time For 5-20 minutes.
Further, in the 6th described step, the nitrogen treatment time is 4-8 hours, and treatment temperature is 500 DEG C-750 DEG C, nitrogen gas purity 99.9%, nitrogen flow is 50-100ml/min, and nitrogen pressure is 1-2.1 times of standard atmospheric pressures.
One aspect of the present invention can effectively improve the precision of processing operation, improve titanium alloy artificial bone and skeleton and Connection reliability and biological compatible degree between the biological tissues such as muscle, it on the other hand can effectively improve titanium alloy artificial bone and lead to Reliability and the flexibility of 3D printing machine-shaping operation are crossed, and reaches the effective structural strength for improving titanium alloy artificial bone With the purpose for reducing titanium alloy artificial bone weight.
Brief description of the drawings
Fig. 1 is this hair preparation method flow chart；
Fig. 2 is material crystalline phase schematic illustration of tissue of the present invention.
Embodiment
Embodiment 1
As shown in figure 1, a kind of 3D printing titanium alloy artificial bone material, is made up of following mass fraction material：Al：5%、Zn： 1.1%、Mg： 18%、Cu：20%、Ni：1.5%、Zr：3%, surplus Ti.
Wherein described Al, Zn, Mg, Cu, Ni, Zr and Ti is elemental metals particle and particle diameter is 30nm.
A kind of 3D printing titanium alloy artificial bone preparation method, comprises the following steps：
The first step, bone modeling, first by CT scan equipment, human body is needed to carry out the bone of titanium alloy bone alternative site Institutional framework is scanned, and establishes the three-dimensional structure data model of the position organization structure of skeleton, then by the three-dimensional of foundation The encoded translated programming voice coding for 3D printing processing and forming operation of structured data model；
Second step, 3D printing equipment debugging, the programming vocoded data that the first step is compiled and edit is downloaded into laser 3D printing system In and preserve, simulation run then is carried out to programming vocoded data by laser 3D printing system runs program, and according to imitative True operation result, with reference to the operation deviation of laser 3D printing system, parameter compensation is carried out to programming vocoded data, obtains bone Bone processing and forming program, is then saved backup；
3rd step, material mixing, according to using needs, Al, Zn, Mg, Cu, Ni, Zr, Nb, Si and Ti raw material are added in proportion Into mixing equipment, it is stirred by mixing equipment progress ultrasonic wave and irradiates preheating, material mixing was completed in 20 minutes, And simultaneously by material temperature constant-speed heating to 120 DEG C, and be incubated standby；
4th step, machine-shaping, the mixed material that the 3rd step is prepared is added in laser 3D printing system, by laser 3D Mixed material machine-shaping is bone blank according to the skeleton shaping procedure that second step preserves by print system, wherein Laser power during laser 3D printing system operation is 260W, and sweep speed 500mm/s, sweep span is 60 μm, laser light Spot is 70 μm.；
5th step, blank surface processing, bone blank veining defect prepared by the 4th step is cleared up, then by blank It is immersed in electrolyte and carries out anodized, the porous surface knot with wiener yardstick is formed on bone blank surface Structure, then the bone blank after completing anodized clear up by deionized water and cold air drying is standby, its Middle electrolyte is made up of following mass fraction material：Hydrofluoric acid 5%, hydrogen peroxide 8%, surplus are ethylene glycol；Carry out at anodic oxidation Reason voltage is 8V, and operating current 1A, the working time is 5-20 minutes.
6th step, nitrogen treatment, the bone blank by the processing of the 5th step is placed in plasma high-temperature nitriding furnace Row nitrogen treatment, it bone blank naturally cooled into normal temperature can obtain finished product titanium alloy bone after then will completing nitrogen treatment Bone part, wherein nitrogen treatment time are 4 hours, and treatment temperature is 500 DEG C, nitrogen gas purity 99.9%, nitrogen flow 50ml/ Min, nitrogen pressure are 1.5 times of standard atmospheric pressures.
In addition, described second step to the 6th step is processed in operation, carried out in argon gas protection environment atmosphere.
