JP2012149097A5 - - Google Patents
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- Publication number
- JP2012149097A5 JP2012149097A5 JP2012106155A JP2012106155A JP2012149097A5 JP 2012149097 A5 JP2012149097 A5 JP 2012149097A5 JP 2012106155 A JP2012106155 A JP 2012106155A JP 2012106155 A JP2012106155 A JP 2012106155A JP 2012149097 A5 JP2012149097 A5 JP 2012149097A5
- Authority
- JP
- Japan
- Prior art keywords
- tacrolimus
- triacetin
- excluding
- external preparation
- external
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 6
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 4
- 229960001967 tacrolimus Drugs 0.000 claims 4
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 4
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 3
- 239000001087 glyceryl triacetate Substances 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 229960002622 triacetin Drugs 0.000 claims 3
- 239000002674 ointment Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000003381 solubilizing effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012106155A JP2012149097A (ja) | 2008-10-08 | 2012-05-07 | タクロリムス外用剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008261987 | 2008-10-08 | ||
| JP2008261987 | 2008-10-08 | ||
| JP2012106155A JP2012149097A (ja) | 2008-10-08 | 2012-05-07 | タクロリムス外用剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532940A Division JP5135441B2 (ja) | 2008-10-08 | 2009-10-07 | タクロリムス外用剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012149097A JP2012149097A (ja) | 2012-08-09 |
| JP2012149097A5 true JP2012149097A5 (enExample) | 2012-11-29 |
Family
ID=42100633
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532940A Active JP5135441B2 (ja) | 2008-10-08 | 2009-10-07 | タクロリムス外用剤 |
| JP2012106155A Pending JP2012149097A (ja) | 2008-10-08 | 2012-05-07 | タクロリムス外用剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532940A Active JP5135441B2 (ja) | 2008-10-08 | 2009-10-07 | タクロリムス外用剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8575189B2 (enExample) |
| EP (1) | EP2345414B1 (enExample) |
| JP (2) | JP5135441B2 (enExample) |
| CN (1) | CN102176913B (enExample) |
| CA (1) | CA2738831C (enExample) |
| ES (1) | ES2478845T3 (enExample) |
| WO (1) | WO2010041684A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010041684A1 (ja) * | 2008-10-08 | 2010-04-15 | 高田製薬株式会社 | タクロリムス外用剤 |
| JP2010132607A (ja) * | 2008-12-05 | 2010-06-17 | Taisho Pharm Ind Ltd | アトピー性皮膚炎治療用軟膏剤 |
| JP2010202546A (ja) * | 2009-03-02 | 2010-09-16 | Taisho Pharm Ind Ltd | アトピー性皮膚炎の治療用軟膏製剤 |
| DE102012207989A1 (de) * | 2012-05-14 | 2013-11-14 | Beiersdorf Ag | Aromatisierte Lippenbutter |
| CN102885761B (zh) * | 2012-09-24 | 2015-08-05 | 浙江万晟药业有限公司 | 一种制备他克莫司软膏的方法 |
| CN103271826B (zh) * | 2013-05-15 | 2014-08-06 | 广东恒健制药有限公司 | 一种他克莫司软膏的工业化生产方法 |
| CN103239391B (zh) * | 2013-05-16 | 2015-03-18 | 江苏知原药业有限公司 | 一种他克莫司软膏 |
| CN104127369A (zh) * | 2014-07-02 | 2014-11-05 | 人福医药集团股份公司 | 他克莫司软膏及其制备方法 |
| CN104612504B (zh) * | 2015-01-23 | 2017-04-26 | 王宗超 | 一种推拉式门窗扇定位器 |
| WO2017068673A1 (ja) * | 2015-10-21 | 2017-04-27 | マルホ株式会社 | 皮膚用の医薬組成物 |
| TWI726027B (zh) * | 2015-12-28 | 2021-05-01 | 日商大塚製藥股份有限公司 | 軟膏 |
| CN107753419B (zh) * | 2017-10-18 | 2020-11-03 | 江苏知原药业有限公司 | 他克莫司外用制剂 |
| AU2019322315A1 (en) * | 2018-08-16 | 2021-02-25 | Dr. Reddy's Laboratories Ltd. | Topical oleaginous compositions |
| WO2020117134A1 (en) * | 2018-12-04 | 2020-06-11 | İlko İlaç Sanayi̇ Ve Ti̇caret A.Ş. | Stable tacrolimus ointment formulation for topical treatment of skin conditions |
| CN110403902A (zh) * | 2019-09-05 | 2019-11-05 | 四川明欣药业有限责任公司 | 一种他克莫司软膏的制备方法 |
| CN113712900A (zh) * | 2020-05-25 | 2021-11-30 | 南京帝昌医药科技有限公司 | 一种枸橼酸托法替布软膏组合物及其制备方法 |
