CN104740706A - Blood pump of medical mechanism - Google Patents

Blood pump of medical mechanism Download PDF

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CN104740706A
CN104740706A CN 201510190173 CN201510190173A CN104740706A CN 104740706 A CN104740706 A CN 104740706A CN 201510190173 CN201510190173 CN 201510190173 CN 201510190173 A CN201510190173 A CN 201510190173A CN 104740706 A CN104740706 A CN 104740706A
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parts
pump
titanium
hours
ceramic material
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CN 201510190173
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焦雷
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焦雷
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/10Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps
    • A61M1/12Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps implantable into the body
    • A61M1/122Heart assist devices, i.e. for assisting an ailing heart, using additional pumping means in the blood circuit
    • CCHEMISTRY; METALLURGY
    • C22METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22CALLOYS
    • C22C14/00Alloys based on titanium
    • CCHEMISTRY; METALLURGY
    • C22METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22FCHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
    • C22F1/00Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
    • C22F1/16Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of other metals or alloys based thereon
    • C22F1/18High-melting or refractory metals or alloys based thereon
    • C22F1/183High-melting or refractory metals or alloys based thereon of titanium or alloys based thereon
    • CCHEMISTRY; METALLURGY
    • C23COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23CCOATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C22/00Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals
    • C23C22/05Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions
    • C23C22/06Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous acidic solutions with pH less than 6
    • C23C22/34Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous acidic solutions with pH less than 6 containing fluorides or complex fluorides
    • CCHEMISTRY; METALLURGY
    • C23COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23CCOATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C28/00Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D
    • C23C28/04Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D only coatings of inorganic non-metallic material
    • C23C28/042Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D only coatings of inorganic non-metallic material including a refractory ceramic layer, e.g. refractory metal oxides, ZrO2, rare earth oxides
    • CCHEMISTRY; METALLURGY
    • C23COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23GCLEANING OR DEGREASING OF METALLIC MATERIAL BY CHEMICAL METHODS OTHER THAN ELECTROLYSIS
    • C23G1/00Cleaning or pickling metallic material with solutions or molten salts
    • C23G1/02Cleaning or pickling metallic material with solutions or molten salts with acid solutions
    • C23G1/10Other heavy metals
    • C23G1/106Other heavy metals refractory metals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/02General characteristics of the apparatus characterised by a particular materials
    • CCHEMISTRY; METALLURGY
    • C23COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23CCOATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C2222/00Aspects relating to chemical surface treatment of metallic material by reaction of the surface with a reactive medium
    • C23C2222/20Use of solutions containing silanes

Abstract

The invention provides a blood pump of a medical mechanism. The blood pump comprises a pump body; the pump body comprises a casting titanium alloy pump body, a zirconium oxide ceramic material layer arranged on the outer surface of the pump body, and a titanium carbide ceramic material layer arranged on the inner surface of the pump body. According to the blood pump, the zirconium oxide ceramic material layer and the titanium carbide ceramic material layer respectively coat the inner surface and the outer surface of the pump body according to the type and speed of the pump body in contact with human cells, so that the anti-hemolysis performance and antithrombus and other performances of the material can be improved.

Description

一种医疗器械血泵 A medical instrument blood pump

[0001] [0001]

技术领域 FIELD

[0002] 本发明涉一种医疗器械血泵,属于植入泵,属于医疗器械技术领域。 [0002] The present invention relates to a medical device blood pump, implantable pump belongs, belongs to the technical field of medical instruments.

背景技术 Background technique

[0003]目前,应用体外循环设备进行心脏外科手术治疗已经成为治疗心脏疾病的一种常规方法。 [0003] At present, the application of cardiopulmonary bypass equipment for cardiac surgery has become a routine method for the treatment of heart disease. 在手术前后有可能出现不同程度的心功能不全,需要心脏辅助装置等手段来替代心脏的泵机能,维持全身血液循环,改善自体心脏功能。 Before and after surgery may have varying degrees of heart failure, cardiac assist devices and other means needed to replace the pump function of the heart to maintain blood circulation, improve the native heart function. 血泵是心室辅助装置的核心组成部分,为心室辅助装置提供动力。 The blood pump is the core component of the ventricular assist device for powering the ventricular assist device. 目前商品化的心室辅助装置血泵多采用气囊挤压或者离心驱动原理,存在气栓、溶血等并发症。 Currently commercially available blood pump ventricular assist device, or to use more centrifugal extrusion airbag driving principle, the presence of air embolism, hemolysis and other complications. 现有泵体材料已经很难满足抗溶血和抗血栓等性能要求。 Existing anti-pump materials have been difficult to meet hemolysis and antithrombotic performance requirements.

发明内容 SUMMARY

[0004] 本发明就是针对上述问题而提出的一种工艺简单、成本低、抗溶血性能良好的医疗器械血泵。 [0004] The present invention is a process for the above problems in a simple, low cost, good anti-haemolytic properties of the blood pump medical instrument.

[0005] 一种医疗器械血泵,血泵包括一泵体,泵体包括:铸造钛合金泵体、泵体外表面的氧化锆系陶瓷材料层和泵体内表面的碳化钛系陶瓷材料层, [0005] A medical instrument blood pump, a blood pump comprising a pump body, the pump comprising: a pump body casting titanium, titanium carbide-based ceramic material and a layer of a ceramic material layer surface of the pump body zirconia outer surface of the pump,

其特征在于,铸造钛合金泵体化学组成为(重量):Zn:14-15 %、A1:6-7 %、Fe:4-5 %,Si: 1-2 %、Mg 1-2 %、Ni 0.7-0.8 %、Cu:0.5-0.6 %、Cd:0.2-0.3 %、Zr:0.07-0.08 %、Ce:0.03-0.04 %、Mn:0.05-0.06 %,V:0.06-0.07 %,B:0.08-0.09 %,余量为Ti 以及不可避免的杂质; Characterized in that the pump casting alloy chemical composition (by weight): Zn: 14-15%, A1: 6-7%, Fe: 4-5%, Si: 1-2%, Mg 1-2%, ni 0.7-0.8%, Cu: 0.5-0.6%, Cd: 0.2-0.3%, Zr: 0.07-0.08%, Ce: 0.03-0.04%, Mn: 0.05-0.06%, V: 0.06-0.07%, B: 0.08-0.09%, the balance is Ti and unavoidable impurities;

铸造钛合金泵体制备方法:包括以下步骤:按照上述比例配制合金,合金材料恪炼、饶注:熔炼温度:1810-1820°C,浇注温度为1750-1760°C ;脱模后,得到的泵体进行热处理:首先将泵体进行加热,升温至950°C,升温速率300°C /小时,保温6小时,后降温至650°C,降温速率100°C /小时,保温7小时,后升温至800°C,升温速率100°C /小时,保温4小时,后再次降温至450°C,降温速率50°C /小时,保温9小时,后再次降温至250°C,降温速率40°C /小时,保温6小时,后空冷至室温, Producing a titanium alloy casting pump body: comprising the steps of: preparing an alloy according to the above ratio, Ke refining alloy material, Rao NOTE: melting temperature: 1810-1820 ° C, the pouring temperature of 1750-1760 ° C; after demolding, obtained pump heat treatment: first heating pump, heated to 950 ° C, heating rate 300 ° C / hr, incubated for 6 hours, after cooling to 650 ° C, cooling rate 100 ° C / h, incubated for 7 hours after warmed to 800 ° C, heating rate 100 ° C / h, for 4 hours, after cooling again to 450 ° C, the cooling rate 50 ° C / hr, incubated 9 hours, after cooling again to 250 ° C, the cooling rate 40 ° C / hr, incubated for 6 hours, cooled to room temperature,

之后对泵体表面进行酸洗和钝化处理,其中: After pickling and the pump housing surface passivation, wherein:

酸洗液组成为(重量):采取98%浓H2SO4 40-50份,36.5%的HCL 15-20份,丙酸1-3份,乙二胺1-5份、烷基咪唑啉季铵盐10-15份;水10-20份; Pickling solution consisting (by weight): 98% concentrated H2SO4 40-50 taken parts, 36.5% of HCL 15-20 parts, 1-3 parts of propionic acid, 1-5 parts of ethylenediamine, alkyl imidazoline quaternary parts 10-15; 10-20 parts of water;

钝化液组成为(重量):聚酰亚胺10-15份,2-(3,4-环氧环己基)乙基三甲氧基硅烷4-10份,N-(2-氨基乙基)-3-氨基丙基甲基二甲氧基硅烷2-3份,氟硼酸钠10-13份,硫酸1-4份,二烷基二硫代磷酸氧钼6-7份,水25-35份; Passivation solution consisting (by weight): 10-15 parts of a polyimide, 2- (3,4-epoxycyclohexyl) ethyltrimethoxysilane 4-10 parts, N- (2- aminoethyl) -3-aminopropyl methyl dimethoxysilane 2-3 parts, 10-13 parts of sodium borofluoride, 1-4 parts of sulfuric acid, oxygen, molybdenum dialkyl dithiophosphate 6-7 parts water 25-35 parts;

