JP2012508164A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012508164A5 JP2012508164A5 JP2011533633A JP2011533633A JP2012508164A5 JP 2012508164 A5 JP2012508164 A5 JP 2012508164A5 JP 2011533633 A JP2011533633 A JP 2011533633A JP 2011533633 A JP2011533633 A JP 2011533633A JP 2012508164 A5 JP2012508164 A5 JP 2012508164A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody construct
- single chain
- acute lymphoblastic
- bispecific single
- cd19xcd3 bispecific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11232308P | 2008-11-07 | 2008-11-07 | |
| US61/112,323 | 2008-11-07 | ||
| US18329109P | 2009-06-02 | 2009-06-02 | |
| US61/183,291 | 2009-06-02 | ||
| PCT/EP2009/007970 WO2010052014A1 (en) | 2008-11-07 | 2009-11-06 | Treatment of acute lymphoblastic leukemia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014226022A Division JP5955921B2 (ja) | 2008-11-07 | 2014-11-06 | 急性リンパ芽球性白血病の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012508164A JP2012508164A (ja) | 2012-04-05 |
| JP2012508164A5 true JP2012508164A5 (https=) | 2013-03-21 |
| JP5647132B2 JP5647132B2 (ja) | 2014-12-24 |
Family
ID=41692882
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011533633A Active JP5647132B2 (ja) | 2008-11-07 | 2009-11-06 | 急性リンパ芽球性白血病の治療 |
| JP2014226022A Active JP5955921B2 (ja) | 2008-11-07 | 2014-11-06 | 急性リンパ芽球性白血病の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014226022A Active JP5955921B2 (ja) | 2008-11-07 | 2014-11-06 | 急性リンパ芽球性白血病の治療 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US20130323247A1 (https=) |
| EP (2) | EP2982696B1 (https=) |
| JP (2) | JP5647132B2 (https=) |
| KR (1) | KR101695327B1 (https=) |
| CN (2) | CN107184977A (https=) |
| AU (4) | AU2009313040B2 (https=) |
| BR (1) | BRPI0921482B1 (https=) |
| CA (1) | CA2742249C (https=) |
| CY (2) | CY1117033T1 (https=) |
| DK (2) | DK2342227T3 (https=) |
| ES (2) | ES2727585T3 (https=) |
| HR (2) | HRP20151168T1 (https=) |
| HU (2) | HUE043326T2 (https=) |
| IL (1) | IL212652A (https=) |
| LT (1) | LT2982696T (https=) |
| ME (2) | ME02363B (https=) |
| MX (1) | MX2011002927A (https=) |
| NZ (1) | NZ591311A (https=) |
| PL (2) | PL2982696T3 (https=) |
| PT (2) | PT2342227E (https=) |
| RS (2) | RS54456B1 (https=) |
| RU (1) | RU2536940C2 (https=) |
| SI (2) | SI2982696T1 (https=) |
| SM (2) | SMT201900278T1 (https=) |
| WO (1) | WO2010052014A1 (https=) |
| ZA (1) | ZA201103255B (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1976886T3 (en) * | 2005-12-16 | 2015-03-02 | Amgen Res Munich Gmbh | Means and methods for the treatment of tumor diseases |
| PT2342227E (pt) * | 2008-11-07 | 2015-11-13 | Amgen Res Munich Gmbh | Tratamento da leucemia linfoblástica aguda |
| CN107227335A (zh) | 2009-10-27 | 2017-10-03 | 安进研发(慕尼黑)股份有限公司 | 用于施用CD19xCD3双特异性抗体的给药方案 |
| NZ609201A (en) * | 2010-10-27 | 2015-01-30 | Amgen Res Munich Gmbh | Means and methods for treating dlbcl |
| CN103533943B (zh) * | 2010-11-10 | 2018-02-13 | 安进研发(慕尼黑)股份有限公司 | 由cd3特异性结合结构域导致的不良作用的预防 |
| KR102345943B1 (ko) * | 2011-04-28 | 2021-12-31 | 암젠 리서치 (뮌헨) 게엠베하 | 잠재적 유해 효과의 위험에 처한 환자에게 cd19xcd3 이중특이적 항체를 투여하기 위한 투여 요법 |
| WO2012158818A2 (en) | 2011-05-16 | 2012-11-22 | Fabion Pharmaceuticals, Inc. | Multi-specific fab fusion proteins and methods of use |
