JP2012508163A5 - - Google Patents
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- Publication number
- JP2012508163A5 JP2012508163A5 JP2011533632A JP2011533632A JP2012508163A5 JP 2012508163 A5 JP2012508163 A5 JP 2012508163A5 JP 2011533632 A JP2011533632 A JP 2011533632A JP 2011533632 A JP2011533632 A JP 2011533632A JP 2012508163 A5 JP2012508163 A5 JP 2012508163A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody construct
- acute lymphoblastic
- lymphoblastic leukemia
- single chain
- construct according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11232308P | 2008-11-07 | 2008-11-07 | |
| US61/112,323 | 2008-11-07 | ||
| US18329109P | 2009-06-02 | 2009-06-02 | |
| US61/183,291 | 2009-06-02 | ||
| US22126909P | 2009-06-29 | 2009-06-29 | |
| US61/221,269 | 2009-06-29 | ||
| PCT/EP2009/007969 WO2010052013A1 (en) | 2008-11-07 | 2009-11-06 | Treatment of pediatric acute lymphoblastic leukemia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015163116A Division JP6130451B2 (ja) | 2008-11-07 | 2015-08-20 | 小児急性リンパ芽球性白血病の新規治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012508163A JP2012508163A (ja) | 2012-04-05 |
| JP2012508163A5 true JP2012508163A5 (https=) | 2013-03-21 |
| JP5798036B2 JP5798036B2 (ja) | 2015-10-21 |
Family
ID=41796119
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011533632A Active JP5798036B2 (ja) | 2008-11-07 | 2009-11-06 | 小児急性リンパ芽球性白血病の新規治療 |
| JP2015163116A Active JP6130451B2 (ja) | 2008-11-07 | 2015-08-20 | 小児急性リンパ芽球性白血病の新規治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015163116A Active JP6130451B2 (ja) | 2008-11-07 | 2015-08-20 | 小児急性リンパ芽球性白血病の新規治療 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US20110262440A1 (https=) |
| EP (4) | EP2918604B1 (https=) |
| JP (2) | JP5798036B2 (https=) |
| KR (1) | KR101695329B1 (https=) |
| CN (2) | CN102209729B (https=) |
| AU (1) | AU2009313039B2 (https=) |
| BR (1) | BRPI0921341A2 (https=) |
| CA (1) | CA2742242C (https=) |
| CY (3) | CY1116160T1 (https=) |
| DK (3) | DK3330293T3 (https=) |
| ES (3) | ES2748126T3 (https=) |
| HK (1) | HK1255590B (https=) |
| HR (3) | HRP20150400T1 (https=) |
| HU (3) | HUE036922T2 (https=) |
| IL (1) | IL212651A (https=) |
| LT (2) | LT2918604T (https=) |
| MX (1) | MX2011002931A (https=) |
| NO (1) | NO2918604T3 (https=) |
| NZ (1) | NZ591312A (https=) |
| PL (3) | PL2918604T3 (https=) |
| PT (3) | PT2344539E (https=) |
| RS (3) | RS59348B1 (https=) |
| RU (3) | RU2536933C2 (https=) |
| SG (1) | SG195549A1 (https=) |
| SI (3) | SI2918604T1 (https=) |
| SM (3) | SMT201900546T1 (https=) |
| WO (1) | WO2010052013A1 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6358588A (ja) * | 1986-08-29 | 1988-03-14 | Toshiba Corp | バ−コ−ド読取装置 |
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| PL2918604T3 (pl) * | 2008-11-07 | 2018-05-30 | Amgen Research (Munich) Gmbh | Leczenie pediatrycznej ostrej białaczki limfoblastycznej |
| US20120039943A1 (en) * | 2009-01-09 | 2012-02-16 | Oxford Biomedica (Uk) Limited | Factors |
| US20150231241A1 (en) * | 2012-08-14 | 2015-08-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
| JP6499079B2 (ja) * | 2012-11-13 | 2019-04-10 | バイオエヌテック アーゲーＢｉｏＮＴｅｃｈ ＡＧ | クローディンを発現するガン疾患を処置するための剤 |
| TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
