JP2012508164A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012508164A5 JP2012508164A5 JP2011533633A JP2011533633A JP2012508164A5 JP 2012508164 A5 JP2012508164 A5 JP 2012508164A5 JP 2011533633 A JP2011533633 A JP 2011533633A JP 2011533633 A JP2011533633 A JP 2011533633A JP 2012508164 A5 JP2012508164 A5 JP 2012508164A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody construct
- single chain
- acute lymphoblastic
- bispecific single
- cd19xcd3 bispecific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11232308P | 2008-11-07 | 2008-11-07 | |
| US61/112,323 | 2008-11-07 | ||
| US18329109P | 2009-06-02 | 2009-06-02 | |
| US61/183,291 | 2009-06-02 | ||
| PCT/EP2009/007970 WO2010052014A1 (en) | 2008-11-07 | 2009-11-06 | Treatment of acute lymphoblastic leukemia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014226022A Division JP5955921B2 (ja) | 2008-11-07 | 2014-11-06 | 急性リンパ芽球性白血病の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012508164A JP2012508164A (ja) | 2012-04-05 |
| JP2012508164A5 true JP2012508164A5 (https=) | 2013-03-21 |
| JP5647132B2 JP5647132B2 (ja) | 2014-12-24 |
Family
ID=41692882
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011533633A Active JP5647132B2 (ja) | 2008-11-07 | 2009-11-06 | 急性リンパ芽球性白血病の治療 |
| JP2014226022A Active JP5955921B2 (ja) | 2008-11-07 | 2014-11-06 | 急性リンパ芽球性白血病の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014226022A Active JP5955921B2 (ja) | 2008-11-07 | 2014-11-06 | 急性リンパ芽球性白血病の治療 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US20130323247A1 (https=) |
| EP (2) | EP2982696B1 (https=) |
| JP (2) | JP5647132B2 (https=) |
| KR (1) | KR101695327B1 (https=) |
| CN (2) | CN102209728A (https=) |
| AU (4) | AU2009313040B2 (https=) |
| BR (1) | BRPI0921482B1 (https=) |
| CA (1) | CA2742249C (https=) |
| CY (2) | CY1117033T1 (https=) |
| DK (2) | DK2342227T3 (https=) |
| ES (2) | ES2558434T3 (https=) |
| HR (2) | HRP20151168T1 (https=) |
| HU (2) | HUE043326T2 (https=) |
| IL (1) | IL212652A (https=) |
| LT (1) | LT2982696T (https=) |
| ME (2) | ME02363B (https=) |
| MX (1) | MX2011002927A (https=) |
| NZ (1) | NZ591311A (https=) |
| PL (2) | PL2342227T3 (https=) |
| PT (2) | PT2982696T (https=) |
| RS (2) | RS58827B1 (https=) |
| RU (1) | RU2536940C2 (https=) |
| SI (2) | SI2342227T1 (https=) |
| SM (2) | SMT201900278T1 (https=) |
| WO (1) | WO2010052014A1 (https=) |
| ZA (1) | ZA201103255B (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20150175T1 (en) * | 2005-12-16 | 2015-03-27 | Amgen Research (Munich) Gmbh | Means and methods for the treatment of tumorous diseases |
| KR101695327B1 (ko) * | 2008-11-07 | 2017-01-11 | 암젠 리서치 (뮌헨) 게엠베하 | 급성 림프구성 백혈병의 치료방법 |
| RS54655B2 (sr) | 2009-10-27 | 2021-04-29 | Amgen Res Munich Gmbh | Dozni režim za primenu cd19xcd3 bispecifičnog antitela |
| CN103459425B (zh) * | 2010-10-27 | 2015-11-25 | 安进研发(慕尼黑)股份有限公司 | 用于治疗dlbcl的组合物 |
| EA026075B1 (ru) * | 2010-11-10 | 2017-02-28 | Эмджен Рисерч (Мьюник) Гмбх | Предотвращение неблагоприятных эффектов, вызванных cd3-специфическими связывающими доменами |
| KR102345943B1 (ko) * | 2011-04-28 | 2021-12-31 | 암젠 리서치 (뮌헨) 게엠베하 | 잠재적 유해 효과의 위험에 처한 환자에게 cd19xcd3 이중특이적 항체를 투여하기 위한 투여 요법 |
| WO2012158818A2 (en) | 2011-05-16 | 2012-11-22 | Fabion Pharmaceuticals, Inc. | Multi-specific fab fusion proteins and methods of use |