对钝化后泵体外表面进行涂覆氧化锆系陶瓷材料;通过涂覆在泵体外表面形成氧化锆系陶瓷材料层,氧化锆系陶瓷材料层厚度0.4_,氧化锆系陶瓷材料层成分包括(重量):氧化锆50-60份,硼化钛20-30份,碳化钛20-30份,氧化硅1_2份,将涂覆后的泵体进行加热,升温至750°C,升温速率250°C /小时,保温4小时,后降温至550°C,降温速率100°C /小时,保温3小时,后再次降温至250°C,降温速率75°C /小时,保温7小时,后空冷至室温,之后对泵体内表面进行涂覆碳化钛系陶瓷材料;通过涂覆在泵体内表面形成碳化钛系陶瓷材料层,碳化钛系陶瓷材料层厚度0.5mm,碳化钛系陶瓷材料层成分包括(重量):碳化钛90份,氮化钛15-20份,碳化铬10份,氧化钛5-8份,将涂覆后的泵体进行加热,升温至600°C,升温速率200°C /小时,保温3小时,后降温至400°C,降温速率100°C /小时,保温 After passivation of the external surface of the pump zirconium oxide-based ceramic material is coated; zirconia-based ceramic material layer is formed by coating the outer surface of the pump, a zirconium oxide based ceramic material 0.4_ thickness, zirconia-based ceramic material comprises a layer component ( by weight): 50-60 parts of zirconium oxide, titanium boride 20-30 parts, 20-30 parts of titanium carbide, silicon oxide 1_2 parts of the pump body is heated after coated, heated to 750 ° C, temperature increase rate 250 ° C / h, for 4 hours, after cooling to 550 ° C, cooling rate 100 ° C / hour, for 3 hours, after cooling again to 250 ° C, the cooling rate 75 ° C / hour, a holding seven hours, air cooling to at room temperature, then coated surface of the pump body of titanium carbide-based ceramic material; forming a layer of titanium carbide-based ceramic material by coating the surface of the pump body, a titanium carbide-based ceramic material thickness of 0.5mm, titanium carbide-based ceramic material comprises a layer component ( by weight): 90 parts of titanium carbide, titanium nitride 15-20 parts, 10 parts of chromium carbide, titanium parts 5-8, the pump is heated after coated, heated to 600 ° C, heating rate 200 ° C / hours, for 3 hours, after cooling to 400 ° C, cooling rate 100 ° C / hour, a holding 7小时,后再次降温至100°C,降温速率50°C /小时,保温12小时,后空冷至室温,得到最终泵体。 7 hours, after cooling again to 100 ° C, the cooling rate 50 ° C / hour, for 12 hours and air cooling to room temperature, to give a final pump.

[0006] 所述的一种医疗器械血泵,铸造钛合金泵体化学组成为:Zn:14 %、A1:6 %、Fe:4%,Si:1 %、Mg I %、Ni 0.7 %、Cu:0.5 %、Cd:0.2 %、Zr:0.07 %、Ce:0.03 %、Mn:0.05% , V:0.06 % , B:0.08 %,余量为Ti以及不可避免的杂质。 A medical instrument blood pump [0006], wherein the pump casting alloy chemical composition: Zn: 14%, A1: 6%, Fe: 4%, Si: 1%, Mg I%, Ni 0.7%, Cu: 0.5%, Cd: 0.2%, Zr: 0.07%, Ce: 0.03%, Mn: 0.05%, V: 0.06%, B: 0.08%, the balance is Ti and unavoidable impurities.

[0007] 所述的一种医疗器械血泵,铸造钛合金泵体化学组成为:Zn: 15 %、Al: 7 %、Fe: 5 %,S1: 2 %、Mg 2 %、Ni 0.8 %、Cu: 0.6 %、Cd: 0.3 %、Zr: 0.08 %、Ce: 0.04%、Mn: 0.06 % , V: 0.07 % , B: 0.09 %,余量为Ti以及不可避免的杂质。 According to [0007] A medical instrument of the blood pump, the pump casting alloy chemical composition: Zn: 15%, Al: 7%, Fe: 5%, S1: 2%, Mg 2%, Ni 0.8%, Cu: 0.6%, Cd: 0.3%, Zr: 0.08%, Ce: 0.04%, Mn: 0.06%, V: 0.07%, B: 0.09%, the balance is Ti and unavoidable impurities.

[0008] 所述的一种医疗器械血泵,铸造钛合金泵体化学组成为:Zn:14.5 %、Al:6.5 %、Fe:4.5 % , S1:1.5 %、Mg 1.5 %、Ni 0.75 %、Cu:0.55 %、Cd: 0.25 %、Zr: 0.075 %、Ce:0.035 %、Mn:0.055 %,V:0.065 %,B:0.085 %,余量为Ti 以及不可避免的杂质。 A medical instrument blood pump [0008], wherein the pump casting alloy chemical composition: Zn: 14.5%, Al: 6.5%, Fe: 4.5%, S1: 1.5%, Mg 1.5%, Ni 0.75%, Cu: 0.55%, Cd: 0.25%, Zr: 0.075%, Ce: 0.035%, Mn: 0.055%, V: 0.065%, B: 0.085%, the balance is Ti and unavoidable impurities.

[0009] 所述的一种医疗器械血泵,氧化锆系陶瓷材料层成分包括:氧化锆50份,硼化钛20份,碳化钛20份,氧化娃I份。 [0009] A medical instrument of the blood pump, zirconia-based ceramic material layer composition comprises: 50 parts of zirconium oxide, 20 parts of titanium boride, titanium carbide 20 parts, parts I baby oxide.

[0010] 所述的一种医疗器械血泵,氧化锆系陶瓷材料层成分包括:氧化锆60份,硼化钛30份,碳化钛30份,氧化娃2份。 According to [0010] A medical instrument blood pump, zirconia-based ceramic material layer composition comprises: 60 parts of zirconium oxide, 30 parts of titanium boride, titanium carbide 30 parts, 2 parts baby oxide.

[0011] 所述的一种医疗器械血泵,氧化锆系陶瓷材料层成分包括:氧化锆55份,硼化钛25份,碳化钛25份,氧化硅1.5份。 According to [0011] A medical instrument blood pump, zirconia-based ceramic material layer composition comprises: 55 parts of zirconium oxide, 25 parts of titanium boride, titanium carbide 25 parts, 1.5 parts silicon oxide.

[0012] 所述的一种医疗器械血泵,碳化钛系陶瓷材料层成分包括:碳化钛90份,氮化钛17份,碳化铬10份,氧化钛6份。 [0012] A medical instrument of the blood pump, titanium carbide-based ceramic material layer composition comprises: 90 parts of titanium carbide, titanium nitride 17 parts, 10 parts of chromium carbide, titanium oxide 6 parts.

[0013] 所述的一种医疗器械血泵,酸洗液组成为(重量):采取98%浓H2SO4 45份,36.5%的HCL 17份,丙酸2份,乙二胺3份、烷基咪唑啉季铵盐13份;水15份。 A medical instrument blood pump [0013], wherein the pickling solution consisting (by weight): 98% concentrated H2SO4 45 taken parts, 36.5% of HCL 17 parts, 2 parts of propionic acid, 3 parts of ethylenediamine, an alkyl group IMIDAZOLINYLQUATERNARYAMMONIUMSALT 13 parts; 15 parts of water.

[0014] 所述的一种医疗器械血泵,钝化液组成为(重量):聚酰亚胺13份,2-(3,4_环氧环己基)乙基三甲氧基硅烷7份,N-(2-氨基乙基)-3-氨基丙基甲基二甲氧基硅烷2.5份,氟硼酸钠12份,硫酸3份,二烷基二硫代磷酸氧钼6.5份,水30份。 A medical instrument blood pump [0014] The passivation solution consisting (by weight): 13 parts of the polyimide, 2- (3,4_ epoxycyclohexyl) ethyltrimethoxysilane 7 parts, N- (2- aminoethyl) -3-aminopropyl methyl dimethoxy silane 2.5 parts of sodium borofluoride 12 parts, 3 parts of sulfuric acid, oxygen, molybdenum dialkyl dithiophosphate, 6.5 parts water 30 parts .