| CN103131777A (zh) * | 2013-02-05 | 2013-06-05 | 南京艾迪康医学检验所有限公司 | 用于检测e2a-pbx融合基因相对表达量的试剂盒 |
| DK3105252T3 (da) | 2014-02-12 | 2019-10-14 | Michael Uhlin | Bispecifikke antistoffer til anvendelse ved stamcelletransplantation |
| TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| SI3149480T1 (sl) | 2014-05-30 | 2019-05-31 | Amgen Research (Munich) Gmbh | Stratifikacija tveganj pri bolnikih z akutno limfoblastno levkemijo prekurzorjev b |
| US20170252364A1 (en) | 2014-07-30 | 2017-09-07 | Mor Research Applications Ltd. | Compositions for treatment of acute lymphoblastic leukemia and methods of use thereof |
| WO2016061368A1 (en) * | 2014-10-15 | 2016-04-21 | The Children's Hospital Of Philadelphia | Compositions and methods for treating b-lymphoid malignancies |
| KR102614189B1 (ko) | 2014-11-17 | 2023-12-18 | 리제너론 파아마슈티컬스, 인크. | Cd3xcd20 이특이적 항체를 이용한 종양의 치료 방법 |
| CN107635578A (zh) | 2015-02-05 | 2018-01-26 | Stc.Unm 公司 | 抗前‑bcr拮抗剂和方法 |
| WO2016161010A2 (en) | 2015-03-30 | 2016-10-06 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to fc gamma receptors |
| JP6961490B2 (ja) | 2015-04-08 | 2021-11-05 | ノバルティス アーゲー | Ｃｄ２０療法、ｃｄ２２療法、およびｃｄ１９キメラ抗原受容体（ｃａｒ）発現細胞との併用療法 |
| AU2016263464B2 (en) * | 2015-05-20 | 2021-12-23 | Amgen Research (Munich) Gmbh | B-cell depletion as a diagnostic marker |
| AU2016325630B2 (en) | 2015-09-23 | 2022-11-17 | Regeneron Pharmaceuticals, Inc. | Optimized anti-CD3 bispecific antibodies and uses thereof |
| AU2016378573A1 (en) * | 2015-12-22 | 2018-07-19 | Regeneron Pharmaceuticals, Inc. | Bispecific anti-CD20/anti-CD3 antibodies to treat acute lymphoblastic leukemia |
| GB201602974D0 (en) * | 2016-02-19 | 2016-04-06 | Clube Jasper R | Engineered cells & methods (1) |
| CA3017743A1 (en) * | 2016-03-14 | 2017-09-21 | Millennium Pharmaceuticals, Inc. | Method of preventing graft versus host disease |
| CA3024725A1 (en) * | 2016-06-06 | 2017-12-14 | Juno Therapeutics, Inc. | Methods for the treatment of b cell malignancies using adoptive cell therapy |
| CA3045339A1 (en) | 2016-12-03 | 2018-06-07 | Juno Therapeutics, Inc. | Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors |
| UY37726A (es) * | 2017-05-05 | 2018-11-30 | Amgen Inc | Composición farmacéutica que comprende constructos de anticuerpos biespecíficos para almacenamiento y administración mejorados |
| AU2018275894B2 (en) | 2017-06-02 | 2025-04-24 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| WO2019089858A2 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| KR102083481B1 (ko) | 2018-03-22 | 2020-03-02 | 강원대학교산학협력단 | 아연-키토산 나노 입자를 포함한 급성 림프구성 백혈병 치료용 약학조성물 |
| CA3110513A1 (en) | 2018-08-31 | 2020-03-05 | Regeneron Pharmaceuticals, Inc. | Dosing strategy that mitigates cytokine release syndrome for cd3/c20 bispecific antibodies |
| JP7680358B2 (ja) * | 2019-01-30 | 2025-05-20 | ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー | 癌抗原を標的とするｄｎａコード化二重特異性ｔ細胞エンゲージャーおよび癌治療薬における使用方法 |
| WO2020232247A1 (en) | 2019-05-14 | 2020-11-19 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| JP7489407B2 (ja) | 2019-05-21 | 2024-05-23 | ノバルティス アーゲー | Ｃｄ１９結合分子及びその使用 |
| JP6881658B2 (ja) | 2019-07-05 | 2021-06-02 | 小野薬品工業株式会社 | Ｐｄ−１／ｃｄ３二重特異性タンパク質による血液がん治療 |
| IL298999A (en) | 2020-06-11 | 2023-02-01 | Provention Bio Inc | Methods and compositions for the prevention of type 1 diabetes |