Embodiment 2
As shown in figure 1, a kind of 3D printing titanium alloy artificial bone material, is made up of following mass fraction material：Al：10%、 Zn：3.5%、Mg：18%、Cu：30%、Ni：2.5%、Zr： 6.1%、Nb：1.5%、Si：3.5%th, surplus Ti.
Wherein described Al, Zn, Mg, Cu, Ni, Zr, Nb, Si and Ti is alloying pellet, and particle diameter is 40nm.
A kind of 3D printing titanium alloy artificial bone preparation method, comprises the following steps：
The first step, bone modeling, first by CT scan equipment, human body is needed to carry out the bone of titanium alloy bone alternative site Institutional framework is scanned, and establishes the three-dimensional structure data model of the position organization structure of skeleton, then by the three-dimensional of foundation The encoded translated programming voice coding for 3D printing processing and forming operation of structured data model；
Second step, 3D printing equipment debugging, the programming vocoded data that the first step is compiled and edit is downloaded into laser 3D printing system In and preserve, simulation run then is carried out to programming vocoded data by laser 3D printing system runs program, and according to imitative True operation result, with reference to the operation deviation of laser 3D printing system, parameter compensation is carried out to programming vocoded data, obtains bone Bone processing and forming program, is then saved backup；
3rd step, material mixing, according to using needs, Al, Zn, Mg, Cu, Ni, Zr, Nb, Si and Ti raw material are added in proportion Into mixing equipment, it is stirred by mixing equipment progress high pressure draught and irradiates preheating, material was completed in 30 minutes and is mixed Close, and simultaneously by material temperature constant-speed heating to 150 DEG C, and be incubated standby；
4th step, machine-shaping, the mixed material that the 3rd step is prepared is added in laser 3D printing system, by laser 3D Mixed material machine-shaping is bone blank according to the skeleton shaping procedure that second step preserves by print system, laser Laser power when 3D printing system is run is 300W, and sweep speed 1000mm/s, sweep span is 40 μm, and laser facula is 60μm；
5th step, blank surface processing, bone blank veining defect prepared by the 4th step is cleared up, then by blank It is immersed in electrolyte and carries out anodized, the porous surface knot with wiener yardstick is formed on bone blank surface Structure, then the bone blank after completing anodized clear up by deionized water and cold air drying is standby, its Middle electrolyte is made up of following mass fraction material：Hydrofluoric acid 8%, hydrogen peroxide 5%, surplus are ethylene glycol；Carry out at anodic oxidation Reason voltage is 8V, and operating current 1A, the working time is 5 minutes；
6th step, nitrogen treatment, the bone blank by the processing of the 5th step is placed in plasma high-temperature nitriding furnace and carries out nitrogen Change is handled, and bone blank is naturally cooled into normal temperature can obtain finished product titanium alloy bone after then completing nitrogen treatment Part, nitrogen treatment time are 8 hours, and treatment temperature is 750 DEG C, nitrogen gas purity 99.9%, nitrogen flow 80ml/min, nitrogen Atmospheric pressure is 2.1 times of standard atmospheric pressures.
Simultaneously, described second step to the 6th step is processed in operation, is carried out in nitrogen environmental protection atmosphere.
One aspect of the present invention can effectively improve the precision of processing operation, improve titanium alloy artificial bone and skeleton and Connection reliability and biological compatible degree between the biological tissues such as muscle, it on the other hand can effectively improve titanium alloy artificial bone and lead to Reliability and the flexibility of 3D printing machine-shaping operation are crossed, and reaches the effective structural strength for improving titanium alloy artificial bone With the purpose for reducing titanium alloy artificial bone weight.
The general principle and principal character and advantages of the present invention of the present invention has been shown and described above.The technology of the industry Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the simply explanation described in above-described embodiment and specification is originally The principle of invention, without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, these changes Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its Equivalent thereof.

Claims (10)

  1. A kind of 1. 3D printing titanium alloy artificial bone material, it is characterised in that described 3D printing titanium alloy artificial bone Material is made up of following mass fraction material：Al：5%—13%、Zn：1.1%—6.5%、Mg：6%—18%、Cu：15%—35%、 Ni：1.5%—3.5%、Zr：2.5%—6.1%、Nb：0—4.5%、Si：0-3.5%, surplus Ti.
