JP2012512891A5 - - Google Patents

Download PDF

Info

Publication number
JP2012512891A5
JP2012512891A5 JP2011542439A JP2011542439A JP2012512891A5 JP 2012512891 A5 JP2012512891 A5 JP 2012512891A5 JP 2011542439 A JP2011542439 A JP 2011542439A JP 2011542439 A JP2011542439 A JP 2011542439A JP 2012512891 A5 JP2012512891 A5 JP 2012512891A5
Authority
JP
Japan
Prior art keywords
group
compound
pharmaceutically acceptable
acceptable salt
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011542439A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012512891A (ja
JP5770102B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/068496 external-priority patent/WO2010080503A1/en
Publication of JP2012512891A publication Critical patent/JP2012512891A/ja
Publication of JP2012512891A5 publication Critical patent/JP2012512891A5/ja
Application granted granted Critical
Publication of JP5770102B2 publication Critical patent/JP5770102B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011542439A 2008-12-19 2009-12-17 複素環化合物と使用方法 Active JP5770102B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13949208P 2008-12-19 2008-12-19
US61/139,492 2008-12-19
PCT/US2009/068496 WO2010080503A1 (en) 2008-12-19 2009-12-17 Heterocyclic compounds and methods of use

Publications (3)

Publication Number Publication Date
JP2012512891A JP2012512891A (ja) 2012-06-07
JP2012512891A5 true JP2012512891A5 (cg-RX-API-DMAC10.html) 2013-02-14
JP5770102B2 JP5770102B2 (ja) 2015-08-26

Family

ID=42316723

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011542439A Active JP5770102B2 (ja) 2008-12-19 2009-12-17 複素環化合物と使用方法

Country Status (22)