| DK3105252T3 (da) * | 2014-02-12 | 2019-10-14 | Michael Uhlin | Bispecifikke antistoffer til anvendelse ved stamcelletransplantation |
| US9732154B2 (en) | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
| US9603927B2 (en) | 2014-02-28 | 2017-03-28 | Janssen Biotech, Inc. | Combination therapies with anti-CD38 antibodies |
| ES2715679T3 (es) | 2014-05-30 | 2019-06-05 | Amgen Res Munich Gmbh | Estratificación del riesgo de pacientes con leucemia linfoblástica aguda de precursores B |
| MX386886B (es) | 2014-09-09 | 2025-03-12 | Janssen Biotech Inc | Combinación de anticuerpos anti-cd38 y ácido todo-trans retinoico para usarse en terapias. |
| AU2015358615B2 (en) | 2014-12-04 | 2021-08-05 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute myeloid leukemia |
| WO2016109549A1 (en) | 2014-12-30 | 2016-07-07 | University Of Utah Research Foundation | Hdac1,2 inhibitors and methods of using the same |
| AU2016222830B2 (en) | 2015-02-24 | 2021-02-25 | Bioatla Llc | Conditionally active biological proteins |
| CN107995913B (zh) * | 2015-05-18 | 2022-02-11 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
| RS66511B1 (sr) | 2015-05-20 | 2025-03-31 | Amgen Res Munich Gmbh | Deplecija b ćelija kao dijagnostički marker |
| MX389805B (es) | 2015-05-20 | 2025-03-11 | Janssen Biotech Inc | Anticuerpos anti-cd38 para el tratamiento de amiloidosis de cadena ligera y otras enfermedades malignas hematológicas positivas para cd38. |
| AU2016282674B2 (en) | 2015-06-22 | 2022-01-13 | Janssen Biotech, Inc. | Combination therapies for heme malignancies with anti-CD38 antibodies and survivin inhibitors |
| US20170044265A1 (en) | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
| CN105154440B (zh) * | 2015-08-14 | 2016-11-30 | 深圳市瀚海基因生物科技有限公司 | 一种基于高通量测序构建白血病微小残留病灶tcr文库的多重pcr引物和方法 |
| DK3827845T3 (da) | 2015-11-03 | 2022-05-23 | Janssen Biotech Inc | Subkutane formuleringer af anti-cd38-antistoffer og anvendelser deraf |
| US10781261B2 (en) | 2015-11-03 | 2020-09-22 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
| RU2651776C2 (ru) * | 2015-12-01 | 2018-04-23 | Общество с ограниченной ответственностью "Международный биотехнологический центр "Генериум" ("МБЦ "Генериум") | Биспецифические антитела против cd3*cd19 |
| GB201602974D0 (en) * | 2016-02-19 | 2016-04-06 | Clube Jasper R | Engineered cells & methods (1) |
| CN109476756B (zh) | 2016-03-15 | 2022-05-31 | 埃泰美德(香港)有限公司 | 一种多特异性Fab融合蛋白及其用途 |
| JP2019527678A (ja) | 2016-06-28 | 2019-10-03 | ユーエムセー・ユトレヒト・ホールディング・ベー・フェー | CD38に特異的に結合する抗体によるIgE媒介疾患の治療 |
| EP3494138A1 (en) | 2016-08-02 | 2019-06-12 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| CA3036745A1 (en) | 2016-10-07 | 2018-04-12 | TCR2 Therapeutics Inc. | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
| US11851491B2 (en) | 2016-11-22 | 2023-12-26 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| JP2021502961A (ja) | 2017-10-31 | 2021-02-04 | ヤンセン バイオテツク,インコーポレーテツド | 高リスク多発性骨髄腫の治療方法 |
| KR20250111232A (ko) * | 2017-12-11 | 2025-07-22 | 암젠 인크 | 이중특이적 항체 생성물의 연속 제조 공정 |
| KR102083481B1 (ko) | 2018-03-22 | 2020-03-02 | 강원대학교산학협력단 | 아연-키토산 나노 입자를 포함한 급성 림프구성 백혈병 치료용 약학조성물 |
| EP3847196A4 (en) | 2018-09-07 | 2023-01-04 | ITabMed (HK) Limited | BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF |
| WO2020132810A1 (en) * | 2018-12-24 | 2020-07-02 | Generon (Shanghai) Corporation Ltd. | Multispecific antigen binding proteins capable of binding cd19 and cd3, and use thereof |