[0015] 一种医疗器械血泵的制造方法,血泵包括一泵体,泵体包括:铸造钛合金泵体、泵体外表面的氧化锆系陶瓷材料层和泵体内表面的碳化钛系陶瓷材料层, [0015] A method for producing a medical instrument of the blood pump, a blood pump comprising a pump body, the pump comprising: a pump body casting titanium, titanium carbide-based ceramic material of the ceramic material layer and the inner surface of the zirconia-based outer surface of the pump layer,

其特征在于,铸造钛合金泵体化学组成为(重量):Zn:14-15 %、A1:6-7 %、Fe:4-5 %,Si: 1-2 %、Mg 1-2 %、Ni 0.7-0.8 %、Cu:0.5-0.6 %、Cd:0.2-0.3 %、Zr:0.07-0.08 %、Ce:0.03-0.04 %、Mn:0.05-0.06 %,V:0.06-0.07 %,B:0.08-0.09 %,余量为Ti 以及不可避免的杂质; Characterized in that the pump casting alloy chemical composition (by weight): Zn: 14-15%, A1: 6-7%, Fe: 4-5%, Si: 1-2%, Mg 1-2%, ni 0.7-0.8%, Cu: 0.5-0.6%, Cd: 0.2-0.3%, Zr: 0.07-0.08%, Ce: 0.03-0.04%, Mn: 0.05-0.06%, V: 0.06-0.07%, B: 0.08-0.09%, the balance is Ti and unavoidable impurities;

铸造钛合金泵体制备方法:包括以下步骤:按照上述比例配制合金,合金材料恪炼、饶注:熔炼温度:1810-1820°C,浇注温度为1750-1760°C ;脱模后,得到的泵体进行热处理:首先将泵体进行加热,升温至950°C,升温速率300°C /小时,保温6小时,后降温至650°C,降温速率100°C /小时,保温7小时,后升温至800°C,升温速率100°C /小时,保温4小时,后再次降温至450°C,降温速率50°C /小时,保温9小时,后再次降温至250°C,降温速率40°C /小时,保温6小时,后空冷至室温, Producing a titanium alloy casting pump body: comprising the steps of: preparing an alloy according to the above ratio, Ke refining alloy material, Rao NOTE: melting temperature: 1810-1820 ° C, the pouring temperature of 1750-1760 ° C; after demolding, obtained pump heat treatment: first heating pump, heated to 950 ° C, heating rate 300 ° C / hr, incubated for 6 hours, after cooling to 650 ° C, cooling rate 100 ° C / h, incubated for 7 hours after warmed to 800 ° C, heating rate 100 ° C / h, for 4 hours, after cooling again to 450 ° C, the cooling rate 50 ° C / hr, incubated 9 hours, after cooling again to 250 ° C, the cooling rate 40 ° C / hr, incubated for 6 hours, cooled to room temperature,

之后对泵体表面进行酸洗和钝化处理,其中: After pickling and the pump housing surface passivation, wherein:

酸洗液组成为(重量):采取98%浓H2SO4 40-50份,36.5%的HCL 15-20份,丙酸1-3份,乙二胺1-5份、烷基咪唑啉季铵盐10-15份;水10-20份; Pickling solution consisting (by weight): 98% concentrated H2SO4 40-50 taken parts, 36.5% of HCL 15-20 parts, 1-3 parts of propionic acid, 1-5 parts of ethylenediamine, alkyl imidazoline quaternary parts 10-15; 10-20 parts of water;

钝化液组成为(重量):聚酰亚胺10-15份,2-(3,4-环氧环己基)乙基三甲氧基硅烷4-10份,N-(2-氨基乙基)-3-氨基丙基甲基二甲氧基硅烷2-3份,氟硼酸钠10-13份,硫酸1-4份,二烷基二硫代磷酸氧钼6-7份,水25-35份; Passivation solution consisting (by weight): 10-15 parts of a polyimide, 2- (3,4-epoxycyclohexyl) ethyltrimethoxysilane 4-10 parts, N- (2- aminoethyl) -3-aminopropyl methyl dimethoxysilane 2-3 parts, 10-13 parts of sodium borofluoride, 1-4 parts of sulfuric acid, oxygen, molybdenum dialkyl dithiophosphate 6-7 parts water 25-35 parts;

对钝化后泵体外表面进行涂覆氧化锆系陶瓷材料;通过涂覆在泵体外表面形成氧化锆系陶瓷材料层,氧化锆系陶瓷材料层厚度0.4_,氧化锆系陶瓷材料层成分包括(重量):氧化锆50-60份,硼化钛20-30份,碳化钛20-30份,氧化硅1_2份,将涂覆后的泵体进行加热,升温至750°C,升温速率250°C /小时,保温4小时,后降温至550°C,降温速率100°C /小时,保温3小时,后再次降温至250°C,降温速率75°C /小时,保温7小时,后空冷至室温,之后对泵体内表面进行涂覆碳化钛系陶瓷材料;通过涂覆在泵体内表面形成碳化钛系陶瓷材料层,碳化钛系陶瓷材料层厚度0.5mm,碳化钛系陶瓷材料层成分包括(重量):碳化钛90份,氮化钛15-20份,碳化铬10份,氧化钛5-8份,将涂覆后的泵体进行加热,升温至600°C,升温速率200°C /小时,保温3小时,后降温至400°C,降温速率100°C /小时,保温 After passivation of the external surface of the pump zirconium oxide-based ceramic material is coated; zirconia-based ceramic material layer is formed by coating the outer surface of the pump, a zirconium oxide based ceramic material 0.4_ thickness, zirconia-based ceramic material comprises a layer component ( by weight): 50-60 parts of zirconium oxide, titanium boride 20-30 parts, 20-30 parts of titanium carbide, silicon oxide 1_2 parts of the pump body is heated after coated, heated to 750 ° C, temperature increase rate 250 ° C / h, for 4 hours, after cooling to 550 ° C, cooling rate 100 ° C / hour, for 3 hours, after cooling again to 250 ° C, the cooling rate 75 ° C / hour, a holding seven hours, air cooling to at room temperature, then coated surface of the pump body of titanium carbide-based ceramic material; forming a layer of titanium carbide-based ceramic material by coating the surface of the pump body, a titanium carbide-based ceramic material thickness of 0.5mm, titanium carbide-based ceramic material comprises a layer component ( by weight): 90 parts of titanium carbide, titanium nitride 15-20 parts, 10 parts of chromium carbide, titanium parts 5-8, the pump is heated after coated, heated to 600 ° C, heating rate 200 ° C / hours, for 3 hours, after cooling to 400 ° C, cooling rate 100 ° C / hour, a holding 7小时,后再次降温至100°C,降温速率50°C /小时,保温12小时,后空冷至室温,得到最终泵体。 7 hours, after cooling again to 100 ° C, the cooling rate 50 ° C / hour, for 12 hours and air cooling to room temperature, to give a final pump.

[0016] 所述泵体内表面为血液通过泵内部时可以接触到泵体内部表面的部分,泵体其余部分为泵体外表面 [0016] The surface of the pump body is blood may contact the interior surface of the pump body through the inner part of the pump, the pump remaining portion of the outer surface of the pump

上述发明内容相对于现有技术的有益效果在于:1)钛合金的成分简单;2)对该成分的钛合金进行酸洗及钝化的表面处理工序,避免出现任何表面黑点等问题,使获得表面整洁;3)通过在根据泵体接触人体细胞的种类和速度不同在泵体的内表面和外表面涂覆碳化钛系陶瓷材料和氧化锆系陶瓷材料层,提高材料的抗溶血和抗血栓等性能。 The above summary of the prior art with respect to the beneficial effect that: component 1) simple titanium alloy; 2) the titanium component surface treatment by pickling and passivation step, the surface to avoid any problems such as dark spots, so clean surface is obtained; 3) in accordance with the kind and anti-human contact and the speed of the pump in different cells and the inner surface of the pump body outer surface coating of titanium carbide-based ceramic material and a zirconia ceramic material layers, to improve the material antihemolytic thrombosis and other properties.

具体实施方式 detailed description

[0017] 为了对本发明的技术特征、目的和效果有更加清楚的理解,现详细说明本发明的具体实施方式。 [0017] For the technical characteristics of the invention, the objects and effects more clearly understood, embodiments of the present invention will now be described in detail.