| EP4294837A1 (en) | 2021-02-16 | 2023-12-27 | Children's Health Care d/b/a Children's Minnesota | Methods for treating b-all by administering a pre-bcr complex antagonist |
| JP2024520444A (ja) | 2021-05-24 | 2024-05-24 | プロヴェンション・バイオ・インコーポレイテッド | １型糖尿病を治療するための方法 |
| EP4415829A1 (en) | 2021-10-15 | 2024-08-21 | Amgen Research (Munich) GmbH | Subcutaneous administration of cd19-binding t cell engaging antibodies |
| WO2025101672A1 (en) | 2023-11-06 | 2025-05-15 | City Of Hope | Methods comprising oncolytic viruses expressing cd19t and bispecific t cell engagers |
| TW202535949A (zh) | 2023-12-20 | 2025-09-16 | 美商必治妥美雅史谷比公司 | 靶向IL-18受體β(IL-18RB)之抗體及相關方法 |
| WO2025250648A1 (en) * | 2024-05-28 | 2025-12-04 | Ohio State Innovation Foundation | Methods and compositions comprising tagless blinatumomab |
| WO2026072671A1 (en) | 2024-09-24 | 2026-04-02 | City Of Hope | Methods comprising oncolytic viruses expressing bcmat and bcma-targeted therapies |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4119397A (en) * | 1996-08-28 | 1998-03-19 | Viva Diagnostika Diagnostische Produkte Gmbh | Novel combination preparations and their use in immunodiagnosis and immunotherapy |
| US7112324B1 (en) * | 1998-04-21 | 2006-09-26 | Micromet Ag | CD 19×CD3 specific polypeptides and uses thereof |
| JP2008501621A (ja) * | 2003-05-31 | 2008-01-24 | マイクロメット アクツィエン ゲゼルシャフト | Ｂ細胞関連疾患を処置するための二重特異性抗ｃｄ３、抗ｃｄ１９抗体構築物を含む薬学的組成物 |
| MXPA06004035A (es) * | 2003-10-16 | 2006-08-31 | Micromet Ag | Aglutinantes cd3 de-inmunizados multi-especificos. |
| HRP20150175T1 (en) | 2005-12-16 | 2015-03-27 | Amgen Research (Munich) Gmbh | Means and methods for the treatment of tumorous diseases |
| PL2383297T3 (pl) * | 2006-08-14 | 2013-06-28 | Xencor Inc | Zoptymalizowane przeciwciała ukierunkowane na CD19 |
| DK2352763T4 (da) * | 2008-10-01 | 2022-10-17 | Amgen Res Munich Gmbh | Bispecifikke enkeltkædede antistoffer med specificitet for højmolekylære målantigener |
| PL2918604T3 (pl) * | 2008-11-07 | 2018-05-30 | Amgen Research (Munich) Gmbh | Leczenie pediatrycznej ostrej białaczki limfoblastycznej |
| CA2747835A1 (en) * | 2009-01-19 | 2010-07-22 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| WO2010083442A1 (en) * | 2009-01-19 | 2010-07-22 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| CA2763633A1 (en) * | 2009-05-27 | 2010-12-02 | Gary T. Wang | Pyrimidine inhibitors of kinase activity |
| BR112012006252A2 (pt) * | 2009-09-20 | 2017-05-23 | Abbott Lab | "formas cristalinas de abt-263 e solvatos para o uso no tratamento de doenças relacionadas á proteína bcl-2". |
| RS54655B2 (sr) * | 2009-10-27 | 2021-04-29 | Amgen Res Munich Gmbh | Dozni režim za primenu cd19xcd3 bispecifičnog antitela |
-
2009
- 2009-11-06 PL PL15154416T patent/PL2918604T3/pl unknown
- 2009-11-06 ES ES17206868T patent/ES2748126T3/es active Active
- 2009-11-06 DK DK17206868.6T patent/DK3330293T3/da active
- 2009-11-06 RS RSP20191232 patent/RS59348B1/sr unknown
- 2009-11-06 PT PT97647101T patent/PT2344539E/pt unknown
- 2009-11-06 BR BRPI0921341A patent/BRPI0921341A2/pt not_active Application Discontinuation
- 2009-11-06 ES ES09764710.1T patent/ES2535257T3/es active Active
- 2009-11-06 MX MX2011002931A patent/MX2011002931A/es active IP Right Grant
- 2009-11-06 EP EP15154416.0A patent/EP2918604B1/en active Active