| WO2020160310A1 (en) * | 2019-01-30 | 2020-08-06 | The Wistar Institute Of Anatomy And Biology | Dna-encoded bispecific t-cell engagers targeting cancer antigens and methods of use in cancer theraputics |
| IL322315A (en) | 2019-05-14 | 2025-09-01 | Provention Bio Inc | Methods and preparations for preventing type 1 diabetes |
| MX2021014644A (es) * | 2019-06-13 | 2022-04-06 | Amgen Inc | Control de perfusion basado en biomasa automatizado en la fabricacion de productos biologicos. |
| WO2021183861A1 (en) | 2020-03-12 | 2021-09-16 | Amgen Inc. | Method for treatment and prophylaxis of crs in patients comprising a combination of bispecifc antibodies binding to cds x cancer cell and tnfalpha or il-6 inhibitor |
| AU2021287998B2 (en) | 2020-06-11 | 2026-03-12 | Benaroya Research Institute At Virginia Mason | Methods and compositions for preventing type 1 diabetes |
| EP4214233A1 (en) | 2020-09-16 | 2023-07-26 | Amgen Inc. | Methods for administering therapeutic doses of bispecific t-cell engaging molecules for the treatment of cancer |
| US12565529B2 (en) | 2021-05-24 | 2026-03-03 | Provention Bio, Inc. | Methods for treating type 1 diabetes |
| US20250282864A1 (en) | 2021-10-15 | 2025-09-11 | Amgen Research (Munich) Gmbh | Subcutaneous administration of cd19-binding t cell engagers |
| US12319747B2 (en) | 2023-07-03 | 2025-06-03 | Medicovestor, Inc. | Methods of using anti-SP17 immunotherapeutics |
| US12364777B2 (en) | 2023-10-20 | 2025-07-22 | Medicovestor, Inc. | Homodimeric antibodies for use in treating cancers and methods of use |
| TW202535949A (zh) | 2023-12-20 | 2025-09-16 | 美商必治妥美雅史谷比公司 | 靶向IL-18受體β(IL-18RB)之抗體及相關方法 |
| US12116410B1 (en) | 2023-12-26 | 2024-10-15 | Medicovestor, Inc. | Methods of manufacturing dimeric antibodies |
| US12600795B2 (en) | 2023-12-26 | 2026-04-14 | Medicovestor, Inc. | Oligomeric IgG for immunotherapeutics and diagnostics |
| US12240900B1 (en) | 2024-02-02 | 2025-03-04 | Medicovestor, Inc. | Nucleic acids, vectors, and cells that encode antibodies and other proteins that bind folate receptor alpha |
| US12258396B1 (en) | 2024-02-02 | 2025-03-25 | Medicovestor, Inc. | Methods of using immunotherapeutics that bind folate receptor alpha |
| US12378314B1 (en) | 2024-02-02 | 2025-08-05 | Medicovestor, Inc. | Proteins that bind folate receptor alpha including fully-human antibodies |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4119397A (en) * | 1996-08-28 | 1998-03-19 | Viva Diagnostika Diagnostische Produkte Gmbh | Novel combination preparations and their use in immunodiagnosis and immunotherapy |
| BG65066B1 (bg) * | 1998-04-21 | 2007-01-31 | Micromet Gessellschaft Fur Biomedicinische Forschung Mbh | CD19 x CD3 СПЕЦИФИЧНИ ПОЛИПЕПТИДИ И ТЯХНОТО ИЗПОЛЗВАНЕ |
| CZ302070B6 (cs) * | 1998-04-21 | 2010-09-29 | Micromet Ag | Jednoretezcový multifunkcní polypeptid, polynukleotid, vektor obsahující tento polynukleotid, bunka transfekovaná tímto polynukleotidem, prostredek obsahující tento polypeptid, polynukleotid nebo vektor a jejich použití a zpusob identifikace aktiváto |
| CA2522586C (en) | 2003-05-31 | 2017-02-21 | Micromet Ag | Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders |
| DE602004030811D1 (de) * | 2003-10-16 | 2011-02-10 | Micromet Ag | Multispezifische deimmunisierte cd3-bindende moleküle |