[0018] 实施例1 [0018] Example 1

一种医疗器械血泵,血泵包括一泵体,泵体包括:铸造钛合金泵体、泵体外表面的氧化锆系陶瓷材料层和泵体内表面的碳化钛系陶瓷材料层, A medical instrument blood pump, a blood pump comprising a pump body, the pump comprising: a pump body casting titanium, titanium carbide-based ceramic material and a layer of a ceramic material layer surface of the pump body zirconia outer surface of the pump,

其特征在于,铸造钛合金泵体化学组成为(重量):Zn:14 %、A1:6 %、Fe:4 %,S1:1 %、Mg I %、Ni 0.7 %、Cu:0.5 %、Cd:0.2 %、Zr:0.07 %、C©:0.03 %、Mn:0.05 %,V:0.06% , B:0.08 %,余量为Ti以及不可避免的杂质; Characterized in that the pump casting alloy chemical composition (by weight): Zn: 14%, A1: 6%, Fe: 4%, S1: 1%, Mg I%, Ni 0.7%, Cu: 0.5%, Cd : 0.2%, Zr: 0.07%, C ©: 0.03%, Mn: 0.05%, V: 0.06%, B: 0.08%, the balance is Ti and unavoidable impurities;

铸造钛合金泵体制备方法:包括以下步骤:按照上述比例配制合金,合金材料恪炼、饶注:熔炼温度:1810°C,浇注温度为1750°C ;脱模后,得到的泵体进行热处理:首先将泵体进行加热,升温至950°C,升温速率300°C /小时,保温6小时,后降温至650°C,降温速率100C /小时,保温7小时,后升温至800°C,升温速率100°C /小时,保温4小时,后再次降温至450°C,降温速率50°C /小时,保温9小时,后再次降温至250°C,降温速率40°C /小时,保温6小时,后空冷至室温, Preparation of Titanium pump casting method: comprising the steps of: preparing an alloy according to the above ratio, Ke refining alloy material, Rao NOTE: melting temperature: 1810 ° C, the pouring temperature is 1750 ° C; after demolding, the resulting heat-treated pump : first heating pump, heated to 950 ° C, heating rate 300 ° C / hr, incubated for 6 hours, after cooling to 650 ° C, the cooling rate of 100C / hour, a holding seven hours, the temperature was raised to 800 ° C, heating rate 100 ° C / h, for 4 hours, after cooling again to 450 ° C, the cooling rate 50 ° C / hr, incubated 9 hours, after cooling again to 250 ° C, the cooling rate 40 ° C / hour, a holding 6 hours, cooled to room temperature,

之后对泵体表面进行酸洗和钝化处理,其中: After pickling and the pump housing surface passivation, wherein:

酸洗液组成为(重量):采取98%浓H2SO4 40份,36.5%的HCL 15份,丙酸I份,乙二胺I份、烷基咪唑啉季铵盐10份;水10份; Pickling solution consisting (by weight): 98% concentrated H2SO4 40 taken parts, 36.5% of HCL 15 parts, parts of acid I, I parts of ethylenediamine, 10 parts of an alkyl imidazoline quaternary ammonium salts; 10 parts of water;

钝化液组成为(重量):聚酰亚胺10份,2-(3,4-环氧环己基)乙基三甲氧基硅烷4份,N- (2-氨基乙基)-3-氨基丙基甲基二甲氧基硅烷2份,氟硼酸钠10份,硫酸I份,二烷基二硫代磷酸氧钼6份,水25份; Passivation solution consisting (by weight): 10 parts of the polyimide, 2- (3,4-epoxycyclohexyl) ethyltrimethoxysilane 4 parts, N- (2- aminoethyl) -3-amino methyl dimethoxy silane 2 parts, 10 parts of sodium borofluoride, the I parts of sulfuric acid, dialkyl dithio phosphate oxygen 6 parts molybdenum, 25 parts of water;

对钝化后泵体外表面进行涂覆氧化锆系陶瓷材料;通过涂覆在泵体外表面形成氧化锆系陶瓷材料层,氧化锆系陶瓷材料层厚度0.4_,氧化锆系陶瓷材料层成分包括(重量):氧化锆50份,硼化钛20份,碳化钛20份,氧化硅I份,将涂覆后的泵体进行加热,升温至7500C,升温速率250°C /小时,保温4小时,后降温至550°C,降温速率100°C /小时,保温3小时,后再次降温至250°C,降温速率75°C /小时,保温7小时,后空冷至室温, After passivation of the external surface of the pump zirconium oxide-based ceramic material is coated; zirconia-based ceramic material layer is formed by coating the outer surface of the pump, a zirconium oxide based ceramic material 0.4_ thickness, zirconia-based ceramic material comprises a layer component ( by weight): 50 parts of zirconium oxide, 20 parts of titanium boride, titanium carbide parts 20, parts of silica I, the pump is heated after coated, heated to 7500C, temperature increase rate 250 ° C / h, for 4 hours, after cooling down to 550 ° C, cooling rate 100 ° C / hour, for 3 hours, after cooling again to 250 ° C, the cooling rate 75 ° C / h, incubated for 7 hours. after cooled to room temperature,

之后对泵体内表面进行涂覆碳化钛系陶瓷材料;通过涂覆在泵体内表面形成碳化钛系陶瓷材料层,碳化钛系陶瓷材料层厚度0.5_,碳化钛系陶瓷材料层成分包括(重量):碳化钛90份,氮化钛20份,碳化铬10份,氧化钛8份,将涂覆后的泵体进行加热,升温至6000C,升温速率200°C /小时,保温3小时,后降温至400°C,降温速率100°C /小时,保温7小时,后再次降温至100°C,降温速率50°C /小时,保温12小时,后空冷至室温,得到最终泵体。 After the surface of the pump body coated titanium carbide-based ceramic material; forming a layer of titanium carbide-based ceramic material by coating the surface of the pump body, a titanium carbide-based ceramic material thickness 0.5_, titanium carbide-based ceramic material comprises a layer component (by weight) : 90 parts of titanium carbide, titanium nitride 20 parts, 10 parts of chromium carbide, 8 parts of titanium oxide, the pump is heated after coated, heated to 6000C, heating rate 200 ° C / hour, for 3 hours, after cooling to 400 ° C, cooling rate 100 ° C / hour, a holding 7 hours, after cooling again to 100 ° C, the cooling rate 50 ° C / hour, for 12 hours and air cooling to room temperature, to give a final pump.

[0019] 实施例2 [0019] Example 2

一种医疗器械血泵,血泵包括一泵体,泵体包括:铸造钛合金泵体、泵体外表面的氧化锆系陶瓷材料层和泵体内表面的碳化钛系陶瓷材料层, A medical instrument blood pump, a blood pump comprising a pump body, the pump comprising: a pump body casting titanium, titanium carbide-based ceramic material and a layer of a ceramic material layer surface of the pump body zirconia outer surface of the pump,

其特征在于,铸造钛合金泵体化学组成为(重量):Zn: 15 %、A1: 7 %、Fe: 5 %,S1:2 %、Mg 2 %、Ni 0.8 %、Cu: 0.6 %、Cd: 0.3 %、Zr: 0.08 %、Ce: 0.04 %、Mn: 0.06%,V: 0.07 % , B: 0.09 %,余量为Ti以及不可避免的杂质; Characterized in that the pump casting alloy chemical composition (by weight): Zn: 15%, A1: 7%, Fe: 5%, S1: 2%, Mg 2%, Ni 0.8%, Cu: 0.6%, Cd : 0.3%, Zr: 0.08%, Ce: 0.04%, Mn: 0.06%, V: 0.07%, B: 0.09%, the balance is Ti and unavoidable impurities;

铸造钛合金泵体制备方法:包括以下步骤:按照上述比例配制合金,合金材料恪炼、饶注:熔炼温度:1820°C,浇注温度为1760°C ;脱模后,得到的泵体进行热处理:首先将泵体进行加热,升温至950°C,升温速率300°C /小时,保温6小时,后降温至650°C,降温速率100C /小时,保温7小时,后升温至800°C,升温速率100°C /小时,保温4小时,后再次降温至450°C,降温速率50°C /小时,保温9小时,后再次降温至250°C,降温速率40°C /小时,保温6小时,后空冷至室温, Preparation of Titanium pump casting method: comprising the steps of: preparing an alloy according to the above ratio, Ke refining alloy material, Rao NOTE: melting temperature: 1820 ° C, the pouring temperature is 1760 ° C; after demolding, the resulting heat-treated pump : first heating pump, heated to 950 ° C, heating rate 300 ° C / hr, incubated for 6 hours, after cooling to 650 ° C, the cooling rate of 100C / hour, a holding seven hours, the temperature was raised to 800 ° C, heating rate 100 ° C / h, for 4 hours, after cooling again to 450 ° C, the cooling rate 50 ° C / hr, incubated 9 hours, after cooling again to 250 ° C, the cooling rate 40 ° C / hour, a holding 6 hours, cooled to room temperature,

之后对泵体表面进行酸洗和钝化处理,其中: After pickling and the pump housing surface passivation, wherein:

酸洗液组成为(重量):采取98%浓H2SO4 50份,36.5%的HCL 20份,丙酸3份,乙二胺5份、烷基咪唑啉季铵盐15份;水20份; Pickling solution consisting (by weight): 98% concentrated H2SO4 50 taken parts, 20 parts of 36.5% of the HCL, propionic acid 3 parts, 5 parts of ethylenediamine, 15 parts of an alkyl imidazoline quaternary ammonium salts; 20 parts water;