- 2009-11-06 JP JP2011533632A patent/JP5798036B2/ja active Active
- 2009-11-06 SM SM20190546T patent/SMT201900546T1/it unknown
- 2009-11-06 EP EP19187179.7A patent/EP3594237A1/en active Pending
- 2009-11-06 CA CA2742242A patent/CA2742242C/en active Active
- 2009-11-06 SI SI200931817T patent/SI2918604T1/en unknown
- 2009-11-06 EP EP17206868.6A patent/EP3330293B1/en active Active
- 2009-11-06 NZ NZ591312A patent/NZ591312A/xx unknown
- 2009-11-06 LT LTEP15154416.0T patent/LT2918604T/lt unknown
- 2009-11-06 SI SI200931995T patent/SI3330293T1/sl unknown
- 2009-11-06 RU RU2011122827/10A patent/RU2536933C2/ru active
- 2009-11-06 PL PL17206868T patent/PL3330293T3/pl unknown
- 2009-11-06 RS RS20180309A patent/RS56989B1/sr unknown
- 2009-11-06 WO PCT/EP2009/007969 patent/WO2010052013A1/en not_active Ceased
- 2009-11-06 PT PT172068686T patent/PT3330293T/pt unknown
- 2009-11-06 RS RS20150306A patent/RS53980B1/sr unknown
- 2009-11-06 PL PL09764710T patent/PL2344539T3/pl unknown
- 2009-11-06 LT LTEP17206868.6T patent/LT3330293T/lt unknown
- 2009-11-06 HU HUE15154416A patent/HUE036922T2/hu unknown
- 2009-11-06 PT PT151544160T patent/PT2918604T/pt unknown
- 2009-11-06 SM SM20180149T patent/SMT201800149T1/it unknown
- 2009-11-06 EP EP09764710.1A patent/EP2344539B1/en active Active
- 2009-11-06 ES ES15154416.0T patent/ES2662929T3/es active Active
- 2009-11-06 CN CN200980144400.7A patent/CN102209729B/zh active Active
- 2009-11-06 US US13/127,538 patent/US20110262440A1/en not_active Abandoned
- 2009-11-06 HR HRP20150400TT patent/HRP20150400T1/hr unknown
- 2009-11-06 AU AU2009313039A patent/AU2009313039B2/en active Active
- 2009-11-06 NO NO15154416A patent/NO2918604T3/no unknown
- 2009-11-06 CN CN201610281293.4A patent/CN106390114A/zh active Pending
- 2009-11-06 KR KR1020117010642A patent/KR101695329B1/ko active Active
- 2009-11-06 DK DK09764710.1T patent/DK2344539T3/en active
- 2009-11-06 SI SI200931185T patent/SI2344539T1/sl unknown
- 2009-11-06 DK DK15154416.0T patent/DK2918604T3/en active
- 2009-11-06 SG SG2013076310A patent/SG195549A1/en unknown
- 2009-11-06 HU HUE09764710A patent/HUE025452T2/en unknown
- 2009-11-06 HU HUE17206868A patent/HUE046222T2/hu unknown
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2011
- 2011-05-03 IL IL212651A patent/IL212651A/en active IP Right Grant
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2014
- 2014-10-13 RU RU2014141180A patent/RU2677324C2/ru active
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2015
- 2015-03-31 CY CY20151100317T patent/CY1116160T1/el unknown
- 2015-04-27 SM SM201500104T patent/SMT201500104B/xx unknown
- 2015-08-20 JP JP2015163116A patent/JP6130451B2/ja active Active
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2018
- 2018-03-12 HR HRP20180426TT patent/HRP20180426T1/hr unknown
- 2018-03-14 CY CY20181100310T patent/CY1120022T1/el unknown
- 2018-11-16 HK HK18114719.1A patent/HK1255590B/en unknown
- 2018-12-14 RU RU2018144313A patent/RU2736802C2/ru active
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2019
- 2019-09-20 HR HRP20191715 patent/HRP20191715T1/hr unknown
- 2019-10-03 CY CY20191101035T patent/CY1122428T1/el unknown
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2022
- 2022-09-16 US US17/932,739 patent/US20230235053A1/en active Pending
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