JP2012503596A5 - - Google Patents
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- JP2012503596A5 JP2012503596A5 JP2011527187A JP2011527187A JP2012503596A5 JP 2012503596 A5 JP2012503596 A5 JP 2012503596A5 JP 2011527187 A JP2011527187 A JP 2011527187A JP 2011527187 A JP2011527187 A JP 2011527187A JP 2012503596 A5 JP2012503596 A5 JP 2012503596A5
- Authority
- JP
- Japan
- Prior art keywords
- glycoprotein
- pore size
- organic solution
- membrane
- ion exchange
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000012528 membrane Substances 0.000 claims description 29
- 241000700605 Viruses Species 0.000 claims description 19
- 239000011148 porous material Substances 0.000 claims description 18
- 102000003886 Glycoproteins Human genes 0.000 claims description 16
- 108090000288 Glycoproteins Proteins 0.000 claims description 16
- 238000001914 filtration Methods 0.000 claims description 8
- 238000004255 ion exchange chromatography Methods 0.000 claims description 8
- 230000000415 inactivating Effects 0.000 claims description 6
- 238000000108 ultra-filtration Methods 0.000 claims description 6
- 230000001580 bacterial Effects 0.000 claims description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 229940088597 Hormone Drugs 0.000 claims description 3
- 239000005556 hormone Substances 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 229940015047 Chorionic Gonadotropin Drugs 0.000 claims 1
- 102000011022 Chorionic Gonadotropin Human genes 0.000 claims 1
- 108010062540 Chorionic Gonadotropin Proteins 0.000 claims 1
- 229940028334 Follicle Stimulating Hormone Drugs 0.000 claims 1
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 claims 1
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 claims 1
- 102000006771 Gonadotropins Human genes 0.000 claims 1
- 108010086677 Gonadotropins Proteins 0.000 claims 1
- 229920005654 Sephadex Polymers 0.000 claims 1
- 239000012507 Sephadex™ Substances 0.000 claims 1
- PSLIMVZEAPALCD-UHFFFAOYSA-N ethanol;ethoxyethane Chemical compound CCO.CCOCC PSLIMVZEAPALCD-UHFFFAOYSA-N 0.000 claims 1
- MDKXBBPLEGPIRI-UHFFFAOYSA-N ethoxyethane;methanol Chemical compound OC.CCOCC MDKXBBPLEGPIRI-UHFFFAOYSA-N 0.000 claims 1
- HWJHWSBFPPPIPD-UHFFFAOYSA-N ethoxyethane;propan-2-one Chemical compound CC(C)=O.CCOCC HWJHWSBFPPPIPD-UHFFFAOYSA-N 0.000 claims 1
- 239000002622 gonadotropin Substances 0.000 claims 1
- 239000003456 ion exchange resin Substances 0.000 claims 1
- 229920003303 ion-exchange polymer Polymers 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 239000000243 solution Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000005374 membrane filtration Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 102000035362 glycosylated proteins Human genes 0.000 description 1
- 108091005600 glycosylated proteins Proteins 0.000 description 1
- 230000003899 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000010129 solution processing Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810200343.7 | 2008-09-24 | ||