钝化液组成为(重量):聚酰亚胺15份,2-(3,4_环氧环己基)乙基三甲氧基硅烷10份,N- (2-氨基乙基)-3-氨基丙基甲基二甲氧基硅烷3份,氟硼酸钠13份,硫酸4份,二烷基二硫代磷酸氧钼7份,水35份; 对钝化后泵体外表面进行涂覆氧化锆系陶瓷材料;通过涂覆在泵体外表面形成氧化锆系陶瓷材料层,氧化锆系陶瓷材料层厚度0.4_,氧化锆系陶瓷材料层成分包括(重量):氧化锆60份,硼化钛30份,碳化钛30份,氧化硅2份,将涂覆后的泵体进行加热,升温至7500C,升温速率250°C /小时,保温4小时,后降温至550°C,降温速率100°C /小时,保温3小时,后再次降温至250°C,降温速率75°C /小时,保温7小时,后空冷至室温, Passivation solution consisting (by weight): 15 parts of the polyimide, 2- (3,4_ epoxycyclohexyl) ethyltrimethoxysilane 10 parts, N- (2- aminoethyl) -3-amino methyl dimethoxy silane 3 parts, 13 parts of sodium borofluoride, 4 parts of sulfuric acid, dialkyl oxymolybdenum dithiophosphate 7 parts, 35 parts of water; post-passivation of the external surface of the pump is coated zirconia based ceramic material; zirconia-based ceramic material is formed on the outer surface of the pump layer by coating, the zirconia-based ceramic material 0.4_ thickness, zirconia-based ceramic material comprises a layer component (by weight): 60 parts of zirconium oxide, titanium boride 30 parts, 30 parts of titanium carbide, silicon oxide, 2 parts of the pump after the coating is heated, temperature was raised to 7500C, temperature increase rate 250 ° C / h, for 4 hours, after cooling to 550 ° C, cooling rate 100 ° C / hour, for 3 hours, after cooling again to 250 ° C, the cooling rate 75 ° C / h, incubated for 7 hours. after cooled to room temperature,

之后对泵体内表面进行涂覆碳化钛系陶瓷材料;通过涂覆在泵体内表面形成碳化钛系陶瓷材料层,碳化钛系陶瓷材料层厚度0.5_,碳化钛系陶瓷材料层成分包括(重量):碳化钛90份,氮化钛20份,碳化铬10份,氧化钛8份,将涂覆后的泵体进行加热,升温至6000C,升温速率200°C /小时,保温3小时,后降温至400°C,降温速率100°C /小时,保温7小时,后再次降温至100°C,降温速率50°C /小时,保温12小时,后空冷至室温,得到最终泵体。 After the surface of the pump body coated titanium carbide-based ceramic material; forming a layer of titanium carbide-based ceramic material by coating the surface of the pump body, a titanium carbide-based ceramic material thickness 0.5_, titanium carbide-based ceramic material comprises a layer component (by weight) : 90 parts of titanium carbide, titanium nitride 20 parts, 10 parts of chromium carbide, 8 parts of titanium oxide, the pump is heated after coated, heated to 6000C, heating rate 200 ° C / hour, for 3 hours, after cooling to 400 ° C, cooling rate 100 ° C / hour, a holding 7 hours, after cooling again to 100 ° C, the cooling rate 50 ° C / hour, for 12 hours and air cooling to room temperature, to give a final pump.

[0020] 实施例3 [0020] Example 3

一种医疗器械血泵,血泵包括一泵体,泵体包括:铸造钛合金泵体、泵体外表面的氧化锆系陶瓷材料层和泵体内表面的碳化钛系陶瓷材料层, A medical instrument blood pump, a blood pump comprising a pump body, the pump comprising: a pump body casting titanium, titanium carbide-based ceramic material and a layer of a ceramic material layer surface of the pump body zirconia outer surface of the pump,

其特征在于,铸造钛合金泵体化学组成为(重量):Zn:14.5 %、Al:6.5 %、Fe:4.5 %,Si: 1.5 %、Mg 1.5 %、Ni 0.75 %、Cu:0.55 %、Cd:0.25 %、Zr:0.075 %、Ce:0.035 %、Mn:0.055 %,V:0.065 %,B:0.085 %,余量为Ti以及不可避免的杂质; Characterized in that the pump casting alloy chemical composition (by weight): Zn: 14.5%, Al: 6.5%, Fe: 4.5%, Si: 1.5%, Mg 1.5%, Ni 0.75%, Cu: 0.55%, Cd : 0.25%, Zr: 0.075%, Ce: 0.035%, Mn: 0.055%, V: 0.065%, B: 0.085%, the balance is Ti and unavoidable impurities;

铸造钛合金泵体制备方法:包括以下步骤:按照上述比例配制合金,合金材料恪炼、饶注:熔炼温度:1815°C,浇注温度为1755°C ;脱模后,得到的泵体进行热处理:首先将泵体进行加热,升温至950°C,升温速率300°C /小时,保温6小时,后降温至650°C,降温速率100C /小时,保温7小时,后升温至800°C,升温速率100°C /小时,保温4小时,后再次降温至450°C,降温速率50°C /小时,保温9小时,后再次降温至250°C,降温速率40°C /小时,保温6小时,后空冷至室温, Preparation of Titanium pump casting method: comprising the steps of: preparing an alloy according to the above ratio, Ke refining alloy material, Rao NOTE: melting temperature: 1815 ° C, the pouring temperature is 1755 ° C; after demolding, the resulting heat-treated pump : first heating pump, heated to 950 ° C, heating rate 300 ° C / hr, incubated for 6 hours, after cooling to 650 ° C, the cooling rate of 100C / hour, a holding seven hours, the temperature was raised to 800 ° C, heating rate 100 ° C / h, for 4 hours, after cooling again to 450 ° C, the cooling rate 50 ° C / hr, incubated 9 hours, after cooling again to 250 ° C, the cooling rate 40 ° C / hour, a holding 6 hours, cooled to room temperature,

之后对泵体表面进行酸洗和钝化处理,其中: After pickling and the pump housing surface passivation, wherein:

酸洗液组成为(重量):采取98%浓H2SO4 45份,36.5%的HCL 17份,丙酸2份,乙二胺3份、烷基咪唑啉季铵盐13份;水15份; Pickling solution consisting (by weight): 98% concentrated H2SO4 45 taken parts, 36.5% of HCL 17 parts, 2 parts of propionic acid, 3 parts of ethylenediamine, 13 parts of an alkyl imidazoline quaternary ammonium salts; 15 parts water;

钝化液组成为(重量):聚酰亚胺13份,2-(3,4-环氧环己基)乙基三甲氧基硅烷7份,N- (2-氨基乙基)-3-氨基丙基甲基二甲氧基硅烷2.5份,氟硼酸钠12份,硫酸3份,二烷基二硫代磷酸氧钼6.5份,水30份; Passivation solution consisting (by weight): 13 parts of the polyimide, 2- (3,4-epoxycyclohexyl) ethyltrimethoxysilane 7 parts, N- (2- aminoethyl) -3-amino methyl dimethoxy silane 2.5 parts of sodium borofluoride 12 parts, 3 parts of sulfuric acid, dialkyl dithio phosphate oxygen 6.5 parts molybdenum, 30 parts of water;

对钝化后泵体外表面进行涂覆氧化锆系陶瓷材料;通过涂覆在泵体外表面形成氧化锆系陶瓷材料层,氧化锆系陶瓷材料层厚度0.4_,氧化锆系陶瓷材料层成分包括(重量):氧化锆55份,硼化钛25份,碳化钛25份,氧化硅1.5份,将涂覆后的泵体进行加热,升温至7500C,升温速率250°C /小时,保温4小时,后降温至550°C,降温速率100°C /小时,保温3小时,后再次降温至250°C,降温速率75°C /小时,保温7小时,后空冷至室温, After passivation of the external surface of the pump zirconium oxide-based ceramic material is coated; zirconia-based ceramic material layer is formed by coating the outer surface of the pump, a zirconium oxide based ceramic material 0.4_ thickness, zirconia-based ceramic material comprises a layer component ( by weight): 55 parts of zirconium oxide, 25 parts of titanium boride, titanium carbide 25 parts, 1.5 parts silicon oxide, to pump the coating is heated, temperature was raised to 7500C, temperature increase rate 250 ° C / h, for 4 hours, after cooling down to 550 ° C, cooling rate 100 ° C / hour, for 3 hours, after cooling again to 250 ° C, the cooling rate 75 ° C / h, incubated for 7 hours. after cooled to room temperature,

之后对泵体内表面进行涂覆碳化钛系陶瓷材料;通过涂覆在泵体内表面形成碳化钛系陶瓷材料层,碳化钛系陶瓷材料层厚度0.5_,碳化钛系陶瓷材料层成分包括(重量):碳化钛90份,氮化钛17份,碳化铬10份,氧化钛7份,将涂覆后的泵体进行加热,升温至6000C,升温速率200°C /小时,保温3小时,后降温至400°C,降温速率100°C /小时,保温7小时,后再次降温至100°C,降温速率50°C /小时,保温12小时,后空冷至室温,得到最终泵体。 After the surface of the pump body coated titanium carbide-based ceramic material; forming a layer of titanium carbide-based ceramic material by coating the surface of the pump body, a titanium carbide-based ceramic material thickness 0.5_, titanium carbide-based ceramic material comprises a layer component (by weight) : 90 parts of titanium carbide, titanium nitride 17 parts, 10 parts of chromium carbide, 7 parts of titanium oxide, the pump is heated after coated, heated to 6000C, heating rate 200 ° C / hour, for 3 hours, after cooling to 400 ° C, cooling rate 100 ° C / hour, a holding 7 hours, after cooling again to 100 ° C, the cooling rate 50 ° C / hour, for 12 hours and air cooling to room temperature, to give a final pump.