| DK3105252T3 (da) * | 2014-02-12 | 2019-10-14 | Michael Uhlin | Bispecifikke antistoffer til anvendelse ved stamcelletransplantation |
| US9603927B2 (en) | 2014-02-28 | 2017-03-28 | Janssen Biotech, Inc. | Combination therapies with anti-CD38 antibodies |
| US9732154B2 (en) * | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
| SI3149480T1 (sl) | 2014-05-30 | 2019-05-31 | Amgen Research (Munich) Gmbh | Stratifikacija tveganj pri bolnikih z akutno limfoblastno levkemijo prekurzorjev b |
| PH12017500442B1 (en) | 2014-09-09 | 2023-05-24 | Janssen Biotech Inc | Combination therapies with anti-cd38 antibodies |
| CN107406506A (zh) | 2014-12-04 | 2017-11-28 | 詹森生物科技公司 | 用于治疗急性髓系白血病的抗cd38抗体 |
| WO2016109549A1 (en) | 2014-12-30 | 2016-07-07 | University Of Utah Research Foundation | Hdac1,2 inhibitors and methods of using the same |
| EP3262217A4 (en) | 2015-02-24 | 2018-07-18 | BioAtla LLC | Conditionally active biological proteins |
| PL3298033T5 (pl) * | 2015-05-18 | 2023-10-30 | TCR2 Therapeutics Inc. | Kompozycje i zastosowania medyczne do reprogramowania TCR z zastosowaniem białek fuzyjnych |
| EA201792546A1 (ru) | 2015-05-20 | 2018-04-30 | Янссен Байотек, Инк. | Антитела к cd38 для лечения амилоидоза легких цепей и прочих cd38-положительных гематологических злокачественных опухолей |
| AU2016263464B2 (en) * | 2015-05-20 | 2021-12-23 | Amgen Research (Munich) Gmbh | B-cell depletion as a diagnostic marker |
| IL256242B2 (en) | 2015-06-22 | 2024-09-01 | Janssen Biotech Inc | Combination therapies for heme malignancies with anti-cd38 antibodies and survivin inhibitors |
| US20170044265A1 (en) | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
| CN105154440B (zh) * | 2015-08-14 | 2016-11-30 | 深圳市瀚海基因生物科技有限公司 | 一种基于高通量测序构建白血病微小残留病灶tcr文库的多重pcr引物和方法 |
| US10781261B2 (en) | 2015-11-03 | 2020-09-22 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
| CA3004152C (en) | 2015-11-03 | 2024-04-16 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-cd38 antibodies and their uses |
| RU2651776C2 (ru) * | 2015-12-01 | 2018-04-23 | Общество с ограниченной ответственностью "Международный биотехнологический центр "Генериум" ("МБЦ "Генериум") | Биспецифические антитела против cd3*cd19 |
| GB201602974D0 (en) * | 2016-02-19 | 2016-04-06 | Clube Jasper R | Engineered cells & methods (1) |
| EP3430058A4 (en) | 2016-03-15 | 2019-10-23 | Generon (Shanghai) Corporation Ltd. | MULTISPECIFIC FAB FUSION PROTEINS AND USES THEREOF |
| US20190233533A1 (en) | 2016-06-28 | 2019-08-01 | Umc Utrecht Holding B.V. | Treatment Of IgE-Mediated Diseases With Antibodies That Specifically Bind CD38 |
| CA3032498A1 (en) | 2016-08-02 | 2018-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| WO2018067993A1 (en) | 2016-10-07 | 2018-04-12 | TCR2 Therapeutics Inc. | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
| JP7291396B2 (ja) * | 2016-11-22 | 2023-06-15 | ティーシーアール2 セラピューティクス インク. | 融合タンパク質を用いたtcrの再プログラミングのための組成物及び方法 |
| MA50514A (fr) | 2017-10-31 | 2020-09-09 | Janssen Biotech Inc | Méthodes de traitement du myélome multiple à haut risque |
| AU2018383679B2 (en) * | 2017-12-11 | 2025-10-09 | Amgen Inc. | Continuous manufacturing process for bispecific antibody products |
| KR102083481B1 (ko) | 2018-03-22 | 2020-03-02 | 강원대학교산학협력단 | 아연-키토산 나노 입자를 포함한 급성 림프구성 백혈병 치료용 약학조성물 |
