JP2014507421A5 - - Google Patents
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- JP2014507421A5 JP2014507421A5 JP2013551282A JP2013551282A JP2014507421A5 JP 2014507421 A5 JP2014507421 A5 JP 2014507421A5 JP 2013551282 A JP2013551282 A JP 2013551282A JP 2013551282 A JP2013551282 A JP 2013551282A JP 2014507421 A5 JP2014507421 A5 JP 2014507421A5
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- JP
- Japan
- Prior art keywords
- conr
- alkyl
- cycloalkyl
- ring
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 5
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims 2
- 102100026596 Bcl-2-like protein 1 Human genes 0.000 claims 2
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims 2
- 230000009286 beneficial effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- -1 CF 3 Chemical group 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- CKUAXEQHGKSLHN-UHFFFAOYSA-N [C].[N] Chemical group [C].[N] CKUAXEQHGKSLHN-UHFFFAOYSA-N 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 238000011287 therapeutic dose Methods 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161436077P | 2011-01-25 | 2011-01-25 | |
| US61/436,077 | 2011-01-25 | ||
| PCT/US2012/022315 WO2012103059A2 (en) | 2011-01-25 | 2012-01-24 | Bcl-2/bcl-xl inhibitors and therapeutic methods using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014507421A JP2014507421A (ja) | 2014-03-27 |
| JP2014507421A5 true JP2014507421A5 (cg-RX-API-DMAC10.html) | 2016-01-28 |
| JP5998152B2 JP5998152B2 (ja) | 2016-09-28 |
Family
ID=46544312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013551282A Active JP5998152B2 (ja) | 2011-01-25 | 2012-01-24 | Ｂｃｌ−２／ｂｃｌ−ｘｌ阻害剤およびそれを使用する治療方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8691184B2 (cg-RX-API-DMAC10.html) |
| EP (2) | EP3459945A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP5998152B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR101762724B1 (cg-RX-API-DMAC10.html) |
| CN (1) | CN103562202B (cg-RX-API-DMAC10.html) |
| AU (1) | AU2012209295B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2825306C (cg-RX-API-DMAC10.html) |
| ES (1) | ES2693107T3 (cg-RX-API-DMAC10.html) |
| SG (1) | SG192126A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2012103059A2 (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA201305571B (cg-RX-API-DMAC10.html) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3689886A1 (en) * | 2013-01-16 | 2020-08-05 | The Regents of The University of Michigan | Bcl-2/bcl-xl inhibitors and their use in the treatment of cancer |
| CN105377289A (zh) | 2013-04-21 | 2016-03-02 | 耶达研究及发展有限公司 | 用于下调Bcl-xL和/或Bcl-w的活性和/或量的试剂 |
| US20170216286A1 (en) | 2014-01-28 | 2017-08-03 | Mayo Foundation For Medical Education And Research | Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid |
| SG11201606239UA (en) | 2014-01-28 | 2016-08-30 | Buck Inst For Res On Aging | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
| US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
| US20190269675A1 (en) | 2014-01-28 | 2019-09-05 | Buck Institute for Research and Aging | Treatment of parkinson's disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents |
| CN105753814A (zh) * | 2015-01-01 | 2016-07-13 | 成都贝斯凯瑞生物科技有限公司 | 取代氮杂环衍生物及其应用 |
| WO2016127135A1 (en) * | 2015-02-06 | 2016-08-11 | Unity Biotechnology, Inc. | Compounds and uses in treatment of senescence-associated conditons |
| EP3261612A1 (en) | 2015-02-26 | 2018-01-03 | Yeda Research and Development Co. Ltd | Method of promoting hair growth |
| MX2018001737A (es) | 2015-08-10 | 2018-09-06 | Dana Farber Cancer Inst Inc | Mecanismo de resistencia a inhibidores de bromodominio bet. |
| EP3445452A4 (en) | 2016-04-21 | 2019-10-30 | BioVentures, LLC | COMPOUNDS FOR INDUCING THE DEGRADATION OF ANTIAPOPTOTIC PROTEINS OF THE BCL-2 FAMILY AND USES THEREOF |
| CN106177955B (zh) * | 2016-08-18 | 2018-03-16 | 广州威溶特医药科技有限公司 | Bcl‑xL抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用 |