Country Link
US (1) US8232273B2 (cg-RX-API-DMAC10.html)
EP (1) EP2373163B1 (cg-RX-API-DMAC10.html)
JP (1) JP5770102B2 (cg-RX-API-DMAC10.html)
KR (1) KR101685718B1 (cg-RX-API-DMAC10.html)
CN (1) CN102316733B (cg-RX-API-DMAC10.html)
AU (1) AU2009335843A1 (cg-RX-API-DMAC10.html)
BR (1) BRPI0918360A8 (cg-RX-API-DMAC10.html)
CA (1) CA2747170C (cg-RX-API-DMAC10.html)
CL (1) CL2011001485A1 (cg-RX-API-DMAC10.html)
CO (1) CO6390075A2 (cg-RX-API-DMAC10.html)
CR (1) CR20110388A (cg-RX-API-DMAC10.html)
DO (1) DOP2011000199A (cg-RX-API-DMAC10.html)
EC (1) ECSP11011213A (cg-RX-API-DMAC10.html)
ES (1) ES2544452T3 (cg-RX-API-DMAC10.html)
IL (1) IL213596A0 (cg-RX-API-DMAC10.html)
MX (1) MX2011006509A (cg-RX-API-DMAC10.html)
NZ (1) NZ593537A (cg-RX-API-DMAC10.html)
PE (1) PE20120334A1 (cg-RX-API-DMAC10.html)
RU (1) RU2525116C2 (cg-RX-API-DMAC10.html)
SG (1) SG172259A1 (cg-RX-API-DMAC10.html)
WO (1) WO2010080503A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201104467B (cg-RX-API-DMAC10.html)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5496876B2 (ja) 2007-04-16 2014-05-21 アッヴィ・インコーポレイテッド 7−置換されていないインドール系Mcl−1阻害薬
US8114893B2 (en) * 2008-12-19 2012-02-14 Genentech, Inc. Compounds and methods of use
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
LT2710013T (lt) 2011-05-20 2016-09-12 Glaxosmithkline Intellectual Property (No. 2) Limited Naujieji junginiai kaip diacilglicerolio aciltransferazės inhibitoriai
TWI561521B (en) * 2011-10-14 2016-12-11 Abbvie Inc Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8940737B2 (en) 2011-10-14 2015-01-27 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
TWI571466B (zh) * 2011-10-14 2017-02-21 艾伯維有限公司 用於治療癌症及免疫與自體免疫疾病之細胞凋亡誘發劑
US8889675B2 (en) 2011-10-14 2014-11-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
JP5955531B2 (ja) * 2011-11-07 2016-07-20 千葉県 抗癌剤
CN107652289B (zh) 2012-06-13 2020-07-21 因塞特控股公司 作为fgfr抑制剂的取代的三环化合物
CN103515415A (zh) * 2012-06-26 2014-01-15 群康科技(深圳)有限公司 叠层结构与其制造方法、以及包含其的电子装置
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
JP6225187B2 (ja) * 2012-08-13 2017-11-01 アッヴィ・インコーポレイテッド アポトーシス誘発剤
MX2015002887A (es) * 2012-09-06 2015-07-06 Plexxikon Inc Compuestos y metodos para la modulacion de cinasas, e indicaciones para ello.
ES2623304T3 (es) 2012-10-11 2017-07-10 F. Hoffmann-La Roche Ag Azaindolinas
US9796729B2 (en) 2012-11-23 2017-10-24 Glaxosmithkline Llc Compounds as diacylglycerol acyltransferase inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
EP2970277B1 (en) 2013-03-15 2021-07-28 Knopp Biosciences LLC Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators
JP6449244B2 (ja) 2013-04-19 2019-01-09 インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation Fgfr抑制剤としての二環式複素環
FR3008979B1 (fr) * 2013-07-23 2015-07-24 Servier Lab Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008975A1 (fr) 2013-07-23 2015-01-30 Servier Lab Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
SG11201606239UA (en) 2014-01-28 2016-08-30 Buck Inst For Res On Aging Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
CN106456699B (zh) 2014-05-05 2021-07-02 生物风险投资有限责任公司 作为抗老化剂抑制抗凋亡的Bcl-2蛋白的组合物和方法
EP3177144A4 (en) 2014-07-22 2018-01-24 Bioventures, LLC. Compositions and methods for selectively depleting senescent cells
SI3572405T1 (sl) * 2014-09-12 2023-12-29 Biohaven Therapeutics Ltd. Amidi benzoimidazol-1,2-il kot aktivatorji kanalov kv 7
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
AU2015360613A1 (en) * 2014-12-09 2017-06-29 Abbvie Inc. Bcl xl inhibitory compounds having low cell permeability and antibody drug conjugates including the same
WO2016094517A1 (en) * 2014-12-09 2016-06-16 Abbvie Inc. Bcl-xl inhibitory compounds and antibody drug conjugates including the same
WO2016131100A1 (en) * 2015-02-18 2016-08-25 The Walter And Eliza Hall Institute Of Medical Research Methods of treating infectious diseases
ES2751669T3 (es) 2015-02-20 2020-04-01 Incyte Corp Heterociclos bicíclicos como inhibidores FGFR
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
US10195213B2 (en) 2015-03-13 2019-02-05 Unity Biotechnology, Inc. Chemical entities that kill senescent cells for use in treating age-related disease
WO2016172218A1 (en) * 2015-04-20 2016-10-27 The Regents Of The University Of Michigan Small molecule inhibitors of mcl-1 and uses thereof
CA2997556C (en) * 2015-09-03 2020-12-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Small molecule inhibitors of dyrk1a and uses thereof
AU2016355303B2 (en) * 2015-11-20 2021-10-07 Mingsight Pharmaceuticals, Inc. Treatment of autoimmune disease
EP3445452A4 (en) 2016-04-21 2019-10-30 BioVentures, LLC COMPOUNDS FOR INDUCING THE DEGRADATION OF ANTIAPOPTOTIC PROTEINS OF THE BCL-2 FAMILY AND USES THEREOF
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
TW202304996A (zh) 2016-06-08 2023-02-01 美商艾伯維有限公司 抗-b7-h3抗體及抗體藥物結合物
WO2018029473A1 (en) * 2016-08-09 2018-02-15 University Of Durham Synthetic retinoids (in cell modulation)
WO2018049214A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer
US20180072741A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyrimidine compounds and uses thereof
CN115819417A (zh) 2016-09-09 2023-03-21 因赛特公司 作为hpk1调节剂的吡唑并吡啶衍生物及其用于治疗癌症的用途
WO2018092064A1 (en) * 2016-11-18 2018-05-24 Novartis Ag Combinations of mdm2 inhibitors and bcl-xl inhibitors
US20180228786A1 (en) 2017-02-15 2018-08-16 Incyte Corporation Pyrazolopyridine compounds and uses thereof
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
US10722495B2 (en) 2017-09-08 2020-07-28 Incyte Corporation Cyanoindazole compounds and uses thereof