| EP3847196A4 (en) | 2018-09-07 | 2023-01-04 | ITabMed (HK) Limited | BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF |
| WO2020132810A1 (en) | 2018-12-24 | 2020-07-02 | Generon (Shanghai) Corporation Ltd. | Multispecific antigen binding proteins capable of binding cd19 and cd3, and use thereof |
| JP7680358B2 (ja) * | 2019-01-30 | 2025-05-20 | ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー | 癌抗原を標的とするdnaコード化二重特異性t細胞エンゲージャーおよび癌治療薬における使用方法 |
| WO2020232247A1 (en) | 2019-05-14 | 2020-11-19 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| MX2021014644A (es) * | 2019-06-13 | 2022-04-06 | Amgen Inc | Control de perfusion basado en biomasa automatizado en la fabricacion de productos biologicos. |
| TW202200615A (zh) | 2020-03-12 | 2022-01-01 | 美商安進公司 | 用於治療和預防患者的crs之方法 |
| IL298999A (en) | 2020-06-11 | 2023-02-01 | Provention Bio Inc | Methods and compositions for the prevention of type 1 diabetes |
| MX2023003041A (es) | 2020-09-16 | 2023-05-09 | Amgen Inc | Métodos para administrar dosis terapéuticas de moléculas de acoplamiento a células t biespecíficas para el tratamiento de cáncer. |
| JP2024520444A (ja) | 2021-05-24 | 2024-05-24 | プロヴェンション・バイオ・インコーポレイテッド | 1型糖尿病を治療するための方法 |
| EP4415829A1 (en) | 2021-10-15 | 2024-08-21 | Amgen Research (Munich) GmbH | Subcutaneous administration of cd19-binding t cell engaging antibodies |
| US12319747B2 (en) | 2023-07-03 | 2025-06-03 | Medicovestor, Inc. | Methods of using anti-SP17 immunotherapeutics |
| US12364777B2 (en) | 2023-10-20 | 2025-07-22 | Medicovestor, Inc. | Homodimeric antibodies for use in treating cancers and methods of use |
| TW202535949A (zh) | 2023-12-20 | 2025-09-16 | 美商必治妥美雅史谷比公司 | 靶向IL-18受體β(IL-18RB)之抗體及相關方法 |
| US12600795B2 (en) | 2023-12-26 | 2026-04-14 | Medicovestor, Inc. | Oligomeric IgG for immunotherapeutics and diagnostics |
| US12116410B1 (en) | 2023-12-26 | 2024-10-15 | Medicovestor, Inc. | Methods of manufacturing dimeric antibodies |
| US12240900B1 (en) | 2024-02-02 | 2025-03-04 | Medicovestor, Inc. | Nucleic acids, vectors, and cells that encode antibodies and other proteins that bind folate receptor alpha |
| US12258396B1 (en) | 2024-02-02 | 2025-03-25 | Medicovestor, Inc. | Methods of using immunotherapeutics that bind folate receptor alpha |
| US12378314B1 (en) | 2024-02-02 | 2025-08-05 | Medicovestor, Inc. | Proteins that bind folate receptor alpha including fully-human antibodies |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4119397A (en) * | 1996-08-28 | 1998-03-19 | Viva Diagnostika Diagnostische Produkte Gmbh | Novel combination preparations and their use in immunodiagnosis and immunotherapy |
| US7112324B1 (en) * | 1998-04-21 | 2006-09-26 | Micromet Ag | CD 19×CD3 specific polypeptides and uses thereof |
| BG65066B1 (bg) * | 1998-04-21 | 2007-01-31 | Micromet Gessellschaft Fur Biomedicinische Forschung Mbh | CD19 x CD3 СПЕЦИФИЧНИ ПОЛИПЕПТИДИ И ТЯХНОТО ИЗПОЛЗВАНЕ |
| JP2008501621A (ja) * | 2003-05-31 | 2008-01-24 | マイクロメット アクツィエン ゲゼルシャフト | B細胞関連疾患を処置するための二重特異性抗cd3、抗cd19抗体構築物を含む薬学的組成物 |
| MXPA06004035A (es) * | 2003-10-16 | 2006-08-31 | Micromet Ag | Aglutinantes cd3 de-inmunizados multi-especificos. |
| CN101331151A (zh) * | 2005-12-16 | 2008-12-24 | 麦克罗梅特股份公司 | 治疗肿瘤性疾病的方式和方法 |