  2. A kind of 2. 3D printing titanium alloy artificial bone material according to claim 1, it is characterised in that：Described Al, Zn, Mg, Cu, Ni, Zr, Nb, Si and Ti are any one in elemental metals particle and alloying pellet, and particle diameter is 30—50nm。
  3. A kind of 3. 3D printing titanium alloy artificial bone preparation method, it is characterised in that：Described 3D printing titanium alloy artificial Bone preparation method comprises the following steps：
    The first step, bone modeling, first by CT scan equipment, human body is needed to carry out the bone of titanium alloy bone alternative site Institutional framework is scanned, and establishes the three-dimensional structure data model of the position organization structure of skeleton, then by the three-dimensional of foundation The encoded translated programming voice coding for 3D printing processing and forming operation of structured data model；
    Second step, 3D printing equipment debugging, the programming vocoded data that the first step is compiled and edit is downloaded into laser 3D printing system In and preserve, simulation run then is carried out to programming vocoded data by laser 3D printing system runs program, and according to imitative True operation result, with reference to the operation deviation of laser 3D printing system, parameter compensation is carried out to programming vocoded data, obtains bone Bone processing and forming program, is then saved backup；
    3rd step, material mixing, according to using needs, Al, Zn, Mg, Cu, Ni, Zr, Nb, Si and Ti raw material are added in proportion Into mixing equipment, it is stirred by mixing equipment and mixes and preheat, material mixing was completed in 10-30 minutes, and simultaneously By material temperature constant-speed heating to 80 DEG C -150 DEG C, and it is incubated standby；
    4th step, machine-shaping, the mixed material that the 3rd step is prepared is added in laser 3D printing system, by laser 3D Mixed material machine-shaping is bone blank according to the skeleton shaping procedure that second step preserves by print system；
    5th step, blank surface processing, bone blank veining defect prepared by the 4th step is cleared up, then by blank It is immersed in electrolyte and carries out anodized, the porous surface knot with wiener yardstick is formed on bone blank surface Structure, then the bone blank after completing anodized clear up by deionized water and cold air drying is standby；
    6th step, nitrogen treatment, the bone blank by the processing of the 5th step is placed in plasma high-temperature nitriding furnace and carries out nitrogen Change is handled, and bone blank is naturally cooled into normal temperature can obtain finished product titanium alloy bone after then completing nitrogen treatment Part.
  4. A kind of 4. 3D printing according to claim 1 titanium alloy artificial bone preparation method, it is characterised in that：Described Second step to the 6th step is processed in operation, is carried out in inert gas shielding environment.
  5. A kind of 5. 3D printing according to claim 4 titanium alloy artificial bone preparation method, it is characterised in that：Described Inert gas is any one in nitrogen, argon gas, helium.
  6. A kind of 6. 3D printing according to claim 1 titanium alloy artificial bone preparation method, it is characterised in that：Described In 3rd step, stirring operation is using any one in ultrasonic wave stirring, high pressure draught stirring, magnetic stirring；Preheating thermal source is Irradiate thermal source.
  7. A kind of 7. 3D printing according to claim 1 titanium alloy artificial bone preparation method, it is characterised in that：Described In 4th step, laser power during laser 3D printing system operation is 100-300W, and sweep speed is 200-2000mm/s, is swept Spacing is retouched as 30-80 μm, laser facula is 40-90 μm.
  8. A kind of 8. 3D printing according to claim 1 titanium alloy artificial bone preparation method, it is characterised in that：Described In 5th step, electrolyte is made up of following mass fraction material：Hydrofluoric acid 5% -10%, hydrogen peroxide 3% -8%, surplus are second two Alcohol.
  9. A kind of 9. 3D printing according to claim 1 titanium alloy artificial bone preparation method, it is characterised in that：Described In 5th step, it is 8V to carry out anodized voltage, and operating current 1A, the working time is 5-20 minutes.
