CN102885761B - 一种制备他克莫司软膏的方法 - Google Patents
一种制备他克莫司软膏的方法 Download PDFInfo
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- CN102885761B CN102885761B CN201210356770.0A CN201210356770A CN102885761B CN 102885761 B CN102885761 B CN 102885761B CN 201210356770 A CN201210356770 A CN 201210356770A CN 102885761 B CN102885761 B CN 102885761B
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- mixed solution
- tacrolimus
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- grams
- white vaseline
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- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 title claims abstract description 42
- 229960001967 tacrolimus Drugs 0.000 title claims abstract description 42
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 title claims abstract description 17
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 48
- 239000011259 mixed solution Substances 0.000 claims abstract description 29
- 239000003871 white petrolatum Substances 0.000 claims abstract description 20
- JKJWYKGYGWOAHT-UHFFFAOYSA-N bis(prop-2-enyl) carbonate Chemical compound C=CCOC(=O)OCC=C JKJWYKGYGWOAHT-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000000243 solution Substances 0.000 claims abstract description 17
- 239000007765 cera alba Substances 0.000 claims abstract description 13
- 229940057995 liquid paraffin Drugs 0.000 claims abstract description 13
- 239000012188 paraffin wax Substances 0.000 claims abstract description 13
- 238000009413 insulation Methods 0.000 claims abstract description 12
- 238000010438 heat treatment Methods 0.000 claims abstract description 8
- 238000002844 melting Methods 0.000 claims abstract description 8
- 230000008018 melting Effects 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims abstract description 5
- 238000001816 cooling Methods 0.000 claims abstract description 4
- -1 heating and melting Substances 0.000 claims abstract description 4
- 239000013521 mastic Substances 0.000 claims abstract description 4
- 150000001993 dienes Chemical class 0.000 claims description 9
- 230000001804 emulsifying effect Effects 0.000 claims description 9
- 239000002674 ointment Substances 0.000 claims description 7
- 238000011282 treatment Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000000047 product Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 239000013067 intermediate product Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 235000008575 Pinus pinea Nutrition 0.000 description 1
- 240000007789 Pinus pinea Species 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 238000004382 potting Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 208000037851 severe atopic dermatitis Diseases 0.000 description 1
- CMXPERZAMAQXSF-UHFFFAOYSA-M sodium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate;1,8-dihydroxyanthracene-9,10-dione Chemical compound [Na+].O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O.CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC CMXPERZAMAQXSF-UHFFFAOYSA-M 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
基本处方 | 1000支 |
他克莫司(折纯) | 10 g |
白蜂蜡 | 300 g |
液状石蜡 | 4000 g |
石蜡 | 300 g |
白凡士林 | 5200 g |
碳酸丙烯酯 | 100 g |
丙二醇 | 100 g |
基本处方 | 1000支 |
他克莫司(折纯) | 3g |
白蜂蜡 | 300 g |
液状石蜡 | 4000 g |
石蜡 | 300 g |
白凡士林 | 5200 g |
碳酸丙烯酯 | 100 g |
丙二醇 | 100 g |