| CN2008102003437A CN101397339B (zh) | 2008-09-24 | 2008-09-24 | 糖蛋白中去除/灭活病毒的方法 |
| PCT/CN2009/071971 WO2010034198A1 (zh) | 2008-09-24 | 2009-05-26 | 糖蛋白中去除/灭活病毒的方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012503596A JP2012503596A (ja) | 2012-02-09 |
| JP2012503596A5 true JP2012503596A5 (zh) | 2013-10-17 |
Family
ID=40516200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011527187A Pending JP2012503596A (ja) | 2008-09-24 | 2009-05-26 | 糖タンパク質におけるウイルスの除去／不活性化方法 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2012503596A (zh) |
| KR (1) | KR20110076908A (zh) |
| CN (1) | CN101397339B (zh) |
| WO (1) | WO2010034198A1 (zh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101397339B (zh) * | 2008-09-24 | 2012-07-25 | 上海天伟生物制药有限公司 | 糖蛋白中去除/灭活病毒的方法 |
| CN102675414A (zh) * | 2011-03-08 | 2012-09-19 | 上海天伟生物制药有限公司 | 糖蛋白中去除/灭活朊病毒的方法 |
| ES2770860T3 (es) | 2015-06-26 | 2020-07-03 | Ferring Bv | Métodos de purificación y/o inactivación viral |
| CN112301004B (zh) * | 2020-10-30 | 2022-08-05 | 苏州良辰生物医药科技有限公司 | 一种灭活猪细小病毒的方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1287138B1 (it) * | 1996-11-07 | 1998-08-04 | Ibsa Inst Biochimique Sa | Procedimento per la separazione e purificazione di fsh e lh |
| CN1199642A (zh) * | 1997-05-16 | 1998-11-25 | Asta药物股份公司 | 治疗不育症的lhrh－拮抗剂 |
| RU2229309C2 (ru) * | 1998-05-07 | 2004-05-27 | Транскариотик Терапиз, Инк. | МОДИФИЦИРОВАНИЕ ЭКСПРЕССИИ ГЕНА FSHβ С ПОМОЩЬЮ ГОМОЛОГИЧНОЙ РЕКОМБИНАЦИИ |
| CN1189475C (zh) * | 1999-01-26 | 2005-02-16 | Ibsa生物化学研究股份有限公司 | 分离和纯化促卵泡激素和黄体生成激素的方法 |
| CA2399020A1 (en) * | 2000-02-22 | 2001-08-30 | Applied Research Systems Ars Holding N.V. | Process of purification of hcg and recombinant hcg purified by that method |
| US6365395B1 (en) * | 2000-11-03 | 2002-04-02 | Millipore Corporation | Process for removing protein aggregates and virus from a protein solution |
| CN1302818A (zh) * | 2000-12-12 | 2001-07-11 | 上海惠海生化制品厂 | 一种人绒毛膜促性腺激素及其制备方法 |
| CN1415628A (zh) * | 2002-08-14 | 2003-05-07 | 上海天伟生物制药有限公司 | 一种提取人尿黄体生成素的方法 |
| ES2543978T3 (es) * | 2003-04-09 | 2015-08-26 | The Chemo-Sero-Therapeutic Research Institute | Proceso para la producción de una preparación de albúmina |
| CN100417663C (zh) * | 2004-07-23 | 2008-09-10 | 南昌市万华生化制品有限公司 | 高纯度尿卵泡刺激素的纯化方法 |
| JP2006151840A (ja) * | 2004-11-26 | 2006-06-15 | Kyowa Hakko Kogyo Co Ltd | ウイルスの除去方法 |
| CN1958603B (zh) * | 2005-11-04 | 2010-05-05 | 上海天伟生物制药有限公司 | 一种人绒毛膜促性腺素的纯化方法 |
| CN101307103B (zh) * | 2007-09-11 | 2012-01-04 | 上海天伟生物制药有限公司 | 一种卵泡刺激素的纯化方法 |
| CN101347613B (zh) * | 2008-09-17 | 2011-10-26 | 上海天伟生物制药有限公司 | 几乎不含亚基的糖蛋白的组合物及其制备方法 |
| CN101397339B (zh) * | 2008-09-24 | 2012-07-25 | 上海天伟生物制药有限公司 | 糖蛋白中去除/灭活病毒的方法 |
-
2008
- 2008-09-24 CN CN2008102003437A patent/CN101397339B/zh active Active
-
2009
- 2009-05-26 KR KR1020117007297A patent/KR20110076908A/ko active Search and Examination
- 2009-05-26 JP JP2011527187A patent/JP2012503596A/ja active Pending
- 2009-05-26 WO PCT/CN2009/071971 patent/WO2010034198A1/zh active Application Filing
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