| CN112022798B (zh) * | 2020-08-11 | 2022-04-29 | 四川大学华西医院 | 一种速效他克莫司软膏、制备方法及应用 |
| CN114159380A (zh) * | 2021-12-27 | 2022-03-11 | 卓和药业集团股份有限公司 | 一种他克莫司乳膏及其制备方法 |
| CN114428133B (zh) * | 2021-12-28 | 2023-06-09 | 江苏知原药业股份有限公司 | 一种用反相色谱法检测他克莫司软膏中杂质xv含量的方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| GB8430455D0 (en) | 1984-12-03 | 1985-01-09 | Fujisawa Pharmaceutical Co | Fr-900506 substance |
| US5254562A (en) * | 1984-12-03 | 1993-10-19 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| US5266692A (en) * | 1984-12-03 | 1993-11-30 | Fujisawa Pharmaceutical Co., Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| JPH0676327B2 (ja) * | 1987-04-14 | 1994-09-28 | 株式会社大塚製薬工場 | ステロイド軟膏製剤 |
| PH26083A (en) | 1987-11-09 | 1992-02-06 | Sandoz Ltd | 11, 28-dioxa-4-azatricyclo [22.3.1.04.9) octacos-18-ene derivatives and pharmaceutical compositions containing them and method of use thereof |
| US5366971A (en) * | 1987-11-09 | 1994-11-22 | Sandoz Ltd. | Use of 11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing them |
| AU656145B2 (en) | 1990-09-04 | 1995-01-27 | Astellas Pharma Inc. | Ointments containing tricyclic compound |
| JPH06256182A (ja) * | 1993-03-05 | 1994-09-13 | L T T Kenkyusho:Kk | 外用製剤 |
| JPH06345646A (ja) | 1993-06-08 | 1994-12-20 | Fujisawa Pharmaceut Co Ltd | ローション剤 |
| JP3506474B2 (ja) * | 1994-01-07 | 2004-03-15 | 帝人株式会社 | 安定性の向上した乾癬治療剤 |
| JP3839502B2 (ja) * | 1994-03-03 | 2006-11-01 | 帝人株式会社 | 湿疹・皮膚炎群治療剤 |
| TW450810B (en) | 1997-02-20 | 2001-08-21 | Fujisawa Pharmaceutical Co | Macrolides antibiotic pharmaceutical composition for preventing and treating skin diseases |
| AU749475B2 (en) | 1998-04-27 | 2002-06-27 | Astellas Pharma Inc. | Medicinal compositions |
| US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| WO2004071510A1 (en) | 2003-02-11 | 2004-08-26 | Cipla Ltd | Pharmaceutical composition comprising immunosuppressants for the treatment of dermatophytosis |
| EP1594484A2 (en) * | 2003-02-17 | 2005-11-16 | Cipla Ltd. | Pharmaceutical patch |
| AU2004257674A1 (en) * | 2003-07-11 | 2005-01-27 | Macrochem Corporation | Pharmaceutical compositions for topical application |
| IL159729A0 (en) * | 2004-01-06 | 2004-06-20 | Doron I Friedman | Non-aqueous composition for oral delivery of insoluble bioactive agents |
| EA011244B1 (ru) * | 2004-03-18 | 2009-02-27 | Панацея Биотек Лтд. | Новые композиции для местной доставки |
| US8741333B2 (en) * | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for treating dermatitis or psoriasis |
| KR100678829B1 (ko) | 2004-12-06 | 2007-02-05 | 한미약품 주식회사 | 타크로리무스의 경구용 마이크로에멀젼 조성물 |
| CA2633464A1 (en) * | 2005-12-14 | 2007-09-07 | Zars Pharma, Inc. | Compositions and methods for dermal delivery of drugs |
| WO2010041684A1 (ja) * | 2008-10-08 | 2010-04-15 | 高田製薬株式会社 | タクロリムス外用剤 |
| JP2010132607A (ja) * | 2008-12-05 | 2010-06-17 | Taisho Pharm Ind Ltd | アトピー性皮膚炎治療用軟膏剤 |
| JP2010202546A (ja) * | 2009-03-02 | 2010-09-16 | Taisho Pharm Ind Ltd | アトピー性皮膚炎の治療用軟膏製剤 |
-
2009
- 2009-10-07 WO PCT/JP2009/067488 patent/WO2010041684A1/ja not_active Ceased
- 2009-10-07 US US13/122,820 patent/US8575189B2/en not_active Expired - Fee Related
- 2009-10-07 JP JP2010532940A patent/JP5135441B2/ja active Active
- 2009-10-07 CA CA2738831A patent/CA2738831C/en active Active
- 2009-10-07 EP EP09819218.0A patent/EP2345414B1/en not_active Not-in-force
- 2009-10-07 ES ES09819218.0T patent/ES2478845T3/es active Active
- 2009-10-07 CN CN200980140109.2A patent/CN102176913B/zh not_active Expired - Fee Related
-
2012
- 2012-05-07 JP JP2012106155A patent/JP2012149097A/ja active Pending
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