CN108186642B (zh) * 2018-01-11 2019-11-08 广西师范大学 一种协同起作用治疗肺癌的药物组合物
US12118414B2 (en) 2018-01-22 2024-10-15 Bioventures, Llc BCL-2 proteins degraders for cancer treatment
US10745388B2 (en) 2018-02-20 2020-08-18 Incyte Corporation Indazole compounds and uses thereof
US10752635B2 (en) 2018-02-20 2020-08-25 Incyte Corporation Indazole compounds and uses thereof
DK3755703T3 (da) 2018-02-20 2022-06-27 Incyte Corp N-(phenyl)-2-(phenyl)pyrimidin-4-carboxamidderivater og relaterede forbindelser som hpk1-inhibitorer til behandling af kræft
US12528810B2 (en) 2018-03-01 2026-01-20 Arizona Board Of Regents On Behalf Of The University Of Arizona Small molecule inhibitors of DYRK/CLK and uses thereof
BR112020018933A2 (pt) 2018-03-19 2020-12-29 Knopp Biosciences Llc Composto, composição farmacêutica, método de tratamento de um transtorno associado a kv7 e método de tratamento de um transtorno associado a uma mutação kcnq2
US11299473B2 (en) 2018-04-13 2022-04-12 Incyte Corporation Benzimidazole and indole compounds and uses thereof
CN119241541A (zh) 2018-05-04 2025-01-03 因赛特公司 Fgfr抑制剂的固体形式和其制备方法
PE20210919A1 (es) 2018-05-04 2021-05-19 Incyte Corp Sales de un inhibidor de fgfr
US12084423B2 (en) 2018-05-18 2024-09-10 Bioventures, Llc Piperlongumine analogues and uses thereof
US10899755B2 (en) 2018-08-08 2021-01-26 Incyte Corporation Benzothiazole compounds and uses thereof
ES2973117T3 (es) 2018-09-25 2024-06-18 Incyte Corp Compuestos de pirazolo[4,3-d]pirimidina como moduladores de ALK2 y/o FGFR
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
AR119494A1 (es) * 2019-07-29 2021-12-22 Servier Lab DERIVADOS DE 6,7-DIHIDRO-5H-PIRIDO[2,3-c]PIRIDAZIN-8-ILO, COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN Y SUS USOS COMO AGENTES PROAPOPTÓTICOS
JP2022543155A (ja) 2019-08-06 2022-10-07 インサイト・コーポレイション Hpk1阻害剤の固体形態
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
GEP20247679B (en) 2019-10-14 2024-10-10 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CA3163875A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
IL293001A (en) 2019-12-04 2022-07-01 Incyte Corp Derivatives of fgfr repressors
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CN112079791A (zh) * 2020-08-21 2020-12-15 宁夏农林科学院农业资源与环境研究所(宁夏土壤与植物营养重点实验室) 单环β-内酰胺类抗生素侧链酸及其酯、其制备方法和应用
IL303048A (en) 2020-11-24 2023-07-01 Novartis Ag Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof
UY39610A (es) 2021-01-20 2022-08-31 Abbvie Inc Conjugados anticuerpo-fármaco anti-egfr
EP4288434A1 (en) 2021-02-02 2023-12-13 Les Laboratoires Servier Selective bcl-xl protac compounds and methods of use
JP2024513575A (ja) 2021-04-12 2024-03-26 インサイト・コーポレイション Fgfr阻害剤及びネクチン-4標的化剤を含む併用療法
KR102605163B1 (ko) * 2021-06-01 2023-11-23 연세대학교 산학협력단 뇌암의 예방 또는 치료용 조성물
AR126101A1 (es) 2021-06-09 2023-09-13 Incyte Corp Heterociclos tricíclicos como inhibidores de fgfr
WO2022261160A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
CN114294905B (zh) * 2021-11-19 2023-04-25 中粮生物科技股份有限公司 利用红外或微波干燥聚羟基脂肪酸酯的方法
CA3256012A1 (en) 2022-05-20 2023-11-23 Les Laboratoires Servier ANTIBODY-DRUG CONJUGATES, MET INHIBITORS BCL-XL, AND THEIR METHODS OF USE
KR20250027281A (ko) 2022-05-20 2025-02-25 노파르티스 아게 Epha2 bcl-xl 억제제 항체-약물 접합체 및 그의 사용 방법
JP2025517435A (ja) 2022-05-20 2025-06-05 ノバルティス アーゲー 抗新生物薬化合物の抗体-薬物コンジュゲートおよびその使用の方法
EP4574175A1 (en) * 2022-08-19 2025-06-25 Beijing Suncell Bio-Medical Co., Ltd. Prodrug for anti-aging related diseases and use method therefor
TW202540186A (zh) 2023-11-22 2025-10-16 瑞士商諾華公司 抗cd7抗體藥物結合物及其使用方法
TW202540185A (zh) 2023-11-22 2025-10-16 法商施維雅藥廠 抗cd74抗體藥物結合物及其使用方法
WO2025130875A1 (zh) * 2023-12-18 2025-06-26 南京瑞初医药有限公司 氮杂环化合物及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3718570A1 (de) * 1987-06-03 1988-12-15 Boehringer Ingelheim Kg Benzo- und thieno-3,4-dihydro-1- pyridinylessigsaeurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
AU2001249399A1 (en) * 2000-03-24 2001-10-08 Cor Therapeutics, Inc. Isoquinolone inhibitors of factor xa
CN1466577A (zh) * 2000-08-01 2004-01-07 СҰҩƷ��ҵ��ʽ���� 3,4-二氢异喹啉衍生物化合物以及将该化合物作为有效成分的药剂
WO2004004727A1 (en) * 2002-07-03 2004-01-15 Axys Pharmaceuticals, Inc. 3,4-dihydroisoquinolin-1-one derivatives as inducers of apoptosis
JP4824563B2 (ja) * 2003-09-23 2011-11-30 メルク・シャープ・エンド・ドーム・コーポレイション イソキノリンカリウムチャネル阻害剤
US7767684B2 (en) * 2003-11-13 2010-08-03 Abbott Laboratories Apoptosis promoters
UA91341C2 (ru) * 2004-07-15 2010-07-26 Амр Текнолоджи, Інк. Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
US7402596B2 (en) * 2005-03-24 2008-07-22 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
EA200801716A1 (ru) * 2006-01-18 2009-04-28 Амген Инк. Тиазольные соединения и их применение
WO2008054749A1 (en) * 2006-10-31 2008-05-08 Schering Corporation 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors
WO2008079292A1 (en) * 2006-12-20 2008-07-03 Amgen Inc. Heterocyclic compounds and their use in treating inflammation, angiogenesis and cancer
ES2566387T3 (es) * 2007-04-02 2016-04-12 Evotec Ag Compuestos heterocíclicos condensados de pirid-2-ilo, y composiciones y usos de los mismos
EP3243814B1 (en) * 2007-04-16 2018-10-17 AbbVie Inc. 7-substituted indole as mcl-1 inhibitors
JP5496876B2 (ja) * 2007-04-16 2014-05-21 アッヴィ・インコーポレイテッド 7−置換されていないインドール系Mcl−1阻害薬
AU2008279776B2 (en) * 2007-07-19 2013-05-23 Merck Sharp & Dohme Corp. Heterocyclic amide compounds as protein kinase inhibitors
EP2193127A4 (en) 2007-09-27 2011-09-14 Inst Medical W & E Hall BENZOTHIAZOLE COMPOUNDS
US8114893B2 (en) * 2008-12-19 2012-02-14 Genentech, Inc. Compounds and methods of use