| HRP20150175T1 (en) | 2005-12-16 | 2015-03-27 | Amgen Research (Munich) Gmbh | Means and methods for the treatment of tumorous diseases |
| PL2383297T3 (pl) * | 2006-08-14 | 2013-06-28 | Xencor Inc | Zoptymalizowane przeciwciała ukierunkowane na CD19 |
| KR101695327B1 (ko) * | 2008-11-07 | 2017-01-11 | 암젠 리서치 (뮌헨) 게엠베하 | 급성 림프구성 백혈병의 치료방법 |
| CA2747835A1 (en) * | 2009-01-19 | 2010-07-22 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| WO2010083442A1 (en) * | 2009-01-19 | 2010-07-22 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| CA2763633A1 (en) * | 2009-05-27 | 2010-12-02 | Gary T. Wang | Pyrimidine inhibitors of kinase activity |
| BR112012006252A2 (pt) * | 2009-09-20 | 2017-05-23 | Abbott Lab | "formas cristalinas de abt-263 e solvatos para o uso no tratamento de doenças relacionadas á proteína bcl-2". |
| RS54655B2 (sr) * | 2009-10-27 | 2021-04-29 | Amgen Res Munich Gmbh | Dozni režim za primenu cd19xcd3 bispecifičnog antitela |
-
2009
- 2009-11-06 KR KR1020117010641A patent/KR101695327B1/ko active Active
- 2009-11-06 WO PCT/EP2009/007970 patent/WO2010052014A1/en not_active Ceased
- 2009-11-06 AU AU2009313040A patent/AU2009313040B2/en active Active
- 2009-11-06 DK DK09760483.9T patent/DK2342227T3/en active
- 2009-11-06 EP EP15185767.9A patent/EP2982696B1/en active Active
- 2009-11-06 SM SM20190278T patent/SMT201900278T1/it unknown
- 2009-11-06 NZ NZ591311A patent/NZ591311A/xx unknown
- 2009-11-06 EP EP09760483.9A patent/EP2342227B1/en active Active
- 2009-11-06 SI SI200931306T patent/SI2342227T1/sl unknown
- 2009-11-06 ME MEP-2015-181A patent/ME02363B/me unknown
- 2009-11-06 RS RS20190593A patent/RS58827B1/sr unknown
- 2009-11-06 JP JP2011533633A patent/JP5647132B2/ja active Active
- 2009-11-06 ME MEP-2019-146A patent/ME03480B/me unknown
- 2009-11-06 PL PL09760483T patent/PL2342227T3/pl unknown
- 2009-11-06 PL PL15185767T patent/PL2982696T3/pl unknown
- 2009-11-06 ES ES09760483.9T patent/ES2558434T3/es active Active
- 2009-11-06 HR HRP20151168TT patent/HRP20151168T1/hr unknown
- 2009-11-06 ES ES15185767T patent/ES2727585T3/es active Active
- 2009-11-06 DK DK15185767.9T patent/DK2982696T3/da active
- 2009-11-06 PT PT15185767T patent/PT2982696T/pt unknown
- 2009-11-06 SI SI200931967T patent/SI2982696T1/sl unknown
- 2009-11-06 PT PT97604839T patent/PT2342227E/pt unknown
- 2009-11-06 MX MX2011002927A patent/MX2011002927A/es active IP Right Grant
- 2009-11-06 LT LTEP15185767.9T patent/LT2982696T/lt unknown
- 2009-11-06 CN CN2009801443998A patent/CN102209728A/zh active Pending
- 2009-11-06 HU HUE15185767A patent/HUE043326T2/hu unknown
- 2009-11-06 US US13/127,541 patent/US20130323247A1/en not_active Abandoned
- 2009-11-06 CN CN201710366308.1A patent/CN107184977A/zh active Pending
- 2009-11-06 RS RS20150797A patent/RS54456B1/sr unknown
- 2009-11-06 RU RU2011122819/10A patent/RU2536940C2/ru active
- 2009-11-06 HU HUE09760483A patent/HUE028175T2/en unknown
- 2009-11-06 BR BRPI0921482-8A patent/BRPI0921482B1/pt active IP Right Grant
- 2009-11-06 CA CA2742249A patent/CA2742249C/en active Active
-
2011
- 2011-05-03 IL IL212652A patent/IL212652A/en active IP Right Grant
- 2011-05-05 ZA ZA2011/03255A patent/ZA201103255B/en unknown
-
2014
- 2014-11-06 JP JP2014226022A patent/JP5955921B2/ja active Active
-
2015
- 2015-10-06 AU AU2015238784A patent/AU2015238784A1/en not_active Abandoned