| DK1976886T3 (en) * | 2005-12-16 | 2015-03-02 | Amgen Res Munich Gmbh | Means and methods for the treatment of tumor diseases |
| CN101331151A (zh) * | 2005-12-16 | 2008-12-24 | 麦克罗梅特股份公司 | 治疗肿瘤性疾病的方式和方法 |
| PL2383297T3 (pl) * | 2006-08-14 | 2013-06-28 | Xencor Inc | Zoptymalizowane przeciwciała ukierunkowane na CD19 |
| PT2342227E (pt) * | 2008-11-07 | 2015-11-13 | Amgen Res Munich Gmbh | Tratamento da leucemia linfoblástica aguda |
| CN102282129A (zh) * | 2009-01-19 | 2011-12-14 | 雅培制药有限公司 | 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂 |
| CN102282128B (zh) * | 2009-01-19 | 2015-06-17 | Abbvie公司 | 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂 |
| MX2011012632A (es) * | 2009-05-27 | 2012-03-06 | Abbott Lab | Inhibidores de actividad de cinasa tipo pirimidina. |
| BR112012006252A2 (pt) * | 2009-09-20 | 2017-05-23 | Abbott Lab | "formas cristalinas de abt-263 e solvatos para o uso no tratamento de doenças relacionadas á proteína bcl-2". |
| CN107227335A (zh) * | 2009-10-27 | 2017-10-03 | 安进研发(慕尼黑)股份有限公司 | 用于施用CD19xCD3双特异性抗体的给药方案 |
-
2009
- 2009-11-06 PT PT97604839T patent/PT2342227E/pt unknown
- 2009-11-06 DK DK09760483.9T patent/DK2342227T3/en active
- 2009-11-06 EP EP15185767.9A patent/EP2982696B1/en active Active
- 2009-11-06 DK DK15185767.9T patent/DK2982696T3/da active
- 2009-11-06 BR BRPI0921482-8A patent/BRPI0921482B1/pt active IP Right Grant
- 2009-11-06 WO PCT/EP2009/007970 patent/WO2010052014A1/en not_active Ceased
- 2009-11-06 PT PT15185767T patent/PT2982696T/pt unknown
- 2009-11-06 HU HUE15185767A patent/HUE043326T2/hu unknown
- 2009-11-06 HU HUE09760483A patent/HUE028175T2/en unknown
- 2009-11-06 EP EP09760483.9A patent/EP2342227B1/en active Active
- 2009-11-06 ES ES15185767T patent/ES2727585T3/es active Active
- 2009-11-06 ES ES09760483.9T patent/ES2558434T3/es active Active
- 2009-11-06 ME MEP-2015-181A patent/ME02363B/me unknown
- 2009-11-06 ME MEP-2019-146A patent/ME03480B/me unknown
- 2009-11-06 AU AU2009313040A patent/AU2009313040B2/en active Active
- 2009-11-06 KR KR1020117010641A patent/KR101695327B1/ko active Active
- 2009-11-06 CA CA2742249A patent/CA2742249C/en active Active
- 2009-11-06 CN CN201710366308.1A patent/CN107184977A/zh active Pending
- 2009-11-06 MX MX2011002927A patent/MX2011002927A/es active IP Right Grant
- 2009-11-06 SI SI200931967T patent/SI2982696T1/sl unknown
- 2009-11-06 RS RS20150797A patent/RS54456B1/sr unknown
- 2009-11-06 PL PL15185767T patent/PL2982696T3/pl unknown
- 2009-11-06 SM SM20190278T patent/SMT201900278T1/it unknown
- 2009-11-06 HR HRP20151168TT patent/HRP20151168T1/hr unknown
- 2009-11-06 US US13/127,541 patent/US20130323247A1/en not_active Abandoned
- 2009-11-06 NZ NZ591311A patent/NZ591311A/xx unknown
- 2009-11-06 CN CN2009801443998A patent/CN102209728A/zh active Pending
- 2009-11-06 SI SI200931306T patent/SI2342227T1/sl unknown
- 2009-11-06 RU RU2011122819/10A patent/RU2536940C2/ru active
- 2009-11-06 RS RS20190593A patent/RS58827B1/sr unknown
- 2009-11-06 LT LTEP15185767.9T patent/LT2982696T/lt unknown
- 2009-11-06 JP JP2011533633A patent/JP5647132B2/ja active Active
- 2009-11-06 PL PL09760483T patent/PL2342227T3/pl unknown
-
2011
- 2011-05-03 IL IL212652A patent/IL212652A/en active IP Right Grant
- 2011-05-05 ZA ZA2011/03255A patent/ZA201103255B/en unknown