Similar Documents

Publication Publication Date Title
JP2012512891A5 (cg-RX-API-DMAC10.html)
JP2007516180A5 (cg-RX-API-DMAC10.html)
RU2376287C2 (ru) Производные бензамида, способ их получения и их применение, фармацевтическая композиция и способ обеспечения ингибирующего действия по отношению к hdac
JP2016509047A5 (cg-RX-API-DMAC10.html)
RU2403258C2 (ru) Тиазолилдигидроиндазолы
RU2011124304A (ru) Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе
JP2004516314A5 (cg-RX-API-DMAC10.html)
JP2014507421A5 (cg-RX-API-DMAC10.html)
JP2017511815A5 (cg-RX-API-DMAC10.html)
RU2010129910A (ru) 8-анилиноимидазопиридины и способы их использования
JP2007528379A5 (cg-RX-API-DMAC10.html)
JP2012510523A5 (cg-RX-API-DMAC10.html)
JP2014510774A5 (cg-RX-API-DMAC10.html)
JP2010510215A5 (cg-RX-API-DMAC10.html)
JP2006502137A5 (cg-RX-API-DMAC10.html)
JP2013529196A5 (cg-RX-API-DMAC10.html)
JP2017511360A5 (cg-RX-API-DMAC10.html)
JP2015520143A5 (cg-RX-API-DMAC10.html)
JP2018520195A5 (cg-RX-API-DMAC10.html)
JP2008526754A5 (cg-RX-API-DMAC10.html)
JP2010536887A5 (cg-RX-API-DMAC10.html)
JP2007191486A5 (cg-RX-API-DMAC10.html)
JP2004534774A5 (cg-RX-API-DMAC10.html)
JP2005507938A5 (cg-RX-API-DMAC10.html)
JP2006523238A5 (cg-RX-API-DMAC10.html)