编号 | 设备名称 | 规格型号 | 制造单位 |
1 | 真空均质乳化机 | MJQ100型 | 无锡市欣田机械有限公司 |
2 | 自动灌装封尾机 | GF-400系列 | 浙江华联制药机械股份有限公司 |
3 | 电子秤 | TCS-60 | 梅特勒-托利多常州衡器有限公司 |
4 | 空调箱 | KAHDZ-08 | 浙江国祥制冷工业有限公司 |
5 | 金松爱妻号洗衣机 | XQB45-845 | 杭州松下家用电器有限公司 |
6 | 干衣机 | NH45-18T | 杭州松下家用电器有限公司 |
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201210356770.0A CN102885761B (zh) | 2012-09-24 | 2012-09-24 | 一种制备他克莫司软膏的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210356770.0A CN102885761B (zh) | 2012-09-24 | 2012-09-24 | 一种制备他克莫司软膏的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102885761A CN102885761A (zh) | 2013-01-23 |
CN102885761B true CN102885761B (zh) | 2015-08-05 |
Family
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CN201210356770.0A Active CN102885761B (zh) | 2012-09-24 | 2012-09-24 | 一种制备他克莫司软膏的方法 |
Country Status (1)
Country | Link |
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CN (1) | CN102885761B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106074363A (zh) * | 2016-07-12 | 2016-11-09 | 华北制药秦皇岛有限公司 | 一种他克莫司软膏剂及其制备方法 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103271826B (zh) * | 2013-05-15 | 2014-08-06 | 广东恒健制药有限公司 | 一种他克莫司软膏的工业化生产方法 |
CN103239391B (zh) * | 2013-05-16 | 2015-03-18 | 江苏知原药业有限公司 | 一种他克莫司软膏 |
CN104127369A (zh) * | 2014-07-02 | 2014-11-05 | 人福医药集团股份公司 | 他克莫司软膏及其制备方法 |
CN105769752B (zh) * | 2016-04-08 | 2018-12-11 | 湖北人福成田药业有限公司 | 制备他克莫司软膏的方法及他克莫司软膏 |
CN112022798B (zh) * | 2020-08-11 | 2022-04-29 | 四川大学华西医院 | 一种速效他克莫司软膏、制备方法及应用 |
CN113181367A (zh) * | 2021-03-30 | 2021-07-30 | 首都医科大学附属北京儿童医院 | 一种治疗结节性硬化症血管纤维瘤药物的制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1059468A (zh) * | 1990-09-04 | 1992-03-18 | 藤泽药品工业株式会社 | 含三环化合物的软膏 |
CN102176913A (zh) * | 2008-10-08 | 2011-09-07 | 高田制药株式会社 | 外用的他克莫司制剂 |
CN102579437A (zh) * | 2011-01-06 | 2012-07-18 | 中国医学科学院医药生物技术研究所 | 含醇的他克莫司组合物及其制备方法 |
-
2012
- 2012-09-24 CN CN201210356770.0A patent/CN102885761B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1059468A (zh) * | 1990-09-04 | 1992-03-18 | 藤泽药品工业株式会社 | 含三环化合物的软膏 |
CN102176913A (zh) * | 2008-10-08 | 2011-09-07 | 高田制药株式会社 | 外用的他克莫司制剂 |
CN102579437A (zh) * | 2011-01-06 | 2012-07-18 | 中国医学科学院医药生物技术研究所 | 含醇的他克莫司组合物及其制备方法 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106074363A (zh) * | 2016-07-12 | 2016-11-09 | 华北制药秦皇岛有限公司 | 一种他克莫司软膏剂及其制备方法 |
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Publication number | Publication date |
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CN102885761A (zh) | 2013-01-23 |
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Address after: 311305, 1, Wang Shan Road, Qingshan Lake Street, Hangzhou, Zhejiang, Ling'an Applicant after: ZHEJIANG WANSHENG PHARMACEUTICAL Co.,Ltd. Address before: 311305, 1, Wang Shan Road, Qingshan Lake Street, Hangzhou, Zhejiang, Ling'an Applicant before: ZHEJIANG WANMA PHARMACEUTICAL Co.,Ltd. |
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Address after: 311305 No.1 Wangjiashan Road, Qingshanhu Street, Lin'an, Hangzhou City, Zhejiang Province Patentee after: Zhejiang Sansheng Mandi Pharmaceutical Co.,Ltd. Country or region after: China Address before: 311305 No.1 Wangjiashan Road, Qingshanhu Street, Lin'an, Hangzhou City, Zhejiang Province Patentee before: ZHEJIANG WANSHENG PHARMACEUTICAL Co.,Ltd. Country or region before: China |