| AU2018314280B2 (en) * | 2017-08-11 | 2023-07-20 | Rsem, Société En Commandite | Treatment of ophthalmic conditions such as macular degeneration, glaucoma, and diabetic retinopathy using pharmaceutical agents that eliminate senescent cells |
| US20200354336A9 (en) * | 2017-08-11 | 2020-11-12 | Unity Biotechnology, Inc. | Treatment of Lung Diseases Using Pharmaceutical Agents that Eliminate Senescent Cells |
| WO2019033122A1 (en) * | 2017-08-11 | 2019-02-14 | Unity Biotechnology, Inc. | TREATMENT OF PULMONARY DISEASES USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS |
| CN107573256B (zh) * | 2017-09-26 | 2020-02-21 | 安徽国星生物化学有限公司 | 一种对氯苯肼盐酸盐连续化生产方法及其装置 |
| CN109718377B (zh) * | 2017-10-31 | 2021-03-26 | 中国科学院脑科学与智能技术卓越创新中心 | KPNB1抑制剂和Bcl-xL抑制剂在制备抗肿瘤药物中的应用 |
| US10588916B2 (en) * | 2017-10-31 | 2020-03-17 | Unity Biotechnology, Inc. | Technology to inhibit vascular changes that lead to vision loss in the eye |
| WO2019133988A1 (en) | 2017-12-30 | 2019-07-04 | Unity Biotechnology, Inc. | Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer |
| USRE50643E1 (en) | 2018-01-10 | 2025-10-21 | Recurium Ip Holdings, Llc | Benzamide compounds |
| US10111873B1 (en) | 2018-01-17 | 2018-10-30 | King Saud University | Dihydropyrimidinone derivatives |
| US12118414B2 (en) | 2018-01-22 | 2024-10-15 | Bioventures, Llc | BCL-2 proteins degraders for cancer treatment |
| KR102708681B1 (ko) | 2018-02-13 | 2024-09-26 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| EP3781556B1 (en) | 2018-04-19 | 2025-06-18 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| KR102738032B1 (ko) | 2018-04-29 | 2024-12-05 | 베이진 엘티디 | Bcl-2 억제제 |
| US10738042B2 (en) | 2018-04-30 | 2020-08-11 | Unity Biotechnology, Inc. | Phosphonamidates that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
| CA3056878C (en) | 2018-04-30 | 2021-03-30 | Unity Biotechnology | Phospholidines that are bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
| EP3788052A4 (en) | 2018-04-30 | 2021-05-26 | Unity Biotechnology, Inc. | ACYLPHOSPHONAMIDATE AND ACYLBENZYLAMINE AS ANTAGONISTS OF THE BCL FAMILY FOR THE CLINICAL MANAGEMENT OF CONDITIONS CAUSED OR MEDIATED BY SENESCENT CELLS AND TREATMENT OF CANCER |
| US10717722B2 (en) | 2018-06-13 | 2020-07-21 | Unity Biotechnology, Inc. | Acyl sulfonamides that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
| PL3820572T3 (pl) | 2018-07-13 | 2024-02-26 | Gilead Sciences, Inc. | Inhibitory pd-1/pd-l1 |
| WO2020024834A1 (en) | 2018-07-31 | 2020-02-06 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases |
| CA3094449C (en) | 2018-07-31 | 2023-02-28 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of bcl-2 inhibitor and mdm2 inhibitor and use thereof in the prevention and/or treatment of diseases |
| AU2019315466B2 (en) | 2018-07-31 | 2022-05-19 | Ascentage Pharma (Suzhou) Co., Ltd. | Synergistic antitumor effect of Bcl-2 inhibitor combined with rituximab and/or bendamustine or Bcl-2 inhibitor combined with CHOP |
| EP3829593A4 (en) * | 2018-07-31 | 2022-04-13 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination of bcl-2/bcl-xl inhibitors and chemotherapeutic agent and use thereof |
| CN114522167A (zh) | 2018-07-31 | 2022-05-24 | 苏州亚盛药业有限公司 | Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途 |
| WO2020041405A1 (en) | 2018-08-22 | 2020-02-27 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
| EP3842426A4 (en) * | 2018-08-22 | 2022-05-18 | Jiangsu Hengrui Medicine Co., Ltd. | PREPARATION PROCESS OF PYRROLO-AMINO-PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF |
| CA3117199C (en) | 2018-10-24 | 2024-03-19 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| CN111410650B (zh) * | 2019-01-04 | 2020-12-08 | 苏州亚盛药业有限公司 | 制备磺胺类药物的方法 |
| EP3820878A4 (en) | 2019-01-04 | 2022-04-20 | Ascentage Pharma (Suzhou) Co., Ltd. | METHOD FOR PREPARING SULFONAMIDE COMPOUNDS |
| TWI770503B (zh) * | 2019-05-13 | 2022-07-11 | 大陸商蘇州亞盛藥業有限公司 | 用於預測bcl-2/bcl-xl抑制劑對癌症的功效的方法和組合物 |
| US20220372042A1 (en) | 2019-10-03 | 2022-11-24 | Newave Pharmaceutical Inc. | Condensed heterocycles as bcl-2 inhibitors |