[0021] 实施例4 [0021] Example 4

一种医疗器械血泵,血泵包括一泵体,泵体包括:铸造钛合金泵体、泵体外表面的氧化锆系陶瓷材料层和泵体内表面的碳化钛系陶瓷材料层, A medical instrument blood pump, a blood pump comprising a pump body, the pump comprising: a pump body casting titanium, titanium carbide-based ceramic material and a layer of a ceramic material layer surface of the pump body zirconia outer surface of the pump,

其特征在于,铸造钛合金泵体化学组成为(重量):Zn:14.3 %、Al:6.2 %、Fe:4.4 %,Si:1.1 %、Mg 1.2 %、Ni 0.73 %、Cu:0.54 %、Cd:0.22 %、Zr:0.072 %、Ce:0.033 %、Mn:0.051 %,V:0.062 %,B:0.084 %,余量为Ti以及不可避免的杂质; Characterized in that the pump casting alloy chemical composition (by weight): Zn: 14.3%, Al: 6.2%, Fe: 4.4%, Si: 1.1%, Mg 1.2%, Ni 0.73%, Cu: 0.54%, Cd : 0.22%, Zr: 0.072%, Ce: 0.033%, Mn: 0.051%, V: 0.062%, B: 0.084%, the balance is Ti and unavoidable impurities;

铸造钛合金泵体制备方法:包括以下步骤:按照上述比例配制合金,合金材料恪炼、饶注:熔炼温度:1813°C,浇注温度为1754°C ;脱模后,得到的泵体进行热处理:首先将泵体进行加热,升温至950°C,升温速率300°C /小时,保温6小时,后降温至650°C,降温速率100C /小时,保温7小时,后升温至800°C,升温速率100°C /小时,保温4小时,后再次降温至450°C,降温速率50°C /小时,保温9小时,后再次降温至250°C,降温速率40°C /小时,保温6小时,后空冷至室温, Preparation of Titanium pump casting method: comprising the steps of: preparing an alloy according to the above ratio, Ke refining alloy material, Rao NOTE: melting temperature: 1813 ° C, the pouring temperature is 1754 ° C; after demolding, the resulting heat-treated pump : first heating pump, heated to 950 ° C, heating rate 300 ° C / hr, incubated for 6 hours, after cooling to 650 ° C, the cooling rate of 100C / hour, a holding seven hours, the temperature was raised to 800 ° C, heating rate 100 ° C / h, for 4 hours, after cooling again to 450 ° C, the cooling rate 50 ° C / hr, incubated 9 hours, after cooling again to 250 ° C, the cooling rate 40 ° C / hour, a holding 6 hours, cooled to room temperature,

之后对泵体表面进行酸洗和钝化处理,其中: After pickling and the pump housing surface passivation, wherein:

酸洗液组成为(重量):采取98%浓H2SO4 44份,36.5%的HCL 16份,丙酸1.4份,乙二胺1.3份、烷基咪唑啉季铵盐11份;水12份; Pickling solution consisting (by weight): 98% concentrated H2SO4 44 taken parts, 36.5% of HCL 16 parts, 1.4 parts of propionic acid, 1.3 parts of ethylenediamine, 11 parts of an alkyl imidazoline quaternary ammonium salts; 12 parts water;

钝化液组成为(重量):聚酰亚胺11份,2-(3,4-环氧环己基)乙基三甲氧基硅烷5份,N- (2-氨基乙基)-3-氨基丙基甲基二甲氧基硅烷2.3份,氟硼酸钠11份,硫酸1.5份,二烷基二硫代磷酸氧钼6.2份,水27份; Passivation solution consisting (by weight): 11 parts of the polyimide, 2- (3,4-epoxycyclohexyl) ethyltrimethoxysilane 5 parts, N- (2- aminoethyl) -3-amino methyl dimethoxy silane 2.3 parts, 11 parts of sodium borofluoride, 1.5 parts of sulfuric acid, dialkyl dithio phosphate oxygen 6.2 parts molybdenum, 27 parts of water;

对钝化后泵体外表面进行涂覆氧化锆系陶瓷材料;通过涂覆在泵体外表面形成氧化锆系陶瓷材料层,氧化锆系陶瓷材料层厚度0.4_,氧化锆系陶瓷材料层成分包括(重量):氧化锆52份,硼化钛23份,碳化钛24份,氧化硅1.1份,将涂覆后的泵体进行加热,升温至7500C,升温速率250°C /小时,保温4小时,后降温至550°C,降温速率100°C /小时,保温3小时,后再次降温至250°C,降温速率75°C /小时,保温7小时,后空冷至室温, After passivation of the external surface of the pump zirconium oxide-based ceramic material is coated; zirconia-based ceramic material layer is formed by coating the outer surface of the pump, a zirconium oxide based ceramic material 0.4_ thickness, zirconia-based ceramic material comprises a layer component ( by weight): 52 parts of zirconium oxide, 23 parts of titanium boride, titanium carbide 24 parts, 1.1 parts silicon oxide, to pump the coating is heated, temperature was raised to 7500C, temperature increase rate 250 ° C / h, for 4 hours, after cooling down to 550 ° C, cooling rate 100 ° C / hour, for 3 hours, after cooling again to 250 ° C, the cooling rate 75 ° C / h, incubated for 7 hours. after cooled to room temperature,

之后对泵体内表面进行涂覆碳化钛系陶瓷材料;通过涂覆在泵体内表面形成碳化钛系陶瓷材料层,碳化钛系陶瓷材料层厚度0.5_,碳化钛系陶瓷材料层成分包括(重量):碳化钛90份,氮化钛16份,碳化铬10份,氧化钛6份,将涂覆后的泵体进行加热,升温至6000C,升温速率200°C /小时,保温3小时,后降温至400°C,降温速率100°C /小时,保温7小时,后再次降温至100°C,降温速率50°C /小时,保温12小时,后空冷至室温,得到最终泵体。 After the surface of the pump body coated titanium carbide-based ceramic material; forming a layer of titanium carbide-based ceramic material by coating the surface of the pump body, a titanium carbide-based ceramic material thickness 0.5_, titanium carbide-based ceramic material comprises a layer component (by weight) : 90 parts of titanium carbide, titanium nitride 16 parts, 10 parts of chromium carbide, titanium oxide 6 parts, the pump is heated after coated, heated to 6000C, heating rate 200 ° C / hour, for 3 hours, after cooling to 400 ° C, cooling rate 100 ° C / hour, a holding 7 hours, after cooling again to 100 ° C, the cooling rate 50 ° C / hour, for 12 hours and air cooling to room temperature, to give a final pump.

[0022] 实施例5 [0022] Example 5

一种医疗器械血泵,血泵包括一泵体,泵体包括:铸造钛合金泵体、泵体外表面的氧化锆系陶瓷材料层和泵体内表面的碳化钛系陶瓷材料层, A medical instrument blood pump, a blood pump comprising a pump body, the pump comprising: a pump body casting titanium, titanium carbide-based ceramic material and a layer of a ceramic material layer surface of the pump body zirconia outer surface of the pump,

其特征在于,铸造钛合金泵体化学组成为(重量):Zn:14.7 %、Al:6.8 %、Fe:4.9 %,Si:1.7 %、Mg 1.6%、Ni 0.77 %、Cu:0.59 %、Cd:0.26 %、Zr:0.078 %、Ce:0.039 %、Mn:0.057 %,V:0.066 %,B:0.089 %,余量为Ti以及不可避免的杂质; Characterized in that the pump casting alloy chemical composition (by weight): Zn: 14.7%, Al: 6.8%, Fe: 4.9%, Si: 1.7%, Mg 1.6%, Ni 0.77%, Cu: 0.59%, Cd : 0.26%, Zr: 0.078%, Ce: 0.039%, Mn: 0.057%, V: 0.066%, B: 0.089%, the balance is Ti and unavoidable impurities;