  10. A kind of 10. 3D printing according to claim 1 titanium alloy artificial bone preparation method, it is characterised in that：It is described The 6th step in, the nitrogen treatment time be 4-8 hours, treatment temperature be 500 DEG C-750 DEG C, nitrogen gas purity 99.9%, nitrogen Flow is 50-100ml/min, and nitrogen pressure is 1-2.1 times of standard atmospheric pressures.
CN201711322896.5A 2017-12-12 2017-12-12 A kind of 3D printing titanium alloy artificial bone material and preparation method Pending CN107802886A (en)

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Cited By (10)

* Cited by examiner, † Cited by third party
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CN109044567A (en) * 2018-08-22 2018-12-21 广州华钛三维材料制造有限公司 A kind of artifical bone and preparation method thereof
CN109080701A (en) * 2018-08-27 2018-12-25 四川中物红宇科技有限公司 A kind of alloy material and vehicle bridge frame for vehicle bridge frame surface
CN109350312A (en) * 2018-11-29 2019-02-19 杭州电子科技大学 A kind of artificial bone manufacturing method and device based on Ultrasonic machining
CN110575289A (en) * 2019-09-20 2019-12-17 重庆新索医药科技有限公司 3D printing method for bone defect prosthesis
CN110744813A (en) * 2019-09-29 2020-02-04 上海凯利泰医疗科技股份有限公司 Printing method, system and device for generating microporous structure
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CN112872714A (en) * 2020-04-13 2021-06-01 广东佳悦美视生物科技有限公司 Preparation method of artificial cornea collar
CN113081396A (en) * 2019-12-23 2021-07-09 宝山钢铁股份有限公司 Skull repairing material and preparation method thereof
CN113693696A (en) * 2021-08-03 2021-11-26 西北有色金属研究院 Medical titanium alloy bone fixing clamp and manufacturing method thereof
CN115301940A (en) * 2022-07-18 2022-11-08 哈尔滨焊接研究院有限公司 Ti-Zr-Cu titanium alloy powder for laser additive manufacturing and preparation method and application thereof

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CN109044567A (en) * 2018-08-22 2018-12-21 广州华钛三维材料制造有限公司 A kind of artifical bone and preparation method thereof
CN109080701A (en) * 2018-08-27 2018-12-25 四川中物红宇科技有限公司 A kind of alloy material and vehicle bridge frame for vehicle bridge frame surface
CN109350312A (en) * 2018-11-29 2019-02-19 杭州电子科技大学 A kind of artificial bone manufacturing method and device based on Ultrasonic machining
WO2020163915A1 (en) * 2019-02-13 2020-08-20 Flex Memory Ventures Pty Ltd Implantable objects fabricated by additive manufacturing and methods of fabricating the same
EP3923872A4 (en) * 2019-02-13 2023-01-11 Flex Memory Ventures Pty Ltd Implantable objects fabricated by additive manufacturing and methods of fabricating the same
CN110575289A (en) * 2019-09-20 2019-12-17 重庆新索医药科技有限公司 3D printing method for bone defect prosthesis
CN110575289B (en) * 2019-09-20 2021-10-22 中国人民解放军陆军军医大学第一附属医院 3D printing method for bone defect prosthesis
CN110744813B (en) * 2019-09-29 2021-12-07 上海凯利泰医疗科技股份有限公司 Printing method, system and device for generating microporous structure
CN110744813A (en) * 2019-09-29 2020-02-04 上海凯利泰医疗科技股份有限公司 Printing method, system and device for generating microporous structure
CN113081396A (en) * 2019-12-23 2021-07-09 宝山钢铁股份有限公司 Skull repairing material and preparation method thereof
CN112872714A (en) * 2020-04-13 2021-06-01 广东佳悦美视生物科技有限公司 Preparation method of artificial cornea collar
CN112872714B (en) * 2020-04-13 2022-08-12 广东佳悦美视生物科技有限公司 Preparation method of artificial cornea collar
CN113693696A (en) * 2021-08-03 2021-11-26 西北有色金属研究院 Medical titanium alloy bone fixing clamp and manufacturing method thereof
CN115301940A (en) * 2022-07-18 2022-11-08 哈尔滨焊接研究院有限公司 Ti-Zr-Cu titanium alloy powder for laser additive manufacturing and preparation method and application thereof

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