| US12516053B2 (en) | 2019-10-28 | 2026-01-06 | Beone Medicines I Gmbh | Bcl-2 inhibitors |
| WO2021110102A1 (en) * | 2019-12-02 | 2021-06-10 | Beigene, Ltd. | Methods of cancer treatment using bcl-2 inhibitor |
| US20230040125A1 (en) * | 2019-12-24 | 2023-02-09 | The Regents Of The University Of California | Targeting the intrinsic apoptotic machinery in glioblastoma |
| WO2021204060A1 (en) * | 2020-04-10 | 2021-10-14 | Ascentage Pharma (Suzhou) Co., Ltd. | Combinations of bcl-2/bcl-xl inhibitors and related uses |
| CN116802179A (zh) | 2020-04-15 | 2023-09-22 | 百济神州有限公司 | Bcl-2抑制剂 |
| EP4146649A4 (en) * | 2020-05-08 | 2024-09-11 | Fochon Biosciences, Ltd. | COMPOUNDS AS BCL-2 INHIBITORS |
| US20250319183A1 (en) | 2021-04-07 | 2025-10-16 | David Avigan | Compositions and methods for the treatment of cancer |
| CN118215660A (zh) * | 2021-08-31 | 2024-06-18 | 百济神州有限公司 | Bcl-2抑制剂的固体形式、其制备方法及用途 |
| WO2023122000A1 (en) * | 2021-12-20 | 2023-06-29 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
| TW202415647A (zh) * | 2022-09-06 | 2024-04-16 | 大陸商西藏海思科製藥有限公司 | 抑制Bcl-2或Bcl-xL的化合物及其在醫藥上的應用 |
| CN115557846B (zh) * | 2022-10-17 | 2023-11-10 | 成都道合尔医药技术有限公司 | 8-氨基辛酸的合成方法 |
| WO2024245312A1 (en) * | 2023-05-30 | 2024-12-05 | Ascentage Pharma (Suzhou) Co., Ltd. | Bcl-2/bcl-xl protein degrader and use thereof |
| CN117756811A (zh) * | 2023-12-29 | 2024-03-26 | 贵州民族大学 | 一种合成多取代基吡咯化合物的方法 |
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| US7432304B2 (en) | 2001-05-30 | 2008-10-07 | The Regents Of The University Of Michigan | Small molecule antagonists of Bcl-2 family proteins |
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| WO2005090297A1 (en) * | 2004-03-19 | 2005-09-29 | Biotie Therapies Corporation | Sulphonamide derivatives |
| WO2006023778A2 (en) | 2004-08-20 | 2006-03-02 | The Regents Of The University Of Michigan | Small molecule inhibitors of anti-apoptotic bcl-2 family members and the uses thereof |
| CN101039662A (zh) * | 2004-08-20 | 2007-09-19 | 密执安州立大学董事会 | 抗－细胞凋亡bcl－2家族成员的小分子抑制剂及其应用 |
| NZ561609A (en) | 2005-05-12 | 2010-03-26 | Abbott Lab | 3-((trifluoromethyl)sulfonyl)benzenesulfonamide and 3-((chloro(difluoro)methyl)sulfonyl)benzenesulfonamide apoptosis promoters |
| WO2007008627A2 (en) * | 2005-07-07 | 2007-01-18 | Abbott Laboratories | Apoptosis promoters |
| JP2009515997A (ja) * | 2005-11-18 | 2009-04-16 | タケダ サン ディエゴ インコーポレイテッド | グルコキナーゼ活性剤 |
| WO2007087441A2 (en) * | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Substituted aromatic compounds for inflammation and immune-related uses |
| ATE498615T1 (de) * | 2006-07-14 | 2011-03-15 | Chemocentryx Inc | Triazolylphenylbenzensulfonamide |
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| EP2406234A1 (en) * | 2009-03-12 | 2012-01-18 | GlaxoSmithKline LLC | Thiazole sulfonamide and oxazole sulfonamide kinase inhibitors |
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| MX2012003007A (es) * | 2009-09-10 | 2012-04-11 | Novartis Ag | Sulfonamidas como inhibidores de las proteinas de la familia bcl-2 para el tratamiento de cancer. |
-
2012
- 2012-01-24 EP EP18186324.2A patent/EP3459945A1/en not_active Withdrawn
- 2012-01-24 AU AU2012209295A patent/AU2012209295B2/en active Active
- 2012-01-24 CA CA2825306A patent/CA2825306C/en active Active
- 2012-01-24 SG SG2013056544A patent/SG192126A1/en unknown
- 2012-01-24 JP JP2013551282A patent/JP5998152B2/ja active Active
- 2012-01-24 EP EP12739376.7A patent/EP2668180B1/en active Active
- 2012-01-24 US US13/356,763 patent/US8691184B2/en active Active
- 2012-01-24 WO PCT/US2012/022315 patent/WO2012103059A2/en not_active Ceased
- 2012-01-24 CN CN201280017060.3A patent/CN103562202B/zh active Active
- 2012-01-24 ES ES12739376.7T patent/ES2693107T3/es active Active
- 2012-01-24 KR KR1020137021901A patent/KR101762724B1/ko active Active
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2013
- 2013-07-23 ZA ZA2013/05571A patent/ZA201305571B/en unknown