KR101695327B1 - 급성 림프구성 백혈병의 치료방법 - Google Patents

급성 림프구성 백혈병의 치료방법 Download PDF

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KR101695327B1
KR101695327B1 KR1020117010641A KR20117010641A KR101695327B1 KR 101695327 B1 KR101695327 B1 KR 101695327B1 KR 1020117010641 A KR1020117010641 A KR 1020117010641A KR 20117010641 A KR20117010641 A KR 20117010641A KR 101695327 B1 KR101695327 B1 KR 101695327B1
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게르하르트 쭈크마이어
에블린 데겐하르트
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암젠 리서치 (뮌헨) 게엠베하
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020117010641A 2008-11-07 2009-11-06 급성 림프구성 백혈병의 치료방법 Active KR101695327B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11232308P 2008-11-07 2008-11-07
US61/112,323 2008-11-07
US18329109P 2009-06-02 2009-06-02
US61/183,291 2009-06-02
PCT/EP2009/007970 WO2010052014A1 (en) 2008-11-07 2009-11-06 Treatment of acute lymphoblastic leukemia

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Publication Number Publication Date
KR20110091668A KR20110091668A (ko) 2011-08-12
KR101695327B1 true KR101695327B1 (ko) 2017-01-11

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US (3) US20130323247A1 (https=)
EP (2) EP2982696B1 (https=)
JP (2) JP5647132B2 (https=)
KR (1) KR101695327B1 (https=)
CN (2) CN102209728A (https=)
AU (4) AU2009313040B2 (https=)
BR (1) BRPI0921482B1 (https=)
CA (1) CA2742249C (https=)
CY (2) CY1117033T1 (https=)
DK (2) DK2342227T3 (https=)
ES (2) ES2558434T3 (https=)
HR (2) HRP20151168T1 (https=)
HU (2) HUE043326T2 (https=)
IL (1) IL212652A (https=)
LT (1) LT2982696T (https=)
ME (2) ME02363B (https=)
MX (1) MX2011002927A (https=)
NZ (1) NZ591311A (https=)
PL (2) PL2342227T3 (https=)
PT (2) PT2982696T (https=)
RS (2) RS58827B1 (https=)
RU (1) RU2536940C2 (https=)
SI (2) SI2342227T1 (https=)
SM (2) SMT201900278T1 (https=)
WO (1) WO2010052014A1 (https=)
ZA (1) ZA201103255B (https=)

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KR20190111324A (ko) 2018-03-22 2019-10-02 강원대학교산학협력단 아연-키토산 나노 입자를 포함한 급성 림프구성 백혈병 치료용 약학조성물

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RS54655B2 (sr) 2009-10-27 2021-04-29 Amgen Res Munich Gmbh Dozni režim za primenu cd19xcd3 bispecifičnog antitela
CN103459425B (zh) * 2010-10-27 2015-11-25 安进研发（慕尼黑）股份有限公司 用于治疗dlbcl的组合物
EA026075B1 (ru) * 2010-11-10 2017-02-28 Эмджен Рисерч (Мьюник) Гмбх Предотвращение неблагоприятных эффектов, вызванных cd3-специфическими связывающими доменами
KR102345943B1 (ko) * 2011-04-28 2021-12-31 암젠 리서치 (뮌헨) 게엠베하 잠재적 유해 효과의 위험에 처한 환자에게 cd19xcd3 이중특이적 항체를 투여하기 위한 투여 요법
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KR20190111324A (ko) 2018-03-22 2019-10-02 강원대학교산학협력단 아연-키토산 나노 입자를 포함한 급성 림프구성 백혈병 치료용 약학조성물

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EP2982696A2 (en) 2016-02-10
DK2982696T3 (da) 2019-05-27
SMT201500328B (it) 2016-02-25
SI2982696T1 (sl) 2019-06-28
AU2017219083A1 (en) 2017-09-14
RU2011122819A (ru) 2012-12-20
DK2342227T3 (en) 2016-02-15
US20190300609A1 (en) 2019-10-03
US20130323247A1 (en) 2013-12-05
AU2015238784A1 (en) 2015-10-29
JP5955921B2 (ja) 2016-07-20
JP2015057417A (ja) 2015-03-26
AU2018260815B2 (en) 2020-03-05
WO2010052014A1 (en) 2010-05-14
BRPI0921482A2 (pt) 2016-01-12
ES2558434T3 (es) 2016-02-04
HUE028175T2 (en) 2016-12-28
CN107184977A (zh) 2017-09-22
ZA201103255B (en) 2013-12-23
NZ591311A (en) 2012-10-26
EP2982696B1 (en) 2019-03-27
EP2982696A3 (en) 2016-02-17
CY1122366T1 (el) 2021-01-27
EP2342227B1 (en) 2015-10-07
ES2727585T3 (es) 2019-10-17
ME02363B (me) 2016-06-20
HRP20190912T1 (hr) 2019-07-26
CY1117033T1 (el) 2017-04-05
BRPI0921482B1 (pt) 2022-09-20
US20240109964A1 (en) 2024-04-04
AU2009313040A1 (en) 2010-05-14
AU2009313040B2 (en) 2015-07-09
HK1220705A1 (en) 2017-05-12
HRP20151168T1 (hr) 2015-12-04
MX2011002927A (es) 2011-04-11
LT2982696T (lt) 2019-06-10
HK1158668A1 (en) 2012-07-20
RS54456B1 (sr) 2016-06-30
CN102209728A (zh) 2011-10-05
RS58827B1 (sr) 2019-07-31
PT2342227E (pt) 2015-11-13
IL212652A0 (en) 2011-07-31
US11597766B2 (en) 2023-03-07
EP2342227A1 (en) 2011-07-13
AU2018260815A1 (en) 2018-11-22
CA2742249A1 (en) 2010-05-14
CA2742249C (en) 2020-07-21
PT2982696T (pt) 2019-06-04
KR20110091668A (ko) 2011-08-12
JP2012508164A (ja) 2012-04-05
AU2017219083B2 (en) 2018-08-09
SMT201900278T1 (it) 2019-07-11
ME03480B (me) 2020-01-20
PL2982696T3 (pl) 2019-08-30
BRPI0921482A8 (pt) 2017-07-11
PL2342227T3 (pl) 2016-04-29
SI2342227T1 (sl) 2015-12-31
IL212652A (en) 2015-05-31
JP5647132B2 (ja) 2014-12-24
RU2536940C2 (ru) 2014-12-27
HUE043326T2 (hu) 2019-08-28

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