铸造钛合金泵体制备方法:包括以下步骤:按照上述比例配制合金,合金材料恪炼、饶注:熔炼温度:1817°C,浇注温度为1759°C ;脱模后,得到的泵体进行热处理:首先将泵体进行加热,升温至950°C,升温速率300°C /小时,保温6小时,后降温至650°C,降温速率100C /小时,保温7小时,后升温至800°C,升温速率100°C /小时,保温4小时,后再次降温至450°C,降温速率50°C /小时,保温9小时,后再次降温至250°C,降温速率40°C /小时,保温6小时,后空冷至室温, Preparation of Titanium pump casting method: comprising the steps of: preparing an alloy according to the above ratio, Ke refining alloy material, Rao NOTE: melting temperature: 1817 ° C, the pouring temperature is 1759 ° C; after demolding, the resulting heat-treated pump : first heating pump, heated to 950 ° C, heating rate 300 ° C / hr, incubated for 6 hours, after cooling to 650 ° C, the cooling rate of 100C / hour, a holding seven hours, the temperature was raised to 800 ° C, heating rate 100 ° C / h, for 4 hours, after cooling again to 450 ° C, the cooling rate 50 ° C / hr, incubated 9 hours, after cooling again to 250 ° C, the cooling rate 40 ° C / hour, a holding 6 hours, cooled to room temperature,

之后对泵体表面进行酸洗和钝化处理,其中: After pickling and the pump housing surface passivation, wherein:

酸洗液组成为(重量):采取98%浓H2SO4 47份,36.5%的HCL 19份,丙酸2.5份,乙二胺4份、烷基咪唑啉季铵盐14份;水19份; Pickling solution consisting (by weight): 98% concentrated H2SO4 47 taken parts, 19 parts of 36.5% of the HCL, 2.5 parts of propionic acid, 4 parts of ethylenediamine, 14 parts of an alkyl imidazoline quaternary ammonium salts; 19 parts water;

钝化液组成为(重量):聚酰亚胺14份,2-(3,4-环氧环己基)乙基三甲氧基硅烷9份,N- (2-氨基乙基)-3-氨基丙基甲基二甲氧基硅烷2.5份,氟硼酸钠12.5份,硫酸3.5份,二烷基二硫代磷酸氧钼6.8份,水34份; Passivation solution consisting (by weight): 14 parts of the polyimide, 2- (3,4-epoxycyclohexyl) ethyltrimethoxysilane 9 parts, N- (2- aminoethyl) -3-amino methyl dimethoxy silane 2.5 parts, 12.5 parts of sodium borofluoride, 3.5 parts of sulfuric acid, dialkyl dithio phosphate oxygen 6.8 parts molybdenum, 34 parts of water;

对钝化后泵体外表面进行涂覆氧化锆系陶瓷材料;通过涂覆在泵体外表面形成氧化锆系陶瓷材料层,氧化锆系陶瓷材料层厚度0.4_,氧化锆系陶瓷材料层成分包括(重量):氧化锆58份,硼化钛29份,碳化钛26份,氧化硅1.9份,将涂覆后的泵体进行加热,升温至7500C,升温速率250°C /小时,保温4小时,后降温至550°C,降温速率100°C /小时,保温3小时,后再次降温至250°C,降温速率75°C /小时,保温7小时,后空冷至室温, After passivation of the external surface of the pump zirconium oxide-based ceramic material is coated; zirconia-based ceramic material layer is formed by coating the outer surface of the pump, a zirconium oxide based ceramic material 0.4_ thickness, zirconia-based ceramic material comprises a layer component ( by weight): 58 parts of zirconium oxide, 29 parts of titanium boride, titanium carbide 26 parts, 1.9 parts silicon oxide, to pump the coating is heated, temperature was raised to 7500C, temperature increase rate 250 ° C / h, for 4 hours, after cooling down to 550 ° C, cooling rate 100 ° C / hour, for 3 hours, after cooling again to 250 ° C, the cooling rate 75 ° C / h, incubated for 7 hours. after cooled to room temperature,

之后对泵体内表面进行涂覆碳化钛系陶瓷材料;通过涂覆在泵体内表面形成碳化钛系陶瓷材料层,碳化钛系陶瓷材料层厚度0.5_,碳化钛系陶瓷材料层成分包括(重量):碳化钛90份,氮化钛19份,碳化铬10份,氧化钛7份,将涂覆后的泵体进行加热,升温至6000C,升温速率200°C /小时,保温3小时,后降温至400°C,降温速率100°C /小时,保温7小时,后再次降温至100°C,降温速率50°C /小时,保温12小时,后空冷至室温,得到最终泵体。 After the surface of the pump body coated titanium carbide-based ceramic material; forming a layer of titanium carbide-based ceramic material by coating the surface of the pump body, a titanium carbide-based ceramic material thickness 0.5_, titanium carbide-based ceramic material comprises a layer component (by weight) : 90 parts of titanium carbide, titanium nitride 19 parts, 10 parts of chromium carbide, 7 parts of titanium oxide, the pump is heated after coated, heated to 6000C, heating rate 200 ° C / hour, for 3 hours, after cooling to 400 ° C, cooling rate 100 ° C / hour, a holding 7 hours, after cooling again to 100 ° C, the cooling rate 50 ° C / hour, for 12 hours and air cooling to room temperature, to give a final pump.

Claims (10)