- 2015-12-09 CY CY20151101123T patent/CY1117033T1/el unknown
- 2015-12-30 SM SM201500328T patent/SMT201500328B/it unknown
-
2017
- 2017-08-25 AU AU2017219083A patent/AU2017219083B2/en active Active
-
2018
- 2018-11-06 AU AU2018260815A patent/AU2018260815B2/en active Active
- 2018-12-13 US US16/218,797 patent/US11597766B2/en active Active
-
2019
- 2019-05-16 HR HRP20190912TT patent/HRP20190912T1/hr unknown
- 2019-05-17 CY CY20191100527T patent/CY1122366T1/el unknown
-
2023
- 2023-02-03 US US18/164,304 patent/US20240109964A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012508164A5 (https=) | ||
| JP2012508163A5 (https=) | ||
| HRP20151168T1 (hr) | Lijeäśenje akutne limfoblastiäśne leukemije | |
| Vebr et al. | A narrative review of cytokine networks: pathophysiological and therapeutic implications for inflammatory bowel disease pathogenesis | |
| HRP20191715T1 (hr) | Liječenje dječje akutne limfoblastične leukemije sa bispecifičnim protutijelima protiv cd3xcd19 | |
| Cortez et al. | CRTAM controls residency of gut CD4+ CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection | |
| Jin et al. | TL1A/TNFSF15 directly induces proinflammatory cytokines, including TNFα, from CD3+ CD161+ T cells to exacerbate gut inflammation | |
| Crane et al. | CXCR4 receptor expression on human retinal pigment epithelial cells from the blood-retina barrier leads to chemokine secretion and migration in response to stromal cell-derived factor 1α | |
| Peligero-Cruz et al. | IL18 signaling promotes homing of mature Tregs into the thymus | |
| US20200352999A1 (en) | Use and production of engineered immune cells to disrupt nfat-ap1 pathway transcription factors | |
| CN111593022B (zh) | vMIP-Ⅱ诱导CD8+ T细胞去磷酸化为Tcm及其在药物中的应用 | |
| Ma et al. | Ebi3 promotes T-and B-cell division and differentiation via STAT3 | |
| Kondo et al. | Mouse gingival single-cell transcriptomic atlas identified a novel fibroblast subpopulation activated to guide oral barrier immunity in periodontitis | |
| JP2016509009A (ja) | T制御性細胞の増殖または枯渇方法 | |
| Liu et al. | Prostaglandin I2-IP signalling regulates human Th17 and Treg cell differentiation | |
| O’Neil et al. | The role of tissue resident memory CD4 T cells in herpes simplex viral and HIV infection | |
| Palmer et al. | IFNγ-producing, virus-specific CD8+ effector cells acquire the ability to produce IL-10 as a result of entry into the infected lung environment | |
| Cervelló et al. | Leucine-rich repeat–containing G-protein–coupled receptor 5–positive cells in the endometrial stem cell niche | |
| Imaeda et al. | Interleukin-33 suppresses Notch ligand expression and prevents goblet cell depletion in dextran sulfate sodium-induced colitis | |
| Zhong et al. | Interleukin-17 promotes osteoclastogenesis and periodontal damage via autophagy in vitro and in vivo | |
| JP2024167242A (ja) | 誘導された制御性T(iTREG)細胞を使用したALS治療 | |
| Partanen | Central nervous system manifestations in Puumala hantavirus infection | |
| Van Belle et al. | Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model | |
| WO2022217373A1 (zh) | 一种降低人免疫缺陷病毒感染的病毒设定点及重建细胞免疫的因子和药物应用 | |
| Sundaram et al. | Measles virus nucleocapsid protein modulates the Signal Regulatory Protein-β1 (SIRPβ1) to enhance osteoclast differentiation in Paget's disease of bone |