-
2014
- 2014-11-06 JP JP2014226022A patent/JP5955921B2/ja active Active
-
2015
- 2015-10-06 AU AU2015238784A patent/AU2015238784A1/en not_active Abandoned
- 2015-12-09 CY CY20151101123T patent/CY1117033T1/el unknown
- 2015-12-30 SM SM201500328T patent/SMT201500328B/it unknown
-
2017
- 2017-08-25 AU AU2017219083A patent/AU2017219083B2/en active Active
-
2018
- 2018-11-06 AU AU2018260815A patent/AU2018260815B2/en active Active
- 2018-12-13 US US16/218,797 patent/US11597766B2/en active Active
-
2019
- 2019-05-16 HR HRP20190912TT patent/HRP20190912T1/hr unknown
- 2019-05-17 CY CY20191100527T patent/CY1122366T1/el unknown
-
2023
- 2023-02-03 US US18/164,304 patent/US20240109964A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012508164A5 (https=) | ||
| JP2012508163A5 (https=) | ||
| HRP20151168T1 (hr) | Lijeäśenje akutne limfoblastiäśne leukemije | |
| Vebr et al. | A narrative review of cytokine networks: pathophysiological and therapeutic implications for inflammatory bowel disease pathogenesis | |
| HRP20191715T1 (hr) | Liječenje dječje akutne limfoblastične leukemije sa bispecifičnim protutijelima protiv cd3xcd19 | |
| Jin et al. | TL1A/TNFSF15 directly induces proinflammatory cytokines, including TNFα, from CD3+ CD161+ T cells to exacerbate gut inflammation | |
| JP6367836B2 (ja) | T制御性細胞の増殖または枯渇方法 | |
| Crane et al. | CXCR4 receptor expression on human retinal pigment epithelial cells from the blood-retina barrier leads to chemokine secretion and migration in response to stromal cell-derived factor 1α | |
| Peligero-Cruz et al. | IL18 signaling promotes homing of mature Tregs into the thymus | |
| US20200352999A1 (en) | Use and production of engineered immune cells to disrupt nfat-ap1 pathway transcription factors | |
| CN111593022B (zh) | vMIP-Ⅱ诱导CD8+ T细胞去磷酸化为Tcm及其在药物中的应用 | |
| Ma et al. | Ebi3 promotes T-and B-cell division and differentiation via STAT3 | |
| Kondo et al. | Mouse gingival single-cell transcriptomic atlas identified a novel fibroblast subpopulation activated to guide oral barrier immunity in periodontitis | |
| Liu et al. | Prostaglandin I2-IP signalling regulates human Th17 and Treg cell differentiation | |
| O’Neil et al. | The role of tissue resident memory CD4 T cells in herpes simplex viral and HIV infection | |
| Palmer et al. | IFNγ-producing, virus-specific CD8+ effector cells acquire the ability to produce IL-10 as a result of entry into the infected lung environment | |
| WO2021216738A2 (en) | Compositions and methods of generating an immune response | |
| Koutsoumparis et al. | Erythropoietin (rhEPOa) promotes endothelial transdifferentiation of stem cells of the apical papilla (SCAP) | |
| JP2024167242A (ja) | 誘導された制御性T(iTREG)細胞を使用したALS治療 | |
| Van Belle et al. | Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model | |
| WO2022217373A1 (zh) | 一种降低人免疫缺陷病毒感染的病毒设定点及重建细胞免疫的因子和药物应用 | |
| US20220305488A1 (en) | Dynamic Profiling of Antitumor Activity of CAR T Cells Using Micropatterned tumor Array Devices | |
| Sundaram et al. | Measles virus nucleocapsid protein modulates the Signal Regulatory Protein-β1 (SIRPβ1) to enhance osteoclast differentiation in Paget's disease of bone | |
| Choi | The role of innate lymphoid cells in the heart and cardiac inflammation | |
| US20260083778A1 (en) | Generation of cd4 t cells |