  1. 1.一种医疗器械血泵,血泵包括一泵体,泵体包括:铸造钛合金泵体、泵体外表面的氧化锆系陶瓷材料层和泵体内表面的碳化钛系陶瓷材料层, 其特征在于,铸造钛合金泵体化学组成为(重量百分比):Zn:14-15 %、Al:6-7 %、Fe:4-5 %,S1:1_2 %、Mg 1-2 %、Ni 0.7-0.8 %、Cu:0.5-0.6 %、Cd:0.2-0.3 %、Zr:0.07-0.08 %、Ce:0.03-0.04 %、Mn:0.05-0.06 %,V:0.06-0.07 %,B:0.08-0.09 %,余量为Ti以及不可避免的杂质; 铸造钛合金泵体制备方法:包括以下步骤:按照上述比例配制合金,合金材料恪炼、饶注:熔炼温度:1810-1820°C,浇注温度为1750-1760°C ;脱模后,得到的泵体进行热处理:首先将泵体进行加热,升温至950°C,升温速率300°C /小时,保温6小时,后降温至650°C,降温速率100°C /小时,保温7小时,后升温至800°C,升温速率100°C /小时,保温4小时,后再次降温至450°C,降温速率50°C /小时,保温9小时,后 A medical instrument blood pump, a blood pump comprising a pump body, the pump comprising: a pump body casting titanium, titanium carbide-based ceramic material layer of a ceramic material layer and the inner surface of the zirconia-based outer surface of the pump, wherein that the pump body casting alloy chemical composition (weight percent): Zn: 14-15%, Al: 6-7%, Fe: 4-5%, S1: 1_2%, Mg 1-2%, Ni 0.7- 0.8%, Cu: 0.5-0.6%, Cd: 0.2-0.3%, Zr: 0.07-0.08%, Ce: 0.03-0.04%, Mn: 0.05-0.06%, V: 0.06-0.07%, B: 0.08-0.09 %, the balance is Ti and unavoidable impurities; preparation of titanium pump casting method: comprising the steps of: preparing an alloy according to the above ratio, Ke refining alloy material, Rao NOTE: melting temperature: 1810-1820 ° C, the pouring temperature is 1750-1760 ° C; after demolding, the pump body obtained is heat-treated: first heating pump, heated to 950 ° C, heating rate 300 ° C / hr, incubated for 6 hours, after cooling to 650 ° C, cooling rate of 100 ° C / hour, a holding seven hours, the temperature was raised to 800 ° C, heating rate 100 ° C / h, for 4 hours, after cooling again to 450 ° C, the cooling rate 50 ° C / hr, incubated for 9 hours Rear 次降温至250°C,降温速率40°C /小时,保温6小时,后空冷至室温, 之后对泵体表面进行酸洗和钝化处理,其中: 酸洗液组成为(重量):采取98%浓H2SO4 40-50份,36.5%的HCL 15-20份,丙酸1-3份,乙二胺1-5份、烷基咪唑啉季铵盐10-15份;水10-20份; 钝化液组成为(重量):聚酰亚胺10-15份,2-(3,4-环氧环己基)乙基三甲氧基硅烷4-10份,N-(2-氨基乙基)-3-氨基丙基甲基二甲氧基硅烷2-3份,氟硼酸钠10-13份,硫酸1-4份,二烷基二硫代磷酸氧钼6-7份,水25-35份; 对钝化后泵体外表面进行涂覆氧化锆系陶瓷材料;通过涂覆在泵体外表面形成氧化锆系陶瓷材料层,氧化锆系陶瓷材料层厚度0.4_,氧化锆系陶瓷材料层成分包括(重量):氧化锆50-60份,硼化钛20-30份,碳化钛20-30份,氧化硅1_2份,将涂覆后的泵体进行加热,升温至750°C,升温速率250°C /小时,保温4小时,后降温至550°C,降 Once cooled to 250 ° C, the cooling rate 40 ° C / hr, incubated for 6 hours, cooled to room temperature, after pickling, and to the pump housing surface passivation, wherein: pickling solution consisting (by weight): 98 to take concentrated H2SO4 40-50% parts, of 36.5% HCL 15-20 parts, 1-3 parts of propionic acid, 1-5 parts of ethylenediamine, 10-15 parts of alkyl imidazoline quaternary ammonium salts; 10-20 parts of water; passivation solution consisting (by weight): 10-15 parts of a polyimide, 2- (3,4-epoxycyclohexyl) ethyltrimethoxysilane 4-10 parts, N- (2- aminoethyl) -3-aminopropyl methyl dimethoxysilane 2-3 parts, 10-13 parts of sodium borofluoride, 1-4 parts of sulfuric acid, oxygen, molybdenum dialkyl dithiophosphate 6-7 parts water 25-35 parts; post-passivation of the external surface of the pump is coated zirconium oxide ceramic material; zirconia-based ceramic material layer is formed by coating the outer surface of the pump, a zirconium oxide based ceramic material 0.4_ thickness, zirconia-based ceramic material layer component comprising (by weight): 50-60 parts of zirconium oxide, titanium boride 20-30 parts, 20-30 parts of titanium carbide, silicon oxide 1_2 parts of the pump body is heated after coated, heated to 750 ° C, heating rate 250 ° C / h, for 4 hours, after cooling to 550 ° C, drop 速率100°C /小时,保温3小时,后再次降温至250°C,降温速率75°C /小时,保温7小时,后空冷至室温,之后对泵体内表面进行涂覆碳化钛系陶瓷材料;通过涂覆在泵体内表面形成碳化钛系陶瓷材料层,碳化钛系陶瓷材料层厚度0.5mm,碳化钛系陶瓷材料层成分包括(重量):碳化钛90份,氮化钛15-20份,碳化铬10份,氧化钛5-8份,将涂覆后的泵体进行加热,升温至600°C,升温速率200°C /小时,保温3小时,后降温至400°C,降温速率100°C /小时,保温7小时,后再次降温至100°C,降温速率50°C /小时,保温12小时,后空冷至室温,得到最终泵体。 Rate of 100 ° C / hour, for 3 hours, after cooling again to 250 ° C, the cooling rate 75 ° C / h, incubated for 7 hours. After cooled to room temperature, then coated surface of the pump body of titanium carbide-based ceramic material; titanium carbide-based ceramic material layer by coating the surface of the pump body, a titanium carbide-based ceramic material thickness of 0.5mm, titanium carbide-based ceramic material comprises a layer component (by weight): 90 parts of titanium carbide, titanium nitride 15-20 parts, 10 parts of chromium carbide, titanium parts 5-8, the pump is heated after coated, heated to 600 ° C, heating rate 200 ° C / hour, for 3 hours, after cooling to 400 ° C, cooling rate 100 ° C / hour, a holding seven hours, after cooling again to 100 ° C, the cooling rate 50 ° C / hour, for 12 hours and air cooling to room temperature, to give a final pump.
  2. 2.如权利要求1所述的一种医疗器械血泵,铸造钛合金泵体化学组成为:Zn:14 %、Al:6 %、Fe:4 % ,Si:1 %、Mg I %、Ni 0.7 %、Cu:0.5 %、Cd:0.2 %、Zr:0.07 %、Ce:0.03%、Mn:0.05 %,V:0.06 %,B:0.08 %,余量为Ti以及不可避免的杂质。 Mg I 1%,%, Ni: 2. A medical instrument as claimed in claim 1, wherein the blood pump, the pump casting alloy chemical composition: Zn: 14%, Al: 6%, Fe: 4%, Si 0.7%, Cu: 0.5%, Cd: 0.2%, Zr: 0.07%, Ce: 0.03%, Mn: 0.05%, V: 0.06%, B: 0.08%, the balance is Ti and unavoidable impurities.
  3. 3.如权利要求1所述的一种医疗器械血泵,铸造钛合金泵体化学组成为:Zn: 15 %、Al: 7 %、Fe: 5 %,S1: 2 %、Mg 2 %、Ni 0.8 %、Cu: 0.6 %、Cd: 0.3 %、Zr: 0.08%、Ce: 0.04 % ,Mn: 0.06 % ,N: 0.07 %,B: (λ 09 %,余量为Ti 以及不可避免的杂质。 3. A medical instrument blood pump according to claim 1, the chemical composition of the cast titanium pump: Zn: 15%, Al: 7%, Fe: 5%, S1: 2%, Mg 2%, Ni 0.8%, Cu: 0.6%, Cd: 0.3%, Zr: 0.08%, Ce: 0.04%, Mn: 0.06%, N: 0.07%, B: (λ 09%, the balance is Ti and unavoidable impurities.
  4. 4.如权利要求1所述的一种医疗器械血泵,铸造钛合金泵体化学组成为:Ζη:14.5 %、Al:6.5 %、Fe:4.5 %,S1:1.5 %、Mg 1.5 %、Ni 0.75 %、Cu:0.55 %、Cd:0.25 %、Zr:0.075 %、Ce:0.035 %、Μη:0.055 %,V:0.065 %,Β:0.085 %,余量为Ti 以及不可避免的杂质。 A medical instrument 4. The blood pump according to claim 1, the chemical composition of the cast titanium pump: Ζη: 14.5%, Al: 6.5%, Fe: 4.5%, S1: 1.5%, Mg 1.5%, Ni 0.75%, Cu: 0.55%, Cd: 0.25%, Zr: 0.075%, Ce: 0.035%, Μη: 0.055%, V: 0.065%, Β: 0.085%, the balance is Ti and unavoidable impurities.
  5. 5.如权利要求1所述的一种医疗器械血泵,氧化锆系陶瓷材料层成分包括:氧化锆50份,硼化钛20份,碳化钛20份,氧化硅I份。 5. A medical instrument blood pump according to claim 1, the zirconium oxide-based material layer of a ceramic composition comprising: 50 parts of zirconium oxide, 20 parts of titanium boride, titanium carbide 20 parts, parts I silica.
  6. 6.如权利要求1所述的一种医疗器械血泵,氧化锆系陶瓷材料层成分包括:氧化锆60份,硼化钛30份,碳化钛30份,氧化硅2份。 A medical instrument according to the blood pump as claimed in claim 1, the zirconium oxide-based material layer of a ceramic composition comprising: 60 parts of zirconium oxide, 30 parts of titanium boride, titanium carbide 30 parts, 2 parts of silicon oxide.
  7. 7.如权利要求1所述的一种医疗器械血泵,氧化锆系陶瓷材料层成分包括:氧化锆55份,硼化钛25份,碳化钛25份,氧化硅1.5份。 7. A medical instrument blood pump according to claim 1, the zirconium oxide-based material layer of a ceramic composition comprising: 55 parts of zirconium oxide, 25 parts of titanium boride, titanium carbide 25 parts, 1.5 parts silicon oxide.
  8. 8.如权利要求1所述的一种医疗器械血泵,碳化钛系陶瓷材料层成分包括:碳化钛90份,氮化钛17份,碳化铬10份,氧化钛6份。 A medical instrument according to the blood pump as claimed in claim 1, titanium carbide-based ceramic material layer composition comprises: 90 parts of titanium carbide, titanium nitride 17 parts, 10 parts of chromium carbide, titanium oxide 6 parts.
  9. 9.如权利要求1-8所述的一种医疗器械血泵,酸洗液组成为(重量):采取98%浓H 2S0445份,36.5%的HCL 17份,丙酸2份,乙二胺3份、烷基咪唑啉季铵盐13份;水15份。 9. A medical instrument blood pump according to claims 1-8, pickling solution consisting (by weight): 98% concentrated H 2S0445 taken parts, 36.5% of HCL 17 parts, 2 parts of propionic acid, ethylenediamine 3 parts, 13 parts of an alkyl imidazoline quaternary ammonium salts; 15 parts of water.
  10. 10.如权利要求1-8所述的一种医疗器械血泵,钝化液组成为(重量):聚酰亚胺13份,2-(3,4_环氧环己基)乙基三甲氧基硅烷7份,N-(2-氨基乙基)-3-氨基丙基甲基二甲氧基硅烷2.5份,氟硼酸钠12份,硫酸3份,二烷基二硫代磷酸氧钼6.5份,水30份。 10. A medical instrument blood pump according to claims 1-8, the passivation solution consisting (by weight): 13 parts of the polyimide, 2- (3,4_ epoxycyclohexyl) ethyl-trimethoxy 7 parts of silane, N- (2- aminoethyl) -3-aminopropyl methyl dimethoxy silane 2.5 parts of sodium borofluoride 12 parts, 3 parts of sulfuric acid, dialkyl dithio phosphate oxygen molybdenum 6.5 parts, water 30 parts.
CN 201510190173 2015-04-21 2015-04-21 Blood pump of medical mechanism CN104740706A (en)

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